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    • 7. 发明专利
    • Topical composition and delivery system and its use
    • GB201814047D0
    • 2018-10-10
    • GB201814047
    • 2016-02-04
    • GREENSPAN MICHAEL HARVEY
    • Topical delivery system comprising a pharmaceutical composition formulated for application directly to a skin of a subject in need thereof, comprising: (a) a therapeutic amount of an active therapeutic agent to treat symptoms of a disease, disorder or condition; (b) chemical drivers comprising an amino benzoate local anaesthetic, ethoxydiglycol and methylsulfonylmethane, wherein the chemical drivers are effective at acting synergistically to deliver the therapeutic agent, and (c) a depot component that is effective to keep the active agent locally in the skin and to reduce distribution of the active agent to the blood stream. Preferably, the anaesthetic is benzocaine, lidocaine, tetracaine or a combination thereof. The composition may comprise a vasoconstrictor. The depot component may be a liposome, polymer or polymersome. Such a liposome may comprise phosphatidyl choline, cholesterol, and at least one anionic or cationic phospholipid. Also claimed is a method of delivering a pharmaceutical composition topically using the composition described supra.