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    • 24. 发明申请
    • Aerosol preparation comprising sealed container and enclosed therein aerosol composition containing marcolide compound
    • 气溶胶制剂,包括密封容器并封闭含有砂糖复合物的气溶胶组合物
    • US20060124903A1
    • 2006-06-15
    • US10559380
    • 2004-06-08
    • Hideki ItoHiromitsu Yoshida
    • Hideki ItoHiromitsu Yoshida
    • C01B31/20C09K3/00
    • A61K9/008A61M15/009B65D83/54B65D83/752
    • An aerosol preparation comprising an enclosure enclosing an aerosol composition containing a macrolide compound (e.g., tacrolimus) serving as an active ingredient has a problem such that the formulation of the aerosol composition is changed with the passage of time so as to reduce the ratio of the active ingredient in the aerosol composition because the macrolide compound as the active ingredient is partly adsorbed to a “gasket” of a valve part made of resinous material. In an aerosol preparation of the invention comprising an aerosol composition containing a macrolide compound and an enclosure enclosing the aerosol composition, a valve part of the enclosure has a “gasket” made of at least one resinous material selected from butyl rubber, ethylene-propylene rubber, chloroprene rubber, polyethylene, polybutylene terephthalate, polyacetal, polyamide, polytetrafluoroethylene, polypropylene and thermoplastic elastomer, thereby solving the problem.
    • 包含封闭含有作为活性成分的大环内酯类化合物(例如他克莫司)的气溶胶组合物的外壳的气溶胶制剂具有这样的问题,使得气溶胶组合物的配方随着时间的推移而改变,以便降低 由于作为活性成分的大环内酯类化合物被部分地吸附到由树脂材料制成的阀部件的“垫圈”上,因此气溶胶组合物中的活性成分。 在包含含有大环内酯化合物的气溶胶组合物和包围气溶胶组合物的外壳的本发明的气溶胶制剂中,外壳的阀部分具有由至少一种树脂材料制成的“垫圈”,所述树脂材料选自丁基橡胶,乙丙橡胶 ,氯丁橡胶,聚乙烯,聚对苯二甲酸丁二醇酯,聚缩醛,聚酰胺,聚四氟乙烯,聚丙烯和热塑性弹性体,从而解决了这个问题。
    • 26. 发明授权
    • Keyboard input device
    • 键盘输入设备
    • US06869240B2
    • 2005-03-22
    • US10378765
    • 2003-03-03
    • Hideki Ito
    • Hideki Ito
    • G06F3/02G06F1/16G06F3/033G09G5/00
    • G06F3/0338G06F3/0213
    • A keyboard input device equipped with a pointing device featuring excellent water-proof performance and is capable of highly precisely detecting the angle of tilt and the direction of tilt of the operation body of the pointing device. The pointing device has a cylindrical operation body erected on a base. When the base is mounted on the back surface side of the support plate, the operation body protrudes toward the key switch side penetrating through the support plate. The base is mounted on the support plate forming a gap of a size A relative to the support plate, and a water-proof rubber of a predetermined thickness is arranged in the gap of the size A to prevent the water from entering the base side of the pointing device.
    • 一种装有指示装置的键盘输入装置,具有优良的防水性能,能够高精度地检测指示装置的操作体的倾斜角度和倾斜方向。 指示装置具有竖立在基座上的圆柱形操作体。 当基座安装在支撑板的背面侧时,操作体朝向穿过支撑板的键开关侧突出。 基座安装在支撑板上,形成相对于支撑板的尺寸A的间隙,并且在尺寸为A的间隙中布置预定厚度的防水橡胶,以防止水进入基座侧 指点设备。