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1. 发明授权

US09387484B2 Magnetic sample purification 有权
标题翻译：磁性样品纯化
公开(公告)号：US09387484B2
公开(公告)日：2016-07-12
申请号：US13500446
申请日：2010-09-27
申请人： Reinhold Wimberger-Friedl , Remco Christiaan Den Dulk
发明人： Reinhold Wimberger-Friedl , Remco Christiaan Den Dulk
IPC分类号： G01N1/28 , H01F1/00 , G01N35/00 , B01L3/00 , B03C1/01 , B03C1/015 , B03C1/28
CPC分类号： B03C1/01 , B01L3/502761 , B03C1/015 , B03C1/288 , G01N35/0098 , Y10T436/25375
摘要： A method and apparatus for extracting magnetic particles from a sample includes placing the sample near a liquid carrier, which is immiscible with it, in a configuration stable under the influence of gravity. The magnetic particles are moved by a magnetic field from the sample and into the carrier. The magnetic particles are non-wetting with respect to the carrier and will therefore form agglomerates in the carrier.
摘要翻译：从样品中提取磁性颗粒的方法和装置包括将样品放置在与其不混溶的液体载体附近，在重力作用下稳定的构型。磁性颗粒通过磁场从样品移动到载体中。磁性颗粒相对于载体是不润湿的，因此在载体中形成附聚物。

2. 发明授权

US08686376B2 Microarray characterization system and method 有权
标题翻译：微阵列表征系统及方法
公开(公告)号：US08686376B2
公开(公告)日：2014-04-01
申请号：US12999639
申请日：2009-06-23
申请人： Reinhold Wimberger-Friedl , Peter Dirksen , Marius Iosif Boamfa , Erik Martinus Hubertus Petrus Van Dijk
发明人： Reinhold Wimberger-Friedl , Peter Dirksen , Marius Iosif Boamfa , Erik Martinus Hubertus Petrus Van Dijk
IPC分类号： F21V9/16
CPC分类号： G01N21/6452 , B01L3/5027 , G02B21/0028
摘要： A system for detecting a plurality of analytes in a sample includes an aperture array and a lens array for generating and focusing a plurality of excitation sub-beams on different sub-regions of a substrate. These sub-regions can be provided with different binding sites for binding different analytes in the sample. By detecting the different luminescent responses in a detector, the presence or amount of different analytes can be determined simultaneously. Alternatively or in addition, collection of the luminescence radiation can be performed using the lens array for directly collecting the luminescence response and for guiding the collected luminescence response to corresponding apertures. The excitation sub-beams may be focused at the side of the substrate opposite of the lens array, and an immersion fluid is provided between the lens array and the substrate to increase the collection efficiency of the luminescence radiation.
摘要翻译：用于检测样品中多个分析物的系统包括孔径阵列和用于在衬底的不同子区域上产生和聚焦多个激发子束的透镜阵列。这些子区域可以具有不同的结合位点，用于结合样品中的不同分析物。通过检测检测器中的不同发光响应，可以同时测定不同分析物的存在或量。或者或另外，可以使用透镜阵列来执行发光辐射的收集，用于直接收集发光响应并且用于将所收集的发光响应引导到相应的孔。激发子光束可以聚焦在与透镜阵列相对的一侧的基板处，并且在透镜阵列和基板之间提供浸没流体以增加发光辐射的收集效率。

3. 发明申请

US20140087955A1 DEVICES AND METHODS FOR EFFICIENT CAPTURE OF NUCLEIC ACIDS 审中-公开
标题翻译：用于有效捕获核酸的装置和方法
公开(公告)号：US20140087955A1
公开(公告)日：2014-03-27
申请号：US14118986
申请日：2012-05-23
申请人： Reinhold Wimberger Friedl , Eva Servoli
发明人： Reinhold Wimberger Friedl , Eva Servoli
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6834 , C12Q2565/629 , C12Q2565/513 , C12Q2537/149
摘要： The present invention relates a device for the efficient binding of nucleic acids on a microarray, comprising a reaction zone comprising a microarray, and a capture zone comprising a porous membrane substrate, wherein the capture zone is capable of specifically capturing sense strands of target molecules, whereas complementary antisense strands are captured in the reaction zone, or vice versa. The invention further envisages temperature regulating units in the device allowing to bring or keep the capture at a temperature not allowing hybridizing or binding of nucleic acid(s) to the capture molecules or to a temperature suitable for nucleic acid hybridization. The invention also relates to a method of efficiently binding nucleic acids on a microarray, comprising introducing a medium containing one or more target molecules in denatured form into a capture zone of a device of the present invention, performing an interaction reaction between the target molecules and immobilized capture molecules in said capture zone, and transporting not bound target molecule strands to a reaction zone comprising a microarray, thereby allowing an interaction between the target molecule strands and immobilized capture molecules on the microarray. In a further aspect the invention relates to the use of such a device for enriching target molecules, specifically selecting a target molecules, expression analysis, comparative genomic hybridization, the detection of SNPs, or for microarray-based genomic selection-based sequencing.
摘要翻译：本发明涉及用于在微阵列上有效结合核酸的装置，其包括包含微阵列的反应区和包含多孔膜底物的捕获区，其中所述捕获区能够特异性捕获目标分子的有义链，而在反应区中捕获互补的反义链，反之亦然。本发明进一步设想该装置中的温度调节单元允许将捕获带入或保持在不允许核酸与捕获分子杂交或结合的温度或适合于核酸杂交的温度。本发明还涉及一种在微阵列上有效结合核酸的方法，包括将含有一种或多种变性形式的靶分子的培养基引入本发明的装置的捕获区，进行靶分子与在所述捕获区中固定捕获分子，并将未结合的靶分子链输送到包含微阵列的反应区，从而允许靶分子链与微阵列上固定的捕获分子之间的相互作用。在另一方面，本发明涉及这种装置用于富集靶分子，特异性选择靶分子，表达分析，比较基因组杂交，SNP检测或用于基于微阵列的基于基因组选择的测序的用途。

4. 发明申请

US20130299015A1 MICRO-PUMP OR NORMALLY-OFF MICRO-VALVE 有权
标题翻译：微型泵或常规微型阀
公开(公告)号：US20130299015A1
公开(公告)日：2013-11-14
申请号：US13980586
申请日：2012-01-20
申请人： Roel Penterman , Johannes Van Eemeren , Reinhold Wimberger-Friedl , Henrik Van Amerongen
发明人： Roel Penterman , Johannes Van Eemeren , Reinhold Wimberger-Friedl , Henrik Van Amerongen
IPC分类号： F16K51/00
CPC分类号： F16K51/00 , B01L3/502738 , B01L2300/0874 , B01L2300/0887 , B01L2400/0655 , F16K99/0001 , F16K99/0015 , F16K99/0057 , F16K99/0059 , F16K2099/008 , F16K2099/0084 , F16K2099/0094 , Y10T137/794
摘要： The invention relates to a micro valve for use in a biosensor, a micro fluidic device, use of such a device, and a micro fluidic element. Biosensors are used for detection of molecules and/or ions, such as protein, drug, DNA, RNA, hormone, glucose, insulin, enzyme, fungus, bacterium, etc., in a biological sample. The sensor can be used for diagnostic application, but for instance also drugs, either therapeutic or abuse, may be detected in for instance blood, urine and saliva.
摘要翻译：本发明涉及用于生物传感器的微型阀，微流体装置，这种装置的使用以及微流体元件。生物传感器用于检测生物样品中的分子和/或离子，例如蛋白质，药物，DNA，RNA，激素，葡萄糖，胰岛素，酶，真菌，细菌等。该传感器可以用于诊断应用，但是例如也可以在例如血液，尿液和唾液中检测治疗或滥用的药物。

5. 发明申请

US20120270332A1 MAGNETIC SAMPLE PURIFICATION 有权
标题翻译：磁性样品净化
公开(公告)号：US20120270332A1
公开(公告)日：2012-10-25
申请号：US13500446
申请日：2010-09-27
申请人： Reinhold Wimberger-Friedl , Remco Christiaan Den Dulk
发明人： Reinhold Wimberger-Friedl , Remco Christiaan Den Dulk
IPC分类号： G01N1/28 , H01F1/00
CPC分类号： B03C1/01 , B01L3/502761 , B03C1/015 , B03C1/288 , G01N35/0098 , Y10T436/25375
摘要： The invention relates to means for extracting magnetic particles (M) from a sample (S). The sample (S) is arranged adjacent to a liquid carrier (C), which is immiscible with it, in a configuration stable under the influence of gravity, and the magnetic particles (M) are moved by a magnetic field (B) from the sample (S) into the carrier (C). Preferably, the magnetic particles (M) are non-wetting with respect to the carrier (C) and will therefore form agglomerates in the carrier (C).
摘要翻译：本发明涉及从样品（S）中提取磁性颗粒（M）的方法。样品（S）以与重力不同的液体载体（C）相邻配置，在重力作用下是稳定的，磁性粒子（M）通过磁场（B）从样品（S）进入载体（C）。优选地，磁性颗粒（M）相对于载体（C）不润湿，因此将在载体（C）中形成附聚物。

6. 发明申请

US20090130025A1 APPARATUS AND METHODS FOR THE PRODUCTION OF ULTRASOUND CONTRAST AGENTS 审中-公开
标题翻译：用于生产超声对比剂的装置和方法
公开(公告)号：US20090130025A1
公开(公告)日：2009-05-21
申请号：US11577820
申请日：2005-10-25
申请人： Marcel Rene Bohmer , Reinhold Wimberger-Friedl
发明人： Marcel Rene Bohmer , Reinhold Wimberger-Friedl
IPC分类号： A61K49/22
CPC分类号： B01F3/04439 , A61K49/223 , B01F5/0475 , B01F5/0476
摘要： Disclosed is a method of making gas bubbles in a liquid, the bubbles having substantially uniform size suitable for responding to ultrasound or other diagnostic tools. Gas (P2) is forced through one or more pores or nozzles, into the liquid (P1), the nozzles or pores being of substantially uniform diameter, the flow of the gas being controlled to thereby cause the formation of substantially monodisperse gas bubbles in the liquid. Moreover, an apparatus is disclosed for making a suspension of gas bubbles in a liquid of a size suitable for responding to ultrasound or other diagnostic tools. Said apparatus comprises means for forcing a gas through an array of nozzles or pores into the liquid, the nozzles or pores being of substantially uniform diameter, and first means for controlling; a flow parameter of the gas so that gas is suspended as substantially monodisperse gas bubbles in the liquid. Furthermore a kit for preparing a dispersion of gas bubbles of substantially uniform size suitable for ultrasound purposes, is disclosed.
摘要翻译：公开了一种在液体中制造气泡的方法，气泡具有适合于响应超声波或其它诊断工具的基本均匀的尺寸。气体（P2）被迫通过一个或多个孔或喷嘴进入液体（P1），喷嘴或孔具有基本上均匀的直径，气体的流动受到控制，从而在该气体中形成基本上单分散的气泡液体。此外，公开了一种用于使气泡悬浮在适于响应于超声波或其它诊断工具的尺寸的液体中的装置。所述设备包括用于迫使气体通过喷嘴或孔阵列进入液体的装置，喷嘴或孔具有基本均匀的直径，以及用于控制的第一装置; 气体的流动参数，使得气体作为基本上单分散的气泡悬浮在液体中。此外，公开了一种用于制备适合于超声波目的基本均匀尺寸的气泡分散体的试剂盒。

7. 发明申请

US20090015930A1 COLLIMATOR 审中-公开
公开(公告)号：US20090015930A1
公开(公告)日：2009-01-15
申请号：US10596316
申请日：2004-12-08
申请人： Rifat A.M. Hikmet , Ties Van Bommel , Peter Van De Witte , Reinhold Wimberger-Friedl , Dirk Burdinski
发明人： Rifat A.M. Hikmet , Ties Van Bommel , Peter Van De Witte , Reinhold Wimberger-Friedl , Dirk Burdinski
IPC分类号： G02B27/30 , B29D11/00 , B05D1/04 , G01T1/00 , G21F3/00 , B29C35/08
CPC分类号： B82Y30/00 , G02B5/005 , G02B5/206 , G02B27/30 , G21K1/025
摘要： A collimator panel comprises: a solid panel having a first face for receiving uncollimated radiation and a second opposite face for providing collimated radiation; and a plurality of elongate particles disposed in the panel and orientated to provide the collimating function. A method of manufacturing a collimator panel comprises the steps of: suspending a plurality of elongate particles in a liquid; applying an electric or magnetic field to the suspension to orientate the particles; and solidifying the liquid to fix the orientation of the particles, thereby forming a collimator panel. A method of manufacturing the elongate particles is also provided.
摘要翻译：准直器面板包括：具有用于接收未预激射辐射的第一面的实心面板和用于提供准直辐射的第二相对面; 以及设置在面板中并且定向以提供准直功能的多个细长颗粒。制造准直器面板的方法包括以下步骤：将多个细长颗粒悬浮在液体中; 对悬浮液施加电场或磁场以使颗粒定向; 并固化液体以固定颗粒的取向，由此形成准直板。还提供了制造细长颗粒的方法。

8. 发明申请

US20080245971A1 Biosensors with Improved Sensitivity 审中-公开
标题翻译：具有提高灵敏度的生物传感器
公开(公告)号：US20080245971A1
公开(公告)日：2008-10-09
申请号：US12088943
申请日：2006-09-27
申请人： Reinhold Wimberger-Friedl , Hendrik Roelof Stapert
发明人： Reinhold Wimberger-Friedl , Hendrik Roelof Stapert
IPC分类号： G01J1/58
CPC分类号： G01N21/6454 , B01L3/5027 , B01L3/502707 , B01L2300/0654 , B01L2300/0681 , B01L2300/0819 , B01L2300/0877 , G01N21/05 , G01N21/6428 , G01N2021/0346
摘要： A sensor is described for use with at least one optical detector (5), the sensor comprising a substrate (11) with optical outlets, a porous membrane (12) and micro fluidic channels (13) for conducting analyte fluid towards sensing locations (10) of the porous membrane (12). The sensing locations (10) are adapted for at least restraining light variable molecules (23) which bind to analytes to be determined. The optical output of the light variable molecules changes when they are in close proximity to a target molecule. The micro fluidic channels (13) are shaped to reflect light emitted from the sensing locations (10) towards the optical outlets and the substrate has diffracting optical elements (15) aligned with microfluidic channels to diffract light towards the optical outlets. The diffracting optical elements can be lenses.
摘要翻译：传感器被描述为与至少一个光学检测器（5）一起使用，传感器包括具有光学出口的基底（11），多孔膜（12）和微流体通道（13），用于将分析物流体传导到感测位置（10 ）多孔膜（12）。感测位置（10）适于至少限制结合要测定的待分析物的光可变分子（23）。光可变分子的光学输出在它们紧邻目标分子时变化。微流体通道（13）成形为将从感测位置（10）发射的光朝向光学出口反射，并且衬底具有与微流体通道对准的衍射光学元件（15），以将光朝向光学出口衍射。衍射光学元件可以是透镜。

9. 发明申请

US20080205017A1 Interconnection and Packaging Method for Biomedical Devices with Electronic and Fluid Functions 审中-公开
标题翻译：具有电子和流体功能的生物医学设备的互连和封装方法
公开(公告)号：US20080205017A1
公开(公告)日：2008-08-28
申请号：US11996515
申请日：2006-07-12
申请人： Ton Nellissen , Reinhold Wimberger-Friedl
发明人： Ton Nellissen , Reinhold Wimberger-Friedl
IPC分类号： H05K7/14
CPC分类号： B01L3/502715 , B01L3/502707 , B01L2200/02 , B01L2200/0689 , B01L2200/12 , B01L2300/0645 , H01L21/50 , H01L23/10 , H01L2224/16 , H01L2224/26175 , H01L2924/01004 , H01L2924/01078 , H01L2924/01079 , H01L2924/1461 , H01L2924/15151 , H05K1/0272 , H05K1/181 , H05K3/0058 , H05K2201/10674 , H05K2203/1147 , H01L2924/00
摘要： An interconnection and packaging method is provided for manufacturing of Lab-on-chip (LOC) and Micro Total Analyses Systems. Different functions, such as biosensors, heaters, coolers, valves, and pumps, are combined in an electronic/mechanical/fluidic module by flip-chip technology using an ultrasound bounding process. A predefined polymeric ring on the chip serves as a seal.
摘要翻译：提供了一种用于制造片上实验室（LOC）和微型总分析系统的互连和封装方法。不同的功能，例如生物传感器，加热器，冷却器，阀门和泵，通过使用超声波界定过程的倒装芯片技术组合在电子/机械/流体模块中。芯片上的预定义的聚合物环用作密封件。

10. 发明授权

US09493822B2 Devices and methods for microarray selection 有权
标题翻译：用于微阵列选择的设备和方法
公开(公告)号：US09493822B2
公开(公告)日：2016-11-15
申请号：US13393255
申请日：2010-08-26
申请人： Pieter Jan Van Der Zaag , Harma Feitsma , Jacob Marinus Jan Den Toonder , Reinhold Wimberger-Friedl
发明人： Pieter Jan Van Der Zaag , Harma Feitsma , Jacob Marinus Jan Den Toonder , Reinhold Wimberger-Friedl
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6834 , C12Q2537/149 , C12Q2527/107
摘要： The present invention relates to a device for the specific selection of target molecules, wherein immobilized capture molecules can be organized in a microarray in the form of spots or lines. In a further aspect the present invention relates to a method of specifically selecting target molecules in a reaction zone, as well as the use of such a device for specifically selecting target molecules, e.g. for target enrichment, or microarray based genome selection (MGS).
摘要翻译：本发明涉及用于特异性选择靶分子的装置，其中固定的捕获分子可以以点或线的形式组织在微阵列中。在另一方面，本发明涉及在反应区中特异性选择靶分子的方法，以及这种用于特异性选择靶分子的装置的使用，例如，用于靶标富集或基于微阵列的基因组选择（MGS）。

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