专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US08642543B2 Methods for treating progressive cognitive disorders related to neurofibrillary tangles 有权
标题翻译：治疗与神经原纤维缠结相关的进行性认知障碍的方法
公开(公告)号：US08642543B2
公开(公告)日：2014-02-04
申请号：US12470427
申请日：2009-05-21
申请人： Nikolaos Tezapsidis , Steven Greco , Mark Smith
发明人： Nikolaos Tezapsidis , Steven Greco , Mark Smith
IPC分类号： A61K38/22
CPC分类号： A61K38/2264 , A61K38/22 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： The described invention provides methods for treating or preventing progression of a progressive cognitive disease, disorder or condition, and methods for improving resilience of cognitive function in a subject in need thereof.
摘要翻译：所述发明提供了用于治疗或预防进行性认知疾病，病症或病症进展的方法，以及用于在有需要的受试者中提高认知功能的弹性的方法。

22. 发明授权

US08312562B2 Impact and/or vibration absorbent material and protective articles making use thereof 有权
标题翻译：冲击和/或吸震材料及其使用的保护制品
公开(公告)号：US08312562B2
公开(公告)日：2012-11-20
申请号：US12715263
申请日：2010-03-01
申请人： Gary Hammons , Roger W. Kramer , Charles Marks , Kevin Porter , Robert Bogard , Traci Skahill , Mark Smith
发明人： Gary Hammons , Roger W. Kramer , Charles Marks , Kevin Porter , Robert Bogard , Traci Skahill , Mark Smith
IPC分类号： A41D19/00
CPC分类号： A41D31/005 , A41D19/01523 , A43B13/187 , A43B13/189 , A47C7/021 , B60N2/522 , B60N2/525 , B60N2/70 , F16F3/093 , F16F2230/36
摘要： An impact and/or vibration absorbent material and protective articles making use of said material. An impact and/or vibration absorbent material of the present invention has at least two material layers. The individual layers of the impact and/or vibration absorbent material may be of different materials, or of the same material with the composition of the material of one layer adjusted to be of dissimilar hardness to an adjacent layer. Each material layer preferably contains a number of holes. The holes in one layer are located and arranged to be offset from the holes in an adjacent layer. The combination of material properties and the inclusion and arrangement of holes renders such a material highly impact and/or vibration absorbent. Through use of a protective article of the present invention, the effects of impact and/or vibration forces on a user of the protective article can be minimized.
摘要翻译：使用所述材料的冲击和/或振动吸收材料和保护制品。本发明的冲击和/或振动吸收材料具有至少两个材料层。冲击和/或振动吸收材料的各个层可以是不同的材料，或者具有相同材料的材料，其中一层材料的组成被调整为与相邻层具有不同的硬度。每个材料层优选地包含许多孔。一层中的孔位于并布置成偏离相邻层中的孔。材料性质的组合和孔的包含和排列使得这种材料具有高度冲击和/或吸振性。通过使用本发明的保护制品，能够使冲击力和/或振动力对保护用品的使用者的影响最小化。

23. 发明申请

US20120251639A1 Mole Eliminating Ointment 审中-公开
标题翻译：摩尔消除软膏
公开(公告)号：US20120251639A1
公开(公告)日：2012-10-04
申请号：US13079133
申请日：2011-04-04
申请人： Mark Smith
发明人： Mark Smith
IPC分类号： A61K36/752 , A61P17/00 , A61K36/81
CPC分类号： A61K36/8962 , A61K8/97 , A61K36/752 , A61K36/81 , A61Q19/02 , A61K2300/00
摘要： A topical treatment, and a method for making and using, for eliminating moles comprising, a mixture of natural extracts, where said extracts include garlic, white potatoes, onions and grapefruit.
摘要翻译：一种局部治疗，以及用于消除摩尔的制造和使用方法，包括天然提取物的混合物，其中所述提取物包括大蒜，白土豆，洋葱和葡萄柚。

24. 发明申请

US20120190124A1 Reversible Covalent Linkage of Functional Molecules 有权
标题翻译：功能分子的可逆共价连接
公开(公告)号：US20120190124A1
公开(公告)日：2012-07-26
申请号：US13389625
申请日：2010-08-09
申请人： Mark Smith , Stephen Caddick , James Baker
发明人： Mark Smith , Stephen Caddick , James Baker
IPC分类号： C07K1/00 , C07D207/456 , C07K1/14 , C07D237/04 , G01N21/75 , C07K14/655 , C07D495/04
CPC分类号： C07K14/655 , A61K47/551 , A61K47/60 , A61K47/62 , A61K49/0017 , C07D207/416 , C07D207/456 , C07D209/52 , C07K14/435 , G01N33/58 , Y02P20/55
摘要： The present invention relates to the use of a compound containing a moiety of formula (I) as a reagent for linking a compound of formula R1—H which comprises a first functional moiety of formula F1 to a second functional moiety of formula F2 wherein X, X′, Y, R1, F1 and F2 are as defined herein. The present invention also provides related processes and products. The present invention is useful for creating functional conjugate compounds, and specifically conjugates in which at least one of the constituent molecules carries a thiol group.
摘要翻译：本发明涉及含有式（I）部分的化合物作为将包含式F1的第一功能部分的式R 1 -H的化合物与式F2的第二功能部分连接的试剂的用途，其中X， X'，Y，R1，F1和F2如本文所定义。本发明还提供了相关的方法和产品。本发明可用于产生功能性缀合化合物，特别是缀合物，其中至少一种构成分子携带巯基。

25. 发明申请

US20120031923A1 CLOSURE VALVE ASSEMBLY FOR A CONTAINER 有权
标题翻译：集装箱封闭阀组件
公开(公告)号：US20120031923A1
公开(公告)日：2012-02-09
申请号：US12850811
申请日：2010-08-05
申请人： Mark Smith , Carsten Pfromm
发明人： Mark Smith , Carsten Pfromm
IPC分类号： B65D47/00
CPC分类号： B65D51/002 , B65D47/2031 , B65D75/5877 , B67D7/06
摘要： The present invention provides a closure assembly for a container having a housing, a retaining ring and a valve. The closure assembly is useful for attachment to a container to provide flowable, aseptic access to the contents of the container.
摘要翻译：本发明提供了一种用于具有壳体，保持环和阀的容器的闭合组件。闭合组件可用于连接到容器以提供可容许的，无菌的进入容器内容物的通道。

26. 发明授权

US08071739B2 Modified nucleotides 有权
标题翻译：修饰的核苷酸
公开(公告)号：US08071739B2
公开(公告)日：2011-12-06
申请号：US12804352
申请日：2010-07-20
申请人： John Milton , Xiaolin Wu , Mark Smith , Joseph Brennan , Colin Barnes , Xiaohai Liu , Silke Ruediger
发明人： John Milton , Xiaolin Wu , Mark Smith , Joseph Brennan , Colin Barnes , Xiaohai Liu , Silke Ruediger
IPC分类号： C07H21/02 , C07H21/04 , C07H19/04 , C12Q1/68
CPC分类号： C12Q1/6869 , C07H1/00 , C07H19/06 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C07H21/00 , C12Q2525/186 , C12Q2535/113 , Y02P20/55 , C12Q2525/197
摘要： The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group covalently attached thereto, such that the 3′ carbon atom has attached a group of the structure —O—Z wherein Z is any of —C(R′)2-O—R″, —C(R′)2-N(R″)2, —C(R′)2-N(H)R″, —C(R′)2-S—R″ and —C(R′)2-F, wherein each R″ is or is part of a removable protecting group; each R′ is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R′)2 represents an alkylidene group of formula ═C(R′″)2 wherein each R′″ may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R″ is exchanged for H or, where Z is —C(R′)2-F, the F is exchanged for OH, SH or NH2, preferably OH, which intermediate dissociates under aqueous conditions to afford a molecule with a free 3′OH; with the proviso that where Z is —C(R′)2-S—R″, both R′ groups are not H.
摘要翻译：本发明提供了修饰的核苷酸或核苷分子，其包含嘌呤或嘧啶碱基和核糖或脱氧核糖糖部分，其具有共价连接到其上的可移除的3'-OH封闭基团，使得3'碳原子连接一组结构-O -Z其中Z是-C（R'）2 -O-R“，-C（R'）2 -N（R”）2，-C（R'）2 -N（H）R“ -C（R'）2 -S-R“和-C（R'）2 -F，其中每个R”为或可移除的保护基团的一部分; 每个R'独立地是氢原子，烷基，取代的烷基，芳基烷基，烯基，炔基，芳基，杂芳基，杂环，酰基，氰基，烷氧基，芳氧基，杂芳氧基或酰氨基，或通过连接基团连接的可检测标记; 或（R'）2表示式≡C（R'“）2的亚烷基，其中每个R”可以相同或不同，并且选自氢和卤素原子和烷基; 并且其中所述分子可以反应以产生其中每个R“被交换为H的中间体，或其中Z是-C（R'）2 -F，F被交换成OH，SH或NH 2，优选OH，其中中间体在水性条件下解离得到具有游离3'OH的分子; 条件是其中Z是-C（R'）2 -S-R“，两个R'基团不是H.

27. 发明授权

US07805776B2 Face protector and protective system 有权
标题翻译：面部保护和保护系统
公开(公告)号：US07805776B2
公开(公告)日：2010-10-05
申请号：US11425598
申请日：2006-06-21
申请人： Daniel Crossman , Clint Alexander Hedge , Mark Smith , Justin Myles
发明人： Daniel Crossman , Clint Alexander Hedge , Mark Smith , Justin Myles
IPC分类号： A42B1/08 , A42B1/06 , F41H1/04
CPC分类号： A42B3/326 , A42B3/044 , A42B3/185 , A42B3/20
摘要： A face protector comprises a protective structure shaped for extending about a person's mandibular region and a mounting for mounting the face protector to a military combat helmet. The protective structure comprises a front portion and opposed left and right side portions extending from the front portion, the front portion having a free upper edge for positioning below eye level and above mouth level when mounted to the helmet, and being size to extend to below a person's chin. The front portion has inner and outer surfaces, and the mounting is positioned to space the inner surface and the upper edge away from the person's mouth and nose when mounted to the helmet to provide a gap for the passage of ambient air therebetween to permit unobstructed breathing. The protective structure comprises a ballistic resistant material for providing protection against high velocity fragments from explosive devices.
摘要翻译：面部保护器包括形状用于围绕人的下颌区域延伸的保护结构和用于将面部保护器安装到军事作战头盔的安装件。保护结构包括前部和从前部延伸的相对的左右侧部分，前部具有自由上边缘，用于定位在眼睛水平下方并且在安装到头盔上时在嘴高度上，并且尺寸延伸到下面一个人的下巴。前部具有内表面和外表面，并且安装件被定位成当安装到头盔上时使内表面和上边缘远离人的嘴和鼻部，以提供用于其间的环境空气通过的间隙，以允许畅通无阻的呼吸。保护结构包括防弹材料，用于提供防止爆炸装置的高速碎片的保护。

28. 发明申请

US20100034741A1 Imaging agents and methods of imaging alpha7-nicotinic cholinergic receptor 审中-公开
标题翻译：成像剂和α7-烟碱型胆碱能受体成像方法
公开(公告)号：US20100034741A1
公开(公告)日：2010-02-11
申请号：US12321951
申请日：2009-01-26
申请人： Martin G. Pomper , John L. Musachio , Hong Fan , Robert F. Dannals , Catherine Foss , Eifion Phillips , John Gordon , Dennis McCarthy , Richard Keith , Mark Smith , Richard Heys , Peter N. Dorff
发明人： Martin G. Pomper , John L. Musachio , Hong Fan , Robert F. Dannals , Catherine Foss , Eifion Phillips , John Gordon , Dennis McCarthy , Richard Keith , Mark Smith , Richard Heys , Peter N. Dorff
IPC分类号： C07D453/02 , C07D453/00 , A61K51/04 , G01N33/53
CPC分类号： C07D491/22 , A61K51/0448 , C07B2200/05 , C07D453/02
摘要： The present invention relates to radiolabelled compounds particularly 1-azabicyclo[2.2.2]octane compounds (i.e., quinuclidine compounds) which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express the α7-nicotinic cholinergic receptor. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled compounds of the invention, particularly tissues, organs, or tumors which express α7-nicotinic cholinergic receptor to which the compounds of the invention have an affinity.
摘要翻译：本发明涉及放射性标记的化合物，特别是1-氮杂双环[2.2.2]辛烷化合物（即奎宁环化合物），其被一个或多个放射性同位素标记并适用于成像或治疗处理组织，器官或肿瘤，其表达 α7-烟碱性胆碱能受体。在另一个实施方案中，本发明涉及使用本发明的放射性标记化合物，特别是表达本发明化合物具有亲和力的α7-烟碱型胆碱能受体的组织，器官或肿瘤来成像组织，器官或肿瘤的方法。

29. 发明授权

US07625897B2 Non-nucleoside reverse transcriptase inhibitors 失效
标题翻译：非核苷逆转录酶抑制剂
公开(公告)号：US07625897B2
公开(公告)日：2009-12-01
申请号：US11541011
申请日：2006-09-29
申请人： Yoshihito David Saito , Mark Smith , Zachary Kevin Sweeney
发明人： Yoshihito David Saito , Mark Smith , Zachary Kevin Sweeney
IPC分类号： C07D253/06 , A61K31/53 , A61P31/18
CPC分类号： C07D237/04 , C07D237/02 , C07D253/06 , C07D253/07 , C07D273/04
摘要： The present invention provides compounds of formula I where R1 to R4 are as defined herein which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides for methods of treating or preventing HIV infection with compounds according to formula I and compositions containing the same. The invention still further provides process for the preparation of compounds of formula I wherein R4 is A1 and X1 is NH or O.
摘要翻译：本发明提供式I化合物，其中R 1至R 4如本文所定义，其可用于治疗或预防人类免疫缺陷病毒（HIV）感染或治疗AIDS或ARC。本发明进一步提供了用式I化合物和含有该化合物的组合物治疗或预防HIV感染的方法。本发明还提供制备其中R 4为Al且X 1为NH或O的式I化合物的方法。

30. 发明申请

US20090260060A1 RICH MEDIA COLLABORATION SYSTEM 有权
标题翻译：多媒体合作系统
公开(公告)号：US20090260060A1
公开(公告)日：2009-10-15
申请号：US12102670
申请日：2008-04-14
申请人： Mark Smith , Kevin Anderson , Michael Harvey
发明人： Mark Smith , Kevin Anderson , Michael Harvey
IPC分类号： G06F3/048 , G06F21/00
CPC分类号： H04L63/105 , G06Q10/10
摘要： A user annotates a shared document with text, sound, images, video, an e-mail message, graphics, screen snapshots, web site snapshots to share with others. The document and its annotations are stored in a digital object repository to which other users have access. Within the closed collaboration system, only users who are authenticated may upload digital objects, annotate digital objects and view objects and their annotations. The user sends a message to other users to invite them to view the object and its annotations and to add their own annotations. An annotated object generates an alert for all of the invited users. A remote authentication gateway authenticates users and has a repository for user metadata. Digital object repositories are separate from the authentication gateway, thus providing for disintermediation of the user metadata from the digital object data. The collaboration system may be hosted by a third party on a server computer available over the Internet that displays a web site. A user is not required to have collaboration system software on his or her computer and may annotate any image on the web site for later viewing by other users of the web site.
摘要翻译：用户使用文本，声音，图像，视频，电子邮件消息，图形，屏幕快照，与其他人共享的网站快照来注释共享文档。文档及其注释存储在其他用户可访问的数字对象存储库中。在封闭的协作系统中，只有经过身份验证的用户才能上传数字对象，注释数字对象，查看对象及其注释。用户向其他用户发送消息，邀请他们查看对象及其注释，并添加自己的注释。注释对象会为所有受邀用户生成警报。远程验证网关对用户进行身份验证，并具有用户元数据的存储库。数字对象存储库与认证网关分离，从而提供用户元数据从数字对象数据的中介。协作系统可以由可通过因特网可用的显示网站的服务器计算机上的第三方托管。用户不需要在他或她的计算机上拥有协作系统软件，并且可以在网站上注释任何图像，以供该网站的其他用户稍后查看。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式