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    • 23. 发明授权
    • Noninvasive method of measuring physiologic parameters
    • 非侵入性测量生理参数的方法
    • US06749567B2
    • 2004-06-15
    • US10142225
    • 2002-05-09
    • Charles L. DavisPatrick D. Harrison
    • Charles L. DavisPatrick D. Harrison
    • A61B500
    • A61B5/0535A61B5/0053A61B5/02007A61B5/02141A61B5/022A61B2562/02
    • The present invention provides means and methods for noninvasively identifying the blood pressure characteristics in each of the seven types of vessels in the circulatory system, including the central venous pressure (CVP) through a single monitoring system using fluid depletion plethysmography. Known pressure is applied to a body region in increasing amounts to force blood volume from the body region in step-wise fashion through each vessel type. Blood volume depletion for each vessel type is measured by the increasing electrical impedance of the body part during depletion and is plotted against the increasing pressure data. The resulting series of slope changes within the plotted curve reveals the blood pressure for each vessel type. The data obtained may further be used to determine vessel wall compliance/tension as well as standard measurements such as pulse and large artery systolic and diastolic pressure. Release of the applied pressure may then yield similar data by measuring blood volume replenishment against the decreasingly applied pressure during the same diagnostic operation. The method is not dependent on oscillometric or pulsatile measurement methods. The electrical leads of the impedance/volume sensor and the means for applying pressure to the body part are coextensive to ensure accurate indication of blood volume depletion and replenishment in the body region under pressure and may be incorporated into a single integrated structure.
    • 本发明提供了用于通过使用流体消耗体积描记术的单个监测系统非循环地鉴定循环系统中七种类型的血管中的每一种中的血压特征的方法和方法,包括中心静脉压(CVP)。 将已知的压力以增加的量施加到身体区域,以通过每种血管类型以逐步方式迫使身体区域的血液体积。 每个血管类型的血容量消耗通过在耗尽期间身体部位的增加的电阻抗来测量,并且相对于增加的压力数据作图。 在绘制的曲线内产生的一系列斜率变化显示每种血管类型的血压。 所获得的数据还可用于确定血管壁顺应性/张力以及标准测量,例如脉搏和大动脉收缩压和舒张压。 然后释放所施加的压力可以通过在相同诊断操作期间通过测量针对递减施加的压力的血液体积补充而产生相似的数据。 该方法不依赖于示波或脉冲测量方法。 阻抗/体积传感器的电引线和用于向身体部分施加压力的装置是共同延伸的,以确保在压力下精确指示身体区域中的血液体积消耗和补充,并且可以将其并入单一的一体化结构。
    • 24. 发明授权
    • Real time ambulatory patient monitor
    • 实时门诊病人监护仪
    • US5544661A
    • 1996-08-13
    • US180867
    • 1994-01-13
    • Charles L. DavisPaul V. Long
    • Charles L. DavisPaul V. Long
    • A61B5/00A61N1/39G06F17/00G06F19/00A61B5/0402
    • A61B5/0006A61B5/0002A61N1/3925G06F19/3418G06F19/345G06F19/3481A61B5/7232A61B5/7264G06F19/322G06F19/3468Y10S128/904
    • A patient monitoring system which includes a portable device and a central station. The portable device includes an ECG and a photo-plethysmograph connected to the patient; arrhythmia analysis apparatus; an expert system for determining if a pre-established critical parameter set has been exceeded; and a wireless wide area communication device for automatically contacting the central station via a public cellular phone network when the critical parameter set has been exceeded. When the central station is contacted, the patient's ECG waveforms, measurements, and trends, are sent to the central monitoring station and a two way voice channel between the patient and the central station is automatically opened. The central station includes a computerized facility which has a station from which a clinician can observe the real time data being sent from the patient, the patients historical records and from which the clinician can talk to the patient and activate therapeutic devices attached to the patient such as an external defibrillator, a pacer or an automatic drug infusion device.
    • 一种患者监视系统,其包括便携式设备和中央站。 便携式设备包括ECG和连接到患者的光学体积描记器; 心律失常分析仪; 用于确定是否已经超过预先建立的关键参数集的专家系统; 以及无线广域通信设备,用于当已经超过关键参数集时,经由公共蜂窝电话网络自动地联络中心站。 当联络中心站时,将患者的ECG波形,测量和趋势发送到中央监测站,患者和中心站之间的双向语音通道将自动打开。 中心站包括一个计算机化设施,其具有一个站点,临床医生可从该站点观察从患者发送的实时数据,患者的历史记录,临床医生可以从该站点与患者对话并激活附接到患者的治疗装置, 作为外部除颤器,起搏器或自动药物输注装置。
    • 25. 发明授权
    • Method for noninvasive blood-pressure measurement by evaluation of
waveform-specific area data
    • US4889133A
    • 1989-12-26
    • US198468
    • 1988-05-25
    • Craig H. NelsonThomas J. DorsettCharles L. Davis
    • Craig H. NelsonThomas J. DorsettCharles L. Davis
    • A61B5/0225
    • A61B5/02225A61B5/0225
    • A microprocessor-controlled, oscillometric method for determining a patient's systolic, diastolic, and mean arterial pressure, practiced in a system comprising an inflatable, occluding cuff, a pump and a valve coupled to the cuff, and monitoring apparatus coupled to the cuff adapted to measure cuff pressure and recurring blood-pressure pulsations occurring in the cuff that are caused by each heart contraction occurring in a measurement cycle. Cuff pressure is raised to a level above the patinet's systolic pressure, and progressively reduced in a stepwise fashion to an ending cuff pressure. A fixed number of pulsations are measured and processed at a first and second cuff-pressure step, and a generally lesser number of oscillations are measured and processed at a third and subsequent cuff-pressure steps. The method includes a first artifact rejection technique used to check for false data relative to the formation of each blood-pressure pulsation. Further, the method includes calculating, for each blood-pressure pulsation, the impulse of a force that is exerted upon the patinet's blood from, and during, each heart contraction that occurs in the measurement cycle. An impulse value is stored relative to each pulsation. A second artifact rejection technique is used, beginning at the second cuff-pressure step, to generate a prediction curve for predicting a next, expected-to-be-stored pulsation impulse value for a next, lower cuff-pressure step. The second artifact rejection technique is also used to repeatedly smooth the prediction curve based on the difference between a pulsation's calculated impulse value and its respective predicted impulse value. A final, smoothed curve is generated reflecting a final impulse value for each cuff-pressure step. From the final curve, the desired blood pressure parameters are derived and displayed in the form of arabic numerals by means of an LCD readout.
    • 27. 发明授权
    • Enclosed electrical devices
    • 封闭电气设备
    • US4394602A
    • 1983-07-19
    • US324757
    • 1981-11-25
    • Waldo D. ApgarCharles L. DavisLoring D. Emery, Jr.Werner F. EsseluhnWalter R. Holbrook
    • Waldo D. ApgarCharles L. DavisLoring D. Emery, Jr.Werner F. EsseluhnWalter R. Holbrook
    • H01L33/48H05K5/00H01J7/44
    • H01L33/483H05K5/0091
    • An enclosed electrical device (42) includes an electrical circuit (50) having elements (48-68) which lie substantially in and along a plane (115). A member (70) is applied to a one side and a member (85) is applied to another side of the circuit (50) for at least partially enclosing the same. Conductors (48) and (49) of circuit (50) are fixedly penetrated, preferably by pins (74) which are fixedly engaged to enclosure members (70) and (85). Such engagement is advantageously provided by making the pins (74) an integral part of member (70), for example by including pins (74) in a premolded member (70). Such engagement is also advantageously provided by making pin-engaging sockets (94) an integral part of member (85), also for example by including the sockets (94) in a premolded member (85). By a preferred friction fit of pins (74) and sockets (94), the enclosure members (70) and (85 ) and circuit elements (48-68) are sufficiently fixed relative to one another to resist forces applied thereto in service.
    • 封闭式电气设备(42)包括具有基本上位于并沿着平面(115)的元件(48-68)的电路(50)。 构件(70)被施加到一侧,并且构件(85)被施加到电路(50)的另一侧,用于至少部分地包围该电路。 电路(50)的导体(48)和(49)固定地穿透,优选地通过固定地接合到外壳构件(70)和(85)的销钉(74)。 这样的接合有利地通过使销钉(74)成为构件(70)的整体部分,例如通过在预成型件(70)中包括销钉(74)来提供。 也可以通过使销接合的插座(94)成为构件(85)的整体部分,而且还例如通过将插座(94)包括在预成型构件(85)中来提供这种接合。 通过销(74)和插座(94)的优选的摩擦配合,封闭构件(70)和(85)和电路元件(48-68)相对于彼此充分固定,以抵抗施加在其上的力。
    • 30. 发明授权
    • Noninvasive-blood-pressure(NIBP) monitoring apparatus with
noninflatable, pressure-information-providing (PIP) structure
    • 无创血压(NIBP)监测装置,具有不可充气,压力信息提供(PIP)结构
    • US5692513A
    • 1997-12-02
    • US316540
    • 1994-09-30
    • Charles L. DavisJohn R. Marshall
    • Charles L. DavisJohn R. Marshall
    • A61B5/022A61B5/00
    • A61B5/02233A61B5/02241A61B5/02208A61B5/02225
    • Noninvasive-blood-pressure (NIBP) monitoring apparatus is disclosed which is usable to perform either oscillometric or auscultatory NIBP. The apparatus includes relatively adjustable, noninflatable, pressure-information-providing (PIP) structure usable to apply NIBP-useful pressure to such limb adjacent such vessel. Also included is pressure-changer structure associated with the PIP structure, and operable to adjust the same to a beginning NIBP-useful pressure, and to subsequent NIBP-useful pressures, with such adjustment effecting the availability of pressure information that can be sensed by such sensor structure. The apparatus is preferably constructed for oscillometric NIBP monitoring and includes a reaction band removably fittable on and circumscribingly about the limb of such living subject. The preferred construction is for portable, self-contained, ambulatory usage. Other embodiments include providing an output communicator for sending NIBP-data signals in various outputs including electrical, wireless and optical, and visually perceptible ones.
    • 公开了可用于执行示波或听诊NIBP的无创血压(NIBP)监测装置。 该装置包括相对可调的,不可充气的,压力信息提供(PIP)结构,可用于将NIBP有用的压力施加到邻近该容器的这种肢体。 还包括与PIP结构相关联的压力变换器结构,并且可操作以将其调整到开始的NIBP有用压力,以及随后的NIBP有用的压力,通过这种调节可以实现可被这样的感测的压力信息的可用性 传感器结构。 该装置优选地被构造用于示波器NIBP监测,并且包括可拆卸地装配并围绕这种活体的肢体的反应带。 优选的结构是便携式,独立的,徒步的使用。 其他实施例包括提供用于发送包括电,无线和光学以及视觉上可察觉的NIBP数据信号的各种输出中的NIBP数据信号的输出通信器。