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21. 发明授权

US06629947B1 Systems and methods for delivering flowable substances for use as implants and surgical sealants 失效
标题翻译：用于输送可用作植入物和手术密封剂的可流动物质的系统和方法
公开(公告)号：US06629947B1
公开(公告)日：2003-10-07
申请号：US09330175
申请日：1999-06-11
申请人： Ronald A. Sahatjian , Robert Boock
发明人： Ronald A. Sahatjian , Robert Boock
IPC分类号： A61F1320
CPC分类号： A61B17/12131 , A61B17/12022 , A61B17/12036 , A61B17/12186 , A61B2017/00495
摘要： A system for delivering a flowable substance capable of changing from liquid to solid for use as implants and surgical sealants includes a first reservoir containing a first flowable substance including a bulking agent, a second reservoir containing a second flowable substance including a reacting agent, and a cannula. A method of delivering flowable substance that changes from liquid to solid for use as implants and surgical sealants includes introducing a cannula having first and second lumens into the body, passing a flowable substance including a bulking agent through the first lumen, passing a second flowable substance including a reacting agent through the second lumen, mixing the first and second flowable substances in the cannula so that the bulking agent reacts with the reacting agent to form a flexible elongated fiber in the cannula, and moving the fiber through the opening in the cannula and into the body to form at least one of an implant and surgical seal.
摘要翻译：用于输送能够从液体变为固体以用作植入物和手术密封剂的可流动物质的系统包括：第一储存器，其包含含有填充剂的第一可流动物质;第二储存器，含有包含反应剂的第二可流动物质;以及套管。一种输送从液体变为固态的可流动物质的方法，用作植入物和手术密封剂包括将具有第一和第二内腔的套管引入体内，使包含填充剂的可流动物质通过第一腔，通过第二可流动物质包括通过所述第二腔的反应剂，将所述第一和第二可流动物质混合在所述套管中，使得所述填充剂与所述反应剂反应以在所述套管中形成柔性细长纤维，并且通过所述插管中的所述开口移动所述纤维，进入体内以形成植入物和手术密封件中的至少一个。

22. 发明授权

US06413203B1 Method and apparatus for positioning radioactive fluids within a body lumen 失效
标题翻译：将放射性流体定位在体腔内的方法和装置
公开(公告)号：US06413203B1
公开(公告)日：2002-07-02
申请号：US09154267
申请日：1998-09-16
申请人： Ronald A. Sahatjian
发明人： Ronald A. Sahatjian
IPC分类号： A61N500
CPC分类号： A61M25/104 , A61M2025/0004 , A61M2025/004 , A61M2025/105 , A61M2025/1072 , A61N5/1002 , A61N2005/1003 , A61N2005/1021
摘要： A device and method for providing radiation to selected radial portions of a segment of the interior wall of a body lumen. In a preferred embodiment, an intravascular catheter is positioned within a desired blood vessel adjacent to a lesion. A radioactive fluid is then injected into the catheter, and the catheter directs the radioactive fluid about the central axis of the vessel in the area of the lesion. This allows selected radial portions of a vessel to have a higher radiation exposure than other portions, which is particularly useful when a lesion does not uniformly extend around the entire circumference of a vessel.
摘要翻译：一种用于向体腔的内壁的段的选定径向部分提供辐射的装置和方法。在优选实施例中，血管内导管位于与病变相邻的期望血管内。然后将放射性流体注射到导管中，并且导管将放射性流体围绕血管的中心轴引导到损伤区域。这允许血管的选定的径向部分具有比其他部分更高的辐射照射，当损伤在血管的整个圆周上不均匀地延伸时特别有用。

23. 发明授权

US06409716B1 Drug delivery 失效
标题翻译：药物递送
公开(公告)号：US06409716B1
公开(公告)日：2002-06-25
申请号：US08946207
申请日：1997-10-07
申请人： Ronald A. Sahatjian , James J. Barry
发明人： Ronald A. Sahatjian , James J. Barry
IPC分类号： A61M3100
CPC分类号： A61M25/104 , A61F2/90 , A61F2230/0013 , A61F2250/0067 , A61K9/0024 , A61K38/49 , A61K48/00 , A61L29/085 , A61L29/145 , A61L29/16 , A61L31/10 , A61L31/145 , A61L31/16 , A61L33/0023 , A61L33/0029 , A61L2300/256 , A61L2300/258 , A61L2300/416 , A61L2300/42 , A61L2300/45 , A61L2300/602 , A61L2300/606 , A61L2300/622 , A61M16/0481 , A61M25/0045 , A61M2025/0046 , A61M2025/0057 , A61M2025/09183 , A61M2025/105 , A61M2025/1086 , A61M2205/0266 , C08L33/02 , C08L35/00
摘要： The invention features a catheter and methods for delivering drug to tissue at a desired location of the wall of a body lumen. The catheter is constructed for insertion in a body lumen and has a catheter shaft and an expandable portion mounted on the catheter shaft. The expandable portion is expandable to a controlled pressure to fill the cross-section of the body lumen and press against the wall of the body lumen. In one embodiment, at least a portion of the exterior surface of the expandable portion is defined by a coating of a tenaciously adhered swellable hydrogel polymer. Incorporated in the hydrogel polymer is an aqueous solution of a preselected drug to be delivered to the tissue or plaque. The hydrogel polymer and drug are selected to allow rapid release of a desired dosage of the drug from the hydrogel polymer coating during compression of the hydrogel polymer coating against the wall of the lumen when the expandable portion is expanded. In other embodiments the polymer is released from the expandable portion in response to pressure, to coat the wall of the body lumen.
摘要翻译：本发明的特征在于导管和用于将药物递送到体腔壁的所需位置处的组织的方法。导管被构造成用于插入体腔，并且具有导管轴和安装在导管轴上的可扩张部分。可膨胀部分可膨胀至受控的压力以填充体腔的横截面并压靠身体腔的壁。在一个实施例中，可膨胀部分的外表面的至少一部分由强力粘附的可溶胀水凝胶聚合物的涂层限定。掺入水凝胶聚合物中的是待递送至组织或斑块的预选药物的水溶液。选择水凝胶聚合物和药物，以便当可膨胀部分膨胀时，水凝胶聚合物涂层在水凝胶聚合物涂层压靠内腔壁时，从水凝胶聚合物涂层快速释放所需剂量的药物。在其它实施方案中，聚合物响应于压力从可膨胀部分释放，以涂覆体腔的壁。

24. 发明授权

US5693014A Balloon catheter 失效
标题翻译：气球导管
公开(公告)号：US5693014A
公开(公告)日：1997-12-02
申请号：US441603
申请日：1995-05-15
申请人： John E. Abele , Ronald A. Sahatjian
发明人： John E. Abele , Ronald A. Sahatjian
IPC分类号： A61F2/958 , A61M25/00 , A61M29/02 , A61M29/00
CPC分类号： A61M25/104 , A61M25/1002 , A61M25/1038 , A61M2025/0047 , A61M2025/1031 , A61M2025/1086 , A61M25/0043 , A61M25/1029
摘要： An expansible balloon catheter has at least a first exterior surface with a given coefficient of friction and a second exterior surface with a greater coefficient of friction. In a compact form only the first exterior surface is exposed to produce a low coefficient of friction during transfer of the collapsed or uninflated balloon to and across a lesion. When inflated, the second surface dominates the first surface and produces an increased coefficient of friction overall thereby to stabilize the balloon in the lesion.
摘要翻译：可膨胀球囊导管至少具有给定摩擦系数的第一外表面和具有更大摩擦系数的第二外表面。在紧凑形式中，仅将第一外表面暴露以在将塌缩或未膨胀的气囊转移到病变处和穿过病变处产生低摩擦系数。当膨胀时，第二表面支配第一表面并产生增加的摩擦系数，从而使气囊在病变中稳定。

25. 发明申请

US20140067039A9 IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：可植入医疗器械
公开(公告)号：US20140067039A9
公开(公告)日：2014-03-06
申请号：US13493532
申请日：2012-06-11
申请人： Ronald A. Sahatjian , Francisca Tan , Patrick T. Mather , ChangDeng Liu , Cheryl J. Campo
发明人： Ronald A. Sahatjian , Francisca Tan , Patrick T. Mather , ChangDeng Liu , Cheryl J. Campo
IPC分类号： A61F2/82
CPC分类号： C08G61/08 , A61F2/88 , A61F2/91 , A61F2/915 , A61F2002/8483 , A61F2002/91541 , A61F2002/9528 , A61F2220/0016 , A61F2250/0039 , A61F2250/0068 , A61L29/14 , A61L31/14 , A61M25/1027 , C08G18/3893 , C08G18/4277 , C08G18/4833 , C08G2230/00 , C08L65/00
摘要： A medical device includes a balloon catheter having an expandable member, e.g., an inflatable balloon, at its distal end and a stent or other endoprosthesis. The stent is, for example, an apertured tubular member formed of a polymer and is assembled about the balloon. The stent has an initial diameter for delivery into the body and can be expanded to a larger diameter by inflating the balloon.
摘要翻译：医疗装置包括球囊导管，其具有在其远端处具有可膨胀构件，例如可膨胀气囊，以及支架或其他内置假体。支架是例如由聚合物形成的多孔管状构件，并围绕气囊组装。支架具有用于输送到身体中的初始直径，并且可以通过使气囊膨胀而扩展到更大的直径。

26. 发明授权

US07371257B2 Stent lining 失效
标题翻译：支架内衬
公开(公告)号：US07371257B2
公开(公告)日：2008-05-13
申请号：US10997088
申请日：2004-11-23
申请人： Ronald A. Sahatjian , James J. Barry , Maria Palasis
发明人： Ronald A. Sahatjian , James J. Barry , Maria Palasis
IPC分类号： A61F2/06
CPC分类号： A61F2/90 , A61F2/0077 , A61F2/958 , A61F2230/0013 , A61F2250/0067 , A61K9/0024 , A61K38/49 , A61K48/00 , A61L29/085 , A61L29/145 , A61L29/16 , A61L31/10 , A61L31/145 , A61L31/16 , A61L33/0011 , A61L33/0023 , A61L33/0029 , A61L33/0047 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61M25/0045 , A61M25/104 , A61M2025/0046 , A61M2025/0057 , A61M2025/09183 , A61M2025/1013 , A61M2025/105 , A61M2025/1086 , A61M2025/1093 , A61M2205/0266 , C08L33/02 , C08L35/00
摘要： The invention features a catheter assembly and methods for delivering a hydrogel-lined stent to a body lumen, and methods for lining a stent with a hydrogel. The assembly includes a catheter which has a balloon at least a portion of which is coated with a hydrogel and an expansible stent mounted on the balloon in a contracted condition for passage with the catheter to a site of a body. Expansion of the balloon lodges the stent in the body with hydrogel coated on the inner surfaces of the stent as a lining.
摘要翻译：本发明的特征在于导管组件和用于将水凝胶衬里的支架输送到体腔的方法以及用水凝胶衬里支架的方法。该组件包括导管，其具有气囊，其至少一部分涂覆有水凝胶，并且在收缩条件下安装在气囊上的可膨胀支架，用于将导管通过至身体部位。气囊的扩张将支架置于体内，水凝胶涂覆在支架的内表面作为衬里。

27. 发明授权

US07291110B2 Catheter lesion diagnostics 有权
标题翻译：导管病变诊断
公开(公告)号：US07291110B2
公开(公告)日：2007-11-06
申请号：US10269160
申请日：2002-10-11
申请人： Ronald A. Sahatjian
发明人： Ronald A. Sahatjian
IPC分类号： A61B8/00 , A61B8/12
CPC分类号： A61B5/6885 , A61B5/02007 , A61B8/08 , A61B8/12 , A61B8/4483 , A61B2017/22001 , A61B2017/22061 , A61B2090/3784 , A61M25/104 , A61M2025/1075 , A61M2025/1086
摘要： Catheter lesion diagnostics are disclosed.
摘要翻译：公开了导管病变诊断。

28. 发明授权

US06896842B1 Medical device balloons containing thermoplastic elastomers 有权
标题翻译：包含热塑性弹性体的医疗装置气球
公开(公告)号：US06896842B1
公开(公告)日：2005-05-24
申请号：US09557258
申请日：2000-04-24
申请人： Bruce Hamilton , Ronald A. Sahatjian
发明人： Bruce Hamilton , Ronald A. Sahatjian
IPC分类号： A61F2/958 , A61L29/04 , A61M25/00 , B29D23/00
CPC分类号： A61M25/1029 , A61L29/049 , A61M25/0045 , A61M25/1002 , A61M2025/1075 , Y10T428/1334 , Y10T428/1352 , Y10T428/139 , Y10T428/1393
摘要： A dilatation balloon and catheter for insertion into a bodily conduit. The catheter (10) includes shaft (12) and a dilatation balloon (24) at the distal end of the shaft. The balloon is inflated via a central lumen (14) in the shaft for delivery of a fluid inflation media. The balloon is fabricated from a combination of a thermoplastic elastomer (TPE), preferably an engineering thermoplastic elastomer (ETE), with a non-compliant structural polymeric material. The combination may be a blend of the non-compliant structural polymer and the TPE. Alternatively, the combination may be a layered balloon having, for example, a non-compliant structural polymer inner layer and a soft, abrasion resistant, elastomeric outer layer. Methods for fabricating the balloon from the combination of a TPE and a non-compliant structural polymer are also disclosed.
摘要翻译：用于插入身体导管的扩张球囊和导管。导管（10）在轴的远端包括轴（12）和膨胀气球（24）。气球通过轴中的中心腔（14）膨胀，用于输送流体充气介质。气球由热塑性弹性体（TPE），优选工程热塑性弹性体（ETE）与非柔顺结构聚合材料的组合制成。该组合可以是不顺应结构聚合物和TPE的混合物。或者，组合可以是具有例如不顺应结构聚合物内层和柔软，耐磨损的弹性体外层的分层气囊。还公开了从TPE和不顺应结构聚合物的组合制造球囊的方法。

29. 发明授权

US5954706A Drug delivery 失效
公开(公告)号：US5954706A
公开(公告)日：1999-09-21
申请号：US473136
申请日：1995-06-07
申请人： Ronald A. Sahatjian
发明人： Ronald A. Sahatjian
IPC分类号： A61M25/00 , A61B17/03 , A61F2/00 , A61F2/90 , A61K9/00 , A61K38/49 , A61K48/00 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/00 , A61M16/04 , A61M29/02 , A61M31/00
CPC分类号： A61M25/104 , A61F2/90 , A61K38/49 , A61K48/00 , A61K9/0024 , A61L29/085 , A61L29/145 , A61L29/16 , A61L31/10 , A61L31/145 , A61L31/16 , A61L33/0023 , A61L33/0029 , A61M16/0481 , A61M25/0045 , A61F2230/0013 , A61F2250/0067 , A61L2300/256 , A61L2300/258 , A61L2300/416 , A61L2300/42 , A61L2300/45 , A61L2300/602 , A61L2300/606 , A61L2300/622 , A61M2025/0046 , A61M2025/0057 , A61M2025/09183 , A61M2025/105 , A61M2025/1086 , A61M2205/0266
摘要： The invention features a catheter and methods for delivering drug to tissue at a desired location of the wall of a body lumen. The catheter is constructed for insertion in a body lumen and has a catheter shaft and an expandable portion mounted on the catheter shaft. The expandable portion is expandable to a controlled pressure to fill the cross-section of the body lumen and press against the wall of the body lumen. In one embodiment, at least a portion of the exterior surface of the expandable portion is defined by a coating of a tenaciously adhered swellable hydrogel polymer. Incorporated in the hydrogel polymer is an aqueous solution of a preselected drug to be delivered to the tissue or plaque. The hydrogel polymer and drug are selected to allow rapid release of a desired dosage of the drug from the hydrogel polymer coating during compression of the hydrogel polymer coating against the wall of the lumen when the expandable portion is expanded. In other embodiments the polymer is released from the expandable portion in response to pressure, to coat the wall of the body lumen.

30. 发明授权

US5928247A Stent placement device with medication dispenser and method 失效
标题翻译：支架放置装置与药物分配器和方法
公开(公告)号：US5928247A
公开(公告)日：1999-07-27
申请号：US999175
申请日：1997-12-29
申请人： James J. Barry , Peter M. Nicholas , Ronald A. Sahatjian
发明人： James J. Barry , Peter M. Nicholas , Ronald A. Sahatjian
IPC分类号： A61F2/82 , A61F2/00 , A61F2/06 , A61F2/84 , A61M25/00 , A61M25/10 , A61F11/00
CPC分类号： A61F2/958 , A61M25/0023 , A61M25/1018 , A61M25/1029 , A61F2250/0067 , A61M2025/0036 , A61M2025/004 , A61M2025/105 , A61M2025/1086 , A61M25/10 , A61M25/1027
摘要： An inflatable medical device and method for the placement of a stent in a body passageway by means of a two stage expansion of the stent and for the delivery of medications to precise location in the passageway. The device includes a catheter shaft (14) having a plurality of lumens (13, 22, 28) disposed therein. The catheter shaft has a distal end adapted to be disposed within a vascular passageway. An inflatable balloon is defined by a generally cylindrical wall and is adapted to receive inflation fluids. The balloon is disposed on the distal end of the shaft. An array of circumferentially arranged inflation conduits (40) is disposed in the wall. The conduits (40) are spaced from each other within the wall of the balloon whereby to form a annular array. An array of medication delivering conduits (25) can be disposed within the wall of the balloon. These conduits are adapted to deliver medications to predetermined locations within the body passageway being treated. A stent (30) is removably disposed around the exterior of the wall of the balloon and is expandable radially outwardly from a narrow insertion diameter to a larger second diameter by the expansion of the balloon (16) and then to a still larger third diameter by inflation of the inflation conduits (40) whereby to expand the body passageway and seat the stent.
摘要翻译：一种可膨胀的医疗装置和方法，用于通过支架的两级膨胀以及将药物输送到通道中的精确位置来将支架放置在身体通道中。该装置包括具有设置在其中的多个管腔（13,22,28）的导管轴（14）。导管轴具有适于设置在血管通路内的远端。可充气气囊由大致圆柱形的壁限定，适于接收充气流体。气球设置在轴的远端。周向布置的充气管道（40）的阵列设置在壁中。导管（40）在球囊的壁内彼此间隔开，从而形成环形阵列。一组药物输送管道（25）可以设置在气囊的壁内。这些导管适于将药物递送至正在治疗的身体通路内的预定位置。支架（30）可移除地设置在球囊的壁的外部周围，并且通过球囊（16）的膨胀而从狭窄的插入直径径向向外扩张到更大的第二直径，然后通过膨胀管道（40）的膨胀，从而扩张身体通道并对支架进行安置。

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