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21. 发明申请

US20070130995A1 Method and apparatus for making fused silica 有权
标题翻译：制造熔融石英的方法和设备
公开(公告)号：US20070130995A1
公开(公告)日：2007-06-14
申请号：US11305857
申请日：2005-12-14
申请人： Daniel Hawtof , Michael Kelley , John Rosettie , Andrew Schermerhorn , Kashyap Shah , John Stone , Pushkar Tandon
发明人： Daniel Hawtof , Michael Kelley , John Rosettie , Andrew Schermerhorn , Kashyap Shah , John Stone , Pushkar Tandon
IPC分类号： C03B37/07 , C03B37/022 , C03C25/10
CPC分类号： C03B19/1423 , C03B19/1453 , C03B19/1476 , C03B2207/66 , C03C3/06 , C03C2201/23 , C03C2201/42
摘要： Disclosed are process and apparatus for making high purity fused silica glass materials. The process involves depositing soot particles onto an essentially planar deposition supporting surface and modulation of motion of the soot-generating device relative to the deposition supporting surface to result in a low local soot density variation. The apparatus is designed to implement the planar deposition process. The invention makes it possible to produce fused silica glass without the use of potentially contaminating refractory bricks.
摘要翻译：公开了制备高纯度熔融石英玻璃材料的方法和设备。该方法包括将烟灰颗粒沉积到基本平坦的沉积支撑表面上，并且调节烟灰产生装置相对于沉积支撑表面的运动以导致低的局部烟灰密度变化。该设备被设计成实现平面沉积过程。本发明使得可以生产熔融石英玻璃而不使用潜在的污染耐火砖。

22. 发明申请

US20060200988A1 Sandwich orifice disc 审中-公开
标题翻译：三明治孔盘
公开(公告)号：US20060200988A1
公开(公告)日：2006-09-14
申请号：US11373656
申请日：2006-03-10
申请人： Christoph Hamann , Michael Kelley
发明人： Christoph Hamann , Michael Kelley
IPC分类号： B23P15/16 , B05B1/26 , F02M61/00
CPC分类号： B23P15/16 , B05B1/14 , F02M61/166 , F02M61/1806 , F02M61/1826 , F02M61/186 , F02M2200/9015 , Y10T29/49432 , Y10T29/49433 , Y10T29/49982
摘要： An example fuel injector orifice plate assembly includes a plastic plate within which is an orifice for metering and directing fuel flow in a desired spray pattern, and a metal support plate for supporting and maintaining the stability of the desired spray pattern generated by the orifices within the plastic plate. The orifice plate includes orifices sized to provide a desired spray pattern of fuel. The metal support plate is more rigid than the orifice plate and provides the desired strength and rigidity for withstanding the cyclical pressure fluctuations caused by operation of the fuel injector.
摘要翻译：示例性燃料喷射器孔板组件包括塑料板，其中是用于计量并引导所需喷射图案中的燃料流的孔，以及金属支撑板，用于支撑和保持由孔内产生的所需喷雾图案的稳定性塑料板。孔板包括尺寸适于提供期望的喷射燃料图案的孔口。金属支撑板比孔板更刚性，并且提供期望的强度和刚度，以承受由燃料喷射器的操作引起的周期性压力波动。

23. 发明申请

US20060024795A1 Interferon-Like molecules and uses thereof 失效
标题翻译：干扰素样分子及其用途
公开(公告)号：US20060024795A1
公开(公告)日：2006-02-02
申请号：US11200389
申请日：2005-08-08
申请人： Andrew Welcher , Duanzhi Wen , Michael Kelley
发明人： Andrew Welcher , Duanzhi Wen , Michael Kelley
IPC分类号： C07H21/04 , C12P21/04 , C07K14/555
CPC分类号： G01N33/6866 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/555 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C12N2799/021
摘要： The present invention provides Interferon-Like (IFN-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing IFN-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with IFN-L polypeptides.
摘要翻译：本发明提供了干扰素样（IFN-L）多肽和编码该多肽的核酸分子。本发明还提供选择性结合剂，载体，宿主细胞和用于产生IFN-L多肽的方法。本发明进一步提供用于诊断，治疗，改善和/或预防与IFN-L多肽相关的疾病，病症和病症的药物组合物和方法。

24. 发明申请

US20060014696A1 Modulators of beta-amyloid peptide aggregation comprising D-amino acids 失效
标题翻译：包含D-氨基酸的β-淀粉样肽聚集体的调节剂
公开(公告)号：US20060014696A1
公开(公告)日：2006-01-19
申请号：US10677076
申请日：2003-09-30
申请人： Mark Findeis , Malcolm Gefter , Gary Musso , Ethan Signer , James Wakefield , Susan Molineaux , Joseph Chin , Jung-Ja Lee , Michael Kelley , Sonja Komar-Panicucci , Christopher Arico-Muendel , Kathryn Phillips , Neil Hayward
发明人： Mark Findeis , Malcolm Gefter , Gary Musso , Ethan Signer , James Wakefield , Susan Molineaux , Joseph Chin , Jung-Ja Lee , Michael Kelley , Sonja Komar-Panicucci , Christopher Arico-Muendel , Kathryn Phillips , Neil Hayward
IPC分类号： A61K38/08 , C07K7/06
CPC分类号： C07K5/101 , A61K38/00 , C07K5/1027 , C07K7/06 , C07K14/4711 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： Compounds that modulate natural β amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a β amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3-5 D-amino acid residues and includes at least two D-amino acid residues independently selected from the group consisting of D-leucine, D-phenylalanine and D-valine. In a particularly preferred embodiment, the peptide is a retro-inverso isomer of a β amyloid peptide, preferably a retro-inverso isomer of Aβ17-21. In certain embodiments, the peptide is modified at the amino-terminus, the carboxy-terminus, or both. Preferred amino-terminal modifying groups include cyclic, heterocyclic, polycyclic and branched alkyl groups. Preferred carboxy-terminal modifying groups include an amide group, an alkyl amide group, an aryl amide group or a hydroxy group. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amyloidogenic diseases using the compounds of the invention, are also disclosed.
摘要翻译：提供调节天然β淀粉样肽聚集的化合物。本发明的调节剂包含优选基于β-淀粉样肽的肽，其完全由D-氨基酸组成。优选地，肽包含3-5个D-氨基酸残基，并且包括独立地选自D-亮氨酸，D-苯丙氨酸和D-缬氨酸的至少两个D-氨基酸残基。在特别优选的实施方案中，肽是β淀粉样肽的逆反异构体，优选Abeta 17-21的逆反异构体。在某些实施方案中，肽在氨基末端，羧基末端或两者都被修饰。优选的氨基末端修饰基团包括环状，杂环，多环和支链烷基。优选的羧基末端修饰基团包括酰胺基，烷基酰胺基，芳基酰胺基或羟基。还公开了包含本发明化合物的药物组合物，以及使用本发明化合物的淀粉样变性疾病的诊断和治疗方法。

25. 发明申请

US20050188387A1 Combination display base and pre-recorded data storage medium 审中-公开
标题翻译：组合显示基座和预录数据存储介质
公开(公告)号：US20050188387A1
公开(公告)日：2005-08-25
申请号：US11063023
申请日：2005-02-22
申请人： Michael Kelley
发明人： Michael Kelley
IPC分类号： G11B33/02 , G11B33/04
CPC分类号： G11B33/0427
摘要： A display base includes a housing adapted for placement on a supporting surface for display. The housing defines a slot adapted for removably receiving a pre-recorded data storage disk. The data storage disk contains communications media documenting a person, place, thing, or event. A tray is slidably received through the slot formed with the housing, and is adapted for movement between a closed position substantially inside of the housing and an open position substantially outside of the housing. A raised hub insert is located on a surface of the disk tray, and is adapted for releasably holding the data storage disk upon movement of the disk tray between the closed and open positions.
摘要翻译：显示器基座包括适于放置在用于显示的支撑表面上的壳体。壳体限定适于可拆卸地接收预先记录的数据存储盘的槽。数据存储盘包含记录人物，地点，事物或事件的通信媒体。托盘通过形成有壳体的槽可滑动地接收，并且适于在基本上在壳体内部的关闭位置和基本上位于壳体外部的打开位置之间移动。凸起的轮毂插入件位于盘托盘的表面上，并且适于在盘托盘在关闭位置和打开位置之间移动时可释放地保持数据存储盘。

26. 发明申请

US20050170193A1 Process for modifying polymeric surfaces using deep UV irradiation 失效
标题翻译：使用深紫外线照射改性聚合物表面的方法
公开(公告)号：US20050170193A1
公开(公告)日：2005-08-04
申请号：US11047939
申请日：2005-02-01
申请人： Michael Kelley , Zhengmao Zhu
发明人： Michael Kelley , Zhengmao Zhu
IPC分类号： A01N25/34 , B05D3/00 , B32B27/16 , B32B27/36 , C08J7/18
CPC分类号： A01N25/34 , C08J7/18 , D06M10/001 , D06M10/08 , D06M14/32 , D06M16/00 , Y10T428/31536 , Y10T428/31786 , A01N59/16 , A01N33/12 , A01N25/10
摘要： A process is described for modifying polymeric surfaces. The process is particularly useful for modification of polyesters, and can be used to impart surface functionality that confers antimicrobial, anti-soiling, or other desirable properties to the polymer. The process comprises the steps of exposing a polymeric substrate to deep UV irradiation, followed by reaction with a grafting agent. In preferred embodiments, a vapor-phase grafting agent undergoes covalent reactions with the UV-modified polymer surface to produce a polymer with improved properties.
摘要翻译：描述了用于改性聚合物表面的方法。该方法对聚酯的改性特别有用，并且可用于赋予聚合物赋予抗微生物，抗污染或其它所需性质的表面官能团。该方法包括以下步骤：将聚合物基材暴露于深紫外线照射，随后与接枝剂反应。在优选的实施方案中，气相接枝剂与UV改性的聚合物表面发生共价反应以产生具有改进性能的聚合物。

27. 发明申请

US20050169121A1 Optical storage device 审中-公开
标题翻译：光存储设备
公开(公告)号：US20050169121A1
公开(公告)日：2005-08-04
申请号：US11068949
申请日：2005-02-28
申请人： Peter Keller , Michael Kelley , Rimas Buntinas , John Lahr
发明人： Peter Keller , Michael Kelley , Rimas Buntinas , John Lahr
IPC分类号： G11B17/22 , G11B20/10 , G11B27/00 , G11B27/034 , G11B27/34 , G11B27/36 , H04H20/82 , G11B7/085
CPC分类号： G11B27/36 , G11B17/22 , G11B20/10 , G11B27/002 , G11B27/034 , G11B27/34 , G11B2220/213 , G11B2220/216 , G11B2220/218 , G11B2220/2545 , G11B2220/2562 , G11B2220/90
摘要： Disclosed is a compact disc recording device that includes a housing, sound receiving means for receiving audio signals, a compact disc recorder for recording onto a compact disc, and data storage structure in the housing for storing audio signals. The compact disc recording device is configured such that a music library of sound tracks is storable in the data storage structure, and the compact disc recording device includes means for selecting a set of sound tracks from the music library to be recorded onto a compact disc by the compact disc recorder. The housing includes a display which identifies at least one sound track of the music library.
摘要翻译：公开了一种光盘记录装置，其包括壳体，用于接收音频信号的声音接收装置，用于记录到光盘上的光盘记录器以及用于存储音频信号的壳体中的数据存储结构。光盘记录装置被配置为使得音轨的音乐库可存储在数据存储结构中，并且光盘记录装置包括用于从音乐库中选择要记录到光盘上的一组声音轨迹的装置，该装置将通过光盘刻录机。壳体包括识别音乐库的至少一个音轨的显示器。

28. 发明申请

US20050002658A1 Apparatus and method for directing air flow to a target surface or substantially enclosed volume 审中-公开
公开(公告)号：US20050002658A1
公开(公告)日：2005-01-06
申请号：US10600252
申请日：2003-06-23
申请人： Virginia Kelley , Michael Kelley
发明人： Virginia Kelley , Michael Kelley
IPC分类号： B60H1/00 , F24H3/02
CPC分类号： B60H1/00564
摘要： An apparatus and method for directing airflow to a target surface or substantially enclosed volume is described. The apparatus comprises of one or more air channels with one or more directed air flow ducts to the surface. Each of the air ducts may feature numerous outlets that disperse unheated or hot air onto a target surface or within a substantially enclosed volume. The one or more air channels may be made of vinyl, rip-stop, or materials that are temerature-appropriate. The apparatus is held in place by it's effective air-weight or secured to prevent slippage during operation. Several such apparatuses may be incorporated into a vehicle to transfer air or gas to individual surfaces. The unit contains a substantially circular air duct and an electrical feed or other power source. The apparatus unit attaches to a hose vent or other external air flow apparatus and extends along the target surface or within the substantially enclosed volume. Air flow may be controlled from a switch or other control mechanism associated with the apparatus or the external air flow apparatus. When the control mechanism is actuated to activate the external air flow apparatus and the apparatus, air flow from the external air flow apparatus. Air pressure resulting from the flow of air substantially inflates the apparatus. The flow of air is discharged through apertures positioned along a surface of an air channel and diffuses the air flow along the target surface. In one embodiment, the air flow is comprised of heated air. Heating the target surface substantially removes condensed water, ice, frost, and the like from the target surface, and prevents further condensation from appearing on the target surface while the apparatus is activated. In addition, heating the air flow to a substantially enclosed volume assists in increasing the temperature of the substantially enclosed volume. In another embodiment, air that has been cooled or lowered in temperature, or air with no temperature adjustment may also be used.

29. 发明授权

US06303567B1 Modulators of &bgr;-amyloid peptide aggregation comprising D-amino acids 失效
公开(公告)号：US06303567B1
公开(公告)日：2001-10-16
申请号：US08703675
申请日：1996-08-27
申请人： Mark A. Findeis , Malcolm L. Gefter , Gary Musso , Ethan R. Signer , James Wakefield , Susan Molineaux , Joseph Chin , Jung-Ja Lee , Michael Kelley , Sonja Komar-Panicucci , Christopher C. Arico-Muendel , Kathryn Phillips , Neil J. Hayward
发明人： Mark A. Findeis , Malcolm L. Gefter , Gary Musso , Ethan R. Signer , James Wakefield , Susan Molineaux , Joseph Chin , Jung-Ja Lee , Michael Kelley , Sonja Komar-Panicucci , Christopher C. Arico-Muendel , Kathryn Phillips , Neil J. Hayward
IPC分类号： A61K3806
CPC分类号： C07K14/4711 , A61K38/00
摘要： Compounds that modulate natural &bgr; amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a &bgr; amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3-5 D-amino acid residues and includes at least two D-amino acid residues independently selected from the group consisting of D-leucine, D-phenylalanine and D-valine. In a particularly preferred embodiment, the peptide is a retro-inverso isomer of a &bgr; amyloid peptide, preferably a retro-inverso isomer of A&bgr;17-21. In certain embodiments, the peptide is modified at the amino-terminus, the carboxy-terminus, or both. Preferred amino-terminal modifying groups include cyclic, heterocyclic, polycyclic and branched alkyl groups. Preferred carboxy-terminal modifying groups include an amide group, an alkyl amide group, an aryl amide group or a hydroxy group. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amyloidogenic diseases using the compounds of the invention, are also disclosed.

30. 发明授权

US5345541A Method and apparatus for approximating a value between two endpoint values in a three-dimensional image rendering device 失效
标题翻译：用于近似三维图像渲染装置中的两个端点值之间的值的方法和装置
公开(公告)号：US5345541A
公开(公告)日：1994-09-06
申请号：US811829
申请日：1991-12-20
申请人： Michael Kelley , Stephanie Winner , Lee Mighdoll
发明人： Michael Kelley , Stephanie Winner , Lee Mighdoll
IPC分类号： G06F17/17 , G06T15/83 , G06T15/87 , G06F15/72 , G06F15/353
CPC分类号： G06T15/87 , G06F17/175 , G06T15/83
摘要： A method and apparatus for approximating a value distributed between two endpoints. The method and apparatus are embodied in a rendering device for calculating pixel shading values for the display of 3-D graphical images. The method approximates a function P(w)=(1-w)A+wB, where w is a provided interpolation weight between 0 and 1, A is a first endpoint value and B is a second endpoint value. The method causes exact evaluation for the cases where P(0)=A and P(1)=B. The method is comprised generally of the steps of: providing an interpolation weight value W comprised of N bit values; assigning a first predetermined pattern of N bits (J) to cause said first extreme parameter value A to be generated and a second predetermined pattern of N bits (K) to cause the second extreme parameter value B to be generated; assigning a third predetermined pattern of N bits (L) as a saturation multiplier, performing a linear interpolation to derive a parameter value for a pixel P, using a function ((J-W)A+WB); and adding a saturation value according to the criteria that if W is less than a saturation threshold, adding the quantity (L.times.A) to the result; or if W is greater than or equal to the saturation threshold, adding the quantity (L.times.B) to the result. The apparatus is comprised of a plurality of multiplexors, carry-save adders and a carry-propagate adder.
摘要翻译：一种用于近似分布在两个端点之间的值的方法和装置。该方法和装置体现在用于计算用于显示3-D图形图像的像素着色值的再现装置中。该方法近似函数P（w）=（1-w）A + wB，其中w是0和1之间的提供的插值权重，A是第一端点值，B是第二端点值。该方法对P（0）= A和P（1）= B的情况进行精确评估。该方法通常包括以下步骤：提供由N个比特值组成的内插加权值W; 分配N位（J）的第一预定模式以产生所述第一极限参数值A和N位（K）的第二预定模式，以产生第二极限参数值B; 分配N位（L）的第三预定模式作为饱和乘数，使用函数（（J-W）A + WB）执行线性插值以导出像素P的参数值。并根据如果W小于饱和阈值的标准增加饱和值，则将数量（LxA）加到结果上; 或者如果W大于或等于饱和阈值，则将数量（LxB）加到结果上。该装置由多个多路复用器，进位存储加法器和进位传播加法器组成。

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