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1. 发明授权

US08268177B2 Microfluidic separation system 有权
标题翻译：微流控分离系统
公开(公告)号：US08268177B2
公开(公告)日：2012-09-18
申请号：US12673160
申请日：2008-08-13
申请人： Jackie Y. Ying , Guolin Xu , Yoke San Daniel Lee
发明人： Jackie Y. Ying , Guolin Xu , Yoke San Daniel Lee
IPC分类号： B03C1/035 , B81B1/00
CPC分类号： B03C1/32 , B03C1/002 , B03C1/01 , B03C1/0332 , B03C1/0335 , B03C1/035 , B03C1/288 , B03C2201/18 , B03C2201/22 , B03C2201/26 , G01N35/0098
摘要： A microfluidic separation system, which comprises a magnetic separator, which itself comprises a magnetic energy source; first and second magnetically conductive members leading from the magnetic energy source and having respective terminal ends that are separated by a gap over which a magnetic field is applied due to the magnetic energy source. The separation system further comprises a microfluidic chip for insertion into the gap, which comprises a body defining channels on respective faces of the body; and an exterior lining that seals the plurality of channels to allow separate test sample volumes to circulate in at least two of the channels. Upon insertion of the chip into the gap, a first test sample volume is confined to circulating closer to the terminal end of the first member and a second test sample volume is confined to circulating closer to the terminal end of the second member.
摘要翻译：微流体分离系统，其包括磁分离器，其本身包括磁能源; 第一和第二导电构件，其从磁能源引出并且具有由由于磁能源而施加磁场的间隙分开的相应末端。分离系统还包括用于插入到间隙中的微流体芯片，其包括在主体的相应面上限定通道的主体; 以及密封多个通道以允许单独的测试样品体积在至少两个通道中循环的外部衬里。当将芯片插入到间隙中时，第一测试样本体积被限制为更靠近第一构件的终端循环，并且第二测试样本体积被限制为更靠近第二构件的终端循环。

2. 发明授权

US09707563B2 Reagent fluid dispensing device, and method of dispensing a reagent fluid 有权
公开(公告)号：US09707563B2
公开(公告)日：2017-07-18
申请号：US13696063
申请日：2011-05-04
申请人： Mo-Huang Li , Jackie Y. Ying , Guolin Xu , Yoke San Daniel Lee , Emril Mohamed Ali , Tseng-Ming Hsieh
发明人： Mo-Huang Li , Jackie Y. Ying , Guolin Xu , Yoke San Daniel Lee , Emril Mohamed Ali , Tseng-Ming Hsieh
IPC分类号： B01L3/00 , B01L3/02 , F04F1/18
CPC分类号： B01L3/52 , F04F1/18
摘要： According to various embodiments, a reagent fluid dispensing device may be provided. The reagent fluid dispensing device may include a chamber for receiving a reagent fluid, the chamber having a first opening and a second opening; a first fluid conduit connected to the first opening of the chamber; a reservoir connected to the first fluid conduit, the reservoir having a first opening, wherein the first opening of the reservoir is connected to the first fluid conduit to form a passive valve, wherein the reservoir is dimensionalized for storing a predetermined volume of the reagent fluid; and a pneumatic conduit connected to the second opening of the chamber, wherein selective application of pneumatic pressure to the chamber through the pneumatic conduit transfers the reagent fluid from the reservoir to the chamber through the first fluid conduit. According to various embodiments, a microfluidic device including the reagent fluid dispensing device, and a method of dispensing a reagent fluid may be provided.

3. 发明申请

US20130136671A1 REAGENT FLUID DISPENSING DEVICE, AND METHOD OF DISPENSING A REAGENT FLUID 有权
标题翻译：试剂流体分配装置和分配试剂流体的方法
公开(公告)号：US20130136671A1
公开(公告)日：2013-05-30
申请号：US13696063
申请日：2011-05-04
申请人： Mo-Huang Li , Jackie Y. Yang , Guolin Xu , Yoke San Daniel Lee , Emril Mohamed Ali , Tseng-Ming Hsieh
发明人： Mo-Huang Li , Jackie Y. Yang , Guolin Xu , Yoke San Daniel Lee , Emril Mohamed Ali , Tseng-Ming Hsieh
IPC分类号： B01L3/00 , B01L3/02
CPC分类号： B01L3/52 , F04F1/18
摘要： According to various embodiments, a reagent fluid dispensing device may be provided. The reagent fluid dispensing device may include a chamber for receiving a reagent fluid, the chamber having a first opening and a second opening; a first fluid conduit connected to the first opening of the chamber; a reservoir connected to the first fluid conduit, the reservoir having a first opening, wherein the first opening of the reservoir is connected to the first fluid conduit to form a passive valve, wherein the reservoir is dimensionalized for storing a predetermined volume of the reagent fluid; and a pneumatic conduit connected to the second opening of the chamber, wherein selective application of pneumatic pressure to the chamber through the pneumatic conduit transfers the reagent fluid from the reservoir to the chamber through the first fluid conduit. According to various embodiments, a microfluidic device including the reagent fluid dispensing device, and a method of dispensing a reagent fluid may be provided.
摘要翻译：根据各种实施例，可以提供试剂流体分配装置。试剂流体分配装置可以包括用于接收试剂流体的腔室，该腔室具有第一开口和第二开口; 连接到所述室的第一开口的第一流体导管; 连接到第一流体管道的储存器，储存器具有第一开口，其中储存器的第一开口连接到第一流体导管以形成被动阀，其中储存器被尺寸化以存储预定体积的试剂流体 ; 以及连接到所述腔室的第二开口的气动导管，其中通过所述气动导管选择性地将气压施加到所述腔室通过所述第一流体导管将所述试剂流体从所述储存器传送到所述腔室。根据各种实施例，可以提供包括试剂流体分配装置的微流体装置和分配试剂流体的方法。

4. 发明申请

US20120024770A1 MICROFLUIDIC SEPARATION SYSTEM 有权
标题翻译：微流体分离系统
公开(公告)号：US20120024770A1
公开(公告)日：2012-02-02
申请号：US12673160
申请日：2008-08-13
申请人： Jackie Y. Ying , Guolin Xu , Yoke San Daniel Lee
发明人： Jackie Y. Ying , Guolin Xu , Yoke San Daniel Lee
IPC分类号： B03C1/035 , B81B1/00
CPC分类号： B03C1/32 , B03C1/002 , B03C1/01 , B03C1/0332 , B03C1/0335 , B03C1/035 , B03C1/288 , B03C2201/18 , B03C2201/22 , B03C2201/26 , G01N35/0098
摘要： A microfluidic separation system, which comprises a magnetic separator, which itself comprises a magnetic energy source; first and second magnetically conductive members leading from the magnetic energy source and having respective terminal ends that are separated by a gap over which a magnetic field is applied due to the magnetic energy source. The separation system further comprises a microfluidic chip for insertion into the gap, which comprises a body defining channels on respective faces of the body; and an exterior lining that seals the plurality of channels to allow separate test sample volumes to circulate in at least two of the channels. Upon insertion of the chip into the gap, a first test sample volume is confined to circulating closer to the terminal end of the first member and a second test sample volume is confined to circulating closer to the terminal end of the second member.
摘要翻译：微流体分离系统，其包括磁分离器，其本身包括磁能源; 第一和第二导电构件，其从磁能源引出并且具有由由于磁能源而施加磁场的间隙分开的相应末端。分离系统还包括用于插入到间隙中的微流体芯片，其包括在主体的相应面上限定通道的主体; 以及密封多个通道以允许单独的测试样品体积在至少两个通道中循环的外部衬里。当将芯片插入到间隙中时，第一测试样本体积被限制为更靠近第一构件的终端循环，并且第二测试样本体积被限制为更靠近第二构件的终端循环。

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