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    • 21. 发明申请
    • Method for Manufacturing Optically Active Tetrahydrothiophene Derivative and Method for Crystallization of Optically Active Tetrahydrothiophene-3-Ol
    • 光学活性四氢噻吩衍生物的制备方法和光活性四氢噻吩-3-O的结晶方法
    • US20080050787A1
    • 2008-02-28
    • US10581366
    • 2004-12-01
    • Hazuki NagaiKaname KonukiMasashi ItoTomohiro Sameshima
    • Hazuki NagaiKaname KonukiMasashi ItoTomohiro Sameshima
    • C12P17/00C07D333/32
    • C12P17/167
    • A method for manufacturing (R)-tetrahydrothiophene-3-ol denoted by formula (II): by bioconversion of tetrahydrothiophene-3-one denoted by formula (I): to (R)-tetrahydrothiophene-3-ol denoted by formula (II). It comprises the steps of: (A) incubating the tetrahydrothiophene-3-one denoted by formula (I) in the presence of a strain, or a preparation of a cultured cell thereof, belonging to Penicillium, Aspergillus, or Streptomyces that is capable of said bioconversion; and (B) collecting the (R)-tetrahydrothiophene-3-ol denoted by formula (II) from incubated solution. A method for crystallization of optically active tetrahydrothiophene-3-ol of improved optical purity, characterized by maintaining a solution comprising optically active tetrahydrothiophene-3-ol and organic solvent at equal to or lower than 1° C. to cause optically active tetrahydrothiophene-3-ol to crystallize from said solution, or characterized by adding optically active tetrahydrothiophene-3-ol dropwise to organic solvent at a solution temperature of equal to or lower than 1° C. to cause optically active tetrahydro thiophene-3-ol to crystallize.
    • 由式(II)表示的(R) - 四氢噻吩-3-醇的制造方法:通过式(I)表示的四氢噻吩-3-酮的生物转化:式(II)表示的(R) - 四氢噻吩-3-醇 )。 其包括以下步骤:(A)在菌株存在下将式(I)表示的四氢噻吩-3-酮或其培养细胞的制剂,属于青霉属,曲霉属或链霉菌属,其能够 说生物转化 和(B)从温育溶液中收集由式(II)表示的(R) - 四氢噻吩-3-醇。 一种提高光学纯度的光学活性四氢噻吩-3-醇的结晶方法,其特征在于将含有光学活性四氢噻吩-3-醇和有机溶剂的溶液保持在等于或低于1℃,使光学活性的四氢噻吩-3 - 醇从所述溶液中结晶,或者特征在于在等于或低于1℃的溶液温度下将光学活性的四氢噻吩-3-醇滴加到有机溶剂中,使光学活性的四氢噻吩-3-醇结晶。
    • 22. 发明申请
    • Primarily cultured adipocytes for gene therapy
    • 主要培养的脂肪细胞进行基因治疗
    • US20060121008A1
    • 2006-06-08
    • US10518472
    • 2003-06-18
    • Masashi ItoYasushi Saito
    • Masashi ItoYasushi Saito
    • A61K48/00C12N5/08C12N15/867C12N15/861
    • C12N5/0653A61K35/12C12N2510/00C12N2510/02
    • The present invention relates to primary cultured adipocytes for gene therapy, where the adipocytes stably maintain a foreign gene encoding a protein that is secreted outside of cells. This invention provides cells suitable for gene therapy, which can replace bone marrow cells and liver cells used for conventional ex vivo gene therapy. The present invention established methods for transferring foreign genes into primary cultured adipocytes, which are suitable for ex vivo gene therapy; can be easily collected and implanted; and can be removed after implantation. Specifically, the present invention established these methods that use retroviral vectors. The present invention also established primary cultured adipocytes for gene therapy, where the adipocytes stably maintain a foreign gene encoding a protein that is secreted outside of cells.
    • 本发明涉及用于基因治疗的原代培养的脂肪细胞,其中脂肪细胞稳定地维持编码在细胞外分泌的蛋白质的外源基因。 本发明提供适用于基因治疗的细胞,其可代替用于常规体外基因治疗的骨髓细胞和肝细胞。 本发明建立了将外源基因转移到适合离体基因治疗的原代培养脂肪细胞中的方法; 可以轻松收集和植入; 并且可以在植入后去除。 具体地,本发明建立了使用逆转录病毒载体的这些方法。 本发明还建立了用于基因治疗的原代培养的脂肪细胞,其中脂肪细胞稳定地保持编码在细胞外分泌的蛋白质的外源基因。
    • 23. 发明申请
    • Graphite-base hydrogen storage material and production method thereof
    • 石墨基储氢材料及其制备方法
    • US20060019162A1
    • 2006-01-26
    • US11175521
    • 2005-07-05
    • Minoru ShirahigeKoji YonetaJunji KatamuraMikio KawaiMasaharu HatanoMasashi Ito
    • Minoru ShirahigeKoji YonetaJunji KatamuraMikio KawaiMasaharu HatanoMasashi Ito
    • H01M4/58C01B31/02
    • H01M8/065B82Y30/00C01B3/0021C01B32/22Y02E60/325
    • Disclosed is a hydrogen storage material and a production method thereof. The hydrogen storage material has a carbon material having: an interlayer space for hydrogen occlusion, produced by removal at least a portion of an organic compound from a graphite intercalation compound comprising graphite and the organic compound intercalated in the graphite; and an active point at which hydrogen is adsorbed, being produced on the remaining organic compound and/or a part of the hexagonal carbon layers defining the interlayer space. It has a layered lattice structure with hexagonal carbon layers and an expanded interlayer space, and its density determined in accordance with He equilibrium pressure density measuring method changes according as pre-equilibrium He pressures and falls in a range of 0.2 to 1.2 g/cm3 at pre-equilibrium pressures of 0.2 MPa and 0.8 MPa. The hydrogen storage material is produced by; preparing an organic-graphite intercalation compound; and reducing the organic-graphite intercalation compound to remove at least a portion of the inserted organic compound from the organic-graphite intercalation compound, thereby forming an interlayer space.
    • 公开了一种储氢材料及其制造方法。 储氢材料具有碳材料,其具有:通过从包含石墨的石墨插层化合物和插入石墨中的有机化合物除去至少一部分有机化合物而产生的用于氢气闭塞的层间空间; 以及在剩余的有机化合物和/或限定层间空间的六方碳层的一部分上产生吸附氢的活性点。 它具有具有六方碳层和扩展的层间空间的层状晶格结构,并且其根据He平衡压力密度测量方法确定的密度根据平衡前He He压力而变化并且在0.2-1.2g / cm 2的范围内变化, 在0.2MPa和0.8MPa的平衡前压力下,SUP> 3。 储氢材料由 制备有机 - 石墨插层化合物; 并且还原有机 - 石墨插层化合物以从有机 - 石墨插入化合物中除去至少一部分插入的有机化合物,由此形成层间空间。
    • 26. 发明授权
    • Communication device, a control device, and a non-transitory computer readable medium
    • 通信设备,控制设备和非暂时计算机可读介质
    • US08976818B2
    • 2015-03-10
    • US13724135
    • 2012-12-21
    • Masashi ItoYasuyuki Kozakai
    • Masashi ItoYasuyuki Kozakai
    • H04J3/06H04J3/00H04L7/04
    • H04L7/04H04J3/0667
    • A communication device transmits a first packet to a first device via a network device, and receives a second packet from the first device. A transmission time between the communication device and the first device is calculated using time indicated by the communication device when the communication device transmitted the first packet, time indicated by the first device when the first device received the first packet, time indicated by the first device when the first device transmitted the second packet, time indicated by the communication device when the communication device received the second packet. A size of the first packet is set so that wait time of the first packet at the network device is within predetermined period. The wait time is calculated by assuming that a third packet transmitted from a second device is inputted to the network device before the first packet is inputted to the network device.
    • 通信设备经由网络设备向第一设备发送第一分组,并从第一设备接收第二分组。 当通信设备发送第一分组时,使用由通信设备指示的时间,当第一设备接收到第一分组时由第一设备指示的时间,由第一设备指示的时间,计算通信设备和第一设备之间的传输时间 当第一设备发送第二分组时,当通信设备接收到第二分组时由通信设备指示的时间。 设置第一分组的大小,使得网络设备处的第一分组的等待时间在预定时间段内。 通过假设在将第一分组输入到网络设备之前,将从第二设备发送的第三分组输入到网络设备来计算等待时间。