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21. 发明授权

US07615552B2 Fused heterocyclic compounds 有权
标题翻译：稠合杂环化合物
公开(公告)号：US07615552B2
公开(公告)日：2009-11-10
申请号：US10985627
申请日：2004-11-10
申请人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Teresa Przewloka , Hao Li , Zachary Demko , Dinesh Chimmanamada
发明人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Teresa Przewloka , Hao Li , Zachary Demko , Dinesh Chimmanamada
IPC分类号： A61K31/517 , A61K31/5377 , C07D265/30 , C07D413/04
CPC分类号： C07D239/95 , C04B35/632 , C07D215/40 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/04 , C07D413/14 , C07D471/04 , C07D475/06 , C07D491/04
摘要： This invention provides fused heterocyclic compounds, pharmaceutical compositions of the compounds, and methods of using the compounds for the treatment of, inter alia, IL-12 related disease and disorders.
摘要翻译：本发明提供稠合杂环化合物，化合物的药物组合物，以及使用该化合物治疗特别是IL-12相关疾病和病症的方法。

22. 发明申请

US20070244328A1 Organocatalysts and Methods of Use in Chemical Synthesis 有权
公开(公告)号：US20070244328A1
公开(公告)日：2007-10-18
申请号：US11628818
申请日：2005-06-30
申请人： Wie Wang , Jian Wang , Hao Li
发明人： Wie Wang , Jian Wang , Hao Li
IPC分类号： C07D207/10 , C07C205/04 , C07C381/00 , C07D315/00 , C07F11/00 , C07D333/22 , C07D211/00 , C07C45/00
CPC分类号： C07D207/09 , C07B2200/07 , C07C45/511 , C07C45/54 , C07C45/72 , C07C45/74 , C07C47/56 , C07C49/203 , C07C49/21 , C07C49/235 , C07C49/647 , C07C49/653 , C07C49/683 , C07C49/697 , C07C49/753 , C07C49/86 , C07C67/343 , C07C201/12 , C07C205/44 , C07C205/45 , C07C213/02 , C07C215/42 , C07C227/32 , C07C239/20 , C07C253/30 , C07C319/14 , C07C391/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D309/30 , C07D317/72 , C07D333/22 , C07C49/258 , C07C49/245 , C07C69/76 , C07C323/22 , C07C255/56 , C07C229/22 , C07C229/28 , C07C229/30 , C07C229/36
摘要： The present invention pertains generally to compositions comprising organocatalysts that facilitate stereo-selective reactions and the method of their synthesis and use. Particularly, the invention relates to metal-free organocatalysts for facilitation of stereo-selective reactions, and the method of their synthesis and use. These compounds have the structure of the Formulas (I) and (II). Where X is independently selected from CH2, N—Ra, O, S or C═O; Y is CH2, N—Ra, O, S or C═O, with the proviso that at least one of X or Y is CH2, and preferably both of X and Y are CH2; Ra is H, an optionally substituted C1-C12 alkyl, preferably an optionally substituted C1-C6alkyl including a C3-C6 cyclic alkyl group, or an optionally substituted aryl group, preferably an optionally substituted phenyl group; Rb is H, an optionally substituted C1-C12 alkyl, preferably an optionally substituted C1-C6 acyclic or a a C3-C6 cyclic alkyl group, CIIO, N(Me)O, CO(S)Ra or the group of Formula (III). Where Rc and Rd are each independently H, F, Cl, an optionally substituted C1-C20 alkyl, preferably an optionally substituted C1-C12 alkyl, more preferably a C1-C6 alkyl, and an optionally substituted aryl group, or together Rc and Rd form an optionally substituted carbocyclic or optionally substituted heterocyclic ring; R1 is OH, OR, NR′R″, NHC(═O)R, NHSO2R; R2 is H, F, Cl, an optionally substituted C1-C20 alkyl, preferably an optionally substituted C1C6 alkyl, an optionally substituted aryl group or a ═O group (which establishes a carbonyl group with the carbon to which ═O is attached; R3 is H, OH, F, Cl, Br, I, Cl, an optionally substituted C1-C20 alkyl, alkenyl or alkynyl (“hydrocarbyl”) group, preferably an optionally substituted C1-C6 alkyl, or an optionally substituted aryl, such that the carbon to which R3 is attached has an R or S configuration; R is II, an optionally substituted C1-C20 alkyl, preferably an optionally substituted C1-C6 alkyl, or an optionally substituted aryl group, R′ and R″ are each independently H, an optionally substituted C1-C20 alkyl group, preferably an optionally substituted C1-C6 alkyl, or an optionally substituted aryl group; or together R′ and R″ form an optionally substituted heterocyclic, preferably a 4 to 7 membered optionally substituted heterocyclic group or an optionally substituted heteroaryl ring with the nitrogen to which R′ and R″ are attached; and wherein said compound is free from a metal catalyst.

23. 发明申请

US20060122156A1 Heteroaryl compounds 有权
标题翻译：杂芳基化合物
公开(公告)号：US20060122156A1
公开(公告)日：2006-06-08
申请号：US11271704
申请日：2005-11-10
申请人： Lijun Sun , Shijie Zhang , Keizo Koya , Dinesh Chimmanamada , Hao Li , David James , Elena Kostik
发明人： Lijun Sun , Shijie Zhang , Keizo Koya , Dinesh Chimmanamada , Hao Li , David James , Elena Kostik
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/655
CPC分类号： C07D213/75 , C07D213/77 , C07D239/47 , C07D239/48 , C07D239/50 , C07D239/56 , C07D251/42 , C07D251/52 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07D491/10
摘要： This invention relates to compounds of formula (I): their compositions and methods of use thereof. The compounds (and compositions) are useful in modulating IL-12 production and processes mediated by IL-12.
摘要翻译：本发明涉及式（I）化合物：它们的组成及其使用方法。化合物（和组合物）可用于调节由IL-12介导的IL-12产生和过程。

24. 发明申请

US20050250774A1 Pyridine compounds 有权
标题翻译：吡啶化合物
公开(公告)号：US20050250774A1
公开(公告)日：2005-11-10
申请号：US10985696
申请日：2004-11-10
申请人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Teresa Przewloka , Hao Li , Howard Ng , Zachary Demko
发明人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Teresa Przewloka , Hao Li , Howard Ng , Zachary Demko
IPC分类号： A61K20060101 , A61K31/5375 , A61K31/5377 , C07D213/77 , C07D401/12 , C07D405/12 , C07D413/02 , C07D413/04 , C07D413/12
CPC分类号： C07D413/12 , C04B35/632 , C07D213/77 , C07D401/12 , C07D405/12
摘要： This invention features compounds of formula (I): pharmaceutical compositions of the compounds, and methods of using the compounds for the treatment of, inter alia, IL-12-related diseases and disorders.
摘要翻译：本发明的特征在于式（I）化合物：化合物的药物组合物，以及使用该化合物治疗特别是IL-12相关疾病和病症的方法。

25. 发明授权

US06958348B2 3-glyoxylamideindoles for treating cancer 失效
标题翻译： 3-乙醛酰胺吲哚治疗癌症
公开(公告)号：US06958348B2
公开(公告)日：2005-10-25
申请号：US10232394
申请日：2002-08-29
申请人： Keizo Koya , Lijun Sun , Mitsunori Ono , Guiqing Liang , David James , Hao Li , Zhi-Qiang Xia
发明人： Keizo Koya , Lijun Sun , Mitsunori Ono , Guiqing Liang , David James , Hao Li , Zhi-Qiang Xia
IPC分类号： A61K31/405 , A61K31/4155 , A61K31/4196 , A61K31/422 , A61K31/423 , A61K31/425 , A61K31/433 , A61K31/4439 , A61K31/4709 , A61P35/00 , C07D209/12 , C07D209/14 , C07D209/18 , C07D401/12 , C07D403/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D521/00 , A61K31/435 , C07D453/02
CPC分类号： C07D249/08 , C07D209/12 , C07D209/18 , C07D231/12 , C07D233/56 , C07D401/12 , C07D403/12 , C07D405/14 , C07D413/12 , C07D417/12
摘要： Disclosed is an anti-cancer compound represented by Structural Formula (I): The variables in Structural Formula (I) are described hereinbelow. Also disclosed is a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by Structural Formula (I) (preferably an effective amount). Also disclosed is a method of treating a subject with cancer by administering to the subject an effective amount of a compound represented by Structural Formula (I).
摘要翻译：公开了由结构式（I）表示的抗癌化合物：结构式（I）中的变量如下所述。还公开了包含药学上可接受的载体或稀释剂和由结构式（I）表示的化合物（优选有效量））的药物组合物。还公开了通过向受试者施用有效量的由结构式（I）表示的化合物来治疗患有癌症的受试者的方法。

26. 发明授权

US09976011B2 Polymer composites and fabrications thereof 有权
公开(公告)号：US09976011B2
公开(公告)日：2018-05-22
申请号：US13183221
申请日：2011-07-14
申请人： Hao Li , Qingson Yu , Liang Chen , Meng Chen
发明人： Hao Li , Qingson Yu , Liang Chen , Meng Chen
IPC分类号： C08K7/08
CPC分类号： C08K7/08 , C08K2201/011 , C08K2201/016
摘要： The present invention provides polymer composites reinforced with high aspect ratio reinforcing fillers selected from calcium phosphate nanofibers, nanoplates, submicron fibers, submicron plates, and combinations thereof. The mechanical and biological properties of the inventive composites are enhanced significantly over current polymer composites and may be employed in various biomedical applications, such as dental restorations.

27. 发明授权

US09642004B2 Access point device and system for wireless local area network, and related methods 有权
公开(公告)号：US09642004B2
公开(公告)日：2017-05-02
申请号：US14130821
申请日：2012-06-18
申请人： Yue Wang , Hao Li , Dong Wang , Hiroshi Miyata
发明人： Yue Wang , Hao Li , Dong Wang , Hiroshi Miyata
IPC分类号： H04L9/00 , H04W12/04 , H04L9/08 , H04L12/46 , H04L29/06 , H04W88/08
CPC分类号： H04W12/04 , H04L9/083 , H04L12/4641 , H04L63/065 , H04L2209/601 , H04L2209/80 , H04W88/08
摘要： The present invention provides an access point device and system for a wireless local area network, and related methods thereof. On the access point device, a same ESS is divided into a plurality of VLANs, wherein the access point device comprises a broadcast key management module which is used for managing broadcast keys encrypting broadcast information and a broadcast key storage device which is used for storing the broadcast keys. The broadcast keys are stored in the broadcast key storage device in a way of corresponding to VLAN IDs of the VLANs, and the broadcast key management module can obtain the corresponding broadcast keys through the VLAN IDs.

28. 发明授权

US09210674B2 Base station timing control using synchronous transport signals 有权
标题翻译：基站定时控制采用同步传输信号
公开(公告)号：US09210674B2
公开(公告)日：2015-12-08
申请号：US13429606
申请日：2012-03-26
申请人： Yifan Lin , Ze Mian Huang , Tao Wang , Lin Sun , Hao Li
发明人： Yifan Lin , Ze Mian Huang , Tao Wang , Lin Sun , Hao Li
IPC分类号： H04W4/00 , H04W56/00 , H04W92/04
CPC分类号： H04W56/001 , H04W92/045
摘要： A base station of a wireless system comprises a local clock source and timing circuitry coupled to the local clock source. The timing circuitry is configured to adjust at least one parameter of the local clock source based at least in part on timing information extracted from designated portions of each of one or more frames of a synchronous transport signal received in the base station. The base station may further comprise a physical layer device, such as a mapper, configured to extract the timing information from the designated portions of each of the one or more frames of the synchronous transport signal. The designated portions of the one or more frames of the synchronous transport signal from which the timing information is extracted may comprise designated overhead bytes of the one or more frames, such as, for example, transport overhead (TOH) bytes.
摘要翻译：无线系统的基站包括耦合到本地时钟源的本地时钟源和定时电路。定时电路被配置为至少部分地基于从在基站中接收的同步传输信号的一个或多个帧的每一个的指定部分提取的定时信息来调整本地时钟源的至少一个参数。基站还可以包括诸如映射器的物理层设备，被配置为从同步传输信号的一个或多个帧中的每一个的指定部分提取定时信息。提取定时信息的同步传输信号的一个或多个帧的指定部分可以包括一个或多个帧的指定的开销字节，例如传输开销（TOH）字节。

29. 发明授权

US08927548B2 Triazole compounds that modulate HSP90 activity 有权
公开(公告)号：US08927548B2
公开(公告)日：2015-01-06
申请号：US13350296
申请日：2012-01-13
申请人： Weiwen Ying , David James , Shijie Zhang , Junghyun Chae , Teresa Kowalczyk-Przewloka , Howard P. Ng , Hao Li , Zachary Demko , Dinesh U. Chimmanamada , Chi-wan Lee , Zhenjian Du , Kevin Foley , Minghu Song , Lijun Sun , Keizo Koya , Dan Zhou , Shuzhen Qin
发明人： Weiwen Ying , David James , Shijie Zhang , Junghyun Chae , Teresa Kowalczyk-Przewloka , Howard P. Ng , Hao Li , Zachary Demko , Dinesh U. Chimmanamada , Chi-wan Lee , Zhenjian Du , Kevin Foley , Minghu Song , Lijun Sun , Keizo Koya , Dan Zhou , Shuzhen Qin
IPC分类号： C07D249/12 , C07D401/04 , C07D405/10 , C07D417/04 , C07D405/14 , C07D409/04 , A61K31/5377 , A61P35/00 , C07D405/04 , C07D403/04 , C07D403/14
CPC分类号： C07D417/04 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/10 , C07D405/14 , C07D409/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

30. 发明申请

US20140362590A1 ELECTRONIC MODULE, LIGHTING DEVICE AND MANUFACTURING METHOD OF THE ELECTRONIC MODULE 审中-公开
标题翻译：电子模块，照明设备和电子模块的制造方法
公开(公告)号：US20140362590A1
公开(公告)日：2014-12-11
申请号：US14238204
申请日：2012-08-10
申请人： Peng Chen , Xiaomian Chen , Yaojun Feng , Hao Li
发明人： Peng Chen , Xiaomian Chen , Yaojun Feng , Hao Li
IPC分类号： H05K1/02 , F21V29/00 , H05K3/28
CPC分类号： H05K1/0206 , H05K3/0061 , H05K3/284 , H05K2201/10106 , H05K2203/10 , H05K2203/1147 , H05K2203/1316 , H05K2203/1327 , Y10T29/49146
摘要： An electronic module to be mounted on a mounting surface may include: a circuit board provided with a heat source, wherein a thermal via is formed through the circuit board and is in thermal contact with the heat source; and a potting material packaging the circuit board at least at the other side opposite to one side of heat source, wherein the potting material has a recess formed in at least part of an area corresponding to the thermal via at the other side of the circuit board and a thermal conductive material, which is thermal-conductively connected to the mounting surface, is filled in the recess.
摘要翻译：安装在安装表面上的电子模块可以包括：设置有热源的电路板，其中热通孔通过电路板形成并与热源热接触; 以及灌封材料至少在与热源一侧相对的另一侧封装所述电路板，其中所述灌封材料具有形成在与所述电路板的另一侧上的热通孔对应的区域的至少一部分中的凹部并且导热连接到安装表面的导热材料填充在凹部中。

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