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21. 发明授权

US06958809B2 Reagent-less whole-blood glucose meter 有权
标题翻译：无试剂全血糖仪
公开(公告)号：US06958809B2
公开(公告)日：2005-10-25
申请号：US10055875
申请日：2002-01-21
申请人： Bernhard B. Sterling , Philip C. Hartstein , Ken I. Li , Mark D. Agostino , David C. Klonoff , Robert D. Gaffney , Jennifer H. Gable , Ken G. Witte , Mike A. Munrow , Daniel S. Goldberger , Julian M. Cortella , James R. Braig , Peter Rule
发明人： Bernhard B. Sterling , Philip C. Hartstein , Ken I. Li , Mark D. Agostino , David C. Klonoff , Robert D. Gaffney , Jennifer H. Gable , Ken G. Witte , Mike A. Munrow , Daniel S. Goldberger , Julian M. Cortella , James R. Braig , Peter Rule
IPC分类号： A61B5/00 , G01N21/35 , G01N33/48
CPC分类号： A61B5/01 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150503 , A61B5/15087 , A61B5/15107 , A61B5/15136 , A61B5/1514 , A61B5/15186 , A61B5/157 , A61B5/6826 , A61B5/6838 , A61B2562/0295 , A61B2562/12 , G01N21/35
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.
摘要翻译：能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。全血系统还具有光束的光路中的检测器。全血系统还具有容纳源和检测器的壳体。全血系统还具有位于束的光路中的样品元件。样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

22. 发明授权

US5615672A Self-emission noninvasive infrared spectrophotometer with body temperature compensation 失效
标题翻译：自发式无创红外分光光度计，具有体温补偿
公开(公告)号：US5615672A
公开(公告)日：1997-04-01
申请号：US353099
申请日：1994-12-09
申请人： James R. Braig , Daniel S. Goldberger , Bernhard B. Sterling
发明人： James R. Braig , Daniel S. Goldberger , Bernhard B. Sterling
IPC分类号： G01N33/49 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1495 , G01N21/35 , G01N33/66
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , G01N21/35 , G01N21/3581
摘要： A method and apparatus for monitoring glucose, ethyl alcohol and other blood constituents in a noninvasive manner. The measurements are made by monitoring infrared absorption of the desired blood constituent in the long infrared wavelength range where the blood constituent has a strong and distinguishable absorption spectrum. The long wavelength infrared energy emitted by the person as heat is monitored and the infrared absorption of particular constituents in the blood (such as glucose or blood alcohol) is measured at characteristic infrared absorption wavelengths for those constituents. The measurements are preferably synchronized with systole and diastole of the cardiac cycle so that the signal contribution caused by veins and tissues (which do not pulse) may be cancelled when a ratio of the detected signals is taken. On the other hand, if no synchronization is provided, the spectrophotometer may measure the arterial, venous and tissue constituent concentrations simultaneously, which may be desired in some circumstances. The internal "blackbody" energy level of an infrared emissions source such as a vascularized appendage prior to glucose absorption is measured and used to compensate temperature dependent effects in the concentration calculation. The internal energy level is then ratioed to the actual measured energy and used to compute the percentage of energy absorbed by the glucose. Discontinuities in the ratio are eliminated by converting the absorption measurements from voltages to watts.
摘要翻译：一种以非侵入性方式监测葡萄糖，乙醇和其他血液成分的方法和装置。通过监测血液成分具有强烈且可区分的吸收光谱的长红外波长范围内的所需血液成分的红外吸收来进行测量。监测由人发射的长波长红外能量作为热，并且对于那些成分在特征红外吸收波长处测量血液中特定成分（如葡萄糖或血液酒精）的红外吸收。所述测量优选与心动周期的收缩和心律舒张同步，使得当检测到的信号的比率被采取时，可以消除由静脉和组织引起的信号贡献（其不脉冲）。另一方面，如果不提供同步，则分光光度计可以同时测量动脉，静脉和组织成分浓度，这在某些情况下可能是期望的。测量红外发射源的内部“黑体”能级，例如葡萄糖吸收之前的血管附着物，并用于补偿浓度计算中的温度依赖性影响。然后将内部能量水平与实际测量的能量进行比率，并用于计算葡萄糖吸收的能量的百分比。通过将吸收测量值从电压转换为瓦特来消除比例的不连续性。

23. 发明授权

US07009180B2 Pathlength-independent methods for optically determining material composition 有权
公开(公告)号：US07009180B2
公开(公告)日：2006-03-07
申请号：US10319409
申请日：2002-12-12
申请人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philip C. Hartstein , Robert D. Gaffney
发明人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philip C. Hartstein , Robert D. Gaffney
IPC分类号： G01N21/35
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B2562/0295 , G01N21/274 , G01N21/314 , G01N21/35 , G01N27/3271
摘要： A method uses spectroscopy to determine an analyte concentration in a sample. The method includes producing an absorbance spectrum of the sample. The method further includes shifting the absorbance spectrum to zero in a wavelength region. The method further includes subtracting a water or other substance contribution from the absorbance spectrum.

24. 发明授权

US06631282B2 Device for isolating regions of living tissue 失效
标题翻译：用于隔离活组织区域的装置
公开(公告)号：US06631282B2
公开(公告)日：2003-10-07
申请号：US09970021
申请日：2001-10-02
申请人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian Cortella , Mark D. Agostino
发明人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian Cortella , Mark D. Agostino
IPC分类号： A61B500
CPC分类号： A61B5/6841 , A61B5/061 , A61B5/14532 , A61B5/1455
摘要： A device and method are provided for use with a non-invasive optical measurement system, such as a thermal gradient spectrometer for improved determination of analyte concentrations within living tissue. In a preferred embodiment, a site selector is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The site selector attaches to a thermal mass window of the spectrometer and thus forms an interface between the patient's skin and the thermal mass window. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the site selector is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the site selector will again form an interface between the gradient spectrometer and the same location of skin as before.
摘要翻译：提供了一种用于非侵入式光学测量系统的装置和方法，所述非侵入性光学测量系统例如用于改善生物体内分析物浓度测定的热梯度光谱仪。在优选实施例中，站点选择器被固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。站点选择器连接到光谱仪的热质量窗口，从而形成患者皮肤和热质量窗口之间的界面。当光谱仪必须临时从病人的皮肤上移除时，例如允许患者移动，将场地选择器固定在前臂上，以保持皮肤上一致的测量部位。当光谱仪后来重新连接到患者时，站点选择器将再次形成梯度光谱仪和与之前相同的皮肤位置之间的界面。

25. 发明授权

US5313941A Noninvasive pulsed infrared spectrophotometer 失效
标题翻译：无创脉冲红外分光光度计
公开(公告)号：US5313941A
公开(公告)日：1994-05-24
申请号：US10634
申请日：1993-01-28
申请人： James R. Braig , Daniel S. Goldberger
发明人： James R. Braig , Daniel S. Goldberger
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , G01N21/35
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , G01N21/35 , G01N21/3581
摘要： A method and apparatus for monitoring glucose, ethyl alcohol and other blood constituents in a noninvasive manner. The measurements are made by monitoring infrared absorption of the desired blood constituent in the long infrared wavelength range where the blood constituent has a strong and distinguishable absorption spectrum. The long wavelength infrared energy is passed through a finger or other vascularized appendage and the measurement made. To prevent the high energy source from burning or causing patient discomfort, only short bursts or pulses of energy are sent through the finger with a very low duty cycle and low optical bandwidth. The bursts are further synchronized with systole and diastole of the cardiac cycle so that only two pulses are sent per heart beat, one during diastole and one during systole. The detection signals measured during application of these bursts of energy are then used to calculate the concentration of the blood constituents in accordance with a polynomial equation.
摘要翻译：一种以非侵入性方式监测葡萄糖，乙醇和其他血液成分的方法和装置。通过监测血液成分具有强烈且可区分的吸收光谱的长红外波长范围内的所需血液成分的红外吸收来进行测量。长波长红外能量通过手指或其他血管附着物进行测量。为了防止高能源燃烧或引起患者不适，只有短脉冲或能量脉冲通过手指以非常低的占空比和低的光学带宽发送。脉冲进一步与心动周期的收缩和舒张同步，使得每个心跳只发送两个脉冲，一个在舒张期期间发送，一个在心脏收缩期间发送。然后使用在应用这些脉冲能量期间测量的检测信号根据多项式方程计算血液成分的浓度。

26. 发明授权

US5067492A Disposable airway adapter 失效
标题翻译：一次性气道适配器
公开(公告)号：US5067492A
公开(公告)日：1991-11-26
申请号：US564179
申请日：1990-08-07
申请人： Mark Yelderman , Daniel S. Goldberger , James R. Braig
发明人： Mark Yelderman , Daniel S. Goldberger , James R. Braig
IPC分类号： A61B5/08 , A61B5/083 , A61B5/097
CPC分类号： A61B5/0836 , A61B5/097
摘要： A disposable endotracheal airway adapter for use in proximity of a patient's mouth in the measurement of the concentraton of respiratory gases. The disposable airway adapter of the invention provides a conduit for patient respiratory gases and allows the passage of infrared radiation through the gases for measuring the constituent concentration of the respiratory gases while keeping the patient gases from coming in contact with the analyzer mechanism. The body of the airway adapter is designed to connect in series with the airway tubing which connects a patient to a mechanical respirator or anesthesia breathing circuit. The body of the airway adapter is very light in weight and is formed of inexpensive material such as polyethylene or polypropylene so that it may be manufactured inexpensively and discarded after each use. An inexpensive optical window in the adapter is also formed of material such as polyethylene or polypropylene so that the gas analyzer can pass light into the sample for analysis. Preferably, the optical windows of the invention are made of the same material as the adapter body. Since the adapter of the invention may be disposed of after use on a single patient, sterilization expenses and cross-contamination may be minimized. Also, calibrating integrity is maintained through a calibration process which accounts for the non-linearity of the absorption spectra of the window material in the region of interest.
摘要翻译：用于测量呼吸气体浓度的患者口腔附近的一次性气管插管气道适配器。本发明的一次性气道适配器提供用于患者呼吸气体的导管，并允许红外辐射通过气体，用于测量呼吸气体的组成浓度，同时保持患者气体不与分析器机构接触。气道适配器的主体设计成与将患者连接到机械呼吸器或麻醉呼吸回路的气道管串联连接。气道适配器的主体重量非常轻，并且由诸如聚乙烯或聚丙烯的廉价材料形成，使得可以在每次使用后廉价地制造和丢弃。适配器中的廉价的光学窗口也由诸如聚乙烯或聚丙烯的材料形成，使得气体分析仪可以将光通过样品进行分析。优选地，本发明的光学窗口由与适配器主体相同的材料制成。由于本发明的适配器可以在使用后在单个患者身上处理，因此可以使灭菌费用和交叉污染最小化。此外，校准完整性通过考虑到感兴趣区域中窗口材料的吸收光谱的非线性的校准过程来维持。

27. 发明授权

US07122154B1 Apparatus for testing breath alcohol with discrimination between alveolar and upper respiratory tract alcohol 失效
标题翻译：用于检测呼吸酒精的装置，区分肺泡和上呼吸道酒精
公开(公告)号：US07122154B1
公开(公告)日：2006-10-17
申请号：US08363615
申请日：1994-12-23
申请人： Glenn C. Forrester , Roger Allen , Roger Herrera , Daniel S. Goldberger , James R. Braig
发明人： Glenn C. Forrester , Roger Allen , Roger Herrera , Daniel S. Goldberger , James R. Braig
IPC分类号： G01N33/497
CPC分类号： A61B5/097 , G01N33/4972 , Y10S436/90 , Y10T436/204165 , Y10T436/204998
摘要： A method and infrared sensing device for determining the concentration of alveolar alcohol in a breath sample exhaled by a subject into an infrared sensing device. The presence of alcohol from the upper respiratory tract of the subject is detected by continuously monitoring alcohol and carbon dioxide, normalizing alcohol values with respect to carbon dioxide, calculating a difference between normalized alcohol concentration and carbon dioxide concentration over time, integrating (summing) the difference, and comparing the integrated difference with a threshold. This technique accurately and consistently detects the presence of mouth alcohol in the sample before the presence of carbon dioxide which originates in deep lung breath.
摘要翻译：一种用于确定受试者呼出的呼吸样品中的肺泡醇浓度成红外感测装置的方法和红外感测装置。通过连续监测酒精和二氧化碳，对二氧化碳标准化酒精度值，计算标准化酒精浓度与二氧化碳浓度之间的差异随时间的推移，检测来自受试者上呼吸道的酒精含量（总和）差异，并将积分差异与阈值进行比较。该技术在二氧化碳的存在之前准确且一致地检测出样品中口腔醇的存在，这种二氧化碳起源于深肺呼吸。

28. 发明授权

US5095913A Shutterless optically stabilized capnograph 失效
标题翻译：无光闸光学稳定的星座
公开(公告)号：US5095913A
公开(公告)日：1992-03-17
申请号：US522208
申请日：1990-05-11
申请人： Mark Yelderman , Daniel S. Goldberger , James R. Braig
发明人： Mark Yelderman , Daniel S. Goldberger , James R. Braig
IPC分类号： A61B5/083 , G01J1/24 , G01J5/12 , G01N21/31 , G01N21/35
CPC分类号： G01N21/3504 , A61B5/083 , G01J1/24 , G01J5/12 , G01N2021/3166 , G01N2201/126
摘要： Methods and apparatus for constructing optically stabilized, shutterless infrared capnographs are disclosed. The capnographs of the present invention provide the absolute concentration of the constituents of the respiratory airstream of a patient, without the thermal drift problems normally associated with thermopile detectors, thereby providing a device with a high degree of accuracy. The present invention eliminates the need for a mechanical shutter to modulate the incident infrared beam and the need for a modulated source, thereby increasing the reliability and response time of the devices disclosed. Capnographs which are substantially unaffected by changes in the ambient temperature at which they operate are provided by connecting pairs of optically filtered thermopiles in series and processing the resulting differential pair.
摘要翻译：公开了用于构造光学稳定的无闸门红外捕集仪的方法和装置。本发明的血氧监护仪提供了患者的呼吸气流的成分的绝对浓度，而没有通常与热电堆检测器相关的热漂移问题，从而提供高精度的装置。本发明不需要机械快门来调制入射的红外光束和调制源的需要，从而增加所公开的设备的可靠性和响应时间。基本上不受其工作环境温度变化影响的测井仪通过串联连接成对的光学过滤的热电堆并处理所得的差分对来提供。

29. 发明授权

US06095986A Disposable anti-fog airway adapter 失效
标题翻译：一次性防雾气道适配器
公开(公告)号：US06095986A
公开(公告)日：2000-08-01
申请号：US123232
申请日：1998-07-28
申请人： James R. Braig , Daniel S. Goldberger , Roger O. Herrera , Mark L. Yelderman
发明人： James R. Braig , Daniel S. Goldberger , Roger O. Herrera , Mark L. Yelderman
IPC分类号： A61B5/097 , A61B5/08
CPC分类号： A61B5/097
摘要： A disposable anti-fog airway adapter for use with a mainstream respiratory gas analyzer which provides a measurement of a patient's inhaled and exhaled gases. The airway adapter includes windows that are constructed of a thin, low heat capacity plastic that rapidly equilibrates to the temperature of the warm moist gases in the patient breathing circuit. In addition, the inside of the windows is also coated with an anti-fog surfactant either by laminating an anti-fog film with the window plastic prior to attaching the window to the airway adapter body or by first attaching the window to the airway adapter body and then applying the surfactant to the airway adapter after the window film is bonded in place so that the surfactant coats the entire inside of the adapter. The surfactant functions to increase the critical wetting tension of the surface it covers so that water on the window spreads into a uniform thin layer which does not absorb very much infrared energy and thus does not significantly reduce the signal strength. "Instant on" operation is accomplished because no heater and the like is necessary to warm up the windows to maintain them at an elevated temperature to prevent fogging. Numerous techniques are also provided for adhering the windows to the airway adapter body so that a substantially airtight seal may be obtained.
摘要翻译：用于主流呼吸气体分析仪的一次性防雾气道适配器，其提供对患者的吸入和呼出气体的测量。气道适配器包括由能够快速平衡到患者呼吸回路中的温湿润气体的温度的薄的低热容塑料构成的窗户。此外，窗户的内部还通过在将窗口附接到气道适配器主体之前层叠防雾膜与窗户塑料，或者通过首先将窗口附接到气道适配器本体上来涂覆防雾表面活性剂然后在将窗膜粘合就位后将表面活性剂施用于气道适配器，使得表面活性剂涂覆在适配器的整个内部。表面活性剂用于增加其覆盖的表面的临界润湿张力，使得窗户上的水扩散到不吸收非常多的红外能量的均匀薄层，因此不显着降低信号强度。实现“即时打开”操作，因为不需要加热器等来预热窗户以将其保持在高温以防止起雾。还提供了许多技术用于将窗口粘附到气道适配器主体，使得可以获得基本上气密的密封。

30. 发明授权

US5376555A Method for testing breath alcohol with discrimination between alveolar and upper respiratory tract alcohol 失效
标题翻译：用于检测呼吸酒精的方法，区分肺泡和上呼吸道酒精
公开(公告)号：US5376555A
公开(公告)日：1994-12-27
申请号：US202282
申请日：1994-02-25
申请人： Glenn C. Forrester , Roger Allen , Roger Herrera , Daniel S. Goldberger , James R. Braig
发明人： Glenn C. Forrester , Roger Allen , Roger Herrera , Daniel S. Goldberger , James R. Braig
IPC分类号： G01N33/497 , G01N21/61
CPC分类号： A61B5/097 , G01N33/4972 , Y10S436/90 , Y10T436/204165 , Y10T436/204998
摘要： A method and infrared sensing device for determining the concentration of alveolar alcohol in a breath sample exhaled by a subject into an infrared sensing device. The presence of alcohol from the upper respiratory tract of the subject is detected by continuously monitoring alcohol and carbon dioxide, normalizing alcohol values with respect to carbon dioxide, calculating a difference between normalized alcohol concentration and carbon dioxide concentration over time, integrating (summing) the difference, and comparing the integrated difference with a threshold. This technique accurately and consistently detects the presence of mouth alcohol in the sample before the presence of carbon dioxide which originates in deep lung breath.
摘要翻译：一种用于确定受试者呼出的呼吸样品中的肺泡醇浓度成红外感测装置的方法和红外感测装置。通过连续监测酒精和二氧化碳，对二氧化碳标准化酒精度值，计算标准化酒精浓度与二氧化碳浓度之间的差异随时间的推移，检测来自受试者上呼吸道的酒精含量（总和）差异，并将积分差异与阈值进行比较。该技术在二氧化碳的存在之前准确且一致地检测出样品中口腔醇的存在，这种二氧化碳起源于深肺呼吸。

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