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21. 发明授权

US07561244B2 Liquid-filled composite with supporting members covalenty bonded to the substrates 失效
标题翻译：液体填充复合材料与支撑构件共价键合到基底
公开(公告)号：US07561244B2
公开(公告)日：2009-07-14
申请号：US10567227
申请日：2004-07-05
申请人： Roel Penterman , Stephen Isadore Klink , Joost Peter André Vogels , Dirk Jan Broer
发明人： Roel Penterman , Stephen Isadore Klink , Joost Peter André Vogels , Dirk Jan Broer
IPC分类号： G02F1/1339
CPC分类号： G02F1/13394 , G02F1/133377 , G02F1/1341 , G02F2001/133368 , G02F2202/023
摘要： A liquid-filled container (1) comprises a first and a second sheet (3, 5) between which a thin film of liquid (7) is dispersed. Supporting members, (9), which extend from the first sheet to the second sheet, are covalently bonded to the first and the second sheet to make the container mechanically robust. In an advantageous embodiment, the thin film of liquid, the supporting members and the second sheet form, in combination, a stratified-phase-separated composite. The liquid-filled container is particularly suitable for use in a liquid crystal display.
摘要翻译：液体填充容器（1）包括第一和第二片（3,5），在其间分散有液体薄膜（7）。从第一片延伸到第二片的支撑构件（9）共价结合到第一和第二片，以使容器机械地坚固。在有利的实施方案中，液体薄膜，支撑构件和第二片组合形成分层相分离的复合材料。充满液体的容器特别适用于液晶显示器。

22. 发明申请

US20080259253A1 Mechanical Structure Including a Layer of Polymerised Liquid Crystal and Method of Manufacturing Such 有权
标题翻译：包含聚合液晶层的机械结构及其制造方法
公开(公告)号：US20080259253A1
公开(公告)日：2008-10-23
申请号：US10597569
申请日：2005-01-27
申请人： Dirk Jan Broer , Christiane Maria Rosette De Witz , Grietje Neeltje Mol , Roel Penterman
发明人： Dirk Jan Broer , Christiane Maria Rosette De Witz , Grietje Neeltje Mol , Roel Penterman
IPC分类号： G02F1/1334 , B29C65/48
CPC分类号： G02B26/02 , B81B3/0024 , B81B2201/032 , B81B2201/047 , Y10T156/11
摘要： A mechanical structure comprises an element which is moveable by nonmechanical means, such as heat or radiation, between a first state having a first shape and a second state having a second shape different. To this end, the element includes a layer of oriented polymerized liquid crystal which exhibits an anisotropic expansion when subjected to such means. In order to facilitate manufacture the element is positioned on a substrate which has a region of high adhesiveness and a region of low adhesiveness for polymerized liquid crystal. To manufacture such structures a layer of oriented polymerizable liquid crystal is formed on a substrate (201) which is provided with a patterned surface that provides adhesive regions (204) with high adhesiveness to polymerized liquid crystal and nonadhesive regions (203) with low adhesiveness to polymerized liquid crystal. After polymerization, for example a thermal shock is applied which causes the layer of polymerized liquid crystal to delaminate at the non-adhering region while remaining fixed to the adhesive regions. Thus, the method does not require time-consuming under-etching steps.
摘要翻译：机械结构包括可在诸如热或辐射之间的非机械装置在具有第一形状的第一状态和具有第二形状的第二状态之间移动的元件。为此，元件包括定向聚合的液晶层，当经受这种方法时，其呈现各向异性膨胀。为了便于制造，元件位于具有高粘合性区域的基底和聚合液晶的低粘合性区域。为了制造这样的结构，在基板（201）上形成定向聚合性液晶层，该基板（201）设置有图案化表面，该图案表面向聚合液晶和非粘合区域（203）提供对粘合性高的粘合性区域（204）聚合液晶。聚合后，例如进行热冲击，使得聚合液晶层在非粘附区域分层，同时保持固定在粘合剂区域上。因此，该方法不需要耗时的蚀刻下步骤。

23. 发明授权

US06788360B2 Stacked liquid cell with liquid-polymer stratified phase separated composite 失效
标题翻译：具有液体 - 聚合物层状相分离复合物的堆叠液体池
公开(公告)号：US06788360B2
公开(公告)日：2004-09-07
申请号：US10203577
申请日：2002-08-09
申请人： Roel Penterman , Dirk Jan Broer
发明人： Roel Penterman , Dirk Jan Broer
IPC分类号： G02F11347
CPC分类号： C09K19/00 , C09K19/38 , C09K19/544 , G02F1/133377 , G02F1/13394 , G02F1/1341 , G02F1/1347 , G02F2001/133368 , Y10T428/3162 , Y10T428/31794
摘要： A stacked liquid cell, such as a stacked liquid crystal cell, comprises a stack of liquid layers and substrate layers between which the liquid layers are dispersed. The stack comprises a liquid and polymeric substrate layers made from a stratified-phase-separated composite. Being part of a stratified-phase-separated composite, in particular one manufactured in accordance with a single-substrate method, the polymeric layer may have a relative small thickness compared a conventional substrate layer which results in a stacked liquid cell having a reduced thickness or, more particular, a stacked liquid cell having a reduced thickness between subjacent liquid layers giving a reduction in parallax effects. A method of manufacturing a liquid cell involves stratifying, on a substrate, a layer of stratified-phase-separable composition into a liquid layer and a polymeric layer to form a stratified-phase-separated composite, the polymeric layer serving as one of the substrate of the liquid cell.
摘要翻译：层叠液晶单元等的层叠液晶单元包括液体层和基板层的叠层，液体层分散在其间。堆叠包括由分层相分离复合材料制成的液体和聚合物基底层。作为分层相分离复合材料的一部分，特别是根据单基底方法制造的复合材料，与常规基底层相比，聚合物层可具有相对较小的厚度，这导致层叠的液晶元件具有减小的厚度或更具体地说，具有降低视差效应的相邻液体层之间的厚度减小的层叠液晶元件。一种制造液晶盒的方法包括在基板上将分层相分离组合物层分层成液体层以及形成层状相分离复合材料的聚合物层，所述聚合物层用作液体池的底物之一。

24. 发明申请

US20110293712A1 COAXIALLY ENCAPSULATED CELL SUSPENSIONS AND MICROTISSUES 审中-公开
标题翻译：同时包被的细胞悬浮液和微量元素
公开(公告)号：US20110293712A1
公开(公告)日：2011-12-01
申请号：US13132534
申请日：2009-11-26
申请人： Ralph Kurt , Emiel Peeters , Roel Penterman , Dirk J. Broer , David Halter
发明人： Ralph Kurt , Emiel Peeters , Roel Penterman , Dirk J. Broer , David Halter
IPC分类号： A61K9/48 , A61K35/12 , C12M1/00
CPC分类号： B01J13/04 , A61K2035/126 , A61L27/38 , A61L27/58
摘要： The present invention provides for the coaxial encapsulation of a plurality of cells in a single elongated compartment. By this encapsulation, the cells are protected by at least one layer of separation material and kept in close contact, which leads to a better vitality of the encapsulated cells and consequently results in higher chances to form microtissue. Methods and devices for the production of such encapsulated cell compartments are disclosed as well as medical uses of such compartments in cell, tissue therapy and tissue engineering.
摘要翻译：本发明提供了在单个细长隔室中的多个电池的同轴封装。通过这种封装，细胞被至少一层分离材料保护并保持紧密接触，这导致包封的细胞更好的活力，从而导致更高的形成微组织的机会。在细胞，组织治疗和组织工程中公开了用于生产这种包封的细胞室的方法和装置以及这些隔室的医学用途。

25. 发明申请

US20100259261A1 MRI RADIO FREQUENCY RECEIVER COMPRISING DIGITAL DOWN CONVERTER 有权
标题翻译：包含数字下变频器的磁共振无线电频率接收机
公开(公告)号：US20100259261A1
公开(公告)日：2010-10-14
申请号：US12665336
申请日：2008-06-16
申请人： Marc Paul Saes , Johan Samuel Van Den Brink , Filips Van Liere , Roel Penterman , Ralph Kurt , Emiel Peeters , Dirk Broer , Michel Paul Barbara Van Bruggen , Hans Van Zon , Miha Fuderer
发明人： Marc Paul Saes , Johan Samuel Van Den Brink , Filips Van Liere , Roel Penterman , Ralph Kurt , Emiel Peeters , Dirk Broer , Michel Paul Barbara Van Bruggen , Hans Van Zon , Miha Fuderer
IPC分类号： G01R33/48
CPC分类号： G01R33/341 , G01R33/3415 , G01R33/3621 , G01R33/3692
摘要： The invention relates to a nuclear magnetic resonance imaging radio frequency—receiver (112; 216; 308; 404), the receiver (112; 216; 308; 404) being adapted to receive analogue signals from at least one radio frequency receiver coil unit (106; 200; 202; 300; 400; 402), the radio frequency receiver (112; 216; 308; 404) comprising: an analogue-digital converter (118; 226) to convert the analogue pre-amplified magnetic resonance signal into a digital signal, means (120; 230) for digital down converting the digital signal and a first communication interface (130; 252) adapted for transmitting the down converted digital signal via a communication link (e.g. wireless, optical or wire-bound).
摘要翻译：本发明涉及一种核磁共振成像射频接收器（112; 216; 308; 404），所述接收器（112; 216; 308; 404）适于接收来自至少一个射频接收器线圈单元 106; 200; 202; 300; 400; 402），所述射频接收器（112; 216; 308; 404）包括：模拟数字转换器（118; 226），用于将所述模拟预放大磁共振信号转换成数字信号，用于数字下变频数字信号的装置（120; 230）和适于经由通信链路（例如无线，光或有线）发送经下变频的数字信号的第一通信接口（130; 252）。

26. 发明申请

US20100252124A1 VALVE FOR A MICROFLUIDIC SYSTEM 审中-公开
标题翻译：微流控系统阀
公开(公告)号：US20100252124A1
公开(公告)日：2010-10-07
申请号：US12743838
申请日：2008-11-18
申请人： Ralph Kurt , Emiel Peeters , Roel Penterman , Martin Ouwerkerk , Christopher James Backhouse
发明人： Ralph Kurt , Emiel Peeters , Roel Penterman , Martin Ouwerkerk , Christopher James Backhouse
IPC分类号： F16K49/00
CPC分类号： F16K99/0001 , B01L3/502738 , B01L2200/146 , B01L2200/147 , B01L2300/0627 , B01L2300/1838 , B01L2400/0638 , B01L2400/0677 , F16K99/0026 , F16K99/0044 , F16K99/0061 , F16K2099/0084 , G01N2035/00247 , Y10T137/6606
摘要： The invention relates to a valve for opening and closing a channel (3) of a microfluidic system, respectively. According to the invention, the valve comprises an actuation medium (2) that undergoes a volume change with changing temperature; and a heater arrangement (5) for generating a temperature gradient in the actuation medium (2) with respect to the actuation medium's (2) distance relative to the channel (3); wherein due to an expansion or a contraction of the actuation medium (2) the channel (3) is closed or opened, respectively. When the heater arrangement (5) is activated in such a way that a higher temperature is generated in the actuation medium (2) which is nearer to the channel (3) and a lower temperature is generated in the actuation medium (2) which is further away from the channel (3) the valve can be closed and vice versa. Accordingly, such a valve for a microfluidic system is provided which can be reliably actuated during a long time of use.
摘要翻译：本发明涉及分别用于打开和关闭微流体系统的通道（3）的阀。根据本发明，该阀包括在变化温度下经历体积变化的致动介质（2）; 以及加热器装置（5），用于相对于所述致动介质（2）相对于所述通道（3）的距离产生所述致动介质（2）中的温度梯度; 其中由于致动介质（2）的膨胀或收缩，通道（3）分别关闭或打开。当加热器装置（5）以这样一种方式启动时，使得在更靠近通道（3）的致动介质（2）中产生较高的温度，并且在致动介质（2）中产生较低的温度更远离通道（3），阀可以关闭，反之亦然。因此，提供了这种用于微流体系统的阀，其可以在长时间使用期间被可靠地致动。

27. 发明授权

US09267109B2 Patterned cell sheets and a method for production of the same 有权
标题翻译：图案化电池片及其制造方法
公开(公告)号：US09267109B2
公开(公告)日：2016-02-23
申请号：US12746767
申请日：2008-12-05
申请人： Emiel Peeters , Roel Penterman , Ralph Kurt , Dirk Jan Wilfred Broer
发明人： Emiel Peeters , Roel Penterman , Ralph Kurt , Dirk Jan Wilfred Broer
IPC分类号： C12N5/00
CPC分类号： C12N5/0068 , C12N2535/10 , C12N2539/10
摘要： The present invention is related to a method for the production of cell sheets comprising at least two different cell types, said method comprising the steps of providing a continuous cell sheet which is disposed on a substrate comprising shape transition properties and/or alterable surface characteristics; exposing said continuous cell sheet to a releasing agent in a patterned fashion; washing the cell sheet after exposure to the releasing agent in order to remove cells which have been affected by the releasing agent, and repopulating the gaps remaining after the cells which have been affected by the releasing agent have been removed with a second cell type.
摘要翻译：本发明涉及生产包含至少两种不同细胞类型的细胞片的方法，所述方法包括以下步骤：提供设置在包含形状转变特性和/或可变表面特性的基底上的连续细胞片; 以图案方式将所述连续细胞片暴露于脱模剂; 在暴露于脱模剂之后洗涤细胞片以除去已经被脱模剂影响的细胞，并且在第二细胞类型已经去除了已经被脱模剂影响的细胞之后剩余的间隙。

28. 发明授权

US08475736B2 Microfluidic device and method of manufacturing the same and sensor incorporating the same 有权
标题翻译：微流体装置及其制造方法及其结合的传感器
公开(公告)号：US08475736B2
公开(公告)日：2013-07-02
申请号：US12746940
申请日：2008-12-08
申请人： Reinhold Wimberger-Friedl , Roel Penterman , Ralph Kurt , Emiel Peeters
发明人： Reinhold Wimberger-Friedl , Roel Penterman , Ralph Kurt , Emiel Peeters
IPC分类号： B01L3/00
CPC分类号： B01L3/5023 , B01L3/502753 , B01L2200/12 , B01L2300/0636 , B01L2300/0654 , B01L2300/0681 , B01L2300/069 , B01L2300/0887 , B01L2300/168 , B01L2400/0406 , B01L2400/0487 , B01L2400/065 , Y10T29/49826
摘要： The present invention provides a microfluidic device, for instance for molecular sieving or for detecting a target substance in a sample fluid. The device comprises a first substrate (120) having a substantially flat first surface that is provided with first recesses (124), and a second substrate (128) having a substantially flat second surface that is provided with second recesses (130). At least some of the first recesses are filled with a porous material (114). Alternate first recesses and second recesses form a meandering channel for a sample fluid. The second recesses may be filled with a further porous material. In an embodiment, a capture substance for binding a target substance is arranged in or on the porous material.
摘要翻译：本发明提供了微流体装置，例如用于分子筛或用于检测样品流体中的目标物质。该装置包括具有基本平坦的第一表面的第一基底（120），第一基底具有第一凹槽（124），第二基底（128）具有基本平坦的第二表面，该第二基底具有第二凹槽（130）。至少一些第一凹部填充有多孔材料（114）。替代的第一凹槽和第二凹槽形成用于样品流体的曲折通道。第二凹部可以被另外的多孔材料填充。在一个实施方案中，用于结合目标物质的捕获物质被布置在多孔材料中或其上。

29. 发明申请

US20080283400A1 Separation Medium for Use in Chromatography 审中-公开
标题翻译：分离介质用于色谱
公开(公告)号：US20080283400A1
公开(公告)日：2008-11-20
申请号：US12096918
申请日：2006-11-28
申请人： Dirk John Broer , Emiel Peeters , Ralph Kurt , Roel Penterman
发明人： Dirk John Broer , Emiel Peeters , Ralph Kurt , Roel Penterman
IPC分类号： G01N27/26 , G01N27/00
CPC分类号： G01N27/44747 , B01D15/20 , B01J20/26 , B01J20/261 , B01J20/267 , B01J20/285 , B01J2220/54
摘要： The invention relates to a separation medium for chromatography which is structured in that way that the flow rate is in one preselected direction larger than perpendicular to that direction.
摘要翻译：本发明涉及一种色谱分离介质，该分离介质以这种方式构成，即流速在垂直于该方向的一个预选方向上。

30. 发明申请

US20110095756A1 MAGNETOCHEMICAL SENSOR 审中-公开
标题翻译：磁化学传感器
公开(公告)号：US20110095756A1
公开(公告)日：2011-04-28
申请号：US12158065
申请日：2006-11-24
申请人： Michel Paul Barbara Van Bruggen , Mischa Megens , Hans Van Zon , Ralph Kurt , Roel Penterman , Emiel Peeters
发明人： Michel Paul Barbara Van Bruggen , Mischa Megens , Hans Van Zon , Ralph Kurt , Roel Penterman , Emiel Peeters
IPC分类号： G01R33/09
CPC分类号： H01F1/0045 , B82Y25/00 , G01N35/0098 , H01F10/3268
摘要： The application is directed to a sensor element for use in a magnetochemical sensor, which comprises a first gel-like material (10), especially a swellable hydrogel such as polyacrylamide, and a magnetic second material (20) in the form of particles, especially magnetite (Fe304) nanoparticles, embedded in the first material along with a receptor for an alalyte, eg glucose. Changes in magnetic field due to interaction with the analyte are detected with GMR element (50). Applications include biosensors, DNA testing devices, and high throughput screening.
摘要翻译：该应用涉及用于磁化学传感器的传感器元件，该传感器元件包括第一凝胶状材料（10），特别是诸如聚丙烯酰胺的可溶胀水凝胶和颗粒形式的磁性第二材料（20），特别是磁铁矿（Fe304）纳米颗粒，与一种alalyte（例如葡萄糖）的受体一起嵌入第一种材料中。用GMR元件（50）检测与分析物相互作用导致的磁场变化。应用包括生物传感器，DNA测试设备和高通量筛选。

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