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21. 发明申请

US20100029597A1 RECA INHIBITORS WITH ANTIBIOTIC ACTIVITY, COMPOSITIONS AND METHODS OF USE 有权
标题翻译：具有抗生物活性的RECA抑制剂，组合物和使用方法
公开(公告)号：US20100029597A1
公开(公告)日：2010-02-04
申请号：US12279243
申请日：2007-02-13
申请人： Guillaume Cottarel , Jamey Wierzbowski , Kollol Pal , Michael Kohanski , Daniel Dwyer , James Collins , Michael Almstetter , Michael Thormann , Andreas Treml
发明人： Guillaume Cottarel , Jamey Wierzbowski , Kollol Pal , Michael Kohanski , Daniel Dwyer , James Collins , Michael Almstetter , Michael Thormann , Andreas Treml
IPC分类号： A61K31/65 , A61K31/352 , A61K31/382 , A61K31/47 , A61P31/04
CPC分类号： A61K45/06 , A61K38/12 , C12Q1/18 , G01N33/5023 , A61K2300/00
摘要： The present invention is directed to the use of RecA inhibitors as antibiotic agents, and provides RecA inhibitors useful in treating infections. Also provided are various compositions and methods associated with RecA inhibition.
摘要翻译：本发明涉及使用RecA抑制剂作为抗生素，并提供可用于治疗感染的RecA抑制剂。还提供了与RecA抑制相关的各种组合物和方法。

22. 发明申请

US20070136827A1 Cis/trans riboregulators 有权
标题翻译：顺式/反式核糖调节剂
公开(公告)号：US20070136827A1
公开(公告)日：2007-06-14
申请号：US10535128
申请日：2003-11-14
申请人： James Collins , Farren Isaacs , Charles Cantor , Daniel Dwyer
发明人： James Collins , Farren Isaacs , Charles Cantor , Daniel Dwyer
IPC分类号： A01K67/027 , C07H21/04 , C12N15/09 , C12N5/06
CPC分类号： C12N15/67 , C12N15/11 , C12N2310/53 , C12Q1/6897
摘要： The present invention provides nucleic acid molecules, DNA constructs, plasmids, and methods for post-transcriptional regulation of gene expression using RNA molecules to both repress and activate translation of an open reading frame. Repression of gene expression is achieved through the presence of a regulatory nucleic acid element (the cis-repressive RNA or crRNA) within the 5′ untranslated region (5′ UTR) of an mRNA molecule. The nucleic acid element forms a hairpin (stem/loop) structure through complementary base pairing. The hairpin blocks access to the mRNA transcript by the ribosome, thereby preventing translation. In particular, in embodiments of the invention designed to operate in prokaryotic cells, the stem of the hairpin secondary structure sequesters the ribosome binding site (RBS). In embodiments of the invention designed to operate in eukaryotic cells, the stem of the hairpin is positioned upstream of the start codon, anywhere within the 5′ UTR of an mRNA. A small RNA (trans-activating RNA, or taRNA), expressed in trans, interacts with the crRNA and alters the hairpin structure. This alteration allows the ribosome to gain access to the region of the transcript upstream of the start codon, thereby activating transcription from its previously repressed state.
摘要翻译：本发明提供核酸分子，DNA构建体，质粒和用于转录后调节基因表达的方法，其使用RNA分子抑制和激活开放阅读框的翻译。通过在mRNA分子的5'非翻译区（5'UTR）内存在调节性核酸元件（顺式抑制性RNA或crRNA）来实现基因表达的抑制。核酸元件通过互补碱基配对形成发夹（茎/环）结构。发夹阻止核糖体进入mRNA转录物，从而阻止翻译。特别地，在设计用于在原核细胞中操作的本发明的实施方案中，发夹二级结构的茎螯合核糖体结合位点（RBS）。在设计用于在真核细胞中操作的本发明的实施方案中，发夹的茎位于起始密码子的上游，位于mRNA的5'UTR内的任何位置。以反式表达的小RNA（反式激活RNA或taRNA）与crRNA相互作用并改变发夹结构。这种改变允许核糖体进入起始密码子上游的转录物区域，从而从其先前的抑制状态激活转录。

23. 发明申请

US20070095851A1 Dispenser 审中-公开
标题翻译：分配器
公开(公告)号：US20070095851A1
公开(公告)日：2007-05-03
申请号：US10561404
申请日：2004-07-09
申请人： Gregor Anderson , James Collins , Ralph Lamble , Allen Pearson , Tom Snow , Paul Turner
发明人： Gregor Anderson , James Collins , Ralph Lamble , Allen Pearson , Tom Snow , Paul Turner
IPC分类号： B65B59/00
CPC分类号： B65D83/0409 , A61J1/03 , A61J7/0076 , A61J7/02 , A61J7/04 , B65D50/041 , B65D2583/0481
摘要： A hand-held dispenser (1) for dispensing a multiplicity of unit products (3) having a storage area (100) for storing the unit products, an outlet opening (311) through which the unit products are dispensable from the dispenser and a dispensing mechanism (350) adapted to dispense a predetermined number of said unit products through the outlet opening per actuation thereof. The dispenser is adapted such that the dispensing mechanism is actuable by pushing the dispenser into a palm of a user and such that the associated predetermined number of unit products is dispensed into that palm.
摘要翻译：一种用于分配具有用于存储单元产品的存储区域（100）的多个单元产品（3）的手持式分配器（1），单元产品通过该出口开口（311）可以从分配器中分出，并且分配机构（350），其适于通过每个致动的出口开口分配预定数量的所述单元产品。分配器适于使得分配机构可通过将分配器推入使用者的手掌而致动，并且使得相关联的预定数量的单位产品被分配到该手掌中。

24. 发明申请

US20070025571A1 Electret Condenser Microphone 审中-公开
标题翻译：驻极体冷凝器麦克风
公开(公告)号：US20070025571A1
公开(公告)日：2007-02-01
申请号：US11530192
申请日：2006-09-08
申请人： James Collins
发明人： James Collins
IPC分类号： H04R25/00
CPC分类号： H04R19/04 , H04R1/38 , H04R19/016
摘要： An electret condenser microphone includes a housing, a diaphragm disposed within the housing, first and second sound inlet ports and an acoustic resistive material disposed within the housing and in the acoustic path between the second inlet port and the diaphragm. The acoustic resistive may further electrically couple a backplate coupled to the diaphragm to an amplifier disposed within the housing.
摘要翻译：驻极体电容麦克风包括壳体，设置在壳体内的隔膜，第一和第二声音入口端口以及设置在壳体内以及在第二入口和隔膜之间的声学路径中的声阻材料。声阻可以进一步将耦合到隔膜的背板电耦合到设置在壳体内的放大器。

25. 发明申请

US20060191509A1 Codco low pressure gas driven engine operating system 审中-公开
标题翻译： Codco低压气体驱动发动机操作系统
公开(公告)号：US20060191509A1
公开(公告)日：2006-08-31
申请号：US11090603
申请日：2005-02-28
申请人： James Collins
发明人： James Collins
IPC分类号： F02B53/00
CPC分类号： F01C1/356 , F02B53/02
摘要： Sometime in 1925 when I was thirteen years old, my older brother and I were sitting on the floor of his garage, putting together a motorcycle to become my means of transportation. Suddenly he said, “Jim, figure out a way to make the pistons go around in a circle.”I would have forgotten all about this, had I not known that he had reworked the single cylinder engine of an Indian Junior Scout motorcycle for his ninety pound step-daughter to ride in the races, in the desert above the City of San Bernardino Calif. She was continually beating the Harley-Davidson motorcycles. The pistons in “The Codco engine” of, “The Codco low pressure gas driven engine operating system,” go around in a circle.
摘要翻译：在1925年，当我十三岁的时候，我的哥哥和我坐在他的车库的地板上，把摩托车放在一起成为我的交通工具。突然他说：“吉姆，想出一个让活塞绕圈子的方法，”我会忘记这一切，如果我不知道他已经为印度少年童军摩托车的单缸发动机在圣贝尔迪诺市加利福尼亚州上空的沙漠中，九十磅重的女儿骑在比赛中，她一直在殴打哈雷戴维森摩托车。 “Codco低压气体驱动发动机操作系统”的“Codco发动机”中的活塞环绕一圈。

26. 发明申请

US20060113791A1 Fluid distribution system 有权
标题翻译：流体分配系统
公开(公告)号：US20060113791A1
公开(公告)日：2006-06-01
申请号：US11328699
申请日：2006-01-10
申请人： Gunter Matt , James Collins , Michael Cain , Paul Adkins
发明人： Gunter Matt , James Collins , Michael Cain , Paul Adkins
IPC分类号： F16L41/08
CPC分类号： F16L21/08 , F16L25/0009
摘要： An outlet plate fitting configured for attaching a secondary component to a fluid pipe section. The fluid pipe section includes opposed flanges that define a receiving groove having a bottom surface. The outlet plate fitting includes a main body, an engagement platform connected to and at a distance from the main body, and a bore extending through the main body and the engagement platform. A first surface of the engagement platform faces away from the main body and is a planar surface with a seal member positioned about the bore. A second surface of the engagement platform faces toward the main body and has a ramped surface, such that rotation of the engagement platform in a first direction within the receiving groove causes the planar surface and seal member into sealing engagement with the bottom surface of the receiving groove.
摘要翻译：出口板配件，其构造成用于将次要部件附接到流体管段。流体管部分包括限定具有底表面的接收槽的相对的凸缘。出口板配件包括主体，与主体连接并且距离主体一定距离的接合平台，以及延伸穿过主体和接合平台的孔。接合平台的第一表面远离主体并且是具有围绕孔定位的密封构件的平坦表面。接合平台的第二表面面向主体并且具有倾斜表面，使得接合平台沿接收槽内的第一方向的旋转使得平面表面和密封构件与接收器的底表面密封接合槽。

27. 发明申请

US20060091320A1 Storage phosphor cassette 失效
标题翻译：存储荧光粉盒
公开(公告)号：US20060091320A1
公开(公告)日：2006-05-04
申请号：US10975874
申请日：2004-10-28
申请人： James Collins , William Wendlandt
发明人： James Collins , William Wendlandt
IPC分类号： G03B42/08
CPC分类号： G03B42/04
摘要： A storage phosphor cassette including a shell having a cavity and a storage phosphor assembly having a substantially rigid plate. The rigid plate is adapted to be removably contained within the cavity of the shell and is also comprised of a material which is optically and/or radiographically transparent. A single storage phosphor screen is supported on one side of the substantially rigid plate such that both surfaces of the storage phosphor screen are optically and/or radiographically visible. In a preferred embodiment, the rigid plate can be comprised of one or more layers of clear acrylic, or at least one layer of glass disposed intermediate two layers of clear acrylic.
摘要翻译：一种存储荧光体盒，包括具有空腔的外壳和具有基本上刚性的板的存储荧光体组件。刚性板适于可拆卸地容纳在壳体的空腔内，并且还包括光学和/或射线透视的材料。单个存储荧光屏被支撑在基本上刚性的板的一侧上，使得存储荧光屏的两个表面是光学和/或放射学上可见的。在一个优选实施例中，刚性板可以由一层或多层透明丙烯酸或至少一层玻璃层构成，两层透明丙烯酸层位于中间。

28. 发明申请

US20060049690A1 Brake booster vacuum prediction algorithm and method of use therefor 失效
标题翻译：制动助力器真空预测算法及其使用方法
公开(公告)号：US20060049690A1
公开(公告)日：2006-03-09
申请号：US11266604
申请日：2005-11-03
申请人： James Collins , Robert Nisonger , Christopher Murphy
发明人： James Collins , Robert Nisonger , Christopher Murphy
IPC分类号： B60T8/44
CPC分类号： B60T13/72 , B60T17/22 , B60T2201/03 , F02D41/021 , F02D2250/41
摘要： An algorithm residing in, for example the ECM of a motor vehicle, which predicts brake booster vacuum for vehicles using vacuum for brake pedal assist. The predicted brake booster vacuum is compared to a calibrated brake booster vacuum threshold to determine if adequate brake booster vacuum is available to meet vehicle braking requirements, whereupon engine operation can be modified, as necessary, to improve intake manifold vacuum such that brake booster vacuum requirements for vehicle braking are better satisfied.
摘要翻译：位于例如机动车辆的ECM中的算法，其预测用于车辆的制动助力器真空用于制动踏板辅助的真空。将预测的制动助力器真空度与校准的制动器增压器真空阈值进行比较，以确定是否有足够的制动器增压器真空度来满足车辆制动要求，从而可以根据需要修改发动机运行，以改进进气歧管真空度，使制动器增压器真空要求对于车辆制动更好的满足。

29. 发明申请

US20050252936A1 Dispensing mechanism using long tubes to vary pressure drop 有权
标题翻译：分配机构使用长管来改变压降
公开(公告)号：US20050252936A1
公开(公告)日：2005-11-17
申请号：US11081109
申请日：2005-03-16
申请人： Patrick Finlay , Kenneth Ritsher , James Collins , Andrzej Skoskiewicz
发明人： Patrick Finlay , Kenneth Ritsher , James Collins , Andrzej Skoskiewicz
IPC分类号： B67B7/00 , B67D1/04
CPC分类号： B67D1/0456
摘要： A fountain-style carbonated soft drink dispenser includes a housing adapted to attach to a beverage container, an actuator for selectively opening a fluid conduit, and one or more long tubes that vary a pressure drop across the dispensing assembly and convey fluid. The resistance through the tube(s) is decreased as the pressure within the container decreases so as to maintain a substantially constant flow rate throughout dispensing.
摘要翻译：喷泉式碳酸软饮料分配器包括适于附接到饮料容器的壳体，用于选择性地打开流体导管的致动器以及改变分配组件上的压降并输送流体的一个或多个长管。当容器内的压力降低时，通过管的电阻降低，以便在分配中保持基本上恒定的流速。

30. 发明申请

US20050242123A1 Dispenser assembly having a porous flow control member 有权
标题翻译：具有多孔流动控制构件的分配器组件
公开(公告)号：US20050242123A1
公开(公告)日：2005-11-03
申请号：US11081280
申请日：2005-03-16
申请人： Patrick Finlay , Kenneth Ritsher , James Collins , Andrzej Skoskiewicz
发明人： Patrick Finlay , Kenneth Ritsher , James Collins , Andrzej Skoskiewicz
IPC分类号： B67D7/76 , B65D83/00 , B67D1/00 , B67D1/04
CPC分类号： B67D1/0456 , B67D2210/0001
摘要： A dispenser assembly that can be used as a dispenser on a container includes a dispenser body having a flow passage, and a porous flow control member positioned in the flow passage such that the liquid must pass through at least a portion of the porous flow control member before being dispensed. The porous flow control member is operable to vary a resistance to flow of the liquid through the dispenser assembly during dispensing. A valve is provided and is movable between an open position that allows the liquid to be dispensed and a closed position that prevents the liquid from being dispensed. A discharge spout directs the flow of liquid discharged from the container. A dip tube is attached to the dispenser body and extends inside the container to supply the liquid to be discharged to the dispenser body. An attachment portion is provided to attach the dispenser assembly to the container.
摘要翻译：可用作容器上的分配器的分配器组件包括具有流动通道的分配器主体和定位在流动通道中的多孔流量控制构件，使得液体必须通过多孔流动控制构件的至少一部分在分配之前。多孔流动控制构件可操作以在分配期间改变通过分配器组件的液体的流动阻力。阀被设置并且可以在允许液体分配的打开位置和防止液体被分配的关闭位置之间移动。排出口引导从容器排出的液体流。汲取管附接到分配器主体并且在容器内部延伸以将待排出的液体供应到分配器主体。提供附接部分以将分配器组件附接到容器。

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