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1. 发明授权

US06629947B1 Systems and methods for delivering flowable substances for use as implants and surgical sealants 失效
标题翻译：用于输送可用作植入物和手术密封剂的可流动物质的系统和方法
公开(公告)号：US06629947B1
公开(公告)日：2003-10-07
申请号：US09330175
申请日：1999-06-11
申请人： Ronald A. Sahatjian , Robert Boock
发明人： Ronald A. Sahatjian , Robert Boock
IPC分类号： A61F1320
CPC分类号： A61B17/12131 , A61B17/12022 , A61B17/12036 , A61B17/12186 , A61B2017/00495
摘要： A system for delivering a flowable substance capable of changing from liquid to solid for use as implants and surgical sealants includes a first reservoir containing a first flowable substance including a bulking agent, a second reservoir containing a second flowable substance including a reacting agent, and a cannula. A method of delivering flowable substance that changes from liquid to solid for use as implants and surgical sealants includes introducing a cannula having first and second lumens into the body, passing a flowable substance including a bulking agent through the first lumen, passing a second flowable substance including a reacting agent through the second lumen, mixing the first and second flowable substances in the cannula so that the bulking agent reacts with the reacting agent to form a flexible elongated fiber in the cannula, and moving the fiber through the opening in the cannula and into the body to form at least one of an implant and surgical seal.
摘要翻译：用于输送能够从液体变为固体以用作植入物和手术密封剂的可流动物质的系统包括：第一储存器，其包含含有填充剂的第一可流动物质;第二储存器，含有包含反应剂的第二可流动物质;以及套管。一种输送从液体变为固态的可流动物质的方法，用作植入物和手术密封剂包括将具有第一和第二内腔的套管引入体内，使包含填充剂的可流动物质通过第一腔，通过第二可流动物质包括通过所述第二腔的反应剂，将所述第一和第二可流动物质混合在所述套管中，使得所述填充剂与所述反应剂反应以在所述套管中形成柔性细长纤维，并且通过所述插管中的所述开口移动所述纤维，进入体内以形成植入物和手术密封件中的至少一个。

2. 发明授权

US08267981B2 Suture anchor with improved drive head 有权
标题翻译：具有改进的驱动头的缝合锚
公开(公告)号：US08267981B2
公开(公告)日：2012-09-18
申请号：US10458482
申请日：2003-06-10
申请人： Robert Boock , Nathan Cauldwell
发明人： Robert Boock , Nathan Cauldwell
IPC分类号： A61B17/04 , A61B17/86 , A61F2/08
CPC分类号： A61B17/0401 , A61B2017/0409 , A61B2017/0414 , A61B2017/044
摘要： A suture anchor is provided including an elongate shank defining a longitudinal axis and having at least one bone-engaging thread formed thereon, and a drive head having a proximal end and a distal end mated to the elongate shank. The drive head has a substantially oval shape and includes at least one suture attachment member formed in a portion of the drive head. The configuration of the drive head is particularly advantages in that it provides a suture anchor having improved physical properties, including a high failure torque and a high stripping strength.
摘要翻译：提供了缝合锚，其包括限定纵向轴线的细长柄，并且具有形成在其上的至少一个骨接合螺纹，以及具有与所述细长柄配合的近端和远端的驱动头。驱动头具有大致椭圆形并且包括形成在驱动头的一部分中的至少一个缝合线附接构件。驱动头的构造是特别的优点，因为它提供了具有改进的物理性能的缝合锚，其包括高故障扭矩和高剥离强度。

3. 发明申请

US20120035445A1 SILICONE BASED MEMBRANES FOR USE IN IMPLANTABLE GLUCOSE SENSORS 有权
标题翻译：用于可植入葡萄糖传感器的硅胶基膜
公开(公告)号：US20120035445A1
公开(公告)日：2012-02-09
申请号：US13277997
申请日：2011-10-20
申请人： Robert Boock , Monica Rixman
发明人： Robert Boock , Monica Rixman
IPC分类号： A61B5/05
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/6848 , B33Y70/00 , C08G77/12 , C08G77/20 , C08G77/46 , C08L83/04 , C08L2666/14
摘要： Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.
摘要翻译：介绍了结合有机硅聚合物的膜系统用于可植入分析物传感器。膜系统的一些层可以包括硅氧烷聚合物与亲水性聚合物，例如三嵌段聚（环氧乙烷） - 聚（环氧丙烷） - 聚（环氧乙烷）聚合物的共混物。这种聚合物共混物提供高氧溶解度和水分析物溶解度。

4. 发明授权

US08064977B2 Silicone based membranes for use in implantable glucose sensors 有权
标题翻译：用于植入式葡萄糖传感器的硅基膜
公开(公告)号：US08064977B2
公开(公告)日：2011-11-22
申请号：US12511982
申请日：2009-07-29
申请人： Robert Boock , Monica Rixman
发明人： Robert Boock , Monica Rixman
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/6848 , B33Y70/00 , C08G77/12 , C08G77/20 , C08G77/46 , C08L83/04 , C08L2666/14
摘要： Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.
摘要翻译：介绍了结合有机硅聚合物的膜系统用于可植入分析物传感器。膜系统的一些层可以包括硅氧烷聚合物与亲水性聚合物，例如三嵌段聚（环氧乙烷） - 聚（环氧丙烷） - 聚（环氧乙烷）聚合物的共混物。这种聚合物共混物提供高氧溶解度和水分析物溶解度。

5. 发明申请

US20110027453A1 CONTINUOUS ANALYTE SENSORS AND METHODS OF MAKING SAME 审中-公开
公开(公告)号：US20110027453A1
公开(公告)日：2011-02-03
申请号：US12829339
申请日：2010-07-01
申请人： Robert Boock , Jeff Jackson , Huashi Zhang , Jason Mitchell
发明人： Robert Boock , Jeff Jackson , Huashi Zhang , Jason Mitchell
IPC分类号： B05D3/00 , B05D1/00 , B05D5/12
摘要： Described here are embodiments of processes and systems for the continuous manufacturing of implantable continuous analyte sensors. In some embodiments, a method is provided for sequentially advancing an elongated conductive body through a plurality of stations, each configured to treat the elongated conductive body. In some of these embodiments, one or more of the stations is configured to coat the elongated conductive body using a meniscus coating process, whereby a solution formed of a polymer and a solvent is prepared, the solution is continuously circulated to provide a meniscus on a top portion of a vessel holding the solution, and the elongated conductive body is advanced through the meniscus. The method may also comprise the step of removing excess coating material from the elongated conductive body by advancing the elongated conductive body through a die orifice. For example, a provided elongated conductive body 510 is advanced through a pre-coating treatment station 520, through a coating station 530, through a thickness control station 540, through a drying or curing station 550, through a thickness measurement station 560, and through a post-coating treatment station 570.

6. 发明申请

US20100274107A1 POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS 有权
公开(公告)号：US20100274107A1
公开(公告)日：2010-10-28
申请号：US12718332
申请日：2010-03-05
申请人： Robert Boock , Monica A. Rixman , Huashi Zhang , Michael J. Estes , Kristina Lawrence
发明人： Robert Boock , Monica A. Rixman , Huashi Zhang , Michael J. Estes , Kristina Lawrence
IPC分类号： A61B5/145
CPC分类号： A61B5/14865 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/72 , A61B5/7475 , B33Y70/00 , C12Q1/006 , G01N27/40
摘要： Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

7. 发明申请

US20100179409A1 SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM 有权
标题翻译：用于在葡萄糖传感器数据流中替换信号文件的系统和方法
公开(公告)号：US20100179409A1
公开(公告)日：2010-07-15
申请号：US12732097
申请日：2010-03-25
申请人： Apurv Ullas Kamath , Aarthi Mahalingam , Ying Li , Mohammad Ali Shariati , James H. Brauker , Mark Brister , Robert Boock
发明人： Apurv Ullas Kamath , Aarthi Mahalingam , Ying Li , Mohammad Ali Shariati , James H. Brauker , Mark Brister , Robert Boock
IPC分类号： A61B5/145 , G06F19/00 , G01N33/48
CPC分类号： A61B5/14865 , A61B5/01 , A61B5/145 , A61B5/14532 , A61B5/14539 , A61B5/1495 , A61B5/6848 , A61B5/7203 , A61B5/725 , A61B5/7257 , A61B5/726 , A61B5/743 , A61B5/7475
摘要： Systems and methods for detecting noise episodes and processing analyte sensor data responsive thereto. In some embodiments, processing analyte sensor data includes filtering the sensor data to reduce or eliminate the effects of the noise episode on the signal.
摘要翻译：用于检测噪声发生并响应于此处理分析物传感器数据的系统和方法。在一些实施例中，处理分析物传感器数据包括过滤传感器数据以减少或消除噪声发作对信号的影响。

8. 发明申请

US20090299156A1 CONTINUOUS MEDICAMENT SENSOR SYSTEM FOR IN VIVO USE 审中-公开
标题翻译：连续使用医疗传感器系统
公开(公告)号：US20090299156A1
公开(公告)日：2009-12-03
申请号：US12365683
申请日：2009-02-04
申请人： Peter C. Simpson , Richard C. Yang , Bradley Shigeto Matsubara , Robert Boock , Eleanor McCarthy , Mark Brister
发明人： Peter C. Simpson , Richard C. Yang , Bradley Shigeto Matsubara , Robert Boock , Eleanor McCarthy , Mark Brister
IPC分类号： A61B5/145 , A61B5/00
CPC分类号： A61B5/14546 , A61B5/0002 , A61B5/064 , A61B5/14532 , A61B5/4094 , A61B5/411 , A61B5/4839 , A61B5/4848 , A61M5/1723 , A61M2005/14296 , A61M2230/201
摘要： Systems and methods for continuous measurement of a medicament in vivo are provided. In some embodiments, the system is configured to provide information associated with medicament titration and includes a continuous analyte sensor and a communication device. In some embodiments, the system is configured for continuous ambulatory drug testing, including an ambulatory host monitor having a continuous sensor, a location module, a processor module and a transmitter. In some embodiments, the system is configured for continuously monitoring a hormone level and includes a continuous hormone sensor and a communication device configured to output hormone information in real time. Yet another embodiment provides an analyte sensor for continuous monitoring of a host's nutritional status, and is configured for both continuous glucose detection and continuous albumin detection.
摘要翻译：提供了用于体内连续测量药物的系统和方法。在一些实施例中，系统被配置为提供与药物滴定相关联的信息，并且包括连续的分析物传感器和通信设备。在一些实施例中，该系统被配置用于连续的动态药物测试，包括具有连续传感器，定位模块，处理器模块和发射器的步行主机监视器。在一些实施例中，系统被配置为连续监测激素水平，并且包括连续激素传感器和被配置为实时输出激素信息的通信装置。另一个实施方案提供了用于连续监测宿主营养状态的分析物传感器，并且被配置用于连续葡萄糖检测和连续白蛋白检测。

9. 发明申请

US20070235331A1 ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE 有权
标题翻译：具有由不间断噪声主要影响的信号噪声分析的分析仪传感器
公开(公告)号：US20070235331A1
公开(公告)日：2007-10-11
申请号：US11750907
申请日：2007-05-18
申请人： Peter Simpson , Robert Boock , James Petisce , Mark Brister , Monica Rixman , Kum Ming Woo , Lisa Nguyen , Seth Brunner , Arthur Chee , Melissa Nicholas , Matthew Wightlin , Jack Pryor , Dubravka Markovic
发明人： Peter Simpson , Robert Boock , James Petisce , Mark Brister , Monica Rixman , Kum Ming Woo , Lisa Nguyen , Seth Brunner , Arthur Chee , Melissa Nicholas , Matthew Wightlin , Jack Pryor , Dubravka Markovic
IPC分类号： G01N27/26
CPC分类号： A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14735 , A61B5/1486 , A61B5/14865 , A61B5/6848 , A61B5/7203
摘要： Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.
摘要翻译：提供涉及具有基本上不受非恒定噪声影响的信噪比的传感器的系统和方法用于主机中的连续分析物测量。在一些实施例中，连续分析物测量系统被配置为完全，经皮，血管内或体外植入。

10. 发明申请

US20070213611A1 DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR 有权
标题翻译：用于连续分析仪传感器的双电极系统
公开(公告)号：US20070213611A1
公开(公告)日：2007-09-13
申请号：US11692154
申请日：2007-03-27
申请人： Peter Simpson , James Brauker , Paul Goode , Apurv Kamath , James Petisce , Kum Woo , Melissa Nicholas , Robert Boock , Monica Rixman , John Burd , Rathbun Rhodes , Mark Tapsak
发明人： Peter Simpson , James Brauker , Paul Goode , Apurv Kamath , James Petisce , Kum Woo , Melissa Nicholas , Robert Boock , Monica Rixman , John Burd , Rathbun Rhodes , Mark Tapsak
IPC分类号： A61B5/15 , A61B5/145
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/14865 , B33Y70/00
摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain.
摘要翻译：本文公开了用于连续分析物传感器（例如连续葡萄糖传感器）的系统和方法。一个这样的系统利用第一和第二工作电极来测量分析物或非分析物相关的信号，这两个电极都包括干涉域。

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