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21. 发明申请

US20130110219A1 UNITARY DUAL-CHAMBER LEADLESS INTRA-CARDIAC MEDICAL DEVICE AND METHOD OF IMPLANTING SAME 有权
标题翻译：单位双室无胸膜内科医疗装置及其相关方法
公开(公告)号：US20130110219A1
公开(公告)日：2013-05-02
申请号：US13352167
申请日：2012-01-17
申请人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi
发明人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi
IPC分类号： A61N1/05
CPC分类号： A61N1/059 , A61B17/3468 , A61N1/0573 , A61N1/37205 , A61N1/3756 , A61N1/3962
摘要： An assembly for introducing a leadless intra-cardiac medical device includes a sheath having an internal passage, wherein the sheath is configured to be maneuvered into the heart of the patient. A housing may be retained within the internal passage, wherein the housing is configured to be pushed out of the sheath, the housing having a first anchoring member configured to anchor the housing to a first implant location within the heart. The assembly may also include an electrode trailing the housing within the internal passage, wherein the electrode is also configured to be pushed out of the sheath. The electrode has a second anchoring member configured to anchor the electrode to a second implant location within the heart. A conductive wire connects the housing to the electrode, wherein movement of the housing out of the sheath causes the electrode to follow the movement to a distal end of the sheath.
摘要翻译：用于引入无引线心脏内心脏医疗装置的组件包括具有内部通道的护套，其中护套构造成被操纵到患者的心脏中。壳体可以被保持在内部通道内，其中壳体构造成被推出护套，壳体具有构造成将壳体锚定到心脏内的第一植入位置的第一锚定构件。该组件还可以包括在内部通道内拖曳壳体的电极，其中电极还构造成被推出护套。电极具有被配置为将电极锚定到心脏内的第二植入位置的第二锚定构件。导电线将壳体连接到电极，其中壳体从鞘的移动导致电极跟随到鞘的远端的运动。

22. 发明授权

US08385999B1 Processing venous oxygen saturation and hematocrit information in an implantable sensor 有权
标题翻译：在植入式传感器中处理静脉血氧饱和度和血细胞比容信息
公开(公告)号：US08385999B1
公开(公告)日：2013-02-26
申请号：US12028261
申请日：2008-02-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
IPC分类号： A61B5/00
CPC分类号： A61N1/39 , A61B5/0031 , A61B5/14535 , A61B5/14551 , A61B5/4836 , A61N1/362
摘要： Methods of processing venous oxygen saturation and hematrocrit information in an implantable sensor are provided. In an embodiment a method for collecting data from an implantable multi-wavelength SvO2 sensor having multiple light sources is provided. The method includes receiving a frame signal that indicates a beginning of the light sources being turned on and receiving a light source signal that indicates a light source is on. The output of a photodetector is sampled to measure the intensity of the transmitted light. The process is repeated for each light source to gather intensity measurements that then can be used to generate venous oxygen saturation and hematocrit measurements.
摘要翻译：提供了在可植入传感器中处理静脉血氧饱和度和血细胞信息的方法。在一个实施例中，提供了一种用于从具有多个光源的可植入多波长SvO2传感器收集数据的方法。该方法包括接收指示光源开始接通的帧信号，并接收指示光源所接通的光源信号。对光检测器的输出进行采样以测量透射光的强度。对于每个光源重复该过程以收集强度测量，然后可以使用该测量来产生静脉血氧饱和度和血细胞比容测量。

23. 发明申请

US20110202105A1 BIOELECTRIC BATTERY FOR IMPLANTABLE DEVICE APPLICATIONS 有权
标题翻译：用于可植入器件应用的BIOELECTRIC BATTERY
公开(公告)号：US20110202105A1
公开(公告)日：2011-08-18
申请号：US13018140
申请日：2011-01-31
申请人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
发明人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
IPC分类号： A61N1/362 , H01M8/16
CPC分类号： A61N1/378 , H01M2/0275 , H01M2/1066 , H01M2/1653 , H01M2/18 , H01M2/361 , H01M4/12 , H01M4/366 , H01M4/48
摘要： A bioelectric battery may be used to power implantable devices. The bioelectric battery may have an anode electrode and a cathode electrode separated by an insulating member comprising a tube having a first end and a second end, wherein said anode is inserted into said first end of said tube and said cathode surrounds said tube such that the tube provides a support for the cathode electrode. The bioelectric battery may also have a membrane surrounding the cathode to reduce tissue encapsulation. Alternatively, an anode electrode, a cathode electrode surrounding the cathode electrode, a permeable membrane surrounding the cathode electrode. An electrolyte is disposed within the permeable membrane and a mesh surrounds the permeable membrane. In an alternative embodiment, a pacemaker housing acts as a cathode electrode for a bioelectric battery and an anode electrode is attached to the housing with an insulative adhesive.
摘要翻译：生物电池可用于为可植入装置供电。生物电池可以具有由包括具有第一端和第二端的管的绝缘构件分开的阳极电极和阴极电极，其中所述阳极插入所述管的所述第一端，所述阴极围绕所述管，使得管为阴极提供支撑。生物电池还可以具有围绕阴极的膜以减少组织包封。或者，阳极电极，围绕阴极电极的阴极电极，围绕阴极电极的可渗透膜。电解质设置在可渗透膜内，并且网围绕可渗透膜。在替代实施例中，起搏器壳体用作生物电池的阴极电极，并且阳极通过绝缘粘合剂附接到壳体。

24. 发明申请

US20100114236A1 HYBRID BATTERY SYSTEM WITH BIOELECTRIC CELL FOR IMPLANTABLE CARDIAC THERAPY DEVICE 审中-公开
标题翻译：具有用于可植入心脏治疗装置的生物电池的混合电池系统
公开(公告)号：US20100114236A1
公开(公告)日：2010-05-06
申请号：US12263348
申请日：2008-10-31
申请人： Naixiong Jiang , Gene A. Bornzin , John W. Poore
发明人： Naixiong Jiang , Gene A. Bornzin , John W. Poore
IPC分类号： A61N1/362 , H01M10/36
CPC分类号： A61N1/378 , A61N1/3956 , A61N1/3981 , H01M8/16 , H01M10/0525 , H01M10/425 , H01M10/44 , H01M16/006 , H02J7/0054 , H02J7/0063 , Y02E60/527
摘要： A system and method for powering an implantable cardiac therapy device (ICTD) via a hybrid battery system. The hybrid battery is comprised of a low voltage and low current bioelectric cell, a high voltage and high current rechargeable cell, and a charging means. Via the charging means, the bioelectric cell maintains the rechargeable cell at or near full power. The rechargeable cell is configured to power some or all operations of the ICTD. Some ICTD operations may be powered directly by the bioelectric cell. The rechargeable cell is further configured to be charged via a continuous charging process, reducing the complexity of the charging circuitry. In an embodiment, at least the bioelectric cell is external to the ICTD, enabling easy replacement of this power source. In an embodiment, a consumable anode of the bioelectric cell is external to the ICTD, enabling replacement of the power source by replacing only the anode.
摘要翻译：通过混合电池系统为植入式心脏治疗装置（ICTD）供电的系统和方法。混合电池包括低电压和低电流生物电池，高电压和高电流可再充电电池以及充电装置。通过充电装置，生物电池将可再充电电池维持在或接近全功率。可充电电池被配置为为ICTD的一些或所有操作供电。一些ICTD操作可以由生物电池直接供电。可再充电电池还被配置为经由连续充电过程进行充电，从而降低充电电路的复杂性。在一个实施例中，至少生物电池在ICTD的外部，使得能够容易地更换该电源。在一个实施例中，生物电池的消耗性阳极在ICTD的外部，能够通过仅替换阳极来替换电源。

25. 发明授权

US07630078B1 Calibrating implantable optical sensors 失效
标题翻译：校准植入光学传感器
公开(公告)号：US07630078B1
公开(公告)日：2009-12-08
申请号：US11683521
申请日：2007-03-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
IPC分类号： G01B9/08
CPC分类号： A61B5/14542 , A61B5/02028 , A61B5/14535 , A61B5/1459 , A61B2560/0223 , A61N1/36557
摘要： A measurement light detector detects light transmitted by a light source of an implantable system that is scattered back into an implantable housing, and produces a measurement signal indicative of the intensity of the light detected by the measurement light detector. A calibration light detector detects a portion of the transmitted light that has not exited the housing, and produces a calibration signal that is indicative of the intensity of the light detected by the calibration light detector, which is indicative of the intensity of the light transmitted by the light source. Changes in the intensity of the transmitted light are compensated for based on the calibration signal produced by the calibration light detector. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.
摘要翻译：测量光检测器检测由可植入系统的光源透射的光，其被散射回到可植入的壳体中，并且产生指示由测量光检测器检测到的光的强度的测量信号。校准光检测器检测未离开壳体的透射光的一部分，并且产生指示由校准光检测器检测的光的强度的校准信号，该校准信号指示由光学器件发射的光的强度光源。基于由校准光检测器产生的校准信号来补偿透射光强度的变化。本说明书不是对本发明的完整描述或限制本发明的范围。本发明的其它特征，方面和目的可以通过对说明书，附图和权利要求的评述来获得。

26. 发明授权

US06804556B1 Methods and apparatus for overdrive pacing heat tissue using an implantable cardiac stimulation device 有权
标题翻译：使用可植入心脏刺激装置的超速起搏热组织的方法和装置
公开(公告)号：US06804556B1
公开(公告)日：2004-10-12
申请号：US10036026
申请日：2001-12-21
申请人： Joseph J. Florio , Gene A. Bornzin , John W. Poore , Douglas T. Kurschinski
发明人： Joseph J. Florio , Gene A. Bornzin , John W. Poore , Douglas T. Kurschinski
IPC分类号： A61N1365
CPC分类号： A61N1/368
摘要： Techniques are described for overdrive pacing the heart using a pacemaker wherein the overdrive pacing rate only increases when at least two intrinsic beats are detected within a determined search period. In one specific technique, an increase in the pacing rate occurs only if two P-waves are detected within X cardiac cycles. In another specific technique, the overdrive pacing rate is increased only if at least two P-waves are detected within a block of N cardiac cycles. In both techniques, the overdrive pacing rate is decreased if no increase has occurred in the last Z cardiac cycles. By increasing the overdrive pacing rate only in response to detection of at least two P-waves within a determined number of cardiac cycles, an excessively high overdrive pacing rate is avoided. Other techniques are described for adaptively adjusting overdrive pacing parameters so as to achieve a determined target degree of pacing of, for example, 95% paced beats. By adaptively adjusting overdrive parameters to maintain a target degree of pacing, the average overdrive pacing rate is minimized while still maintaining a high number of paced beats, thereby reducing the risk of a tachyarrhythmia occurring within the patient.
摘要翻译：描述了使用起搏器超速起搏心脏的技术，其中在确定的搜索周期内检测到至少两个固有节拍时，超速起搏速率仅增加。在一种特定技术中，只有在X个心动周期内检测到两个P波时，起搏速率才会增加。在另一个具体技术中，只有在N个心动周期的块内检测到至少两个P波时，才能增加超速起搏速率。在两种技术中，如果在最后Z个心动周期中没有发生增加，则超速起搏速率将降低。通过仅在确定的心跳周期内响应于至少两个P波的检测来增加超速起搏速率，避免了过高的超速起搏速率。描述了用于自适应地调节过驱动起搏参数的其它技术，以便实现例如95％起搏节拍的确定的目标起搏程度。通过自适应地调整过驱动参数以保持目标起搏程度，平均超速起搏速度最小化，同时仍然保持大量的起搏节奏，从而降低患者内出现快速性心律失常的风险。

27. 发明授权

US06766195B1 Method and apparatus for detecting natural electrical coherence within the heart and for administering therapy based thereon 有权
标题翻译：用于检测心脏内的自然电相干性并用于基于其进行治疗的方法和装置
公开(公告)号：US06766195B1
公开(公告)日：2004-07-20
申请号：US09686630
申请日：2000-10-10
申请人： Gene A. Bornzin , Peter Boileau , Joseph J. Florio , John W. Poore , Kelly H. McClure
发明人： Gene A. Bornzin , Peter Boileau , Joseph J. Florio , John W. Poore , Kelly H. McClure
IPC分类号： A61N0118
CPC分类号： A61N1/3962 , A61N1/395
摘要： Techniques are provided for detecting natural electrical coherence within the heart and for administering or adjusting therapy based upon whether natural electrical coherence is detected. In one example, an implantable cardioverter defibrillator (ICD), upon detecting atrial fibrillation, delays administering an atrial defibrillation pulse until a period of natural electrical coherence is detected between the left and the right atria of the heart. The ICD may further delay the pulse until the ventricles of the heart are refractory so as to help prevent triggering ventricular fibrillation. The pulses are administered at a time selected based upon the period of electrical coherence to reduce the amount of electrical energy required within the pulse to reliably defibrillate the heart. Other types of therapy besides defibrillation therapy such as anti-tachycardia pacing pulses may also be timed based upon detection periods of natural electrical coherence. Method and apparatus embodiments are described.
摘要翻译：提供了用于检测心脏内的自然电连贯性的技术，并且用于基于是否检测到自然电连贯来施用或调整治疗。在一个实例中，在检测心房颤动时，植入式心律转复除颤器（ICD）延迟施用心房除颤脉冲，直到在心脏的左心房和右心房之间检测到自然电相干的时间段。 ICD可以进一步延迟脉冲，直到心脏的心室难以耐受，以便有助于防止触发心室颤动。在基于电相干周期选择的时间施加脉冲以减少脉冲内所需的电能量以可靠地除颤心脏。除了除颤疗法之外的其他类型的治疗，如抗心动过速起搏脉冲也可以基于自然电连续性的检测周期来计时。描述了方法和设备实施例。

28. 发明授权

US06731985B2 Implantable cardiac stimulation system and method for automatic capture verification calibration 有权
标题翻译：植入式心脏刺激系统和自动捕获验证校准方法
公开(公告)号：US06731985B2
公开(公告)日：2004-05-04
申请号：US09981555
申请日：2001-10-16
申请人： John W. Poore , Kerry Bradley , Laurence S. Sloman , Gene A. Bornzin , Joseph J. Florio
发明人： John W. Poore , Kerry Bradley , Laurence S. Sloman , Gene A. Bornzin , Joseph J. Florio
IPC分类号： A61N1362
CPC分类号： A61N1/3712
摘要： An implantable cardiac stimulation device and associated method perform an automatic calibration procedure for evaluating whether automatic capture verification can be recommended. The calibration procedure calculates and displays a number of variables for use by a medical practitioner in programming automatic capture operating parameters. An average paced depolarization integral (PDI) is determined from the cardiac signals following delivery of multiple stimulation pulse below and above capture threshold such that both pure lead polarization signals and evoked response signals may be analyzed. From the paced depolarization integral data, a capture threshold, a stimulation response curve, a minimum evoked response, a maximum lead polarization, an evoked response sensitivity, an evoked response safety margin, and a polarization safety margin are determined. Based on these variables, the calibration procedure determines if automatic capture verification can be recommended. If so, the stimulation device calculates a capture detection threshold. The automatic capture verification recommendation and the estimated calibration variables are displayed.
摘要翻译：可植入心脏刺激装置和相关方法执行自动校准程序，以评估是否可以推荐自动捕获验证。校准程序计算并显示许多变量，供医生在编程自动捕获操作参数时使用。平均节奏去极化积分（PDI）是在多次刺激脉冲传递后低于和高于捕获阈值的心脏信号确定的，以便可以分析纯铅极化信号和诱发响应信号。从起搏去极化积分数据中，确定捕获阈值，刺激响应曲线，最小诱发响应，最大引线极化，诱发响应灵敏度，诱发响应安全裕度和极化安全裕度。基于这些变量，校准过程确定是否可以推荐自动捕获验证。如果是，则刺激装置计算捕获检测阈值。显示自动捕获验证建议和估计的校准变量。

29. 发明授权

US09265436B2 Leadless intra-cardiac medical device with built-in telemetry system 有权
标题翻译：无内置心内膜医疗设备内置遥测系统
公开(公告)号：US09265436B2
公开(公告)日：2016-02-23
申请号：US13352147
申请日：2012-01-17
申请人： Xiaoyi Min , John W. Poore , Gene A. Bornzin
发明人： Xiaoyi Min , John W. Poore , Gene A. Bornzin
IPC分类号： A61B5/0408 , A61N1/05 , A61B5/042 , A61N1/375 , A61N1/372 , A61N1/368 , A61N1/39 , A61B5/00
CPC分类号： A61N1/37229 , A61B5/0006 , A61B5/042 , A61B5/686 , A61N1/362 , A61N1/368 , A61N1/3756 , A61N1/3787 , A61N1/3956 , A61N1/3968
摘要： A leadless intra-cardiac medical device is configured to be implanted entirely within a heart of a patient. The device includes an intra-cardiac extension and a housing. The intra-cardiac extension includes a loop body having at least one loop segment retaining at least one coil group that is configured to one or both of receive and transmit radio frequency (RF) energy, wherein the loop body is configured to extend into a first chamber of the heart. The housing is in electrical communication within the loop body, and includes a transceiver, control logic and an energy source. The housing is configured to be securely attached to an interior wall portion of a second chamber of the heart, wherein the transceiver is configured to communicate with an external device through the RF energy.
摘要翻译：无引线心脏内心脏医疗设备被配置为完全植入患者的心脏内。该装置包括心脏内延伸部和壳体。心脏内延伸包括环体，其具有至少一个环段，保留至少一个线圈组，该线圈组配置为接收和发射射频（RF）能量中的一个或两个，其中该环体被配置为延伸到第一心脏室。壳体在环体内部电气通信，并且包括收发器，控制逻辑和能量源。壳体构造成牢固地附接到心脏的第二腔室的内壁部分，其中收发器被配置为通过RF能量与外部设备通信。

30. 发明授权

US09065332B2 Power converter with first and second resonant circuits 有权
标题翻译：具有第一和第二谐振电路的功率转换器
公开(公告)号：US09065332B2
公开(公告)日：2015-06-23
申请号：US13361736
申请日：2012-01-30
申请人： John W. Poore , Gene A. Bornzin
发明人： John W. Poore , Gene A. Bornzin
IPC分类号： H02M7/5383 , H02M3/145 , H03F3/217 , H02M3/155 , H02J17/00
CPC分类号： H02M3/145 , H02J17/00 , H02J50/12 , H02M7/5383 , H02M2003/1557 , H03F3/2176
摘要： A high voltage resonant step-up convertor converts a lower voltage signal to a higher voltage signal. The converter may be used, for example, to supply power via electromagnetic coupling to an implantable medical device. In some embodiments, a power converter comprises a driver circuit and a resonant circuit. The resonant circuit generates a high voltage output signal at a selected frequency. The driver circuit is controlled by a low voltage signal and periodically generates a higher frequency signal (e.g., approximately twice the selected frequency) to drive the resonant circuit. In some embodiments, the driver circuit comprises another resonant circuit and a switching circuit. The switching circuit periodically pumps current to the other resonant circuit and isolates the two resonant circuits. The other resonant circuit periodically pumps current to the output resonant circuit.
摘要翻译：高压谐振升压转换器将较低电压信号转换为较高电压信号。转换器可以用于例如通过电磁耦合向可植入医疗装置供电。在一些实施例中，功率转换器包括驱动器电路和谐振电路。谐振电路以选定的频率产生高电压输出信号。驱动器电路由低电压信号控制，并且周期性地产生较高频率信号（例如，大约是所选频率的两倍）以驱动谐振电路。在一些实施例中，驱动器电路包括另一个谐振电路和开关电路。开关电路周期性地将电流泵送到另一个谐振电路并隔离两个谐振电路。另一个谐振电路周期性地将电流泵送到输出谐振电路。

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