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1. 发明申请

WO2012054057A1 ALKALINE PHOSPHATASE TO CORRECT INSULIN RESISTANCE, HYPERINSULINEMIA, AND DYSLIPIDEMIA 审中-公开
标题翻译：碱性磷酸酶修复胰岛素抵抗，高胰岛素和糖尿病
公开(公告)号：WO2012054057A1
公开(公告)日：2012-04-26
申请号：PCT/US2010/053745
申请日：2010-10-22
申请人： ZOLTAN KISS CONSULTING , ZOLTAN, Kiss
发明人： ZOLTAN, Kiss
IPC分类号： A61K38/46
CPC分类号： A61K38/465 , A61K35/20 , A61K35/50 , A61K38/46 , C12N9/16 , C12Y301/03001 , A61K2300/00
摘要： This invention provides an alkaline phosphatase or an active derivative of placental alkaline phosphatase to prevent or reduce one, two, or all three of interrelated metabolic disorders, i.e. insulin resistance, hyperinsulinemia, and dyslipidemia. Alkaline phosphatase or an active derivative of placental alkaline phosphatase is suitable to prevent or reduce diseases and disorders relating to insulin resistance, hyperinsulinemia, and dyslipidemia including type 2 diabetes, epithelial cancers, myopia, acne, acanthosis nigricans, polycystic ovary syndrome, cutaneous papillomas, hypertension, renal dysfunction, microvascular and macrovascular diseases, atherosclerosis, nonalcoholic fat liver, dyslipidemia, sleep-disordered breathing, atherosclerosis, coronary artery (heart) disease, cardiovascular disease, heart failure, accelerated aging, stroke, and neurological diseases such as Alzheimer.
摘要翻译：本发明提供碱性磷酸酶或胎盘碱性磷酸酶的活性衍生物，以预防或减少相关代谢紊乱，即胰岛素抵抗，高胰岛素血症和血脂异常中的一种，两种或全部三种。碱性磷酸酶或胎盘碱性磷酸酶的活性衍生物适用于预防或减少与胰岛素抵抗，高胰岛素血症和血脂异常有关的疾病和障碍，包括2型糖尿病，上皮癌，近视，痤疮，黑棘皮病，多囊卵巢综合征，皮肤乳头状瘤，高血压，肾功能不全，微血管和大血管疾病，动脉粥样硬化，非酒精性脂肪肝，血脂异常，睡眠呼吸障碍，动脉粥样硬化，冠状动脉（心脏）疾病，心血管疾病，心力衰竭，加速老化，中风和神经系统疾病如阿尔茨海默病。

2. 发明申请

US20140133137A1 MODULAR ILLUMINATING TILE 审中-公开
标题翻译：模块化照明
公开(公告)号：US20140133137A1
公开(公告)日：2014-05-15
申请号：US14232300
申请日：2012-07-04
申请人： Zoltan Kiss
发明人： Zoltan Kiss
IPC分类号： F21V33/00
CPC分类号： F21V33/006 , E04F13/0862 , E04F15/02194 , E04F15/082 , F21S2/005 , H05B33/0803 , H05B33/0815 , H05B33/0872 , Y02B20/341
摘要： A modular illuminating tile (1) comprising a carrier board (8); at least one illuminating element (10) fixed on the carrier board (8); power supply supplying electrical energy to the illuminating element (10), a protective cover associated with the illuminating element (10). The at least one illuminating element (10) is soldered on the carrier board (8); the power supply is connected via wiring (9) to at least one electrical connecting means (11) adjoined mechanically on the carrier board (8), whereas the at least one connecting means (11) is fixed on the carrier board (8) so as to permit arbitrarily mechanical and electrical serial connection of several modular illuminating tiles (1).
摘要翻译：一种包括承载板（8）的模块化照明瓦（1）固定在所述承载板（8）上的至少一个照明元件（10）。向所述照明元件（10）供应电能的电源，与所述照明元件（10）相关联的保护盖。所述至少一个照明元件（10）焊接在所述承载板（8）上; 电源通过布线（9）连接到与承载板（8）机械连接的至少一个电连接装置（11），而至少一个连接装置（11）固定在承载板（8）上以允许多个模块化照明瓦片（1）的任意机械和电气串联连接。

3. 发明申请

US20130251701A1 ALKALINE PHOSPHATASE TO CORRECT INSULIN RESISTANCE, HYPERINSULINEMIA, AND DYSLIPIDEMIA 审中-公开
标题翻译：碱性磷酸酶修复胰岛素抵抗，高胰岛素和糖尿病
公开(公告)号：US20130251701A1
公开(公告)日：2013-09-26
申请号：US13879080
申请日：2010-10-22
申请人： Zoltan Kiss
发明人： Zoltan Kiss
IPC分类号： A61K38/46 , C12N9/16
CPC分类号： A61K38/465 , A61K35/20 , A61K35/50 , A61K38/46 , C12N9/16 , C12Y301/03001 , A61K2300/00
摘要： This invention provides an alkaline phosphatase or an active derivative of placental alkaline phosphatase to prevent or reduce one, two, or all three of interrelated metabolic disorders, i.e. insulin resistance, hyperinsulinemia, and dyslipidemia. Alkaline phosphatase or an active derivative of placental alkaline phosphatase is suitable to prevent or reduce diseases and disorders relating to insulin resistance, hyperinsulinemia, and dyslipidemia including type 2 diabetes, epithelial cancers, myopia, acne, acanthosis nigricans, polycystic ovary syndrome, cutaneous papillomas, hypertension, renal dysfunction, microvascular and macrovascular diseases, atherosclerosis, nonalcoholic fat liver, dyslipidemia, sleep-disordered breathing, atherosclerosis, coronary artery (heart) disease, cardiovascular disease, heart failure, accelerated aging, stroke, and neurological diseases such as Alzheimer.
摘要翻译：本发明提供碱性磷酸酶或胎盘碱性磷酸酶的活性衍生物，以预防或减少相关代谢紊乱，即胰岛素抵抗，高胰岛素血症和血脂异常中的一种，两种或全部三种。碱性磷酸酶或胎盘碱性磷酸酶的活性衍生物适用于预防或减少与胰岛素抵抗，高胰岛素血症和血脂异常有关的疾病和障碍，包括2型糖尿病，上皮癌，近视，痤疮，黑棘皮病，多囊卵巢综合征，皮肤乳头状瘤，高血压，肾功能不全，微血管和大血管疾病，动脉粥样硬化，非酒精性脂肪肝，血脂异常，睡眠呼吸障碍，动脉粥样硬化，冠状动脉（心脏）疾病，心血管疾病，心力衰竭，加速老化，中风和神经系统疾病如阿尔茨海默病。

4. 发明申请

US20130154833A1 METER MAINTENANCE AND TAMPERING DETECTION SYSTEM AND METHOD 有权
标题翻译：仪表维护和篡改检测系统及方法
公开(公告)号：US20130154833A1
公开(公告)日：2013-06-20
申请号：US13331658
申请日：2011-12-20
申请人： Zoltan Kiss , Petros Raptis
发明人： Zoltan Kiss , Petros Raptis
IPC分类号： G08B13/08
CPC分类号： H04Q9/00 , H04Q2209/60
摘要： Methods, systems, and devices for managing an end-device connected to a commodity delivery network. One device includes computer-readable medium containing instructions for managing the end-device and a processor for executing the instructions. The instructions include instructions for detecting tampering of the end-device, ignoring the detected tampering when the end-device has been placed in an ignore mode, and automatically disconnecting the end-device from the commodity delivery system based on the detected tampering when the end-device has not been placed in the ignore mode.
摘要翻译：用于管理连接到商品交付网络的终端设备的方法，系统和设备。一个设备包括包含用于管理终端设备的指令和用于执行指令的处理器的计算机可读介质。指令包括用于检测终端设备的篡改的指令，当终端设备已经被置于忽略模式时忽略检测到的篡改，并且当终端设备已经被置于忽略模式时，根据检测到的篡改自动地将终端设备与商品传送系统断开连接 - 设备尚未置于忽略模式。

5. 发明授权

US07964188B2 Use of placental alkaline phosphatase to promote skin cell proliferation 有权
标题翻译：使用胎盘碱性磷酸酶促进皮肤细胞增殖
公开(公告)号：US07964188B2
公开(公告)日：2011-06-21
申请号：US11528172
申请日：2006-09-27
申请人： Zoltan Kiss
发明人： Zoltan Kiss
IPC分类号： A61K31/74 , A61K38/43
CPC分类号： A61K8/66 , A61K38/465 , A61Q19/08 , C12Y301/03001
摘要： Methods for promoting survival and stimulating proliferation of cells in the epidermis and dermis of undamaged mammalian skin are disclosed. The methods comprise the step of administering to an area of the skin a composition comprising a therapeutically effective amount of human placental alkaline phosphatase, or an active derivative. The composition can be administered topically or by injection. Embodiments of the invention also provide regimens for restoring or maintaining the strength and thickness of aging skin, comprising periodically administering a composition by topical application. Other embodiments of the invention further provide methods for promoting survival and stimulating proliferation of cells in the epidermis and dermis of transplanted skin. A composition for topical application is also provided by some embodiments of the invention.
摘要翻译：公开了用于促进存活和刺激未受损哺乳动物皮肤的表皮和真皮细胞增殖的方法。所述方法包括向皮肤区域施用包含治疗有效量的人胎盘碱性磷酸酶或活性衍生物的组合物的步骤。组合物可以局部施用或通过注射施用。本发明的实施方案还提供了恢复或维持老化皮肤的强度和厚度的方案，其包括通过局部施用周期性施用组合物。本发明的其它实施方案还提供促进存活和刺激移植皮肤表皮和真皮细胞增殖的方法。用于局部施用的组合物也由本发明的一些实施方案提供。

6. 发明申请

US20100158888A1 USE OF ALKALINE PHOSPHATASE TO MAINTAIN HEALTHY TISSUE MASS IN MAMMALS 有权
标题翻译：碱性磷酸酶对母体健康组织质量的使用
公开(公告)号：US20100158888A1
公开(公告)日：2010-06-24
申请号：US12715976
申请日：2010-03-02
申请人： Zoltan Kiss
发明人： Zoltan Kiss
IPC分类号： A61K38/46 , A61P3/02 , A61P21/00 , A61P3/00 , A61P17/02
CPC分类号： A61K38/465 , C12Y301/03001
摘要： Embodiments of the present invention relate to the use of placental alkaline phosphatase, and other members of the alkaline phosphatase family, to enhance protein synthesis in the muscle as well as the survival of non-cancerous differentiated cells in the muscle, adipose and other tissues. The ability of alkaline phosphatase to selectively enhance the survival of healthy cells and increase protein synthesis has many therapeutic applications. The use of alkaline phosphatase may prevent the loss of body weight and muscle mass typically experienced by diseased (such as cancer) or aging patients, or developing fetuses subjected to harmful conditions, or by patients who are treated with a toxic therapy including chemotherapy.
摘要翻译：本发明的实施方案涉及使用胎盘碱性磷酸酶和碱性磷酸酶家族的其它成员来增强肌肉中的蛋白质合成以及肌肉，脂肪和其它组织中非癌分化细胞的存活。碱性磷酸酶选择性增强健康细胞存活和增加蛋白质合成的能力有很多治疗应用。碱性磷酸酶的使用可以防止患病（例如癌症）或老化患者或发展中的有胎儿患有体重和肌肉量的损失，或通过包括化疗在内的有毒疗法治疗的患者。

7. 发明申请

US20090317372A1 SMALL MOLECULES FOR THE REDUCTION OF HIGH BLOOD GLUCOSE LEVEL 审中-公开
标题翻译：用于降低高血糖水平的小分子
公开(公告)号：US20090317372A1
公开(公告)日：2009-12-24
申请号：US12394789
申请日：2009-02-27
申请人： Zoltan Kiss
发明人： Zoltan Kiss
IPC分类号： A61K38/46 , A61K31/382 , A61K38/40 , A61P3/10
CPC分类号： A61K31/382 , A61K38/1741 , A61K38/40 , A61K38/465 , A61K45/06 , C12Y301/03001 , A61K2300/00
摘要： Embodiments of the present invention include the in vivo use of a family of heterocyclic compounds containing a quaternary ammonium group as exemplified by the thioxanthone and thioxanthene compounds [3-(3,4-dimethyl-9-oxo-9H-thioxanthen-2-yloxy)-2-hydroxypropyl]trimethylammonium chloride, or CCcompound1, N,N,-diethyl-N-methyl-2-[9-oxo-9H-thioxanthen-2-yl)methoxy]ethanaminium iodide, or CCcompound3, and N,N,N-trimethyl-3-(9H-thioxanthen-9-ylidene)-propane-1-aminium iodide, or CCcompound19 to reduce higher than normal blood glucose level within or close to the normal range in subjects with insulin resistance, hyperglycemia, and diabetes thereby also reducing or preventing associated diseases, complications, and pathological states.
摘要翻译：本发明的实施方案包括体内使用含有季铵基的杂环化合物族，例如噻吨酮和噻吨酮化合物[3-（3,4-二甲基-9-氧代-9H-噻吨-2-基氧基）-2-羟丙基]三甲基氯化铵或CC化合物1，N，N， - 二乙基-N-甲基-2- [9-氧代-9H-噻吨-2-基]甲氧基]乙胺碘化物，或CCcompound3，N，N ，N-三甲基-3-（9H-噻吨-9-亚基） - 丙烷-1-碘鎓碘化物或CCcompound19，以降低胰岛素抵抗，高血糖和高血糖患者正常范围内或接近正常范围内的正常血糖水平糖尿病，从而也减少或预防相关疾病，并发症和病理状态。

8. 发明授权

US07423029B1 Compounds to promote regeneration of bone marrow 失效
标题翻译：促进骨髓再生的化合物
公开(公告)号：US07423029B1
公开(公告)日：2008-09-09
申请号：US11690260
申请日：2007-03-23
申请人： Zoltan Kiss
发明人： Zoltan Kiss
IPC分类号： A61K31/33 , A61K31/38
CPC分类号： A61K31/33 , A61K31/20 , A61K31/38 , A61K38/1816 , A61K38/193 , A61K38/196 , A61K38/202 , A61K38/2073 , A61K2300/00
摘要： Embodiments of the present invention include the use of heterocyclic trialkyl ammonium-containing compounds to promote regeneration of bone marrow from endogenous or exogenous stem/progenitor cells and to normalize blood cell and platelet counts.
摘要翻译：本发明的实施方案包括使用含杂环三烷基铵的化合物来促进骨髓从内源性或外源性干/祖细胞再生并使血细胞和血小板计数正常化。

9. 发明授权

US07374754B2 Use of placental alkaline phosphatase to promote skin cell proliferation 有权
标题翻译：使用胎盘碱性磷酸酶促进皮肤细胞增殖
公开(公告)号：US07374754B2
公开(公告)日：2008-05-20
申请号：US10653622
申请日：2003-09-02
申请人： Zoltan Kiss
发明人： Zoltan Kiss
IPC分类号： A61K38/43 , A61K31/74
CPC分类号： A61K8/66 , A61K38/465 , A61Q19/08 , C12Y301/03001
摘要： Methods for stimulating proliferation of cells in the epidermis and dermis of mammalian skin are disclosed. The methods comprise the step of administering to an area of the skin a composition comprising a therapeutically effective amount of human placental alkaline phosphatase, or an active derivative. The composition can be administered topically or by injection. The invention also provides a regimen for restoring or maintaining the strength and thickness of aging skin, comprising periodically administering a composition by topical application. The invention further provides methods for stimulating proliferation of cells in the epidermis and dermis of transplanted skin. A composition for topical application is also provided by the invention.
摘要翻译：公开了刺激哺乳动物皮肤表皮和真皮细胞增殖的方法。所述方法包括向皮肤区域施用包含治疗有效量的人胎盘碱性磷酸酶或活性衍生物的组合物的步骤。组合物可以局部施用或通过注射施用。本发明还提供了恢复或维持老化皮肤的强度和厚度的方案，其包括通过局部施用周期性施用组合物。本发明还提供了刺激皮肤表皮和真皮细胞增殖的方法。本发明还提供了用于局部应用的组合物。

10. 发明申请

US20080114055A1 Thioxanthone Compounds to Reverse Weight Loss 审中-公开
标题翻译：噻吨酮化合物以减轻体重
公开(公告)号：US20080114055A1
公开(公告)日：2008-05-15
申请号：US11558533
申请日：2006-11-10
申请人： Zoltan Kiss
发明人： Zoltan Kiss
IPC分类号： A61K31/382 , A61P35/00 , A61P31/00 , A61P11/00
CPC分类号： C07D335/12
摘要： One embodiment of the invention uses thioxanthone compounds containing a choline or choline analogue moiety, such as CCcompound1 or [3-(3,4-Dimethyl-9-oxo-9H-thioxanthen-2-yloxy)-2-hydroxypropyl]trimethyl-ammonium chloride, to reduce or reverse body weight loss in various mouse models of human tumors. Another embodiment of the invention discloses a method for reducing or reversing cachexia or disease-induced body weight loss in human and other mammals using thioxanthone compounds containing a choline analogue moiety.
摘要翻译：本发明的一个实施方案使用含有胆碱或胆碱类似物部分的噻吨酮化合物，例如CC化合物1或[3-（3,4-二甲基-9-氧代-9H-噻吨-2-基氧基）-2-羟丙基]三甲基铵氯化物，以减少或逆转人类肿瘤的各种小鼠模型中的体重减轻。本发明的另一个实施方案公开了一种使用含有胆碱类似物部分的噻吨酮化合物来减少或逆转人类和其它哺乳动物的恶病质或疾病引起的体重减轻的方法。

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