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21. 发明授权

US09687464B2 Anti-cancer agent delivery vehicles capable of improved loading 有权
公开(公告)号：US09687464B2
公开(公告)日：2017-06-27
申请号：US13634036
申请日：2011-03-11
申请人： Motoichi Kurisawa , Kun Liang , Susi Tan , Joo Eun Chung , Jackie Y. Ying
发明人： Motoichi Kurisawa , Kun Liang , Susi Tan , Joo Eun Chung , Jackie Y. Ying
IPC分类号： A61K31/33 , A61K31/282 , A61K9/00 , A61K9/107 , A61K31/337 , A61K31/353 , A61K31/704 , A61K31/7088 , A61K45/06 , A61K47/48
CPC分类号： A61K31/282 , A61K9/0019 , A61K9/1075 , A61K31/337 , A61K31/353 , A61K31/704 , A61K31/7088 , A61K45/06 , A61K47/48215 , A61K47/60 , A61K2300/00
摘要： There is provided a conjugate of a delivery agent containing a chemical moiety and at least one flavonoid. The flavonoid exists in a monomeric form or dimeric form before conjugation and remains in the monomeric form or dimeric form after conjugation. Preferably, the conjugate comprises two flavonoids. The delivery agent is conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. An anti-cancer agent delivery vehicle comprising an anti-cancer agent and the conjugate is also provided.

22. 再颁专利

USRE44820E1 Nanocrystalline apatites and composites, prostheses incorporating them, and methods of their production 有权
标题翻译：纳米晶磷灰石和复合材料，并入其中的假体及其生产方法
公开(公告)号：USRE44820E1
公开(公告)日：2014-04-01
申请号：US13536924
申请日：2012-06-28
申请人： Jackie Y. Ying , Edward S. Ahn , Atsuski Nakahira
发明人： Jackie Y. Ying , Edward S. Ahn , Atsuski Nakahira
IPC分类号： A61F2/28 , C01B15/16
CPC分类号： A61L27/12 , A61F2/30767 , A61F2310/00239 , A61F2310/00293 , A61F2310/00796 , A61L27/32 , A61L2400/12 , B82Y30/00 , C01B25/32 , C03C4/0007 , C03C14/00 , C04B35/117 , C04B35/447 , C04B35/46 , C04B35/488 , C04B35/6262 , C04B35/62675 , C04B35/645 , C04B2235/3212 , C04B2235/3217 , C04B2235/3225 , C04B2235/3232 , C04B2235/3244 , C04B2235/3246 , C04B2235/5409 , C04B2235/5445 , C04B2235/5454 , C04B2235/549 , C04B2235/608 , C04B2235/656 , C04B2235/6562 , C04B2235/6567 , C04B2235/668 , C04B2235/77 , C04B2235/785 , C04B2235/80 , C04B2235/96 , C04B2235/9653 , F16C2240/64 , Y10S977/776
摘要： Methods for synthesis of nanocrystalline apatites are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the recovered product. Particulate apatite compositions having average crystal size of less than 150 nm are provided. Products also can have a surface area of at least 40 m2/g and can be of high density.Hydroxyapatite material is investigated in particular detail. Compositions of the invention can be used as prosthetic implants and coatings for prosthetic implants.
摘要翻译：提出了纳米晶磷灰石的合成方法，以及一系列具体的反应参数，可以根据具体方式调整回收产物的特性。提供平均晶体尺寸小于150nm的颗粒状磷灰石组合物。产品还可以具有至少40m 2 / g的表面积，并且可以具有高密度。详细研究了羟基磷灰石材料。本发明的组合物可以用作假体植入物和用于假体植入物的涂层。

23. 发明申请

US20130189604A1 NANOCOMPOSITES 有权
公开(公告)号：US20130189604A1
公开(公告)日：2013-07-25
申请号：US13522944
申请日：2011-03-30
申请人： Jackie Y. Ying , Jun Yang
发明人： Jackie Y. Ying , Jun Yang
IPC分类号： H01M4/92 , H01M4/88 , H01M4/96 , H01M4/86
CPC分类号： H01M4/921 , B01J23/50 , B01J27/045 , B01J35/002 , B01J35/004 , B01J35/006 , H01M4/8657 , H01M4/8842 , H01M4/926 , H01M4/96
摘要： The invention pertains to heterogenous noble metal nanostructures comprising silver salts and different noble metals, and methods for synthesis and use of various nanocomposite materials having silver salts and different noble metals.
摘要翻译：本发明涉及包含银盐和不同贵金属的异质贵金属纳米结构体，以及合成和使用具有银盐和不同贵金属的各种纳米复合材料的方法。

24. 发明授权

US08450105B2 Mechanically reversible gel 有权
标题翻译：机械可逆凝胶
公开(公告)号：US08450105B2
公开(公告)日：2013-05-28
申请号：US12299199
申请日：2007-05-04
申请人： Jackie Y. Ying , Shona Pek , Andrew C A Wan
发明人： Jackie Y. Ying , Shona Pek , Andrew C A Wan
IPC分类号： C12M1/12 , C12N11/14 , C12N5/00 , C12N5/02
CPC分类号： C08G77/46 , C01B33/14 , C01B33/163 , C08G77/50
摘要： A process for making a gel comprising combining a silanol species comprising at least two silanol groups per molecule and a hydrophilic hydroxyl species comprising at least two hydroxyl groups per molecule. The gel is capable of being converted to a liquid by application of a mechanical shear force and the liquid is capable of being converted to the gel in the absence of the mechanical shear force.
摘要翻译：一种制备凝胶的方法，其包括每分子组合含有至少两个硅烷醇基团的硅烷醇物质和每分子包含至少两个羟基的亲水羟基物质。该凝胶能够通过施加机械剪切力而转化为液体，并且液体能够在不存在机械剪切力的情况下转化为凝胶。

25. 发明授权

US08398931B2 Recirculating reactor 失效
标题翻译：循环反应器
公开(公告)号：US08398931B2
公开(公告)日：2013-03-19
申请号：US12875737
申请日：2010-09-03
申请人： Jackie Y. Ying , Su Seong Lee , Jaehong Lim , Siti Nurhanna binte Riduan
发明人： Jackie Y. Ying , Su Seong Lee , Jaehong Lim , Siti Nurhanna binte Riduan
IPC分类号： B01J8/00 , B01J8/06
CPC分类号： B01J8/025 , B01J8/0214 , B01J8/20 , B01J8/22 , B01J19/0093 , B01J2208/00867 , B01J2219/00788 , B01J2219/00835 , B01J2219/00873 , B01J2219/00905
摘要： The invention provides a recirculating reactor for converting a substrate to a product. The reactor comprises a reaction chamber and a recirculation system, said recirculation system comprising a separator. The reaction chamber contains a catalyst, and comprises a chamber body, a chamber inlet and a chamber outlet. The recirculation system is adapted for recirculating liquid from the chamber outlet to the chamber inlet, and the separator is used for separating a by-product from the liquid.
摘要翻译：本发明提供一种用于将基材转化成产物的再循环反应器。反应器包括反应室和再循环系统，所述再循环系统包括分离器。反应室包含催化剂，并且包括室主体，室入口和室出口。再循环系统适于将液体从室出口再循环到室入口，并且分离器用于从液体中分离副产物。

26. 发明授权

US08343443B2 Fluid processing and transfer using inter-connected multi-chamber device 有权
标题翻译：使用相互连接的多室装置的流体处理和转移
公开(公告)号：US08343443B2
公开(公告)日：2013-01-01
申请号：US12935576
申请日：2008-06-23
申请人： Jackie Y. Ying , Guolin Xu , Hock Ming Jeremy Loh
发明人： Jackie Y. Ying , Guolin Xu , Hock Ming Jeremy Loh
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： G01N35/1095 , B01L3/5027 , B01L3/50851 , B01L2200/026 , B01L2200/04 , B01L2200/0642 , B01L2200/0647 , B01L2300/0672 , B01L2300/0809 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2400/0487 , Y10T137/0391 , Y10T436/11 , Y10T436/2575
摘要： A micro-fluidic device comprises a body. The body defines pneumatic ports, chambers for receiving liquids, and a connecting conduit. Each port is sealed with a seal and is shaped to couple to a pneumatic conduit through the seal. At least some of the chambers each have a top opening and a bottom opening. The top openings are in fluid communication with corresponding ports. The bottom openings are in fluid communication with one another through the connecting conduit, which is above the bottom openings. Selective application of pneumatic pressures to the chambers through the pneumatic conduits can transfer a liquid from one chamber to another through the connecting conduit, for example, for processing bio-samples within the device.
摘要翻译：微流体装置包括主体。主体定义气动端口，用于接收液体的腔室和连接导管。每个端口用密封件密封，并且成形为通过密封件连接到气动导管。至少一些室各自具有顶部开口和底部开口。顶部开口与相应的端口流体连通。底部开口通过位于底部开口上方的连接导管彼此流体连通。通过气动导管将气压压力选择性地施加到腔室可以将液体从一个腔室传送到另一个腔室，例如通过连接导管，用于处理装置内的生物样品。

27. 发明申请

US20120107925A1 DEVICES FOR SEPARATING CELLS AND METHODS OF USING THEM 审中-公开
标题翻译：用于分离细胞的装置和使用它们的方法
公开(公告)号：US20120107925A1
公开(公告)日：2012-05-03
申请号：US13257972
申请日：2010-03-19
申请人： Mo Huang Li , Jackie Y. Ying , Jiashen Wei , Chye Cheong Wai
发明人： Mo Huang Li , Jackie Y. Ying , Jiashen Wei , Chye Cheong Wai
IPC分类号： C12N5/00 , C12M1/00
CPC分类号： B01D67/0062 , B01D63/087 , B01D69/02 , B01D69/10 , B01D71/02 , B01D2325/028 , B01L3/5023 , B01L3/5635 , B01L2200/025
摘要： The present invention refers to a device for separating cells of a defined size from a sample and to a system comprising such devices and further components. Such devices can comprise different components, such as inlet module, intermediate module, outlet module and microsieve. The present invention also refers to methods of operating such devices and uses thereof.
摘要翻译：本发明涉及一种用于将具有规定大小的细胞与样品分离的装置，以及包括这种装置和其它组分的系统。这样的装置可以包括不同的部件，例如入口模块，中间模块，出口模块和微型切片。本发明还涉及操作这种装置的方法及其用途。

28. 发明申请

US20120035288A1 FORMING COPOLYMER FROM BICONTINUOUS MICROEMULSION COMPRISING MONOMERS OF DIFFERENT HYDROPHILICITY 失效
标题翻译：由包含不同亲水单体的双酚微胶囊形成共聚物
公开(公告)号：US20120035288A1
公开(公告)日：2012-02-09
申请号：US13257570
申请日：2009-03-19
申请人： Edwin Pei Yong Chow , Jackie Y. Ying
发明人： Edwin Pei Yong Chow , Jackie Y. Ying
IPC分类号： C08J9/04 , G02C7/04 , A61F2/14 , C08F20/28 , C08F2/24
CPC分类号： C08F220/18 , C08F2/22 , C08F226/10 , C08J9/283 , C08J2207/10 , C08J2333/06
摘要： A copolymer defines interconnected pores and comprises polymerized monomers. The monomers comprise a first monomer more hydrophilic than 2-hydroxyethyl methacrylate (HEMA), and a second monomer as hydrophilic as, or less hydrophilic than, HEMA. In a method of forming a polymer, a bicontinuous microemulsion comprising water, a surfactant, and a combination of monomers copolymerizable for forming a porous copolymer is provided. The combination of monomers comprises the first and second monomers. The monomers in the bicontinuous microemulsion are polymerized to form the porous copolymer. The first monomer may comprise N-vinylpyrrolidone (NVP) or methacrylic acid (MAA). The second monomer may comprise HEMA or methyl methacrylate (MMA).
摘要翻译：共聚物定义相互连通的孔并且包含聚合的单体。所述单体包含比甲基丙烯酸羟乙酯（HEMA）更亲水的第一单体，以及与HEMA亲水或亲水性低的HEMA的第二单体。在形成聚合物的方法中，提供了包含水，表面活性剂和可共聚形成多孔共聚物的单体的组合的双连续微乳液。单体的组合包括第一和第二单体。将双连续微乳液中的单体聚合形成多孔共聚物。第一单体可以包含N-乙烯基吡咯烷酮（NVP）或甲基丙烯酸（MAA）。第二单体可以包含HEMA或甲基丙烯酸甲酯（MMA）。

29. 发明申请

US20120024770A1 MICROFLUIDIC SEPARATION SYSTEM 有权
标题翻译：微流体分离系统
公开(公告)号：US20120024770A1
公开(公告)日：2012-02-02
申请号：US12673160
申请日：2008-08-13
申请人： Jackie Y. Ying , Guolin Xu , Yoke San Daniel Lee
发明人： Jackie Y. Ying , Guolin Xu , Yoke San Daniel Lee
IPC分类号： B03C1/035 , B81B1/00
CPC分类号： B03C1/32 , B03C1/002 , B03C1/01 , B03C1/0332 , B03C1/0335 , B03C1/035 , B03C1/288 , B03C2201/18 , B03C2201/22 , B03C2201/26 , G01N35/0098
摘要： A microfluidic separation system, which comprises a magnetic separator, which itself comprises a magnetic energy source; first and second magnetically conductive members leading from the magnetic energy source and having respective terminal ends that are separated by a gap over which a magnetic field is applied due to the magnetic energy source. The separation system further comprises a microfluidic chip for insertion into the gap, which comprises a body defining channels on respective faces of the body; and an exterior lining that seals the plurality of channels to allow separate test sample volumes to circulate in at least two of the channels. Upon insertion of the chip into the gap, a first test sample volume is confined to circulating closer to the terminal end of the first member and a second test sample volume is confined to circulating closer to the terminal end of the second member.
摘要翻译：微流体分离系统，其包括磁分离器，其本身包括磁能源; 第一和第二导电构件，其从磁能源引出并且具有由由于磁能源而施加磁场的间隙分开的相应末端。分离系统还包括用于插入到间隙中的微流体芯片，其包括在主体的相应面上限定通道的主体; 以及密封多个通道以允许单独的测试样品体积在至少两个通道中循环的外部衬里。当将芯片插入到间隙中时，第一测试样本体积被限制为更靠近第一构件的终端循环，并且第二测试样本体积被限制为更靠近第二构件的终端循环。

30. 发明授权

US08007663B2 Mesostructured zeolitic materials and methods of making and using the same 有权
公开(公告)号：US08007663B2
公开(公告)日：2011-08-30
申请号：US12136642
申请日：2008-06-10
申请人： Jackie Y. Ying , Javier García-Martinez
发明人： Jackie Y. Ying , Javier García-Martinez
IPC分类号： C10G25/00 , C10G25/03
CPC分类号： B01J29/40 , B01J20/18 , B01J20/186 , B01J29/005 , B01J29/0308 , B01J29/041 , B01J29/084 , B01J29/106 , B01J29/18 , B01J29/80 , B01J2229/62 , B82Y30/00 , C01B39/02 , C01B39/023 , C01B39/026 , C01B39/04 , C10G1/086 , C10G11/02 , C10G11/05 , C10G11/18 , C10G45/04 , C10G47/02 , C10G2300/1033 , C10G2300/1074 , C10G2300/1096 , C10G2400/02 , C10G2400/20 , Y10T428/26
摘要： One aspect of the present invention relates to mesostructured zeolites. The invention also relates to a method of preparing mesostructured zeolites, as well as using them as cracking catalysts for organic compounds and degradation catalysts for polymers.

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