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21. 发明授权

US06933720B2 Sequence preconditioning for ultra-fast magnetic resonance imaging 有权
标题翻译：超快速磁共振成像的序列预处理
公开(公告)号：US06933720B2
公开(公告)日：2005-08-23
申请号：US10012036
申请日：2001-12-11
申请人： Weiguo Zhang
发明人： Weiguo Zhang
IPC分类号： G01R33/561 , G01R33/565 , G01V3/00 , A61B5/055
CPC分类号： G01R33/56554
摘要： An improved magnetic resonance imaging (MRI) methodology uses an abbreviated initial MRI sequence to generate sequence diagnostic parameters. The sequence diagnostic parameters have a fixed relationship to certain sequence-conditioning parameters, and are used for calculating characteristic values of the sequence-conditioning parameters. The read out gradient pulse sequence is modified in accordance with the calculated characteristic values of the sequence-conditioning parameters. The modified read out gradient pulse sequence is then incorporated into a subsequent MRI pulse sequence used for obtaining a diagnostic image. The methodology has particular application in so called ultra fast MRI process which include echo-planar imaging (EPI) and echo-volume imaging (EVI).
摘要翻译：改进的磁共振成像（MRI）方法使用缩写的初始MRI序列来产生序列诊断参数。序列诊断参数与某些序列调节参数具有固定关系，用于计算序列调节参数的特征值。读出的梯度脉冲序列根据计算的序列调节参数的特征值进行修改。然后将经修改的读出梯度脉冲序列并入用于获得诊断图像的后续MRI脉冲序列。该方法在所谓的超快MRI过程中具有特殊应用，包括回波平面成像（EPI）和回波体积成像（EVI）。

22. 发明授权

US06913651B2 Apparatus and method for electroless deposition of materials on semiconductor substrates 有权
公开(公告)号：US06913651B2
公开(公告)日：2005-07-05
申请号：US10103015
申请日：2002-03-22
申请人： Igor Ivanov , Jonathan Weiguo Zhang , Artur Kolics
发明人： Igor Ivanov , Jonathan Weiguo Zhang , Artur Kolics
IPC分类号： C23C18/16 , H01L21/288 , B05C5/00 , B05C11/00
CPC分类号： C23C18/1676 , C23C18/1628 , C23C18/163 , C23C18/1632 , C23C18/168 , C23C18/1682 , H01L21/288
摘要： An apparatus of the invention has a closable chamber that can be sealed and is capable of withstanding an increased pressure and high temperature. The chamber contains a substrate holder that can be rotated around a vertical axis, and an edge-grip mechanism inside the substrate holder. The deposition chamber has several inlet ports for the supply of various process liquids, such as deposition solutions, DI water for rinsing, etc., and a port for the supply of a gas under pressure. The apparatus is also provided with reservoirs and tanks for processing liquids and gases, as well as with a solution heater and a control system for controlling temperature and pressure in the chamber. The heater can be located outside the working chamber or built into the substrate holder, or both heaters can be used simultaneously. Uniform deposition is achieved by carrying out the deposition process under pressure and under temperature slightly below the boiling point of the solution. The solution can be supplied from above via a shower head formed in the cover, or through the bottom of the chamber. Rinsing or other auxiliary solutions are supplied via a radially moveable chemical dispensing arm that can be arranged above the substrate parallel thereto.

23. 发明授权

US06263228B1 Method and apparatus for providing separate water-dominant and fat-dominant images from single scan single point dixon MRI sequences 有权
标题翻译：用于从单次扫描单点狄克逊MRI序列提供单独的水主导和脂肪占优势图像的方法和装置
公开(公告)号：US06263228B1
公开(公告)日：2001-07-17
申请号：US09141338
申请日：1998-08-27
申请人： Weiguo Zhang , David M. Kramer , Andrew Li
发明人： Weiguo Zhang , David M. Kramer , Andrew Li
IPC分类号： A61B505
CPC分类号： G01R33/4828 , G01R33/56563
摘要： A method and apparatus for producing water-dominant and fat-dominant MR signal data for use in constructing separate images from single-scan single-point Dixon MRI sequences is disclosed. The effects of field inhomogeneities are removed by quantitating the signal phase by taking the argument of the MR signal multiplied by itself. A region-growing algorithm guided by a polynomial model is used to unwrap the phase which is then used to separately generate water-pixel data and fat-pixel data for producing separate images. The invention can be used for constructing images from both 2-D and 3-D spin-echo and/or field-echo acquisitions.
摘要翻译：公开了一种用于制造用于构建单扫描单点狄克逊MRI序列的分离图像的水占优势和脂肪占优势的MR信号数据的方法和装置。通过将MR信号的自变量乘以自身来量化信号相位来消除场不均匀性的影响。使用由多项式模型引导的区域增长算法用于展开相位，然后用于分开产生用于产生分离图像的水像像素数据和脂肪像素数据。本发明可用于从2D和3-D自旋回波和/或场回波采集中构建图像。

24. 发明授权

US6114853A NMR methods for qualification of sequence-induced B.sub.0 oscillation and correction of the resultant image artifacts in MRI 失效
标题翻译：序列诱导的B0振荡鉴定的NMR方法和MRI中产生的图像伪影的校正
公开(公告)号：US6114853A
公开(公告)日：2000-09-05
申请号：US882400
申请日：1997-06-25
申请人： Weiguo Zhang
发明人： Weiguo Zhang
IPC分类号： G01R33/30 , A61B5/055 , G01R33/48 , G01R33/565 , G01U3/00
CPC分类号： G01R33/56563
摘要： Nuclear magnetic resonance (NMR) methods are invented which allow for quantification of sequence-induced B.sub.0 oscillation in magnetic resonance imaging (MRI). The techniques can be used to study any system malfunction which induces sequence-synchronized phase oscillation of the MR signals. When the oscillation is spatially uniform, methods are also developed to correct the acquired NMR data for minimizing the effects of the oscillation.
摘要翻译：发明了核磁共振（NMR）方法，其允许定量磁共振成像（MRI）中的序列诱导的B0振荡。这些技术可用于研究任何导致MR信号的序列同步相位振荡的系统故障。当振荡在空间上均匀时，还开发了用于校正获取的NMR数据以最小化振荡的影响的方法。

25. 发明申请

US20120213914A1 Apparatus and Method for Electroless Deposition of Materials on Semiconductor Substrates 有权
标题翻译：半导体衬底上材料的无电沉积的装置和方法
公开(公告)号：US20120213914A1
公开(公告)日：2012-08-23
申请号：US13408039
申请日：2012-02-29
申请人： Igor C. Ivanov , Jonathan Weiguo Zhang , Artur Kolics
发明人： Igor C. Ivanov , Jonathan Weiguo Zhang , Artur Kolics
IPC分类号： B05D5/12
CPC分类号： C23C18/1676 , C23C18/1628 , C23C18/163 , C23C18/1632 , C23C18/168 , C23C18/1682 , H01L21/288
摘要： An apparatus is provided having a closable chamber that can be sealed and is capable of withstanding an increased pressure and high temperature. The chamber has several inlet ports for the supply of various process liquids, such as deposition solutions, water for rinsing, etc., and a port for the supply of a gas under pressure. The apparatus also includes a solution heater and a control system for controlling temperature and pressure in the chamber. Uniform deposition is achieved by carrying out the deposition process under pressure and under temperature slightly below the boiling point of the solution. The solution can be supplied from above via a shower head formed in the cover, or through the bottom of the chamber. Rinsing or other auxiliary solutions are supplied via a radially moveable chemical dispensing arm that can be arranged above the substrate parallel thereto.
摘要翻译：提供一种装置，其具有能够被密封并且能够承受增加的压力和高温的可关闭室。该室具有用于供应各种处理液体的多个入口，例如沉积溶液，用于冲洗的水等，以及用于在压力下供应气体的端口。该装置还包括解决方案加热器和用于控制室内的温度和压力的控制系统。通过在压力下和稍低于溶液沸点的温度下进行沉积工艺来实现均匀沉积。该解决方案可以从上面通过形成在盖中的淋浴喷头或者通过室的底部供应。冲洗或其它辅助溶液经由可平行于其上的衬底上方的可径向移动的化学分配臂供应。

26. 发明授权

US08003159B2 Methods and systems for processing a microelectronic topography 有权
标题翻译：用于处理微电子拓扑的方法和系统
公开(公告)号：US08003159B2
公开(公告)日：2011-08-23
申请号：US11108589
申请日：2005-04-18
申请人： Igor C. Ivanov , Weiguo Zhang
发明人： Igor C. Ivanov , Weiguo Zhang
IPC分类号： B05D3/04
CPC分类号： H01L21/68728 , H01L21/67051 , H01L21/6708 , Y02P80/30
摘要： Methods and systems are provided which are adapted to process a microelectronic topography, particularly in association with an electroless deposition process. In general, the methods may include loading the topography into a chamber, closing the chamber to form an enclosed area, and supplying fluids to the enclosed area. In some embodiments, the fluids may fill the enclosed area. In addition or alternatively, a second enclosed area may be formed about the topography. As such, the provided system may be adapted to form different enclosed areas about a substrate holder. In some cases, the method may include agitating a solution to minimize the accumulation of bubbles upon a wafer during an electroless deposition process. As such, the system provided herein may include a means for agitating a solution in some embodiments. Such a means for agitation may be distinct from the inlet/s used to supply the solution to the chamber.
摘要翻译：提供了适于处理微电子拓扑的方法和系统，特别是与无电沉积工艺相关联。通常，方法可以包括将形貌加载到腔室中，关闭腔室以形成封闭区域，并将流体供应到封闭区域。在一些实施例中，流体可以填充封闭区域。另外或替代地，围绕地形可以形成第二封闭区域。因此，所提供的系统可以适于在基板保持器周围形成不同的封闭区域。在一些情况下，该方法可以包括搅拌溶液以在无电沉积工艺期间使气泡在晶片上的累积最小化。因此，本文提供的系统可以包括在一些实施例中用于搅拌溶液的装置。用于搅拌的这种手段可能不同于用于将溶液供应到室的入口。

27. 发明授权

US07883739B2 Method for strengthening adhesion between dielectric layers formed adjacent to metal layers 有权
标题翻译：用于加强与金属层相邻形成的介电层之间的附着力的方法
公开(公告)号：US07883739B2
公开(公告)日：2011-02-08
申请号：US10462343
申请日：2003-06-16
申请人： Igor C. Ivanov , Weiguo Zhang , Artur Kolics
发明人： Igor C. Ivanov , Weiguo Zhang , Artur Kolics
IPC分类号： B05D5/12 , H01L21/4763
CPC分类号： H01L21/64 , C23C8/02 , C23C18/1605 , C23C18/1632 , C23C18/1683 , C23C18/1803 , C23C28/00 , C23C28/321 , C23C28/322 , C23C28/34 , C23C28/345 , C23C28/3455 , H01L21/288 , H01L21/321 , H01L21/76843 , H01L21/76849 , H01L21/76855 , H01L21/76856 , H01L21/76864 , H01L21/76874 , Y10T428/1241 , Y10T428/12493 , Y10T428/12549 , Y10T428/23 , Y10T428/24628
摘要： A method is provided which includes forming a metal layer and converting at least a portion of the metal layer to a hydrated metal oxide layer. Another method is provided which includes selectively depositing a dielectric layer upon another dielectric layer and selectively depositing a metal layer adjacent to the dielectric layer. Consequently, a microelectronic topography is formed which includes a metal feature and an adjacent dielectric portion comprising lower and upper layers of hydrophilic and hydrophobic material, respectively. A topography including a metal feature having a single layer with at least four elements lining a lower surface and sidewalls of the metal feature is also provided herein. The fluid/s used to form such a single layer may be analyzed by test equipment configured to measure the concentration of all four elements. In some cases, the composition of the fluid/s may be adjusted based upon the analysis.
摘要翻译：提供了一种方法，其包括形成金属层并将金属层的至少一部分转化为水合金属氧化物层。提供了另一种方法，其包括在另一电介质层上选择性地沉积电介质层，并且选择性地沉积与电介质层相邻的金属层。因此，形成微电子拓扑，其包括分别包括亲水和疏水材料的下层和上层的金属特征和相邻电介质部分。本文还提供了包括具有单层的金属特征的地形，其中至少四个元件衬在下表面和金属特征的侧壁。用于形成这种单层的流体可以通过配置成测量所有四个元素的浓度的测试设备进行分析。在一些情况下，可以基于分析来调整流体的组成。

28. 发明授权

US06448773B1 Method and system for measuring and compensating for eddy currents induced during NMR imaging operations 有权
标题翻译：用于测量和补偿在NMR成像操作期间引起的涡流的方法和系统
公开(公告)号：US06448773B1
公开(公告)日：2002-09-10
申请号：US09512323
申请日：2000-02-24
申请人： Weiguo Zhang
发明人： Weiguo Zhang
IPC分类号： G01V300
CPC分类号： G01R33/56518
摘要： A method and apparatus is disclosed for measuring and compensating the effects of eddy currents induced during NMR imaging operations. A cubic or cylindrical sample is placed in the imaging volume of a MRI system at a position centrally located with respect to the main magnetic field and oriented with its longitudinal axis parallel to a desired measuring direction. A magnetic field gradient pulse is applied for inducing eddy currents as well as for generating a slice-selective spin-echo signal. The spin-echo signal is acquired immediately after the termination of each eddy-current inducing gradient pulse. Two slices are selected along the desired measurement direction at symmetrical equal distance from the center of the main magnetic field. Two spin-echo signals are acquired for each slice with the polarity of the eddy-current inducing gradient pulse reversed between the two echo signals. Quantitative values for eddy-current induced field gradients and B0 oscillations are determined based on the precessing frequencies of the acquired NMR signals. NMR imaging is improved by compensating for eddy currents effects by applying the quantified values of the field gradients and B0 oscillations to set an appropriate pre-emphasis network. Gradient pulses in MRI/MRS pulse sequences may also be selectively pre-distorted or modified to compensate for resulting gradient-switching induced eddy currents. Other aspects of the disclosed method include measuring the time course of gradient switching, altering the pulse sequences to measure eddy currents having long time constants, repeatedly measuring the eddy currents to assist in pre-emphasis adjustments, and measuring EC-induced field gradients and B0 oscillation in the presence of moderately large background field inhomogeneities.
摘要翻译：公开了用于测量和补偿在NMR成像操作期间感应的涡流的影响的方法和装置。将立方体或圆柱形样品放置在相对于主磁场中心定位的位置处的MRI系统的成像体积中，并且其纵向轴线平行于期望的测量方向。施加磁场梯度脉冲以诱导涡流以及用于产生切片选择性自旋回波信号。在每个涡电流感生梯度脉冲终止之后立即获取自旋回波信号。沿着与主磁场中心对称等距的所需测量方向选择两个切片。对于每个切片获取两个自旋回波信号，其中涡电流感应梯度脉冲的极性在两个回波信号之间相反。基于获取的NMR信号的进动频率来确定涡流感应场梯度和B0振荡的定量值。通过应用场梯度和B0振荡的量化值来补偿涡流效应来改善NMR成像，以设置适当的预加重网络。 MRI / MRS脉冲序列中的梯度脉冲也可以被选择性地预失真或修改以补偿所得到的梯度切换感应涡流。所公开方法的其他方面包括测量梯度切换的时间过程，改变脉冲序列以测量具有长时间常数的涡流，重复测量涡流以辅助预加重调整，以及测量EC诱导的场梯度和B0 存在中等大背景场不均匀性的情况下的振荡。

29. 发明申请

US20120282483A1 Method for Strengthening Adhesion Between Dielectric Layers Formed Adjacent to Metal Layers 有权
标题翻译：加强与金属层相邻的介电层之间的粘附强化方法
公开(公告)号：US20120282483A1
公开(公告)日：2012-11-08
申请号：US13540036
申请日：2012-07-02
申请人： Igor C. Ivanov , Weiguo Zhang , Artur Kolics
发明人： Igor C. Ivanov , Weiguo Zhang , Artur Kolics
IPC分类号： C23C8/00 , B05D5/00 , B05D3/10 , B32B15/04
CPC分类号： H01L21/64 , C23C8/02 , C23C18/1605 , C23C18/1632 , C23C18/1683 , C23C18/1803 , C23C28/00 , C23C28/321 , C23C28/322 , C23C28/34 , C23C28/345 , C23C28/3455 , H01L21/288 , H01L21/321 , H01L21/76843 , H01L21/76849 , H01L21/76855 , H01L21/76856 , H01L21/76864 , H01L21/76874 , Y10T428/1241 , Y10T428/12493 , Y10T428/12549 , Y10T428/23 , Y10T428/24628
摘要： A method is provided which includes forming a metal layer and converting at least a portion of the metal layer to a hydrated metal oxide layer. Another method is provided which includes selectively depositing a dielectric layer upon another dielectric layer and selectively depositing a metal layer adjacent to the dielectric layer. Consequently, a microelectronic topography is formed which includes a metal feature and an adjacent dielectric portion comprising lower and upper layers of hydrophilic and hydrophobic material, respectively. A topography including a metal feature having a single layer with at least four elements lining a lower surface and sidewalls of the metal feature is also provided herein. The fluid/s used to form such a single layer may be analyzed by test equipment configured to measure the concentration of all four elements. In some cases, the composition of the fluid/s may be adjusted based upon the analysis.
摘要翻译：提供了一种方法，其包括形成金属层并将金属层的至少一部分转化为水合金属氧化物层。提供了另一种方法，其包括在另一电介质层上选择性地沉积电介质层并且选择性地沉积与电介质层相邻的金属层。因此，形成微电子拓扑，其包括分别包括亲水和疏水材料的下层和上层的金属特征和相邻电介质部分。本文还提供了包括具有单层的金属特征的地形，其中至少四个元件衬在下表面和金属特征的侧壁。用于形成这种单层的流体可以通过配置成测量所有四个元素的浓度的测试设备进行分析。在一些情况下，可以基于分析来调整流体的组成。

30. 发明授权

US08114975B2 Protein tyrosine kinase substrate LAT and its use in the identification of (ANT) agonists of the kinase 失效
标题翻译：蛋白酪氨酸激酶底物LAT及其用于鉴定激酶的（ANT）激动剂
公开(公告)号：US08114975B2
公开(公告)日：2012-02-14
申请号：US11218020
申请日：2005-08-31
申请人： Lawrence E. Samelson , Weiguo Zhang
发明人： Lawrence E. Samelson , Weiguo Zhang
IPC分类号： C07H21/04
CPC分类号： C07K16/40 , C07K14/705 , C07K14/7051 , C07K2319/00 , C12N9/1205 , G01N33/5041 , G01N33/573 , G01N2333/9121 , G01N2500/00
摘要： The invention generally relates to compositions and methods for identifying and testing tyrosine kinase signaling pathway agonists and antagonists, and more particularly, methods and compositions for screening compounds and identifying compounds that will modulate the interaction of protein tyrosine kinase substrates with their intracellular ligands, as well as between their intracellular ligands and other members of the signaling pathway.
摘要翻译：本发明一般涉及用于鉴定和测试酪氨酸激酶信号通路激动剂和拮抗剂的组合物和方法，更具体地说，用于筛选化合物和鉴定将调节蛋白质酪氨酸激酶底物与其细胞内配体相互作用的化合物的方法和组合物，以及在它们的细胞内配体和信号通路的其他成员之间。

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