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21. 发明申请

WO2008072135A2 A MATRIX BASED ELECTROPORATION AND LYSIS ARRAY 审中-公开
标题翻译：基于MATRIX的电气和LYSIS阵列
公开(公告)号：WO2008072135A2
公开(公告)日：2008-06-19
申请号：PCT/IB2007/054929
申请日：2007-12-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VULTO, Simone, I., E. , JOHNSON, Mark, T. , VAN DAM, Dirkjan, B. , FRENCH, Ian , DE HOOG, Thomas, J. , PONJEE, Marc, W., G. , RENSEN, Judith, M.
发明人： VULTO, Simone, I., E. , JOHNSON, Mark, T. , VAN DAM, Dirkjan, B. , FRENCH, Ian , DE HOOG, Thomas, J. , PONJEE, Marc, W., G. , RENSEN, Judith, M.
IPC分类号： A61N1/32
CPC分类号： A61N1/327 , A61N1/0424 , A61N1/0476
摘要： An electroporation device for applying an electric field to a sample, has a planar array of electrodes (80), to provide an open surface suitable to receive the sample, and a matrix of intersecting control lines (40,50), and switching elements (30,35) at the intersections, coupled to the control lines, to control the electrodes, so that selecting intersecting ones of the control lines selects a corresponding electrode to be driven to create the electric field. The matrix of control lines can be implemented using large area integration and means that fewer control lines are needed, and so larger arrays of electrodes become more feasible, and gaps between electrodes can be smaller. The open surface is more suitable than sandwich structures for application to a surface of a solid sample such as skin.
摘要翻译：用于向样品施加电场的电穿孔装置具有平面阵列的电极（80），以提供适于接收样品的开放表面，以及交叉控制线（40,50）和开关元件（耦合到控制线的交点处，以控制电极，使得选择相交的控制线选择要驱动的相应电极以产生电场。可以使用大面积集成实现控制线的矩阵，意味着需要更少的控制线，因此更大的电极阵列变得更可行，并且电极之间的间隙可以更小。开放表面比夹层结构更适用于固体样品如皮肤的表面。

22. 发明申请

WO2007107934A1 MICROELECTRONIC DEVICE WITH HEATING ARRAY 审中-公开
标题翻译：具有加热阵列的微电子设备
公开(公告)号：WO2007107934A1
公开(公告)日：2007-09-27
申请号：PCT/IB2007/050911
申请日：2007-03-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JOHNSON, Mark, T. , FISH, David, A. , PONJEE, Marc, W., G.
发明人： JOHNSON, Mark, T. , FISH, David, A. , PONJEE, Marc, W., G.
IPC分类号： B01J19/00
CPC分类号： B01L3/50273 , B01L3/5027 , B01L3/502792 , B01L7/52 , B01L2200/147 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2300/1827 , B01L2300/1883 , B01L2400/0406 , B01L2400/0415 , B01L2400/0442 , B01L2400/0448
摘要： The invention relates to different designs of a microelectronic device comprising an array of heating elements (HE) with local driving units (CU2) and optionally with an array of sensor elements (SE) adjacent to a sample chamber (SC). By applying appropriate currents to the heating elements (HE), the sample chamber can be heated according to a desired temperature profile. The local driving units comprise means for compensating variations of their individual characteristics.
摘要翻译：本发明涉及微电子装置的不同设计，其包括具有局部驱动单元（CU2）的加热元件阵列（HE）和可选地具有与样本室（SC）相邻的传感器元件阵列（SE）的阵列。通过向加热元件（HE）施加适当的电流，可以根据期望的温度分布来加热样品室。本地驱动单元包括用于补偿其各自特征的变化的装置。

23. 发明申请

WO2008072166A1 METHOD AND APPARATUS FOR CELL ANALYSIS 审中-公开
标题翻译：细胞分析的方法和装置
公开(公告)号：WO2008072166A1
公开(公告)日：2008-06-19
申请号：PCT/IB2007/054994
申请日：2007-12-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JOHNSON, Mark, T. , RENSEN, Judith, M. , VAN DAM, Dirkjan, B. , FRENCH, Ian , DE HOOG, Thomas, J. , PONJEE, Marc, W., G. , VULTO, Simone, I., E. , VOSSENAAR, Erik, R.
发明人： JOHNSON, Mark, T. , RENSEN, Judith, M. , VAN DAM, Dirkjan, B. , FRENCH, Ian , DE HOOG, Thomas, J. , PONJEE, Marc, W., G. , VULTO, Simone, I., E. , VOSSENAAR, Erik, R.
IPC分类号： C12M3/00
CPC分类号： C12M35/02 , H04N1/60
摘要： A method and apparatus for investigating the electroporation properties of cells suspended in a fluid. The apparatus comprises: first and second substrates spaced apart from each other; a first array of electrodes formed on a surface of the first substrate; at least one electrode formed on the surface of the second substrate facing the first array of electrodes. The at least one electrode and the first array of electrodes thereby define the upper and lower bounds of an analysis volume for receiving the fluid, the analysis volume comprising an array of volume portions. Circuitry is arranged to modify the amplitude and duration of a voltage applied to at least the first array of electrodes so as to generate and modify an electric field in one or more volume portions of the device. Thus, the 10 electroporation properties of the cells may be investigated by generat ing electric fields of different amplitudes or durations in one or more volume portions of the apparatus with the fluid placed therein.
摘要翻译：用于研究悬浮在流体中的细胞的电穿孔性质的方法和装置。该装置包括：彼此间隔开的第一和第二基板; 形成在所述第一基板的表面上的第一电极阵列; 形成在所述第二基板的面向所述第一电极阵列的表面上的至少一个电极。由此，至少一个电极和第一电极阵列限定用于接收流体的分析体积的上限和下限，分析体积包括体积部分的阵列。布置电路以修改施加到至少第一电极阵列的电压的幅度和持续时间，以便产生和修改器件的一个或多个体积部分中的电场。因此，可以通过在放置其中的流体的一个或多个体积部分中产生不同幅度或持续时间的电场来研究电池的10个电穿孔性质。

24. 发明申请

WO2008041190A2 METHODS AND SYSTEMS FOR DETECTION WITH FRONT IRRADIATION 审中-公开
标题翻译：用于检测前辐射的方法和系统
公开(公告)号：WO2008041190A2
公开(公告)日：2008-04-10
申请号：PCT/IB2007/054022
申请日：2007-10-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JOHNSON, Mark, T. , PONJEE, Marc, W., G. , BALISTRERI, Marcello, L., M. , VAN HERPEN, Maarten M., J., W. , KLUNDER, Derk, J., W.
发明人： JOHNSON, Mark, T. , PONJEE, Marc, W., G. , BALISTRERI, Marcello, L., M. , VAN HERPEN, Maarten M., J., W. , KLUNDER, Derk, J., W.
IPC分类号： G01N21/64 , B01L3/00
CPC分类号： G01N21/6428 , B01L3/5027 , G01N21/6454
摘要： A radiation detection system (100) is described comprising a measurement region (104) in a measurement chamber adapted for receiving at least one sample (108) to be examined and adapted for receiving excitation radiation for impingement on the at least one sample (108) and for generating sample radiation. The radiation detection system (100) furthermore comprises at least one detector element (106) for detection of the generated sample radiation. The radiation detection system thereby is a front irradiation system, i.e. the excitation radiation is incident on a first side of the measurement region (104) in a measurement chamber and the at least one detector element (106) is positioned at a second side of the measurement region (104) in a measurement chamber, the second side being opposite to the first side with respect to the measurement region (104) in a measurement chamber, such that detection occurs at the side facing the first side. The detection system (100) also comprises optical means (112) adapted for guiding said excitation radiation aside the at least one detector element (106).
摘要翻译：描述了辐射检测系统（100），其包括在测量室中的测量区域（104），其适于接收待检查的至少一个样品（108）并适于接收用于冲击至少一个样品（108）的激发辐射，并用于产生样品辐射。辐射检测系统（100）还包括用于检测所产生的样品辐射的至少一个检测器元件（106）。因此，辐射检测系统是前照射系统，即激发辐射入射在测量室中的测量区域（104）的第一侧上，并且所述至少一个检测器元件（106）位于第二侧测量室中的测量区域（104），第二侧在测量室中相对于测量区域（104）与第一侧相对，使得在面向第一侧的一侧发生检测。检测系统（100）还包括适于将所述激发辐射引导到所述至少一个检测器元件（106）旁边的光学装置（112）。

25. 发明申请

WO2008012703A1 RADIATION DETECTORS USING EVANESCENT FIELD EXCITATION 审中-公开
标题翻译：使用现场激励的辐射探测器
公开(公告)号：WO2008012703A1
公开(公告)日：2008-01-31
申请号：PCT/IB2007/052612
申请日：2007-07-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KLUNDER, Derk, J., W. , VAN HERPEN, Maarten, M., J., W. , BALISTRERI, Marcello, L., M. , PONJEE, Marc, W., G. , JOHNSON, Mark, T.
发明人： KLUNDER, Derk, J., W. , VAN HERPEN, Maarten, M., J., W. , BALISTRERI, Marcello, L., M. , PONJEE, Marc, W., G. , JOHNSON, Mark, T.
IPC分类号： G01N21/64 , G01N15/14 , C12Q1/68 , B01L3/00 , G01N33/551
CPC分类号： G01N21/6454 , B01L3/5027 , G01N21/6428 , G01N21/648 , G01N2021/7786
摘要： A detection system (100, 150, 180, 200, 220, 250) for detecting luminescence from at least one sample (108) when excited by incident excitation radiation. Detecting luminescence may allow to detect, for example, biological, chemical or bio-chemical particles. The detection system (100, 150, 180, 200, 220, 250) comprising at least one optical component (102) with at least a first surface (104). The first surface (104) of the at least one optical component (102) is located to internally reflect incident excitation radiation to create an evanescent field outside the at least one optical component (102) for exciting the at least one sample (108). The detection system also comprises at least one detector element (110) that is in direct contact with the at least one optical component (102) to detect the luminescence from at least one excited sample (108) through the at least one optical component (102).
摘要翻译：用于当由入射激发辐射激发时用于检测来自至少一个样品（108）的发光的检测系统（100,150,180,200,220,250）。检测发光可以允许检测例如生物，化学或生物化学颗粒。所述检测系统（100,150,180,200,220,250）包括具有至少一个第一表面（104）的至少一个光学部件（102）。所述至少一个光学部件（102）的第一表面（104）位于内部反射入射的激发辐射，以在所述至少一个光学部件（102）外部产生消逝场，用于激发所述至少一个样品（108）。检测系统还包括至少一个与至少一个光学部件（102）直接接触的检测器元件（110），以检测来自至少一个激发的样品（108）的至少一个光学部件（102）的发光）。

26. 发明申请

WO2007063457A2 BIO CHIP DEVICE WITH A SAMPLE COMPARTMENT AND A LIGHT SENSITIVE ELEMENT, METHOD FOR THE DETECTION OF FLUORESCENT PARTICLES WITHIN AT LEAST ONE SAMPLE COMPARTMENT OF A BIO CHIP DEVICE 审中-公开
标题翻译：具有样品室和光敏元件的生物芯片装置，用于检测生物芯片装置的至少一个样品室内的荧光颗粒的方法
公开(公告)号：WO2007063457A2
公开(公告)日：2007-06-07
申请号：PCT/IB2006/054397
申请日：2006-11-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PONJEE, Marc, W., G. , JOHNSON, Mark, T. , BALISTRERI, Marcello, L., M. , VAN HERPEN, Maarten, M., J., W. , KLUNDER, Derk, J., W.
发明人： PONJEE, Marc, W., G. , JOHNSON, Mark, T. , BALISTRERI, Marcello, L., M. , VAN HERPEN, Maarten, M., J., W. , KLUNDER, Derk, J., W.
IPC分类号： G01N21/64 , G01N21/25
CPC分类号： G01N21/6454
摘要： The invention provides a bio chip device comprising at least one sample compartment and at least one light sensitive element, the at least one sample compartment being provided on a first side of the at least one light sensitive element, wherein incident light is provided incident from a second side opposite of the first side of the at least one light sensitive element. Further, the invention provides a method for the detection of fluorescent particles within at least one sample compartment of a bio chip device.
摘要翻译：本发明提供了一种生物芯片装置，其包括至少一个样品隔室和至少一个光敏元件，所述至少一个样品隔室设置在所述至少一个光敏元件的第一侧上，其中入射光从所述至少一个光敏元件的第一侧的相反的第二侧入射。此外，本发明提供了用于检测生物芯片装置的至少一个样品隔室内的荧光颗粒的方法。

27. 发明申请

WO2007034437A2 A MICRO-FLUIDIC DEVICE BASED UPON ACTIVE MATRIX PRINCIPLES 审中-公开
标题翻译：基于有源矩阵原理的微流体设备
公开(公告)号：WO2007034437A2
公开(公告)日：2007-03-29
申请号：PCT/IB2006/053434
申请日：2006-09-22
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PONJEE, Marc, W., G. , STAPERT, Hendrik, R. , JOHNSON, Mark, T.
发明人： PONJEE, Marc, W., G. , STAPERT, Hendrik, R. , JOHNSON, Mark, T.
CPC分类号： B01L3/502707 , B01L3/502715 , B01L2200/10 , B01L2200/143 , B01L2300/023 , B01L2300/0636 , B01L2300/0645 , B01L2300/0819 , B01L2300/1822 , B01L2300/1827 , B01L2400/0415
摘要： A micro-fluidic device (1) including a two-dimensional array of a plurality of components (2) for processing a fluid and/or for sensing properties of the fluid is suggested. Each component (2) is coupled to at least one control terminal (9,10) enabling an active matrix to change the state of each component individually. The components comprise at least one heater element (13). The active matrix includes a two-dimensional array of electronic components (12) realized in thin film technology. The active matrix provides a high versatility of the device. The thin film technology ensures a very cost efficient manufacturing also of large devices.
摘要翻译：提出了包括用于处理流体和/或感测流体性质的多个组件（2）的二维阵列的微流体装置（1）。每个组件（2）耦合到至少一个控制终端（9,10），使得有源矩阵能够单独改变每个组件的状态。这些部件包括至少一个加热元件（13）。有源矩阵包括以薄膜技术实现的电子元件（12）的二维阵列。有源矩阵提供了高通用性的器件。薄膜技术确保了大型设备的高性价比制造。

28. 发明申请

WO2007034374A2 A MICRO-FLUIDIC DEVICE BASED UPON ACTIVE MATRIX PRINCIPLES 审中-公开
标题翻译：基于有源矩阵原理的微流体设备
公开(公告)号：WO2007034374A2
公开(公告)日：2007-03-29
申请号：PCT/IB2006/053256
申请日：2006-09-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JOHNSON, Mark, T. , PONJEE, Marc, W., G.
发明人： JOHNSON, Mark, T. , PONJEE, Marc, W., G.
CPC分类号： B01L3/502707 , B01L3/502715 , B01L2200/10 , B01L2200/143 , B01L2300/023 , B01L2300/0636 , B01L2300/0645 , B01L2300/0819 , B01L2300/1822 , B01L2300/1827 , B01L2400/0415
摘要： A micro-fluidic device (1) including a two-dimensional array of a plurality of components (2) for processing a fluid and/or for sensing properties of the fluid is suggested. Each component (2) is coupled to at least one control terminal (9,10) enabling an active matrix to change the state of each component individually. The active matrix includes a two- dimensional array of electronic components (12) realized in thin film technology. The active matrix provides a high versatility of the device. The thin film technology ensures a very cost efficient manufacturing also of large devices.
摘要翻译：提出了包括用于处理流体和/或感测流体性质的多个组件（2）的二维阵列的微流体装置（1）。每个组件（2）耦合到至少一个控制终端（9,10），使得有源矩阵能够单独改变每个组件的状态。有源矩阵包括以薄膜技术实现的电子元件（12）的二维阵列。有源矩阵提供了高通用性的器件。薄膜技术确保了大型设备的高性价比制造。

29. 发明申请

WO2007105146A1 DRIVING AN IN-PLANE PASSIVE MATRIX DISPLAY 审中-公开
标题翻译：驾驶无人机被动矩阵显示
公开(公告)号：WO2007105146A1
公开(公告)日：2007-09-20
申请号：PCT/IB2007/050740
申请日：2007-03-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JOHNSON, Mark, T. , BUDZELAAR, Franciscus, P., M. , VERSCHUEREN, Alwin, R., M. , VAN DELDEN, Martinus, H., W., M. , ROOSENDAAL, Sander, J. , GILLIES, Murray, F.
发明人： JOHNSON, Mark, T. , BUDZELAAR, Franciscus, P., M. , VERSCHUEREN, Alwin, R., M. , VAN DELDEN, Martinus, H., W., M. , ROOSENDAAL, Sander, J. , GILLIES, Murray, F.
IPC分类号： G09G3/34
CPC分类号： G09G3/3446 , G02F2001/1676 , G09G2300/06
摘要： A driving circuit for driving an in-plane moving particle device has a pixel (P) comprising movable charged particles (PA). The pixel (P) has a reservoir electrode (RE), a display electrode (DE), and a gate electrode (GE) laterally placed in-between the reservoir electrode (RE) and the display electrode (DE). The driving circuit (DC) comprises a driver (DR), a controller (CO) which receives an input signal (OS) representing an image to be displayed on the moving particle device. The controller (CO) controls the driver (DR) to supply a first voltage difference (VDl) between the reservoir electrode (RE) and the gate electrode (GE) and a second voltage difference (VD2) between the gate electrode (GE) and the display electrode (DE). The image is written to the pixel (P) during a write phase (TW) by moving particles (PA) from the reservoir electrode (RE) via the gate electrode (GE) to the display electrode (DE) if the optical state of the pixel (P) should change in conformity with the image. If during the write phase (TW) the optical state of the pixel (P) should not change, the first voltage difference (VDl) has a first write level and the second voltage difference (VD2) has a second write level, both write levels are selected to repulse the particles (PA) from the gate electrode (GE). During a repulsion period (TR), the first voltage difference (VDl) has a level more repulsive to the particles than the first write level, and/or the second voltage difference (VD2) has a level more repulsive than the second write level.
摘要翻译：用于驱动面内移动粒子装置的驱动电路具有包括可移动带电粒子（PA）的像素（P）。像素（P）具有横向放置在储存器电极（RE）和显示电极（DE）之间的储存器电极（RE），显示电极（DE）和栅电极（GE）。驱动电路（DC）包括驱动器（DR），控制器（CO），其接收表示要在移动粒子装置上显示的图像的输入信号（OS）。控制器（CO）控制驱动器（DR）以在储存电极（RE）和栅电极（GE）之间提供第一电压差（VD1），并且在栅电极（GE）和显示电极（DE）。在写入阶段（TW）期间，通过将粒子（PA）从储存电极（RE）经由栅电极（GE）移动到显示电极（DE），将图像写入像素（P），如果光学状态像素（P）应该与图像一致。如果在写入阶段（TW）期间，像素（P）的光学状态不应该改变，则第一电压差（VD1）具有第一写入电平，并且第二电压差（VD2）具有第二写入电平，两个写入电平被选择为从栅电极（GE）中击退颗粒（PA）。在排斥周期（TR）期间，第一电压差（VD1）具有比第一写入电平更为排斥粒子的电平，和/或第二电压差（VD2）具有比第二写入电平更具有排斥性的电平。

30. 发明申请

WO2009060350A1 MICROELECTRONIC SENSOR DEVICE 审中-公开
标题翻译：微电子传感器装置
公开(公告)号：WO2009060350A1
公开(公告)日：2009-05-14
申请号：PCT/IB2008/054493
申请日：2008-10-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN HERPEN, Maarten, M.J.W. , VOSSEN, Dirk, L.J , GILLIES, Murray, F. , KLUNDER, Derk, J.W. , JOHNSON, Mark, T. , PONJEE, Marc, W.G.
发明人： VAN HERPEN, Maarten, M.J.W. , VOSSEN, Dirk, L.J , GILLIES, Murray, F. , KLUNDER, Derk, J.W. , JOHNSON, Mark, T. , PONJEE, Marc, W.G.
IPC分类号： G01N21/55 , G01N21/64 , G01N33/551
CPC分类号： G01N21/7743 , G01N21/13 , G01N21/554 , G01N21/6452 , G01N21/648 , G01N33/5438
摘要： The invention concerns a microelectronic sensor device (100) for the detection of target components (19) near a binding surface (12). The sensor (100) comprises an aperture defining structure (20), at least one aperture (4) having a smallest in plane aperture dimension (W1) smaller than a diffraction limit defined by the radiation wavelength and a medium for containing the target components (10). A source (21) is provided for emitting a beam of radiation (101) having a wavelength incident at the aperture defining structure (20), for providing evanescent radiation, in response to the radiation (101) incident at the structure (20), in a detection volume (13) formed in the aperture (14). In addition a detector (31) is provided for determining radiation (102) from the target component (10) present in the detection volume (13), in response to the emitted incident radiation (101) from the source (21). An electrode (112) is provided near the aperture defining structure (20), so as to transport the target components (10) in between the apertures (4) by applying an electric field; and a charging circuit (113) for charging the electrode (112).
摘要翻译：本发明涉及用于检测接合表面（12）附近的目标部件（19）的微电子传感器装置（100）。传感器（100）包括孔限定结构（20），具有小于由辐射波长限定的衍射极限的平面孔尺寸（W1）最小的至少一个孔（4）和用于容纳目标成分的介质 10）。源（21）被提供用于发射具有入射在孔限定结构（20）处的波长的辐射束（101），用于响应于在结构（20）处入射的辐射（101）来提供渐逝辐射，在形成在孔（14）中的检测体积（13）中。此外，响应于来自源（21）的发射入射辐射（101），提供检测器（31），用于根据存在于检测体积（13）中的目标成分（10）来确定辐射（102）。在孔限定结构（20）附近设置电极（112），以便通过施加电场将目标部件（10）传送到孔（4）之间; 以及用于对电极（112）充电的充电电路（113）。

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