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    • 21. 发明申请
    • Protein compositions for promoting wound healing and skin regeneration
    • 用于促进伤口愈合和皮肤再生的蛋白质组合物
    • US20070014777A1
    • 2007-01-18
    • US11430574
    • 2006-05-09
    • Zoltan Kiss
    • Zoltan Kiss
    • A61K38/46A61K38/40A61K38/17A61K38/54
    • A61K38/1741A61K38/40A61K38/465A61K38/57C12Y301/03001A61K2300/00
    • Methods for stimulating proliferation and inhibiting death of cells in the epidermis and dermis of wounded and non-wounded as well as transplanted mammalian skin and transplanted skin cell suspensions are described. The methods include the steps of administering to an area of wounded or non-wounded skin therapeutically effective amounts of α1-antitrypsin, alkaline phosphatase (such as placental alkaline phosphatase), transferrin, and α1-acid glycoprotein in compositions that contain at least two of these proteins, or their active derivatives, as the major active components. The compositions can be administered topically and/or by injection, or both. The invention also provides regimens for restoring or maintaining the strength and thickness of wounded, non-wounded and transplanted skin as well as developing new skin from skin cell suspensions comprising periodically administering one or more compositions topically and/or by injection.
    • 描述了刺激增殖和抑制伤口和未受伤的表皮和真皮细胞以及移植的哺乳动物皮肤和移植的皮肤细胞悬浮液中的细胞死亡的方法。 所述方法包括以下步骤:给受伤或非伤口皮肤的区域施用治疗有效量的α1 - 胰蛋白酶,碱性磷酸酶(例如胎盘碱性磷酸酶),转铁蛋白和α 含有这些蛋白质或其活性衍生物中的至少两种作为主要活性成分的组合物中的1α-酸性糖蛋白。 组合物可以局部施用和/或通过注射或两者施用。 本发明还提供了恢复或维持受伤的,未受伤的和移植的皮肤的强度和厚度以及从皮肤细胞悬浮液开发新皮肤的方案,其包括局部地和/或通过注射周期性地施用一种或多种组合物。
    • 24. 发明授权
    • Compositions and methods to control abnormal cell growth
    • 控制异常细胞生长的组成和方法
    • US07943606B2
    • 2011-05-17
    • US12572793
    • 2009-10-02
    • Zoltan Kiss
    • Zoltan Kiss
    • A61K31/382C07D335/16
    • C07D335/08C07D335/16
    • A class of compounds commonly containing a trialkylammonium group have been synthesized and characterized as anticancer compounds. They can be used alone or in combination with other therapies to treat cancer and other cell proliferative diseases. Representative compounds of this class, N,N-diethyl-N-methyl-2-[(9-oxo-9H-thioxanthen-2-yl)methoxy]ethanaminium iodide and N,N-diethyl-N-allyl-3-(2-methyl-9H-thioxanthen-9-ylidene)-propane-1-aminium bromide, were shown in various tumor models to decrease tumor volume, enhance the effects of other chemotherapeutic agents including cisplatin, reduce chemotherapy-induced loss of body weight, and increase survival of animals co-treated with toxic amounts of cisplatin. These compounds had even greater effects on tumor volume, body weight, and survival when administered together with the human protein placental alkaline phosphatase.
    • 通常含有三烷基铵基团的一类化合物已被合成并被表征为抗癌化合物。 它们可以单独使用或与其他疗法组合用于治疗癌症和其他细胞增殖性疾病。 该类的代表性化合物是N,N-二乙基-N-甲基-2 - [(9-氧代-9H-噻吨-2-基)甲氧基]乙胺碘化物和N,N-二乙基-N-烯丙基-3-( 2-甲基-9H-噻吨-9-亚基) - 丙烷-1-氨基溴化物,显示在各种肿瘤模型中,以减少肿瘤体积,增强其他化学治疗剂(包括顺铂)的作用,减少化疗引起的体重下降, 并增加用有毒量的顺铂共同处理的动物的存活。 当与人类蛋白质胎盘碱性磷酸酶一起施用时,这些化合物对肿瘤体积,体重和存活率具有更大的影响。
    • 26. 发明授权
    • Alkaline phosphatase compositions to reduce skin cancer
    • 碱性磷酸酶组合物以减少皮肤癌
    • US07718170B2
    • 2010-05-18
    • US11465876
    • 2006-08-21
    • Zoltan Kiss
    • Zoltan Kiss
    • A61K38/46
    • A61K38/57A61K38/40A61K38/465A61K45/06C12Y301/03001A61K2300/00
    • Compositions of human proteins, methods and regimens for reducing the occurrence and growth of skin cancer, including melanoma, are provided. The methods include steps of administering topically on the skin tumor or a skin cancer-free area of compositions containing therapeutically effective amounts of human alkaline phosphatase, transferrin and α1-antitrypsin. In some embodiments, the composition is topically administered and includes all three proteins. Alkaline phosphatase, alone or in combination with transferrin and α1-antitrypsin can also be administered by injection with or without simultaneous or sequential topical administration. Administration of compositions topically and/or by injection can be part of a more complex cancer therapy including chemotherapy, radiotherapy, surgery, and electrochemotherapy.
    • 提供了人类蛋白质的组合物,用于减少包括黑素瘤在内的皮肤癌的发生和生长的方法和方案。 所述方法包括以下步骤:局部施用皮肤肿瘤或含有治疗有效量的人碱性磷酸酶,转铁蛋白和α1-抗胰蛋白酶的组合物的无皮肤癌的区域。 在一些实施方案中,组合物被局部施用并包括所有三种蛋白质。 单独或与转铁蛋白和α1-抗胰蛋白酶组合的碱性磷酸酶也可以通过注射给予或不用同时或顺序的局部给药。 局部和/或通过注射给药的组合物可以是更复杂的癌症治疗的一部分,包括化疗,放射治疗,手术和电化疗。
    • 27. 发明授权
    • Use of alkaline phosphatase to maintain healthy tissue mass in mammals
    • 使用碱性磷酸酶维持哺乳动物的健康组织
    • US07695714B2
    • 2010-04-13
    • US11463022
    • 2006-08-08
    • Zoltan Kiss
    • Zoltan Kiss
    • A61K38/46
    • A61K38/465C12Y301/03001
    • Embodiments of the present invention relate to the use of placental alkaline phosphatase, and other members of the alkaline phosphatase family, to enhance protein synthesis in the muscle as well as the survival of non-cancerous differentiated cells in the muscle, adipose and other tissues. The ability of alkaline phosphatase to selectively enhance the survival of healthy cells and increase protein synthesis has many therapeutic applications. The use of alkaline phosphatase may prevent the loss of body weight and muscle mass typically experienced by diseased (such as cancer) or aging patients, or developing fetuses subjected to harmful conditions, or by patients who are treated with a toxic therapy including chemotherapy.
    • 本发明的实施方案涉及使用胎盘碱性磷酸酶和碱性磷酸酶家族的其它成员来增强肌肉中的蛋白质合成以及肌肉,脂肪和其它组织中非癌分化细胞的存活。 碱性磷酸酶选择性增强健康细胞存活和增加蛋白质合成的能力有很多治疗应用。 碱性磷酸酶的使用可以防止患病(例如癌症)或老化患者,或发展有害病症的胎儿或通过包括化疗在内的有毒疗法治疗的患者经历的体重和肌肉量的丧失。
    • 28. 发明申请
    • PLACENTAL ALKALINE PHOSPHATASE TO CONTROL DIABETES
    • 普通碱性磷酸酶控制糖尿病
    • US20090130080A1
    • 2009-05-21
    • US12361310
    • 2009-01-28
    • Zoltan Kiss
    • Zoltan Kiss
    • A61K38/46
    • C12N9/16A61K9/127A61K31/00A61K38/00A61K38/28A61K45/06C12Y301/03001A61K2300/00
    • The present invention provides methods for using human placental alkaline phosphatase or an active derivative to reduce blood glucose level in a mammal. Treatment regimens provided by the invention may be used to control Type 1 and Type 2 forms of diabetes in humans. The methods and treatment regimens may be effective to maintain the human's blood glucose level below about 10 mM, and preferably within the normal range of 4 mM to 7 mM. The methods and treatment regimens may be used in combination with administration of known anti-diabetic medicaments. Also provided by the invention is a method for inducing weight loss or reducing an expected weight gain caused by or associated with obesity or Type 2 diabetes. The invention further provides a preparation for administration to a human, the preparation comprising homogeneous purified human placental alkaline phosphatase in a physiologically acceptable carrier.
    • 本发明提供使用人胎盘碱性磷酸酶或活性衍生物降低哺乳动物血糖水平的方法。 本发明提供的治疗方案可用于控制人类1型和2型糖尿病。 方法和治疗方案可能有效地将人的血糖水平维持在低于约10mM,优选在4mM至7mM的正常范围内。 方法和治疗方案可以与已知的抗糖尿病药物的给药组合使用。 本发明还提供了一种诱导体重减轻或减少由肥胖或2型糖尿病引起或与之相关的预期体重增加的方法。 本发明还提供了一种用于给予人的制剂,所述制剂包含在生理上可接受的载体中的均质纯化的人胎盘碱性磷酸酶。