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21. 发明授权

US06663757B1 Method and device for the convective movement of liquids in microsystems 失效
标题翻译：微系统中液体对流运动的方法和装置
公开(公告)号：US06663757B1
公开(公告)日：2003-12-16
申请号：US09868199
申请日：2001-08-06
申请人： Günter Führ , Torsten Müller , Thomas Schnelle , Rolf Hagedorn
发明人： Günter Führ , Torsten Müller , Thomas Schnelle , Rolf Hagedorn
IPC分类号： B01L300
CPC分类号： B01F13/0076 , B01F3/1235 , B01F13/0077 , F15D1/02
摘要： The aim of the invention is to convectively move at least one liquid in a channel of a microsystem which comprises a predetermined channel direction. To this end, the liquid is, in a partial section of the channel, subjected to an electric field gradient and optionally to a thermal gradient. The gradients are generated in the partial section corresponding to a predetermined field direction, whereby the field direction differs from the channel direction.
摘要翻译：本发明的目的是对流地移动包括预定通道方向的微系统的通道中的至少一个液体。为此，液体在通道的部分部分中经历电场梯度并且任选地经受热梯度。在对应于预定场方向的部分部分中生成梯度，由此场方向与频道方向不同。

22. 发明授权

US06801311B1 Process and device for the detection of microscopically small objects 有权
标题翻译：检测微小物体的过程和设备
公开(公告)号：US06801311B1
公开(公告)日：2004-10-05
申请号：US09889908
申请日：2001-12-12
申请人： Günter Fuhr , Thomas Schnelle , Christoph Reichle , Henning Glasser , Torsten Müller
发明人： Günter Fuhr , Thomas Schnelle , Christoph Reichle , Henning Glasser , Torsten Müller
IPC分类号： G01N1502
CPC分类号： B03C5/028 , B03C5/026 , G01N15/1031 , G01N15/1056 , G01N15/1484 , G01N2015/1006 , G01N2015/105 , G01N2015/1075 , G01N2015/1415 , G01N2015/1447 , G01N2015/1495
摘要： For object detection, particularly in fluidic microsystems, optical imaging of at least one resting or moving object (10) on a structured mask (20) with at least one segment from a flat section (80), in which the object (10) is located at least partially or temporarily and which has a characteristic dimension smaller than the dimension of the object (10) or its movement path, to a detector unit, detection of the quantity of light transmitted by the structured mask (20), and generation of a detector signal which has a predetermined relationship with the quantity of light, and evaluation of the detector signal in regard to the presence of the object (10), its position, its shape and/or the temporal change of the position are performed.
摘要翻译：对于物体检测，特别是在流体微系统中，至少一个静止或移动的物体（10）在结构化掩模（20）上的光学成像，其具有来自平坦部分（80）的至少一个部分，其中物体（10）至少部分地或临时地定位，并且具有比物体（10）或其移动路径的尺寸小的特征尺寸，到检测器单元，由结构化掩模（20）传输的光量的检测，以及执行与光量具有预定关系的检测器信号，以及关于物体（10）的存在，其位置，形状和/或位置的时间变化的检测器信号的评估。

23. 发明授权

US06610188B1 Electrode array for field cages 失效
标题翻译：现场笼的电极配置
公开(公告)号：US06610188B1
公开(公告)日：2003-08-26
申请号：US09308841
申请日：1999-07-30
申请人： Günter Fuhr , Thomas Schnelle , Stefan Fiedler , Stephen Graham Shirley
发明人： Günter Fuhr , Thomas Schnelle , Stefan Fiedler , Stephen Graham Shirley
IPC分类号： G01N2726
CPC分类号： B03C5/026 , C12M33/00 , C12M47/04 , G05D3/12
摘要： An electrode configuration for field cages, especially in microsystems, comprises a large number of electrodes in which an electrical potential can be applied to each end region through a feed region. The end region is arranged to form the field cage and inhomogeneous shielding fields outside the field cage. To reduce thermal convection, the feed region has a strip form whose width is substantially smaller than characteristic dimensions of the end region.
摘要翻译：用于现场保持架的电极构造，特别是在微系统中，包括大量的电极，其中可以通过进料区域将电势施加到每个端部区域。端部区域被布置成形成场笼和场笼外的不均匀屏蔽场。为了减少热对流，进料区域具有宽度大大小于端部区域的特征尺寸的带状。

24. 发明授权

US06492175B1 Microsystem for cell permeation and cell fusion 有权
标题翻译：用于细胞渗透和细胞融合的微系统
公开(公告)号：US06492175B1
公开(公告)日：2002-12-10
申请号：US09868022
申请日：2001-08-06
申请人： Torsten Müller , Thomas Schnelle , Günter Fuhr , Stephen Graham Shirley , Gabriele Gradl
发明人： Torsten Müller , Thomas Schnelle , Günter Fuhr , Stephen Graham Shirley , Gabriele Gradl
IPC分类号： C12N1502
CPC分类号： C12N15/87 , C12M35/02 , C12N13/00
摘要： An electroporation and/or fusion treatment of microscopic objects occurs in a medium between at least two electrodes, with the electrodes being miniaturized electrodes in a microsystem with a channel structure which is set up for the flow-through of the medium with the objects.
摘要翻译：在至少两个电极之间的介质中发生微观物体的电穿孔和/或融合处理，其中电极是具有通道结构的微系统中的小型化电极，其被设置用于具有物体的介质的流过。

25. 发明授权

US08262883B2 Methods and devices for separating particles in a liquid flow 有权
标题翻译：用于分离液体流中的颗粒的方法和装置
公开(公告)号：US08262883B2
公开(公告)日：2012-09-11
申请号：US10549886
申请日：2004-03-17
申请人： Torsten Müller , Thomas Schnelle , Rolf Hagedorn
发明人： Torsten Müller , Thomas Schnelle , Rolf Hagedorn
IPC分类号： B01D57/02
CPC分类号： B03C5/005
摘要： Methods and devices for the separation of particles (20, 21, 22) in a compartment (30) of a fluidic microsystem (100) are described, in which the movement of a liquid (10) in which particles (20, 21, 22) are suspended with a predetermined direction of flow through the compartment (30), and the generation of a deflecting potential in which at least a part of the particles (20, 21, 22) is moved relative to the liquid in a direction of deflection are envisaged, whereby further at least one focusing potential is generated, so that at least a part of the particles is moved opposite to the direction of deflection relative to the liquid by dielectrophoresis under the effect of high-frequency electrical fields, and guiding of particles with different electrical, magnetic or geometric properties into different flow areas (11, 12) in the liquid takes place.
摘要翻译：描述了用于在流体微系统（100）的隔室（30）中分离颗粒（20,21,22）的方法和装置，其中液体（10）的运动，其中颗粒（20,21,22 ）以预定的流动方向悬挂通过隔室（30），并产生偏转电位，其中至少一部分颗粒（20,21,22）在偏转方向上相对于液体移动被设想为进一步产生至少一个聚焦电位，使得至少一部分颗粒在高频电场的作用下通过介电电泳相对于液体的偏转方向移动，并且引导颗粒在不同的流动区域（11,12）中发生不同的电，磁或几何特性。

26. 发明授权

US08128797B2 Microfluidic system and corresponding operating method 失效
标题翻译：微流控系统及相应的操作方法
公开(公告)号：US08128797B2
公开(公告)日：2012-03-06
申请号：US12161267
申请日：2007-01-17
申请人： Torsten Müller , Thomas Schnelle
发明人： Torsten Müller , Thomas Schnelle
IPC分类号： B03C5/02
CPC分类号： C12N13/00 , B01L3/502761 , B01L2200/0668 , B01L2300/0645 , B01L2400/0421
摘要： The invention relates to an operating method for a microfluidic system, including the following steps: feeding of a carrier flow with particles (5) of a first particle type suspended therein into the microfluidic system; charging of a plurality of electrical field cages (1′, 1″) in the microfluidic system with the supplied particles (5) of the first particle type; the supplying of a carrier flow with particles (6) of a second particle type suspended therein into the microfluidic system; and charging the field cages (1′, 1″) in the microfluidic system with the supplied particles (6) of the second particle type in such a manner that a particle (5) of the first particle type and a particle (6) of the second particle type is present in at least one of the field cages (1′, 1′). The invention also relates to a corresponding microfluidic system.
摘要翻译：本发明涉及一种用于微流体系统的操作方法，包括以下步骤：将载体流与悬浮于其中的第一颗粒类型的颗粒（5）进料到微流体系统中; 在微流体系统中与所提供的第一颗粒类型的颗粒（5）充电多个电场笼（1'，1“）; 将载体流与悬浮在其中的第二颗粒类型的颗粒（6）供应到微流体系统中; 以及将所述微流体系统中的所述场笼（1'，1“）与所提供的所述第二颗粒类型的颗粒（6）以使得所述第一颗粒类型的颗粒（5）和所述第一颗粒类型的颗粒（6）第二粒子类型存在于至少一个场笼（1'，1'）中。本发明还涉及相应的微流体系统。

27. 发明授权

US07738695B2 Method and device for 3 dimensional imaging of suspended micro-objects providing high-resolution microscopy 有权
标题翻译：用于提供高分辨率显微镜的悬浮微物体三维成像的方法和装置
公开(公告)号：US07738695B2
公开(公告)日：2010-06-15
申请号：US10532147
申请日：2003-10-24
申请人： Spencer Shorte , Torsten Müller , Thomas Schnelle
发明人： Spencer Shorte , Torsten Müller , Thomas Schnelle
IPC分类号： G06K9/00
CPC分类号： G02B21/22 , G01N2015/144 , G01N2015/1445 , G01N2015/1452 , G02B21/367
摘要： A method for high-resolution image recording of at least one object with a microscope, includes the steps of: (a) positioning the object in a receptacle being arranged in the optical axis of the microscope, (b) generating at least two first data sets per object which represent intermediate images of the object with at least two different orientations relative to the optical axis of the microscope, wherein the different orientations of the object are provided by moving the object relative to the receptacle, and (c) evaluating the data sets for obtaining quantitative three dimensional information.
摘要翻译：一种用显微镜对至少一个物体进行高分辨率图像记录的方法，包括以下步骤：（a）将物体放置在布置在显微镜的光轴上的容器中，（b）产生至少两个第一数据通过相对于显微镜的光轴具有至少两个不同取向来表示对象的每个对象的集合，其中通过相对于插座移动对象来提供对象的不同取向，以及（c）评估数据用于获得定量三维信息。

28. 发明授权

US07501233B2 Method for measuring the vitality of cells 失效
标题翻译：测量细胞活力的方法
公开(公告)号：US07501233B2
公开(公告)日：2009-03-10
申请号：US10416278
申请日：2001-11-09
申请人： Gabriele Gradl , Thomas Schnelle , Torsten Müller , Christoph Reichle
发明人： Gabriele Gradl , Thomas Schnelle , Torsten Müller , Christoph Reichle
IPC分类号： C12Q1/00
CPC分类号： G01N27/447 , G01N33/48735
摘要： A method is described for non-destructive measurement of vitality of biological cells, especially for determination of apoptosis, in which the at least one cell is exposed to high-frequency alternating, especially rotating, electric fields and/or impedance test fields, and at least one rotation measurement, one dielectrophoresis measurement and/or one impedance measurement is performed with the cell for at least one frequency range or individual frequencies, from which at least one measurement parameter is determined that is characteristic of the vitality state of the cell.
摘要翻译：描述了一种用于非破坏性测量生物细胞的活力的方法，特别是用于确定细胞凋亡，其中至少一个细胞暴露于高频交替，特别是旋转的电场和/或阻抗测试领域，以及在对于至少一个频率范围或单独的频率，用该小区执行至少一次旋转测量，一次介电电泳测量和/或一个阻抗测量，从该单元测量至少一个测量参数是该单元的活力状态的特征。

29. 发明授权

US07455758B2 Fluidic microsystem comprising field-forming passivation layers provided on microelectrodes 有权
标题翻译：流体微系统包括在微电极上提供的场形成钝化层
公开(公告)号：US07455758B2
公开(公告)日：2008-11-25
申请号：US10536674
申请日：2003-11-26
申请人： Torsten Müller , Thomas Schnelle
发明人： Torsten Müller , Thomas Schnelle
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2200/0668 , B01L2300/0645 , B01L2300/16 , B01L2400/0415 , B03C5/026
摘要： Described is a fluidic microsystem (100) including at least one channel (10) through which a particle suspension can flow; and first and second electrode devices (40, 60) which are arranged on first and second channel walls (21, 31) for generating electrical alternating-voltage fields in the channel (10); wherein the first electrode device (40) for field shaping in the channel includes at least one first structure element (41, 51); and the second electrode device (60) includes an area-like electrode layer (61) with a closed second electrode surface which includes a second passivation layer (70); wherein the effective electrode surface of the first structure element (41, 51), of which element (41, 51) there is at least one, is smaller than the second electrode surface; and the second passivation layer (70) is a closed layer which completely covers the second electrode layer (61).
摘要翻译：描述了流体微系统（100），其包括至少一个通道（10），颗粒悬浮液可以通过该通道流动; 以及布置在第一和第二通道壁（21,31）上的用于在通道（10）中产生电气交变电压场的第一和第二电极装置（40,60）。其中用于所述通道中的场成形的所述第一电极装置（40）包括至少一个第一结构元件（41,51）; 并且所述第二电极器件（60）包括具有闭合的第二电极表面的区域状电极层（61），所述第二电极表面包括第二钝化层（70）。其中，所述元件（41,51）中至少有一个的所述第一结构元件（41,51）的有效电极表面小于所述第二电极表面; 并且所述第二钝化层（70）是完全覆盖所述第二电极层（61）的封闭层。

30. 发明申请

US20070125650A1 Treatment of Biological Samples Using Dielectrophoresis 有权
标题翻译：使用电泳法处理生物样品
公开(公告)号：US20070125650A1
公开(公告)日：2007-06-07
申请号：US11531679
申请日：2006-09-13
申请人： Mario Scurati , Torsten Mueller , Thomas Schnelle
发明人： Mario Scurati , Torsten Mueller , Thomas Schnelle
IPC分类号： B03C5/02
CPC分类号： B03C5/026
摘要： A plurality of planar electrodes (5) in a microchannel (4) is used for separation, lysis and PCR in a chip (10). Cells from a sample are brought to the electrodes (5). Depending on sample properties, phase pattern, frequency and voltage of the electrodes and flow velocity are chosen to trap target cells (16) using DEP, whereas the majority of unwanted cells (17) flushes through. After separation the target cell (16) are lysed while still trapped. Lysis is carried out by applying RF pulses and/or thermally so as to change the dielectric properties of the trapped cells. After lysis, the target cells (16) are amplified within the microchannel (4), so as to obtain separation, lysis and PCR on same chip (1).
摘要翻译：微通道（4）中的多个平面电极（5）用于芯片（10）中的分离，裂解和PCR。来自样品的细胞被带到电极（5）。根据样品性质，选择电极的相图，频率和电压以及流速，以使用DEP捕获靶细胞（16），而大多数不需要的细胞（17）冲洗通过。分离后，靶细胞（16）裂解，同时仍被捕获。通过施加RF脉冲和/或热来进行裂解以改变被捕获的细胞的介电性质。裂解后，在微通道（4）内扩增靶细胞（16），以在同一芯片（1）上获得分离，裂解和PCR。

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