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1. 发明申请

US20110293712A1 COAXIALLY ENCAPSULATED CELL SUSPENSIONS AND MICROTISSUES 审中-公开
标题翻译：同时包被的细胞悬浮液和微量元素
公开(公告)号：US20110293712A1
公开(公告)日：2011-12-01
申请号：US13132534
申请日：2009-11-26
申请人： Ralph Kurt , Emiel Peeters , Roel Penterman , Dirk J. Broer , David Halter
发明人： Ralph Kurt , Emiel Peeters , Roel Penterman , Dirk J. Broer , David Halter
IPC分类号： A61K9/48 , A61K35/12 , C12M1/00
CPC分类号： B01J13/04 , A61K2035/126 , A61L27/38 , A61L27/58
摘要： The present invention provides for the coaxial encapsulation of a plurality of cells in a single elongated compartment. By this encapsulation, the cells are protected by at least one layer of separation material and kept in close contact, which leads to a better vitality of the encapsulated cells and consequently results in higher chances to form microtissue. Methods and devices for the production of such encapsulated cell compartments are disclosed as well as medical uses of such compartments in cell, tissue therapy and tissue engineering.
摘要翻译：本发明提供了在单个细长隔室中的多个电池的同轴封装。通过这种封装，细胞被至少一层分离材料保护并保持紧密接触，这导致包封的细胞更好的活力，从而导致更高的形成微组织的机会。在细胞，组织治疗和组织工程中公开了用于生产这种包封的细胞室的方法和装置以及这些隔室的医学用途。

2. 发明申请

US20090001284A1 Biosensor with One-Dimensional Sub-Diffraction-Limited Apertures Composed of a Grid and a Polarizer 有权
$Biosensor with One-Dimensional Sub-Diffraction-Limited Apertures Composed of a Grid and a Polarizer$
标题翻译：具有由网格和偏振器组成的一维子衍射限制光圈的生物传感器
公开(公告)号：US20090001284A1
公开(公告)日：2009-01-01
申请号：US12158347
申请日：2006-12-11
申请人： Maarten van Herpen , Dirk J. Broer , Emiel Peeters , Derk J.W Klunder , Hendrik R. Stapert
发明人： Maarten van Herpen , Dirk J. Broer , Emiel Peeters , Derk J.W Klunder , Hendrik R. Stapert
IPC分类号： G01J1/58
CPC分类号： G01N21/648 , Y10T436/11
摘要： A method and sensor for the detection of luminescence radiation generated by at least one luminophore is disclosed. In the context of the present invention the biosensor comprises a grid (120) defined as arrays of apertures with the apertures having a first dimension below and a second dimension above the diffraction limit of the excitation light (102) in a medium, a polarizer (115), and luminophores (117) positioned in a volume selected from the group consisting of: the volume inside the apertures of the grid (120), the volume in between the array of slits (120) and the polarizer (115) and a volume that extends into the polarizer (115), wherein the grid (120) providing a transmission axis extending in a first direction and the polarizer (115) providing a transmission axis extending in a second direction, the first direction and the second direction being substantially perpendicular with respect to each other, wherein the excitation radiation (102) is polarized such that it is substantially suppressed by one of the at least one grid (120) and polarizer (115) and substantially not suppressed by the other of the at least one grid (120) and polarizer (115).
摘要翻译：公开了一种用于检测由至少一个发光体产生的发光辐射的方法和传感器。在本发明的上下文中，生物传感器包括定义为孔阵列的格栅（120），孔格具有第一尺寸，第二维度高于介质中的激发光（102）的衍射极限，偏振器（ 115）和位于选自以下的体积中的发光体（117）：栅格（120）的孔内的体积，狭缝阵列（120）和偏振器（115）之间的体积和延伸到偏振器（115）的体积，其中提供沿第一方向延伸的透射轴的格栅（120）和提供沿第二方向延伸的透射轴的偏振器（115），第一方向和第二方向基本上垂直于彼此垂直，其中所述激发辐射（102）被极化，使得其基本上被所述至少一个格栅（120）和偏振器（115）中的一个所抑制，并且基本上不被所述o 该至少一个格栅（120）和偏振器（115）。

3. 发明授权

US08075841B2 Biosensor with one-dimensional sub-diffraction-limited apertures composed of a grid and a polarizer 有权
$Biosensor with one-dimensional sub-diffraction-limited apertures composed of a grid and a polarizer$
标题翻译：具有由栅格和偏振器组成的一维亚衍射限制孔的生物传感器
公开(公告)号：US08075841B2
公开(公告)日：2011-12-13
申请号：US12158347
申请日：2006-12-11
申请人： Maarten Van Herpen , Dirk J. Broer , Emiel Peeters , Derk J. W Klunder , Hendrik R. Stapert
发明人： Maarten Van Herpen , Dirk J. Broer , Emiel Peeters , Derk J. W Klunder , Hendrik R. Stapert
IPC分类号： G01N21/64 , G01N21/00 , G01J3/00 , G01N21/76
CPC分类号： G01N21/648 , Y10T436/11
摘要： A method and sensor for the detection of luminescence radiation generated by at least one luminophore is disclosed. In the context of the present invention the biosensor comprises a grid (120) defined as arrays of apertures with the apertures having a first dimension below and a second dimension above the diffraction limit of the excitation light (102) in a medium, a polarizer (115), and luminophores (117) positioned in a volume selected from the group consisting of: the volume inside the apertures of the grid (120), the volume in between the array of slits (120) and the polarizer (115) and a volume that extends into the polarizer (115), wherein the grid (120) providing a transmission axis extending in a first direction and the polarizer (115) providing a transmission axis extending in a second direction, the first direction and the second direction being substantially perpendicular with respect to each other, wherein the excitation radiation (102) is polarized such that it is substantially suppressed by one of the at least one grid (120) and polarizer (115) and substantially not suppressed by the other of the at least one grid (120) and polarizer (115).
摘要翻译：公开了一种用于检测由至少一个发光体产生的发光辐射的方法和传感器。在本发明的上下文中，生物传感器包括定义为孔阵列的格栅（120），孔格具有第一尺寸，第二维度高于介质中的激发光（102）的衍射极限，偏振器（ 115）和位于选自以下的体积中的发光体（117）：栅格（120）的孔内的体积，狭缝阵列（120）和偏振器（115）之间的体积和延伸到偏振器（115）的体积，其中提供沿第一方向延伸的透射轴的格栅（120）和提供沿第二方向延伸的透射轴的偏振器（115），第一方向和第二方向基本上垂直于彼此垂直，其中所述激发辐射（102）被极化，使得其基本上被所述至少一个格栅（120）和偏振器（115）中的一个所抑制，并且基本上不被所述o 该至少一个格栅（120）和偏振器（115）。

4. 发明授权

US07030950B2 Method of manufacturing a compensator layer with retardation foils exhibiting tilt angles parallel to planes normal to the foils and angled with respect to one another 失效
标题翻译：制造具有延迟箔的补偿层的方法，其具有平行于垂直于箔的平面并相对于彼此成角度的平面的倾斜角
公开(公告)号：US07030950B2
公开(公告)日：2006-04-18
申请号：US10893875
申请日：2004-07-20
申请人： Peter Van De Witte , Johannes A. M. M. Van Haaren , Rifat A. M. Hikmet , Dirk J. Broer
发明人： Peter Van De Witte , Johannes A. M. M. Van Haaren , Rifat A. M. Hikmet , Dirk J. Broer
IPC分类号： G02F1/1335
CPC分类号： G02B5/3083 , G02B5/3016 , G02F1/133632 , G02F1/1396 , G02F2413/105
摘要： A method of manufacturing a compensator layer features forming first and second retardation foils by polymerizing or vitrifying liquid-crystalline material comprising liquid-crystal molecules in manner wherein the liquid-crystal molecules in the polymerized or vitrified liquid-crystalline material of the first and second retardation foils respectively exhibit first and second tilt angles which are respectively parallel to first and second planes that are normal to major surfaces of the foils and that are angled with respect to one another by an angle of 60–120 degrees.
摘要翻译：一种制造补偿层的方法，其特征在于，通过聚合或玻璃化包含液晶分子的液晶材料形成第一和第二延迟膜，其中聚合或玻璃化液晶材料中的液晶分子具有第一和第二延迟箔分别表现出第一和第二倾斜角度，它们分别平行于与箔的主表面垂直的第一和第二平面，并且相对于彼此成角度为60-120度的角度。

5. 发明授权

US06193937B1 Apparatus for manufacturing a broadband cholesteric polarizer 失效
标题翻译：用于制造宽带胆甾型偏振器的装置
公开(公告)号：US06193937B1
公开(公告)日：2001-02-27
申请号：US09264911
申请日：1999-03-09
申请人： Dirk J. Broer , Johannes A. M. M. Van Haaren
发明人： Dirk J. Broer , Johannes A. M. M. Van Haaren
IPC分类号： B01J1908
CPC分类号： G02B5/3016
摘要： The Application describes a method and devices for manufacturing a broadband cholesteric polarizer having a well-defined bandwidth and edge position. To this end, a liquid-crystalline cholesterically ordered layer comprising reactive chiral monomers and reactive nematogenic monomers having a different reactivity is polymerized by exposure to radiation. The invention is characterized in that the intensity of the radiation is increased substantially, preferably by a factor of 10 or more, when a desired edge position of the band is reached. As a result, the bandwidth and edge position of the reflection band reached at that moment are frozen as it were. A monochromatic sensor can be used to determine whether said edge position has been reached, the wavelength used by the sensor corresponding to the wavelength of the desired edge position of the band. Broadband, cholesteric polarizers having a well-defined bandwidth and edge position can very advantageously be used in a display.
摘要翻译：本申请描述了用于制造具有明确的带宽和边缘位置的宽带胆甾型偏振器的方法和装置。为此，包含反应性手性单体和具有不同反应性的反应性起丝单体的液晶胆甾醇排序层通过暴露于辐射而聚合。本发明的特征在于，当达到带的期望的边缘位置时，辐射的强度基本上增加，优选地增加10倍或更多倍。结果，此时达到的反射带的带宽和边缘位置被冻结。可以使用单色传感器来确定所述边缘位置是否已经达到，传感器使用的波长对应于所述带的期望边缘位置的波长。具有良好定义的带宽和边缘位置的宽带胆甾型偏振器可以非常有利地用于显示器中。

6. 发明授权

US5808713A Flat-panel picture display device 失效
标题翻译：平板图像显示装置
公开(公告)号：US5808713A
公开(公告)日：1998-09-15
申请号：US710625
申请日：1996-09-20
申请人： Dirk J. Broer , Reinder Smid , Alexander V. Henzen
发明人： Dirk J. Broer , Reinder Smid , Alexander V. Henzen
IPC分类号： G02F1/1335 , G02F1/13357 , G02F1/13363
CPC分类号： G02F1/133615 , G02F1/133536 , G02F1/13362 , G02F2001/133543 , G02F2001/13355 , G02F2001/133638
摘要： Flat-panel picture display device comprising a picture display panel for modulating the state of polarization of polarized light coupled into said panel in conformity with a picture to be displayed. The light is polarized by means of a reflective polarizer which is integrated or not integrated with the picture display panel. At least a part of the picture display panel functions as an optical waveguide, notably for the beam component b.sub.2 having the state of polarization which is not suitable for modulation. An analyzer is present at a first surface of the picture display panel. The polarizing means in the form of a reflective polarizer are present at a second surface of the picture display panel, which surface is located opposite the first surface. A light-directing system is present at the surface of the polarizer remote from the picture display panel, which system is used for sending the light leaving the picture display panel at this surface without contributing to the formation of the image to the picture display panel again so that it will as yet have a chance of being converted into light having the desired state of polarization.
摘要翻译：平板图像显示装置，包括用于根据要显示的图像调制耦合到所述面板中的偏振光的偏振状态的图像显示面板。光通过集成或不与图像显示面板集成的反射偏振器来极化。图像显示面板的至少一部分用作光波导，特别是用于具有不适于调制的偏振状态的光束分量b2。分析仪存在于图像显示面板的第一表面。反射偏振器形式的偏振装置存在于图像显示面板的第二表面，该表面位于与第一表面相对的位置。远离图像显示面板的偏振器的表面上存在导光系统，该系统用于将离开图像显示面板的光发送到该表面，而不会再次将图像形成到图像显示面板因此它仍然有机会转化为具有所需偏振状态的光。

7. 发明授权

US5712485A Radiation-dose indicator and lamp and tanning apparatus comprising such a radiation-dose indicator 失效
标题翻译：辐射剂量指示剂和包含这种辐射剂量指示剂的灯和鞣制装置
公开(公告)号：US5712485A
公开(公告)日：1998-01-27
申请号：US652396
申请日：1996-05-23
申请人： Dirk J. Broer , Johannes A. F. Peek , Ingrid E. J. R. Heynderickx
发明人： Dirk J. Broer , Johannes A. F. Peek , Ingrid E. J. R. Heynderickx
IPC分类号： G01J1/48 , G01J1/50
CPC分类号： G01J1/48
摘要： Radiation-dose indicator as well as a lamp and a tanning apparatus comprising such a radiation-dose indicator. The invention provides a novel type of radiation-dose indicator which is reliable and accurate. The indicator comprises an optically active layer which includes a liquid-crystalline material as well as a radiation-sensitive compound. This compound is converted under the influence of radiation in such a way as to change the order of the liquid-crystalline material. Preferably, a trans-isomer is used as the radiation-sensitive compound, which is converted to the corresponding cis-isomer under the influence of radiation. In this way, the order of the liquid-crystalline material is broken. Indicators in accordance with the invention can very advantageously be used in UV- and IR-lamps as well as in tanning apparatus.
摘要翻译：辐射剂量指示剂以及包含这种辐射剂量指示剂的灯和鞣制装置。本发明提供了可靠且准确的新型辐射剂量指示剂。指示剂包括光学活性层，其包括液晶材料以及辐射敏感性化合物。这种化合物在辐射的影响下以改变液晶材料的顺序的方式转化。优选地，使用反式异构体作为辐射敏感性化合物，其在辐射的影响下转化为相应的顺式异构体。以这种方式，液晶材料的顺序被破坏。根据本发明的指示器可以非常有利地用于UV和IR灯以及在鞣制装置中。

8. 发明授权

US5686153A Optical temperature indicator 失效
标题翻译：光学温度指示器
公开(公告)号：US5686153A
公开(公告)日：1997-11-11
申请号：US783186
申请日：1997-01-15
申请人： Ingrid E.J.R. Heynderickx , Dirk J. Broer
发明人： Ingrid E.J.R. Heynderickx , Dirk J. Broer
IPC分类号： G01K11/12 , C09K19/38 , C09K19/40 , C09K19/54 , G01K11/16 , G02F1/13 , G02F1/137 , C09K19/02
CPC分类号： C09K19/408 , C09K19/3833 , C09K19/544 , G01K11/165 , Y10T428/1045
摘要： The invention relates to an optical temperature indicator. The indicator comprises an optically active layer of a transparent polymeric material in which liquid-crystalline material is dispersed. The molecules of the liquid-crystalline material form part of a polymeric structure via covalent bonds, for example as side-chain groups. The polymeric structure is preferably based on a siloxane. Such an indicator exhibits a good mechanical stability, while the opacity is preserved for a long period of time.
摘要翻译：本发明涉及一种光学温度指示器。指示剂包括其中分散有液晶材料的透明聚合材料的光学活性层。液晶材料的分子通过共价键形成聚合物结构的一部分，例如作为侧链基团。聚合物结构优选基于硅氧烷。这种指示剂表现出良好的机械稳定性，而不透明度长时间保存。

9. 发明授权

US5188760A Liquid crystalline material and display cell containing said material 失效
标题翻译：液晶材料和显示细胞含有材料
公开(公告)号：US5188760A
公开(公告)日：1993-02-23
申请号：US679981
申请日：1991-04-03
申请人： Rifat A. M. Hikmet , Dirk J. Broer
发明人： Rifat A. M. Hikmet , Dirk J. Broer
IPC分类号： C09K19/12 , C09K19/38 , C09K19/44 , C09K19/54 , G02F1/13 , G02F1/1334
CPC分类号： C09K19/38 , C09K19/542 , G02F1/1334 , G02F2001/13345
摘要： A liquid crystalline material in the form of an anisotropic gel comprising a polymerized liquid crystalline material and a low-molecular weight liquid crystalline material, can be used in a display cell, said polymerized material forming a permanently oriented network in the low-molecular weight liquid crystalline material.

10. 发明授权

US08064035B2 Polarization gratings in mesogenic films 有权
标题翻译：介晶膜中的极化光栅
公开(公告)号：US08064035B2
公开(公告)日：2011-11-22
申请号：US12683933
申请日：2010-01-07
申请人： Michael J. Escuti , Carlos Sanchez , Cornelis W. M. Bastiaansen , Dirk J. Broer
发明人： Michael J. Escuti , Carlos Sanchez , Cornelis W. M. Bastiaansen , Dirk J. Broer
IPC分类号： G02F1/13
CPC分类号： G02B27/283 , G02B5/1833 , G02B5/3016 , G02B5/32 , G02F1/1323 , G02F1/13342 , G02F1/133788 , G02F2201/305 , G02F2203/07
摘要： A polarizer including a polarization grating comprising a polarization sensitive photo-alignment layer and a liquid crystal composition arranged on said photo-alignment layer. An alignment pattern, corresponding to the polarization pattern of a hologram, is recorded in the photo-alignment layer, and the liquid crystal composition is aligned on the photo-alignment layer.
摘要翻译：一种偏振器，包括偏振光栅，包括偏振敏感光取向层和布置在所述光取向层上的液晶组合物。对应于全息图的偏振图案的对准图案记录在光取向层中，液晶组合物在光取向层上排列。

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