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21. 发明申请

WO2020182395A1 ESTIMATING GENERATION RATE OF SUBSTANCE IN DIALYSIS PATIENTS 审中-公开
公开(公告)号：WO2020182395A1
公开(公告)日：2020-09-17
申请号：PCT/EP2020/053563
申请日：2020-02-12
申请人： GAMBRO LUNDIA AB
发明人： STERNBY, Jan
IPC分类号： G16H20/17
摘要： A computer system may implement a method of calculating the generation rate of a substance in a dialysis patient, e.g. urea, creatinine or beta-2-microglobulin, based on data for one or more treatment sessions of intermittent dialysis therapy. The computer system obtains a concentration value ( Cs ) for the substance in the blood of the dialysis patient at the start of a treatment session, and a standard Kt/V value ( stdKt/V ) for the substance over a predefined time period ( t ), which includes the one or more treatment sessions. The computer system then computes the generation rate ( G; G/V ) as a function of stdKt/V , the first blood concentration value ( Cs ) and the predefined time period ( t ).

22. 发明申请

WO2018095690A1 APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT 审中-公开
公开(公告)号：WO2018095690A1
公开(公告)日：2018-05-31
申请号：PCT/EP2017/077528
申请日：2017-10-26
申请人： GAMBRO LUNDIA AB
发明人： WALLENBORG, Anders , NILSSON, Anders , SOLEM, Kristian , HERTZ, Thomas , ROVATTI, Paolo , LODI, Carlo, Alberto , SURACE, Alessandro , STERNBY, Jan
IPC分类号： A61M1/16 , A61M1/34
摘要： An extracorporeal blood treatment apparatus suitable for e.g. hemodiafiltration or hemofiltration pre-dilution treatment is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line (8) at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.

23. 发明申请

WO2018001614A1 DETECTION OF A DISRUPTION OF A FLUID CONNECTION BETWEEN TWO FLUID CONTAINING SYSTEMS 审中-公开
标题翻译：两种含流体系统间流体连通的破坏检测
公开(公告)号：WO2018001614A1
公开(公告)日：2018-01-04
申请号：PCT/EP2017/061271
申请日：2017-05-11
申请人： GAMBRO LUNDIA AB
发明人： STERNBY, Jan , OLDE, Bo
IPC分类号： A61M1/36
CPC分类号： A61M1/3656 , A61M2205/15 , A61M2205/18 , A61M2205/3331 , A61M2205/50 , A61M2230/06
摘要： A monitoring device is configured to detect a disruption of a fluid connection between two fluid containing systems. The monitoring device implements a monitoring method that comprises: activating a first monitoring technique (30) that operates to detect the disruption and generate a corresponding alarm signal while a second monitoring technique is deactivated, obtaining at least one of a first count (#FA1) of false alarms generated by the primary monitoring technique a second count (#FA2) of false alarms generated by the second monitoring technique if activated, and selectively (31), based on at least one of the first and second counts (#FA1, #FA2), activating the second monitoring technique (32) to operate, instead of or jointly with the first monitoring technique (30), to detect the disruption and generate the corresponding alarm signal. The monitoring device may be connected to or part of an apparatus for blood treatment and operable to detect a disconnection of an extracorporeal blood circuit from a vascular system of a patient, e.g. a venous-side disconnection.
摘要翻译：监测装置被配置为检测两个含有流体的系统之间的流体连接的中断。监控设备实现监控方法，该监控方法包括：启动第一监控技术（30），该第一监控技术（30）用于检测中断并产生相应的警报信号，同时停用第二监控技术，获得第一计数（＃FA1）如果被激活，则由主监视技术产生的虚假警报的第二计数（＃FA2）由第二监视技术产生的虚假警报，并且基于第一和第二计数（＃FA1，＃2）中的至少一个选择性地 FA2），代替第一监测技术（30）或与第一监测技术（30）一起，激活第二监测技术（32）以检测中断并产生相应的警报信号。监测装置可连接到用于血液处理的装置或其一部分，并且可操作用于检测体外血液回路与患者的血管系统（例如血液）的断开。静脉侧断开。

24. 发明申请

WO2019002065A1 A SYSTEM AND A METHOD FOR RENAL REPLACEMENT THERAPY 审中-公开
公开(公告)号：WO2019002065A1
公开(公告)日：2019-01-03
申请号：PCT/EP2018/066519
申请日：2018-06-21
申请人： GAMBRO LUNDIA AB
发明人： NILSSON, Roger , ERICSON, Björn , STERNBY, Jan , HERTZ, Thomas , JANSSON, Olof , HOBRO, Sture , LINDGREN, Henrik , FORS, Jonas , HÅKANSSON, Annmargret , WALLENBORG, Anders
IPC分类号： G16H40/40
摘要： A system (1) and method for renal replacement therapy, where the system comprises a blood treatment unit (4) connected to a blood circuit (2) for extracorporeal circulation of blood, and a method for operating the system (1). The system (1) comprises inter alia a blood pump (19), a pre-dilution line (10), a post-dilution line (11), flow control means (12) and a control unit (31) configured to control the system (1) according to control instructions. The control instructions comprise to, during a treatment, determine a system parameter value and an indication of membrane fouling of the membrane (7), and to activate an automatic anti-fouling measure in order to create a flushing of the blood treatment unit (4) comprising an increase of a pre-dilution flow rate Qpre to more than 100% of a present value of the post-dilution flow rate Qpost.

25. 发明申请

WO2018095694A1 APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT 审中-公开
公开(公告)号：WO2018095694A1
公开(公告)日：2018-05-31
申请号：PCT/EP2017/077566
申请日：2017-10-27
申请人： GAMBRO LUNDIA AB
发明人： WALLENBORG, Anders , NILSSON, Anders , SOLEM, Kristian , HERTZ, Thomas , ROVATTI, Paolo , LODI, Carlo, Alberto , SURACE, Alessandro , STERNBY, Jan
IPC分类号： A61M1/16 , A61M1/34
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and/or the substitution fluid, measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.

26. 发明申请

WO2018001996A1 CONNECTION TEST FOR BLOOD TREATMENT MACHINES II 审中-公开
标题翻译：血液处理设备的连接测试II
公开(公告)号：WO2018001996A1
公开(公告)日：2018-01-04
申请号：PCT/EP2017/065770
申请日：2017-06-27
申请人： GAMBRO LUNDIA AB
发明人： STERNBY, Jan , ERICSON, Björn
IPC分类号： A61M1/16 , A61M1/36
摘要： A control device for a blood treatment machine performs a connection test (50) by causing the blood treatment machine to switch (51, 53) between a first and a second operating state by reversing a blood pump so as to change a flow direction of blood through both a dialyzer and access devices connected to a patient. Based on an output signal of at least one sensor in the blood treatment machine (52, 54), the control device computes (55) an efficiency change parameter that represents a change in in-vivo clearance of the blood treatment machine during the switch of the blood treatment machine between the first and second operating states. The control device evaluates (56) the efficiency change parameter to jointly detect connection errors at the dialyzer, resulting in co-current flow of treatment fluid and blood through the dialyzer, and at the access devices, resulting in access recirculation of blood.
摘要翻译：用于血液处理机的控制装置通过使血液处理机在第一操作状态和第二操作状态之间切换（51,53），通过如此反转血泵来执行连接测试（50）以便通过透析器和连接到患者的接入装置来改变血液的流动方向。基于血液处理机器（52,54）中的至少一个传感器的输出信号，控制装置计算（55）效率变化参数，该效率变化参数表示血液处理机器在切换期间的体内间隙的变化血液处理机在第一和第二操作状态之间。控制装置评估（56）效率变化参数以联合检测透析器处的连接错误，导致治疗流体和血液并流通过透析器并且在进入装置处导致血液进入再循环。 p>

27. 发明申请

WO2016206948A1 FILTERING A PRESSURE SIGNAL FROM A PRESSURE SENSOR IN A BLOOD PROCESSING APPARATUS 审中-公开
标题翻译：从血液加工设备中的压力传感器过滤压力信号
公开(公告)号：WO2016206948A1
公开(公告)日：2016-12-29
申请号：PCT/EP2016/062619
申请日：2016-06-03
申请人： GAMBRO LUNDIA AB
发明人： OLDE, Bo , STERNBY, Jan , SOLEM, Kristian
IPC分类号： A61M1/36 , A61B5/00 , A61B5/021
CPC分类号： A61M1/3639 , A61B5/02108 , A61B5/7214 , A61B5/7246 , A61B5/725 , A61M1/3656 , A61M2205/15 , A61M2205/3331 , A61M2230/30
摘要： A signal filtering device acquires a pressure signal from a pressure sensor in a blood processing apparatus having a known disturbance generator that generates a disturbance in the pressure signal. The signal filtering device obtains (401) a current set of principal components representing the disturbance. The respective principal component in the current set is generated by Principal Component Analysis, PCA, of a plurality of characteristic waveforms representing the disturbance. The signal filtering device further operates to detect (403) presence in the pressure signal of a current disturbance that originates from the disturbance generator, computes (404) a scaling factor for the respective principal component with respect to the current disturbance, and subtracts (405) the respective principal component, scaled in magnitude by the respective scaling factor, from the pressure signal. The signal filtering device may be associated with or included in the blood processing apparatus.
摘要翻译：信号滤波装置从具有产生压力信号的干扰的已知扰动发生器的血液处理装置中的压力传感器获取压力信号。信号滤波装置获得（401）表示干扰的当前组成的主要分量。通过主成分分析PCA生成表示干扰的多个特征波形的当前集合中的各个主分量。信号滤波装置进一步操作以检测（403）来自干扰发生器的电流干扰的压力信号的存在，计算（404）相对于当前扰动的相应主分量的缩放因子，并减去（405））相应的主要分量，其大小由相应的缩放因子与压力信号相比较。信号过滤装置可以与血液处理装置相关联或包括在血液处理装置中。

28. 发明申请

WO2022073778A1 ESTIMATING RESIDUAL RENAL FUNCTION 审中-公开
公开(公告)号：WO2022073778A1
公开(公告)日：2022-04-14
申请号：PCT/EP2021/076441
申请日：2021-09-27
申请人： GAMBRO LUNDIA AB
发明人： STERNBY, Jan
IPC分类号： G16H10/40 , G16H50/20 , G16H20/40 , G16H50/30
摘要： A computer system may implement a method of estimating residual renal function in a dialysis patient based on data for two consecutive treatment sessions of intermittent dialysis therapy. The computer system obtains first and second blood concentration values (C1, C2) for a substance, e.g. urea, creatinine, at start and end of a first treatment session, and a third blood concentration value (C3) at start of a second treatment session. The computer system also obtains time points (t1, t2, t3) for the start and the end of the first treatment session and the start of the second treatment session. The computer system then estimates the residual renal function as a function of the first, second and third concentration values (C1, C2, C3), and the time points (t1, t2, t3). The method obviates the need to include data representing collection of urine from the patient.

29. 发明申请

WO2019121167A1 DIALYSIS SYSTEM HAVING CARBON DIOXIDE GENERATION AND PRIME 审中-公开
公开(公告)号：WO2019121167A1
公开(公告)日：2019-06-27
申请号：PCT/EP2018/084368
申请日：2018-12-11
申请人： GAMBRO LUNDIA AB
发明人： HOBRO, Sture , STERNBY, Jan , LINDEN, Torbjörn , JANSSON, Olof
IPC分类号： A61M1/36
摘要： An extracorporeal therapy system includes: (i) a dialysis fluid circuit including dialysis fluid preparation structure configured to prepare a dialysis fluid for an extracorporeal therapy treatment; (ii) a blood circuit including a blood filter for use during the extracorporeal therapy treatment; (iii) a blood pump operable to pump blood through the blood circuit and blood filter; and (iv) a control unit operable with the dialysis fluid preparation structure and the blood pump, the control unit programmed to prepare a gas generation fluid different than the dialysis fluid for the extracorporeal therapy treatment, wherein the gas generation fluid generates carbon dioxide ("CO 2 ") gas, and wherein the CO 2 gas is used to prime the blood circuit including the blood filter.

30. 发明申请

WO2016188950A1 APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT I 审中-公开
标题翻译：用于提取血液治疗的装置
公开(公告)号：WO2016188950A1
公开(公告)日：2016-12-01
申请号：PCT/EP2016/061568
申请日：2016-05-23
申请人： GAMBRO LUNDIA AB
发明人： ROVATTI, Paolo , SURACE, Alessandro , LODI, Carlo Alberto , WALLENBORG, Anders , NILSSON, Anders , SOLEM, Kristian , STERNBY, Jan , HERTZ, Thomas
IPC分类号： A61M1/16 , A61M1/36
CPC分类号： A61M1/1607 , A61M1/1609 , A61M1/1613 , A61M1/3609 , A61M2205/3317
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and blood trough the filtration unit (2), measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.
摘要翻译：提供了一种体外血液处理装置，其包括连接到血液回路（17）和透析液回路（32）的过滤单元（2），用于制备和调节透析液的组成的制备装置（9）用于测量透析液（即用过的透析液）的电导率的传感器（11）; 控制单元（12），其被配置为设置透析液中的钠浓度，并且在初始设定点设定透析液之后，使透析液和血液循环通过过滤单元（2），测量透析液的初始电导率值在治疗开始时，基于所测量的用过的透析液的初始电导率值和透析液的相应电导率值，计算初始等离子体电导率的值，将透析液循环至计算执行初始血浆导电性，维持透析流体导电性基本上恒定。

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