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21. 发明授权

US08440674B2 Substituted pyrimidine compounds as RAF inhibitors and methods of use 失效
标题翻译：取代的嘧啶化合物作为RAF抑制剂和使用方法
公开(公告)号：US08440674B2
公开(公告)日：2013-05-14
申请号：US13163666
申请日：2011-06-17
申请人： Frenel F. De Morin , Jian J. Chen , Elizabeth M. Doherty , Stephen A. Hitchcock , Qi Huang , Joseph L. Kim , Gang Liu , Thomas Nixey , Nick A. Paras , Jeffrey Petkus , Daniel Martin Retz , Adrian Leonard Smith , Jiawang Zhu
发明人： Frenel F. De Morin , Jian J. Chen , Elizabeth M. Doherty , Stephen A. Hitchcock , Qi Huang , Joseph L. Kim , Gang Liu , Thomas Nixey , Nick A. Paras , Jeffrey Petkus , Daniel Martin Retz , Adrian Leonard Smith , Jiawang Zhu
IPC分类号： A01N43/54
CPC分类号： C07D401/14 , C07D239/84 , C07D239/95 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The present invention comprises a new class of compounds capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula I wherein R1 is and A1, A2, A3, A4, X, Z, Z′, R1, R2, R3, R4, R5 and R6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译：本发明包括能够调节Raf激酶的新一类化合物，因此可用于治疗Raf激酶介导的疾病，包括黑素瘤，肿瘤和其它癌症相关病症。该化合物具有通式I，其中R1为和A1，A2，A3，A4，X，Z，Z'，R1，R2，R3，R4，R5和R6如本文所定义。本发明还包括药物组合物，用于治疗Raf激酶介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。

22. 发明申请

US20110306587A1 UNSATURATED NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS 有权
标题翻译：不饱和氮杂环化合物作为PDE10抑制剂有用
公开(公告)号：US20110306587A1
公开(公告)日：2011-12-15
申请号：US13105860
申请日：2011-05-11
申请人： Jennifer R. ALLEN , Jian J. Chen , Michael J. Frohn , Essa Hu , Qingyian Liu , Alexander J. Pickrell , Shannon Rumfelt , Robert M. Rzasa , Wenge Zhong
发明人： Jennifer R. ALLEN , Jian J. Chen , Michael J. Frohn , Essa Hu , Qingyian Liu , Alexander J. Pickrell , Shannon Rumfelt , Robert M. Rzasa , Wenge Zhong
IPC分类号： A61K31/4439 , A61K31/497 , C07D417/14 , A61K31/4545 , C07D413/14 , C07D409/14 , C07D491/107 , C07D487/10 , C07D405/14 , A61P25/16 , A61P25/18 , A61P25/00 , A61P25/28 , A61P25/30 , A61P25/24 , A61P3/04 , A61P25/14 , C07D401/14
CPC分类号： C07D401/14 , C07C53/18 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/056 , C07D491/08 , C07D491/107 , C07D513/04
摘要： Unsaturated nitrogen heterocyclic compounds of formula (I): as defined in the specification, compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, Huntington's Disease, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
摘要翻译：式（I）的不饱和氮杂环化合物：如说明书中所定义，含有它们的组合物，以及制备这些化合物的方法。本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，亨廷顿舞蹈病，非胰岛素依赖性糖尿病，精神分裂症，双相障碍，强迫症等。

23. 发明申请

US20110118234A1 Urea Compounds as Gamma Secretase Modulators 审中-公开
标题翻译：尿素化合物作为γ分泌酶调节剂
公开(公告)号：US20110118234A1
公开(公告)日：2011-05-19
申请号：US12990999
申请日：2009-05-04
申请人： Kaustav Biswas , Jian J. Chen , James R. Falsey , Vijay Keshav Gore , Qingyian Liu , Vu Van Ma , Stephanie J. Mercede , Robert M. Rzasa , Christopher M. Tegley , Jiawang Zhu
发明人： Kaustav Biswas , Jian J. Chen , James R. Falsey , Vijay Keshav Gore , Qingyian Liu , Vu Van Ma , Stephanie J. Mercede , Robert M. Rzasa , Christopher M. Tegley , Jiawang Zhu
IPC分类号： A61K31/55 , C07D213/53 , A61K31/44 , C07D405/12 , A61K31/4433 , C07D413/12 , A61K31/5377 , C07D403/12 , A61K31/47 , A61K31/4439 , A61K31/444 , A61P25/28
CPC分类号： C07D213/40 , C07D213/61 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds Formula (I) that are gamma secretase modulators and are therefore useful for the treatment of diseases treatable by modulation of gamma secretase such as Alzheimer's disease. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
摘要翻译：本发明提供了作为γ-分泌酶调节剂的式（I）化合物，因此可用于治疗通过调节γ-分泌酶如阿尔茨海默病可治疗的疾病。还提供含有这些化合物的药物组合物和制备这些化合物的方法。

24. 发明申请

US20100329959A1 USE OF ACID WASHING TO PROVIDE PURIFIED SILICON CRYSTALS 有权
标题翻译：使用酸洗提供纯化硅水晶
公开(公告)号：US20100329959A1
公开(公告)日：2010-12-30
申请号：US12670263
申请日：2008-07-23
申请人： Scott Nichol , Jian J. Chen
发明人： Scott Nichol , Jian J. Chen
IPC分类号： C01B33/037 , H01L21/322 , C30B9/10
CPC分类号： C30B9/10 , C01B33/037 , C30B29/06
摘要： A method for purifying silicon wherein silicon is crystallized from a solvent metal. The method comprises the steps of providing a molten liquid containing silicon, a solvent metal and impurities, cooling the molten liquid to form first silicon crystals and a first mother liquor, separating the first silicon crystals from the first mother liquor, contacting the first silicon crystals with compound which will dissolve the first mother liquor and separating the washed crystals from the wash solution.
摘要翻译：一种纯化硅的方法，其中硅从溶剂金属中结晶。该方法包括以下步骤：提供含有硅，溶剂金属和杂质的熔融液体，冷却熔融液体以形成第一硅晶体和第一母液，将第一硅晶体与第一母液分离，使第一硅晶体用化合物溶解第一母液并将洗涤的晶体与洗涤溶液分离。

25. 发明授权

US06583572B2 Inductive plasma processor including current sensor for plasma excitation coil 有权
公开(公告)号：US06583572B2
公开(公告)日：2003-06-24
申请号：US09820709
申请日：2001-03-30
申请人： Robert G. Veltrop , Jian J. Chen , Thomas E. Wicker
发明人： Robert G. Veltrop , Jian J. Chen , Thomas E. Wicker
IPC分类号： H01J724
CPC分类号： H01J37/32174 , H01J37/321
摘要： An inductive plasma processor includes an RF plasma excitation coil having plural windings, each having a first end connected in parallel to be driven by a single RF source via a single matching network. Second ends of the windings are connected to ground by termination capacitors, in turn connected by a lead to ground. A current sensor including a winding around a toroidal core is coupled to the lead between each termination capacitor and ground. The current sensor is surrounded by a grounded shield. There is minimum electromagnetic interference from an ambient RF environment to the current sensor, to provide an accurate current sensor.

26. 发明授权

US06463875B1 Multiple coil antenna for inductively-coupled plasma generation systems 有权
标题翻译：用于电感耦合等离子体发生系统的多线圈天线
公开(公告)号：US06463875B1
公开(公告)日：2002-10-15
申请号：US09711935
申请日：2000-11-15
申请人： Jian J. Chen , Robert G. Veltrop , Thomas E. Wicker
发明人： Jian J. Chen , Robert G. Veltrop , Thomas E. Wicker
IPC分类号： H05H146
CPC分类号： H01J37/321
摘要： A radio frequency plasma multiple-coil antenna allows for controllable, uniform inductive coupling within a plasma reactor. According to exemplary embodiments, multiple coils are positioned on a dielectric window of a plasma chamber, and are powered by a single radio frequency generator and tuned by a single matching network. Each coil is either planar or a combination of a planar coil and a vertically stacked helical coil. The input end of each coil is connected to an input tuning capacitor and the output end is terminated to the ground through an output tuning capacitor. The location of the maximum inductive coupling of the radio frequency to the plasma is mainly determined by the output capacitor, while the input capacitor is mainly used to adjust current magnitude into each coil. By adjusting the current magnitude and the location of the maximum inductive coupling within each coil, the plasma density in different radial and azimuthal regions can be varied and controlled, and therefore, radially and azimuthally uniform plasma can be achieved.
摘要翻译：射频等离子体多线圈天线允许等离子体反应器内的可控的，均匀的电感耦合。根据示例性实施例，多个线圈位于等离子体室的电介质窗口上，并且由单个射频发生器供电并由单个匹配网络调谐。每个线圈是平面的或平面线圈和垂直堆叠的螺旋线圈的组合。每个线圈的输入端连接到输入调谐电容器，输出端通过输出调谐电容端接到地。射频对等离子体的最大感应耦合的位置主要由输出电容决定，而输入电容主要用于调整每个线圈的电流幅值。通过调整每个线圈内的最大电感耦合的电流大小和位置，可以改变和控制不同径向和方位区域中的等离子体密度，因此可以实现径向和方位均匀的等离子体。

27. 发明授权

US5990627A Hot relight system for electrodeless high intensity discharge lamps 失效
标题翻译：无极高强度放电灯的热重系统
公开(公告)号：US5990627A
公开(公告)日：1999-11-23
申请号：US728571
申请日：1996-10-10
申请人： Jian J. Chen , A. Bowman Budinger , Walter P. Lapatovich
发明人： Jian J. Chen , A. Bowman Budinger , Walter P. Lapatovich
IPC分类号： F21K5/00 , H01J65/04 , H05B41/24 , H05B41/38 , H05B41/36
CPC分类号： H05B41/24 , H05B41/384 , Y02B20/206
摘要： An electrodeless high intensity discharge lamp includes an electrodeless lamp capsule having an enclosed volume containing a mixture of starting gas and chemical dopant material excitable by high frequency power to a state of luminous emission, an applicator for coupling high frequency power to the lamp capsule, a gas nozzle directed toward the lamp capsule and a gas controller coupled to the gas nozzle. The gas controller receives gas from a gas source and supplies a gas puff of limited duration to the lamp capsule through the gas nozzle in response to termination of the state of luminous emission. The lamp capsule is rapidly cooled by the gas puff to a temperature required for restart.
摘要翻译：无电极高强度放电灯包括无电极灯胶囊，其具有包含起始气体和通过高频功率激发的化学掺杂剂材料与发光状态的混合物的封闭体积，用于将高频功率耦合到灯泡的施加器，指向灯壳的气体喷嘴和连接到气体喷嘴的气体控制器。气体控制器从气体源接收气体，并响应于发光状态的终止，通过气体喷嘴将有限持续时间的气体吹送到灯泡。灯泡通过气泡快速冷却至重新启动所需的温度。

28. 发明授权

US08957073B2 Unsaturated nitrogen heterocyclic compounds useful as PDE10 inhibitors 有权
标题翻译：用作PDE10抑制剂的不饱和氮杂环化合物
公开(公告)号：US08957073B2
公开(公告)日：2015-02-17
申请号：US13105860
申请日：2011-05-11
申请人： Jennifer R. Allen , Jian J. Chen , Michael J. Frohn , Essa Hu , Qingyian Liu , Alexander J. Pickrell , Shannon Rumfelt , Robert M. Rzasa , Wenge Zhong
发明人： Jennifer R. Allen , Jian J. Chen , Michael J. Frohn , Essa Hu , Qingyian Liu , Alexander J. Pickrell , Shannon Rumfelt , Robert M. Rzasa , Wenge Zhong
IPC分类号： C07D403/14 , A61K31/517 , C07D239/42 , C07D237/26 , A61K31/497 , C07D401/14 , C07D241/38 , C07D413/14 , A61K31/5355 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D491/08 , C07D487/08 , C07D487/10 , C07D491/107 , A61P3/04 , A61P7/12 , A61P25/18
CPC分类号： C07D401/14 , C07C53/18 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/056 , C07D491/08 , C07D491/107 , C07D513/04
摘要： Unsaturated nitrogen heterocyclic compounds of formula (I): as defined in the specification, compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, Huntington's Disease, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
摘要翻译：式（I）的不饱和氮杂环化合物：如说明书中所定义，含有它们的组合物，以及制备这些化合物的方法。本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，亨廷顿舞蹈病，非胰岛素依赖性糖尿病，精神分裂症，双相障碍，强迫症等。

29. 发明授权

US08778941B2 TRPM8 antagonists and their use in treatments 有权
公开(公告)号：US08778941B2
公开(公告)日：2014-07-15
申请号：US13529880
申请日：2012-06-21
申请人： James Brown , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Qingyian Liu , Holger Monenschein , Thomas T. Nguyen , Nobuko Nishimura , Wenge Zhong
发明人： James Brown , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Qingyian Liu , Holger Monenschein , Thomas T. Nguyen , Nobuko Nishimura , Wenge Zhong
IPC分类号： C07D401/14 , C07D213/75 , C07D213/40 , C07D405/12 , C07D413/12
CPC分类号： C07D213/53 , C07C275/30 , C07D213/40 , C07D213/75 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12
摘要： Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

30. 发明授权

US08587321B2 System and method for current-based plasma excursion detection 有权
标题翻译：基于电流等离子体偏移检测的系统和方法
公开(公告)号：US08587321B2
公开(公告)日：2013-11-19
申请号：US12890089
申请日：2010-09-24
申请人： Jian J. Chen , Mohamad A. Ayoub
发明人： Jian J. Chen , Mohamad A. Ayoub
IPC分类号： G01R31/14
CPC分类号： H01J37/32935 , H01J37/32183
摘要： A system and method for the detection of plasma excursions, such as arcs, micro-arcs, or other plasma instability, during plasma processing by directly monitoring RF current just prior to reaching an RF power electrode of a plasma processing chamber is provided. The monitored RF current may be converted to an RF voltage and then passed through a succession of analog filters and amplifiers to provide a plasma excursion signal. The plasma excursion signal is compared to a preset value, and at points where the plasma excursion signal exceeds the preset value, an alarm signal is generated. The alarm signal is then fed back into a system controller so that an operator can be alerted and/or the processing system can be shut down. In one embodiment, the RF current amplified and converted to a digital signal for digital filtering and processing. In certain embodiments, multiple processing regions can be monitored by a single detection control unit.
摘要翻译：提供了一种用于在等离子体处理期间通过在到达等离子体处理室的RF功率电极之前直接监视RF电流来检测诸如电弧，微弧或其他等离子体不稳定性的等离子体偏移的系统和方法。监控的RF电流可以转换成RF电压，然后通过一系列模拟滤波器和放大器，以提供等离子体偏移信号。将等离子体偏移信号与预设值进行比较，并且在等离子体偏移信号超过预设值的点处，产生报警信号。然后将报警信号反馈回系统控制器，以便可以警告操作员和/或处理系统被关闭。在一个实施例中，RF电流被放大并转换成用于数字滤波和处理的数字信号。在某些实施例中，多个处理区域可以由单个检测控制单元监视。

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