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1. 发明申请

US20140121157A1 METHODS FOR TREATING PROGRESSIVE COGNITIVE DISORDERS RELATED TO NEUROFIBRILLARY TANGLES 审中-公开
标题翻译：治疗与神经衰弱有关的进步性认知障碍的方法
公开(公告)号：US20140121157A1
公开(公告)日：2014-05-01
申请号：US14030661
申请日：2013-09-18
申请人： Nikolaos Tezapsidis , Steven Greco , Mark Smith
发明人： Nikolaos Tezapsidis , Steven Greco , Mark Smith
IPC分类号： A61K38/22 , A61K38/28
CPC分类号： A61K38/2264 , A61K38/22 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： The described invention provides methods for treating or preventing progression of a progressive cognitive disease, disorder or condition, and methods for improving resilience of cognitive function in a subject in need thereof.
摘要翻译：所述发明提供了用于治疗或预防进行性认知疾病，病症或病症进展的方法，以及用于在有需要的受试者中提高认知功能的弹性的方法。

2. 发明申请

US20150038409A1 Leptin Compositions and Methods for Treating Progressive Cognitive Function Disorders Resulting from Accumulation of Neurofibrillary Tangles and Amyloid Beta 审中-公开
标题翻译：瘦素组合物和方法治疗由神经原纤维缠结和淀粉样蛋白β积累引起的进行性认知功能障碍
公开(公告)号：US20150038409A1
公开(公告)日：2015-02-05
申请号：US14097818
申请日：2013-12-05
申请人： Nikolaos Tezapsidis , Steven Greco , Mark Smith
发明人： Nikolaos Tezapsidis , Steven Greco , Mark Smith
IPC分类号： A61K38/22 , A61K31/7056
CPC分类号： A61K38/22 , A61K31/7056 , A61K38/2264 , A61K45/06 , C12Q1/485 , G01N33/5058 , G01N2800/2821 , G01N2800/2828 , A61K2300/00
摘要： The present disclosure provides compositions containing a leptin product and methods of clinical therapy and diagnostic methods for progressive cognitive disorders. According to one aspect, the described invention provides a method for treating a progressive cognitive disorder. According to another aspect, the described invention provides a method for improving resilience of cognitive function in a subject in need thereof. According to another aspect, the described invention provides a method for identifying an effective therapeutic agent for treating a progressive cognitive dysfunction disease or disorder that results from at least one of accumulation of Aβ, hyperphosphorylation of tau, or accumulation of neurofibrillary tangles.
摘要翻译：本公开提供了含有瘦素产物的组合物和用于进行性认知障碍的临床治疗和诊断方法的方法。根据一个方面，所述发明提供了治疗进行性认知障碍的方法。根据另一方面，本发明提供了一种用于提高有需要的受试者的认知功能的弹性的方法。根据另一方面，所述发明提供了鉴定用于治疗进行性认知功能障碍疾病或病症的有效治疗剂的方法，所述有效治疗剂由A和BGR的累积，tau的高度磷酸化或神经原纤维缠结的积累中的至少一种引起。

3. 发明授权

US08642543B2 Methods for treating progressive cognitive disorders related to neurofibrillary tangles 有权
标题翻译：治疗与神经原纤维缠结相关的进行性认知障碍的方法
公开(公告)号：US08642543B2
公开(公告)日：2014-02-04
申请号：US12470427
申请日：2009-05-21
申请人： Nikolaos Tezapsidis , Steven Greco , Mark Smith
发明人： Nikolaos Tezapsidis , Steven Greco , Mark Smith
IPC分类号： A61K38/22
CPC分类号： A61K38/2264 , A61K38/22 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： The described invention provides methods for treating or preventing progression of a progressive cognitive disease, disorder or condition, and methods for improving resilience of cognitive function in a subject in need thereof.
摘要翻译：所述发明提供了用于治疗或预防进行性认知疾病，病症或病症进展的方法，以及用于在有需要的受试者中提高认知功能的弹性的方法。

4. 发明申请

US20090291894A1 METHODS FOR TREATING PROGRESSIVE COGNITIVE DISORDERS RELATED TO NEUROFIBRILLARY TANGLES 有权
标题翻译：治疗与神经衰弱有关的进步性认知障碍的方法
公开(公告)号：US20090291894A1
公开(公告)日：2009-11-26
申请号：US12470427
申请日：2009-05-21
申请人： Nikolaos Tezapsidis , Steven Greco
发明人： Nikolaos Tezapsidis , Steven Greco
IPC分类号： A61K38/22
CPC分类号： A61K38/2264 , A61K38/22 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： The described invention provides methods for treating or preventing progression of a progressive cognitive disease, disorder or condition, and methods for improving resilience of cognitive function in a subject in need thereof.
摘要翻译：所述发明提供了用于治疗或预防进行性认知疾病，病症或病症进展的方法，以及用于在有需要的受试者中提高认知功能的弹性的方法。

5. 发明申请

US20120010132A9 METHODS FOR TREATING PROGRESSIVE COGNITIVE DISORDERS RELATED TO NEUROFIBRILLARY TANGLES 有权
标题翻译：治疗与神经衰弱有关的进步性认知障碍的方法
公开(公告)号：US20120010132A9
公开(公告)日：2012-01-12
申请号：US12470427
申请日：2009-05-21
申请人： Nikolaos Tezapsidis , Steven Greco
发明人： Nikolaos Tezapsidis , Steven Greco
IPC分类号： A61K38/22
CPC分类号： A61K38/2264 , A61K38/22 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： The described invention provides methods for treating or preventing progression of a progressive cognitive disease, disorder or condition, and methods for improving resilience of cognitive function in a subject in need thereof.
摘要翻译：所述发明提供了用于治疗或预防进行性认知疾病，病症或病症进展的方法，以及用于在有需要的受试者中提高认知功能的弹性的方法。

6. 发明申请

US20100113358A1 LEPTIN COMPOSITIONS AND METHODS FOR TREATING PROGRESSIVE COGNITIVE FUNCTION DISORDERS RESULTING FROM ACCUMULATION OF NEUROFIBRILLARY TANGLES AND AMLYOID BETA 失效
标题翻译： LEPTIN组合物和治疗由神经衰弱和AMLYOID BETA累积引起的进行性认知功能障碍的方法
公开(公告)号：US20100113358A1
公开(公告)日：2010-05-06
申请号：US12612613
申请日：2009-11-04
申请人： Nikolaos Tezapsidis , Steven J. Greco , Mark Smith
发明人： Nikolaos Tezapsidis , Steven J. Greco , Mark Smith
IPC分类号： A61K38/22 , A61P25/00 , A61P25/28 , C12Q1/48 , G01N33/573 , G01N33/00
CPC分类号： A61K38/22 , A61K31/7056 , A61K38/2264 , A61K45/06 , C12Q1/485 , G01N33/5058 , G01N2800/2821 , G01N2800/2828 , A61K2300/00
摘要： The present disclosure provides compositions containing a leptin product and methods of clinical therapy and diagnostic methods for progressive cognitive disorders. According to one aspect, the described invention provides a method for treating a progressive cognitive disorder. According to another aspect, the described invention provides a method for improving resilience of cognitive function in a subject in need thereof. According to another aspect, the described invention provides a method for identifying an effective therapeutic agent for treating a progressive cognitive dysfunction disease or disorder that results from at least one of accumulation of Aβ, hyperphosphorylation of tau, or accumulation of neurofibrillary tangles.
摘要翻译：本公开提供了含有瘦素产物的组合物和用于进行性认知障碍的临床治疗和诊断方法的方法。根据一个方面，所述发明提供了治疗进行性认知障碍的方法。根据另一方面，本发明提供了一种用于提高有需要的受试者的认知功能的弹性的方法。根据另一方面，所述发明提供了鉴定用于治疗进行性认知功能障碍疾病或病症的有效治疗剂的方法，所述有效治疗剂由A和BGR的累积，tau的高度磷酸化或神经原纤维缠结的积累中的至少一种引起。

7. 发明授权

US08716220B2 Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amyloid beta 失效
标题翻译：瘦素组合物和治疗由神经原纤维缠结和淀粉样蛋白β积累引起的进行性认知功能障碍的方法
公开(公告)号：US08716220B2
公开(公告)日：2014-05-06
申请号：US12612613
申请日：2009-11-04
申请人： Nikolaos Tezapsidis , Steven J. Greco , Mark Smith
发明人： Nikolaos Tezapsidis , Steven J. Greco , Mark Smith
IPC分类号： A61K38/22
CPC分类号： A61K38/22 , A61K31/7056 , A61K38/2264 , A61K45/06 , C12Q1/485 , G01N33/5058 , G01N2800/2821 , G01N2800/2828 , A61K2300/00
摘要： The present disclosure provides compositions containing a leptin product and methods of clinical therapy and diagnostic methods for progressive cognitive disorders. According to one aspect, the described invention provides a method for treating a progressive cognitive disorder. According to another aspect, the described invention provides a method for improving resilience of cognitive function in a subject in need thereof. According to another aspect, the described invention provides a method for identifying an effective therapeutic agent for treating a progressive cognitive dysfunction disease or disorder that results from at least one of accumulation of Aβ, hyperphosphorylation of tau, or accumulation of neurofibrillary tangles.
摘要翻译：本公开提供了含有瘦素产物的组合物和用于进行性认知障碍的临床治疗和诊断方法的方法。根据一个方面，所述发明提供了治疗进行性认知障碍的方法。根据另一方面，本发明提供了一种用于提高有需要的受试者的认知功能的弹性的方法。根据另一方面，所述发明提供了鉴定用于治疗进行性认知功能障碍疾病或病症的有效治疗剂的方法，所述有效治疗剂由A和BGR的累积，tau的高度磷酸化或神经原纤维缠结的积累中的至少一种引起。

8. 发明申请

US20070066527A1 Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology 失效
标题翻译：瘦素作为抗淀粉样变性生物学和延迟发病和减少阿尔茨海默氏病样病理学的方法
公开(公告)号：US20070066527A1
公开(公告)日：2007-03-22
申请号：US11516224
申请日：2006-09-06
申请人： Nikolaos Tezapsidis
发明人： Nikolaos Tezapsidis
IPC分类号： A61K38/17
CPC分类号： A61K38/17
摘要： The present invention relates to methods for treating, preventing, or diagnosing the pathology of progressive cognitive disorders resulting from accumulation of an amyloid peptide, in particular, Alzheimer's disease, Down's syndrome and cerebral amyloid angiopathy, in mammalian subjects using a composition comprising therapeutically effective amount of a leptin, leptin mimic, leptin derivative, leptin agonist, or AMP-dependent protein kinase activator, alone, or in combination with, one or more lipolytic/antilipogenic compounds. It further relates to methods for improving cognitive function using a composition comprising a therapeutically effective amount of leptin, a leptin mimic, a leptin derivative, an AMP-dependent protein kinase activator, a leptin agonist, a leptin blocker, a mimic of a leptin blocker, a leptin antagonist, an AMP-dependent protein kinase inhibitor; or a pharmaceutically acceptable salt thereof
摘要翻译：本发明涉及用于使用包含治疗有效量的组合物来治疗，预防或诊断由哺乳动物受试者中的淀粉样肽，特别是阿尔茨海默病，唐氏综合征和脑淀粉样血管病变积聚引起的进行性认知障碍的病理学的方法瘦素，瘦素模拟物，瘦蛋白衍生物，瘦蛋白激动剂或AMP依赖性蛋白激酶活化剂，单独或与一种或多种脂肪分解/抗脂肪生成化合物组合。本发明还涉及使用包含治疗有效量的瘦素，瘦素模拟物，瘦蛋白衍生物，AMP依赖性蛋白激酶激活剂，瘦蛋白激动剂，瘦蛋白阻滞剂，瘦蛋白阻断剂的模拟物的组合物来改善认知功能的方法，瘦素拮抗剂，AMP依赖性蛋白激酶抑制剂; 或其药学上可接受的盐

9. 发明授权

US08227408B2 Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology 失效
标题翻译：瘦素作为抗淀粉样变性生物学和延迟发病和减少阿尔茨海默氏病样病理学的方法
公开(公告)号：US08227408B2
公开(公告)日：2012-07-24
申请号：US11516224
申请日：2006-09-06
申请人： Nikolaos Tezapsidis
发明人： Nikolaos Tezapsidis
IPC分类号： A61K38/22
CPC分类号： A61K38/17
摘要： The present invention relates to methods for treating, preventing, or diagnosing the pathology of progressive cognitive disorders resulting from accumulation of an amyloid peptide, in particular, Alzheimer's disease, Down's syndrome and cerebral amyloid angiopathy, in mammalian subjects using a composition comprising therapeutically effective amount of a leptin, leptin mimic, leptin derivative, leptin agonist, or AMP-dependent protein kinase activator, alone, or in combination with, one or more lipolytic/antilipogenic compounds. It further relates to methods for improving cognitive function using a composition comprising a therapeutically effective amount of leptin, a leptin mimic, a leptin derivative, an AMP-dependent protein kinase activator, a leptin agonist, a leptin blocker, a mimic of a leptin blocker, a leptin antagonist, an AMP-dependent protein kinase inhibitor; or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及用于使用包含治疗有效量的组合物来治疗，预防或诊断由哺乳动物受试者中的淀粉样肽，特别是阿尔茨海默病，唐氏综合征和脑淀粉样血管病变积聚引起的进行性认知障碍的病理学的方法瘦素，瘦素模拟物，瘦蛋白衍生物，瘦蛋白激动剂或AMP依赖性蛋白激酶活化剂，单独或与一种或多种脂肪分解/抗脂肪生成化合物组合。本发明还涉及使用包含治疗有效量的瘦素，瘦素模拟物，瘦蛋白衍生物，AMP依赖性蛋白激酶激活剂，瘦蛋白激动剂，瘦蛋白阻滞剂，瘦蛋白阻断剂的模拟物的组合物来改善认知功能的方法，瘦素拮抗剂，AMP依赖性蛋白激酶抑制剂; 或其药学上可接受的盐。

10. 发明申请

US20130065825A1 Compositions and Methods for Delaying Senescence or Cell Death in Neurons 审中-公开
标题翻译：延迟神经元衰老或细胞死亡的组成和方法
公开(公告)号：US20130065825A1
公开(公告)日：2013-03-14
申请号：US13613030
申请日：2012-09-13
申请人： Steven J. Greco , Nikolaos Tezapsidis
发明人： Steven J. Greco , Nikolaos Tezapsidis
IPC分类号： A61K38/22 , A61P25/28 , C12N5/0793
CPC分类号： A61K38/2264
摘要： The described invention provides methods and compositions for enhancing the enzymatic activity of Sirtuin family members by using Leptin, Leptin analogs, Leptin derivatives, or Leptin agonists. The described invention further provides compositions and methods for delaying senescence or cell death in neurons using the compositions.
摘要翻译：所述发明提供了通过使用瘦蛋白，瘦蛋白类似物，瘦蛋白衍生物或瘦蛋白激动剂来增强Sirtuin家族成员的酶活性的方法和组合物。所述发明还提供了使用该组合物延迟神经元衰老或细胞死亡的组合物和方法。

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