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21. 发明申请

WO2012171882A1 ANTIGEN-SPECIFIC CENTRAL-MEMORY T CELL PREPARATIONS HAVING HIGH CD4+ FRACTION 审中-公开
标题翻译：具有高CD4 +分子的抗原特异性中央记忆细胞制备
公开(公告)号：WO2012171882A1
公开(公告)日：2012-12-20
申请号：PCT/EP2012/061041
申请日：2012-06-11
申请人： VOLK, Hans-dieter , SCHMÜCK, Michael , REINKE, Petra
发明人： VOLK, Hans-dieter , SCHMÜCK, Michael , REINKE, Petra
IPC分类号： C12N5/0783
CPC分类号： A61K35/26 , A61K35/17 , C12N5/0636 , C12N2501/2302 , C12N2501/2307 , C12N2501/727
摘要： The invention relates to a method for generation of T cell preparations that are specific for at least one target antigen, comprising the steps of expanding lymphoid cells in vitro in the presence of a target antigen or peptide fragments thereof in an expansion step, isolating cells that secrete interferon gamma and culturing, the cells in the presence of interleukin 2 and interleukin 7 and either an inhibitor of the mTOR Complex 1, or in the presence of an inhibitor of IL-2/IL-2R interaction. The invention further relates to preparations obtained by the method of the invention.
摘要翻译：本发明涉及一种用于产生对至少一种靶抗原特异性的T细胞制备物的方法，包括以下步骤：在扩增步骤中在靶抗原或其肽片段的存在下体外扩增淋巴样细胞，分离细胞分泌干扰素γ，并在白细胞介素2和白细胞介素7存在下培养细胞，以及mTOR复合物1的抑制剂，或在IL-2 / IL-2R相互作用的抑制剂存在下培养。本发明还涉及通过本发明的方法获得的制剂。

22. 发明申请

WO2011107595A1 HIGH THROUGHPUT ANALYSIS OF T-CELL RECEPTOR REPERTOIRES 审中-公开
标题翻译： T细胞受体代谢物的高通量分析
公开(公告)号：WO2011107595A1
公开(公告)日：2011-09-09
申请号：PCT/EP2011/053314
申请日：2011-03-04
申请人： CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN , REINKE, Petra , VOLK, Hans-Dieter , BABEL, Nina
发明人： REINKE, Petra , VOLK, Hans-Dieter , BABEL, Nina
IPC分类号： G01N33/50
CPC分类号： G01N33/5308 , Y02A50/58
摘要： A method for analysis of a T cell repertoire is provided, whereby T cell receptor protein sequences are obtained from lymphocytes, TCR sequences are aligned with a TCR sequence data base, and TCR sequences aligning to data base sequences are selected and their frequency distribution is determined. The TCR sequence data base is obtained by stimulating lymphocytes in vitro with antigens, selecting T cells responding to stimulation and obtaining TCR sequences from the selected cells, or comprises TCR specific for a tumour or an adoptively transferred T cell. Additionally, a method to obtain antigen-specific T cells for adoptive transfer is provided, whereby T cells responding to stimulation with antigens are selected, T cells comprising certain TCR sequences are obtained by culturing individual clones or by transferring a transgenic TCR into a T cell.
摘要翻译：提供了一种分析T细胞谱的方法，由此从淋巴细胞获得T细胞受体蛋白序列，TCR序列与TCR序列数据库进行比对，并选择与数据碱基序列相对应的TCR序列，并确定其频率分布。通过用抗原体外刺激淋巴细胞来获得TCR序列数据库，选择响应于刺激的T细胞并从所选择的细胞获得TCR序列，或包含对肿瘤或过继转移的T细胞特异的TCR。另外，提供了用于获得用于过继转移的抗原特异性T细胞的方法，由此选择响应于用抗原刺激的T细胞，通过培养单个克隆或通过将转基因TCR转移到T细胞中获得包含某些TCR序列的T细胞。

23. 发明申请

WO2008135419A3 ANTI-IL-6-AGENTS FOR IMPROVING PRIMARY FUNCTIONING OF ALLOGENIC GRAFTS 审中-公开
标题翻译：用于改善异源植物初级功能的抗IL-6剂
公开(公告)号：WO2008135419A3
公开(公告)日：2008-12-31
申请号：PCT/EP2008055124
申请日：2008-04-25
申请人： CHARITE UNIVERSITAETSMEDIZIN , SAWITZKI BIRGIT , GONG WEIHUA , PASCHER ANDREAS , VOLK HANS-DIETER
发明人： SAWITZKI BIRGIT , GONG WEIHUA , PASCHER ANDREAS , VOLK HANS-DIETER
IPC分类号： A61K38/20 , A61K39/395 , A61P37/06 , C07K16/24 , C07K16/28
CPC分类号： C07K16/2866 , A61K31/365 , A61K31/407 , A61K38/1774 , A61K2039/505 , C07K2317/76
摘要： The present invention relates to the use of interleukin-6 antagonists for preventing, treating or ameliorating delayed graft function and/or for improving primary and/or long term graft function, particularly in kidney transplantation, and corresponding medicaments.
摘要翻译：本发明涉及白细胞介素-6拮抗剂在预防，治疗或改善移植物功能延迟和/或改善原发和/或长期移植物功能中的用途，特别是在肾移植中以及相应的药物中的用途。

24. 发明申请

WO2007128482A1 USE OF A B-CELL-DEPLETING ANTIBODY FOR TREATMENT OF POLYOMA VIRUS INFECTIONS 审中-公开
标题翻译：使用B细胞去除抗体治疗多瘤病毒感染
公开(公告)号：WO2007128482A1
公开(公告)日：2007-11-15
申请号：PCT/EP2007/003878
申请日：2007-05-02
申请人： CHARITÉ - UNIVERSITÄTSMEDIZIN BERLIN , REINKE, Petra , VOLK, Hans-Dieter , HAMMER, Markus , BABEL, Nina , BOLD, Gana
发明人： REINKE, Petra , VOLK, Hans-Dieter , HAMMER, Markus , BABEL, Nina , BOLD, Gana
IPC分类号： A61K39/395 , A61P31/20 , A61K31/675 , A61P13/12 , A61P37/06 , C07K16/28
CPC分类号： C07K16/2887 , A61K2039/505 , C07K2317/24
摘要： The present invention relates to uses of a B-cell-depleting antibody for the treatment of a polyoma virus infection.
摘要翻译：本发明涉及B细胞消耗性抗体用于治疗多瘤病毒感染的用途。

25. 发明申请

WO0053224A3 USE OF INHIBITORS OF ENDOTOXIN FOR THE TREATMENT OF HEART FAILURE AND OF CACHEXIA 审中-公开
标题翻译：内毒素抑制剂用于治疗心脏衰竭和慢性乙型肝炎的用途
公开(公告)号：WO0053224A3
公开(公告)日：2002-04-04
申请号：PCT/EP0002299
申请日：2000-03-09
申请人： MAX DELBRUECK CENTRUM , ANKER STEFAN , COATS ANDREW , VOLK HANS DIETER , RAUCHHAUS MATHIAS , SCHUMANN RALF REINER
发明人： ANKER STEFAN , COATS ANDREW , VOLK HANS-DIETER , RAUCHHAUS MATHIAS , SCHUMANN RALF REINER
IPC分类号： A61K31/575 , A61P9/04
CPC分类号： A61K31/575
摘要： A method of treating, preventing or ameliorating chronic heart failure or acute heart failure in a patient the method comprising administering to the patient an effective amount of: a compound that is able to bind to an endotoxin (lipopolysaccharide; LPS) molecule, for example LPS binding protein, BPI, lipoproteins, bile acids or an antibody capable of binding LPS, a compound that is able to bind to an endotoxin (lipopolysaccharide; LPS) molecule or bacterium in the gut, for example charcoal, a bile acid or Fuller's earth, an antibacterial agent that is substantially active in the gut, an agent that is able to inhibit the response by a cell to endotoxin (lipopolysaccharide; LPS), an agent that may form a barrier or that otherwise impedes translocation of bacteria or endotoxin (LPS) from the gut into the patient's circulation. A method of treating, preventing or ameliorating endotoxin-mediated immune activation in acute or chronic heart failure in a patient the method comprising administering to the patient an effective amount of: a compound that is able to bind to an endotoxin (lipopolysaccharide; LPS) molecule, for example LPS binding protein, BPI, lipoproteins, bile acids or an antibody capable of binding LPS, a compound that is able to bind to an endotoxin (lipopolysaccharide; LPS) molecule or bacterium in the gut, for example charcoal, a bile acid or Fuller's earth, an antibacterial agent that is substantially active in the gut, an agent that is able to inhibit the response by a cell to endotoxin (lipopolysaccharide; LPS), an agent that may form a barrier or that otherwise impedes translocation of bacteria or endotoxin (LPS) from the gut into the patient's circulation.
摘要翻译：一种治疗，预防或改善患者的慢性心力衰竭或急性心力衰竭的方法，该方法包括向患者施用有效量的：能够结合内毒素（脂多糖; LPS）分子的化合物，例如LPS 结合蛋白质，BPI，脂蛋白，胆汁酸或能够结合LPS的抗体，能够结合肠中的内毒素（脂多糖; LPS）分子或细菌的化合物，例如活性炭，胆汁酸或富勒氏土，在肠道中基本上具有活性的抗菌剂，能够抑制细胞对内毒素（脂多糖; LPS）的反应的试剂，可能形成屏障或另外阻碍细菌或内毒素（LPS）易位的药剂，从肠道到患者的流通。一种在患者急性或慢性心力衰竭中治疗，预防或改善内毒素介导的免疫激活的方法，该方法包括向患者施用有效量的：能够结合内毒素（脂多糖; LPS）分子的化合物，例如LPS结合蛋白，BPI，脂蛋白，胆汁酸或能够结合LPS的抗体，能够结合肠中的内毒素（脂多糖; LPS）分子或细菌的化合物，例如活性炭，胆汁酸或富勒的地球，在肠中基本上具有活性的抗菌剂，能够抑制细胞对内毒素（脂多糖; LPS）的反应的试剂，可能形成屏障或以其它方式阻碍细菌易位的药剂或内毒素（LPS）从肠道进入患者的循环。

26. 发明申请

WO0163286A3 METHOD FOR ANTIGEN-SPECIFIC STIMULATION OF T-LYMPHOCYTES WITH SYNTHETIC PEPTIDE LIBRARIES 审中-公开
标题翻译：方法用合成肽库的T淋巴细胞抗原特异性刺激
公开(公告)号：WO0163286A3
公开(公告)日：2002-03-14
申请号：PCT/EP0101773
申请日：2001-02-17
申请人： KERN FLORIAN , VOLK HANS DIETER , REINKE PETRA , FAULHABER NICOLE , SUREL INGOLF PASCAL , KHATAMZAS ELHAM
发明人： KERN FLORIAN , VOLK HANS-DIETER , REINKE PETRA , FAULHABER NICOLE , SUREL INGOLF-PASCAL , KHATAMZAS ELHAM
IPC分类号： G01N33/53 , A61K35/26 , A61P37/04 , C12N5/06 , C12Q1/02 , G01N33/50 , A61K39/00 , A61K38/08 , A61K38/10 , A61K38/16 , A61K39/245 , C12N5/08 , G01N33/68
CPC分类号： G01N33/505
摘要： The invention relates to a method for the antigen-specific stimulation of T-lymphocytes with synthetic peptide libraries, comprising the following steps: a) dividing the whole amino acid sequence of the antigen into protein fragments with partial amino acid sequences; b) synthesising a peptide library containing these protein fragments; c) incubating a suspension containing CD8- and/or CD4-T-lymphocytes with all of the protein fragments of the peptide library in a single culture batch. The method can be used for immunostimulation of T-lymphocytes of mammals, especially humans, as well as for diagnosis purposes, in order to determine whether a mammal, especially a human being, has previously responded to a specific protein with its/his/her immune system, and the strength of this response.
摘要翻译：本发明涉及一种用于用合成肽文库的T淋巴细胞的抗原特异性刺激的方法，包括以下步骤：a）将抗原的总氨基酸序列与部分氨基酸序列的蛋白片段，b）合成含有这些蛋白片段的肽文库 ; c）中温育CD8和/或含有该肽库的所有蛋白质片段CD4 + T淋巴细胞悬浮在单一培养物制备。该方法既可以用于哺乳动物，特别是人类的T淋巴细胞的免疫刺激以及用于诊断来确定是否哺乳动物，尤其是人，已响应特定的蛋白质，其免疫系统有多强这个答案，

27. 发明申请

WO9936568A3 METHOD FOR IDENTIFYING T-CELL STIMULATING PROTEIN FRAGMENTS 审中-公开
标题翻译：一种鉴定T细胞刺激蛋白片段
公开(公告)号：WO9936568A3
公开(公告)日：2000-04-06
申请号：PCT/DE9900175
申请日：1999-01-15
申请人： KERN FLORIAN , VOLK HANS DIETER , WALDEN PETER , SCHEFFOLD ALEXANDER , BLASCZYK RAINER
发明人： KERN FLORIAN , VOLK HANS-DIETER , WALDEN PETER , SCHEFFOLD ALEXANDER , BLASCZYK RAINER
IPC分类号： C07K1/02 , C07K1/04 , C07K7/06 , C07K7/08 , C07K14/045 , C12Q1/02 , G01N33/68 , G01N33/50 , A61K38/17 , C12P21/00
CPC分类号： G01N33/6863
摘要： The invention relates to a method for identifying T-cell stimulating protein fragments using the following steps: a) detecting the amino acid sequence of an antigen; b) subdividing the found amino acid sequence of the antigen into protein fragments; c) synthesizing at least one protein fragment; d) incubating a suspension containing t-cells with the protein fragments; e) identifying an induced T-cell cytokine or activation marker by flow-through cytometry, and; f) assigning the T-cells, with which T-cell cytokines and/or activation markers were identified, to the protein fragments which were incubated with the T-cells. The corresponding protein fragments/peptides are synthetically produced with the assistance of the detected positive sequence, and said corresponding protein fragments/peptides can be utilized to produce a medicament for immunostimulation.
摘要翻译：本发明涉及用于鉴定T细胞刺激蛋白片段，包括以下步骤的方法：a）确定的抗原的氨基酸序列，b）将所述抗原的发现氨基酸序列导入蛋白质片段，c）中合成至少一种蛋白片段d）培养一含T细胞悬浮液与蛋白质的片段，e）鉴定诱导T细胞的细胞因子或活化标记，通过流式细胞术，以及f）分配所述T细胞，其中T细胞的细胞因子和/或活化标记物鉴定为蛋白质片段，其温育与T细胞。与所确定的正序的辅助下的相应蛋白片段/肽合成制备，并且可以被用于免疫刺激的药物中的用途。

28. 发明专利

DE112012002430T5 Antigenspezifische zentrale Gedächtnis-T-Zellpräparationen mit hohem CD4+ Anteil 未知
公开(公告)号：DE112012002430T5
公开(公告)日：2014-03-06
申请号：DE112012002430
申请日：2012-06-11
申请人： REINKE PETRA , SCHMUECK MICHAEL , VOLK HANS-DIETER
发明人： VOLK HANS-DIETER , SCHMUECK MICHAEL , REINKE PETRA
IPC分类号： C12N5/0783 , A61K35/17
摘要： Die Erfindung betrifft ein Verfahrung zur Erzeugung von T-Zellpräparationen, die für mindestens ein Zielantigen spezifisch sind, umfassend die Schritte Expandieren von lymphoiden Zellen in vitro in der Gegenwart eines Zielantigens oder Peptidfragmenten davon in einem Expansionsschritt, Isolieren von Zellen, die Interferon gamma sekretieren und Kultivieren der Zellen in Gegenwart von Interleukin-2 und Interleukin-7 und enweder eines Inhibitors des mTor Komplexes 1 oder in Gegenwart eines Inhibitors der Interleukin-2(IL-2)-Interleukin-2-Rezeptor(IL-2R)-Interaktion. Die Erfindung betrifft weiterhin Präparationen, die durch das Verfahren der Erfindung erhalten werden.

29. 发明专利

DE19948126A1 未知
公开(公告)号：DE19948126A1
公开(公告)日：2001-04-12
申请号：DE19948126
申请日：1999-10-06
申请人： MAX DELBRUECK CENTRUM , VOLK HANS DIETER
发明人： ANKER STEFAN D , VOLK HANS-DIETER
IPC分类号： A61K31/00 , A61K31/365 , A61K31/436 , A61K31/454 , A61K31/52 , A61K31/522 , A61K38/17 , A61P9/00 , A61P21/00
摘要： The invention relates to an agent for the treatment of cachexia due to chronic cardiac insufficiency, cirrhosis of the liver, chronic obstructive lung disease or chronic kidney insufficiency and/or cardiogenic shock. Said agent contains an effective amount of an immunosuppressive substance or a mixture of such substances and makes possible a new therapeutic method for weight loss therapy following a disease (cachexia) and for therapy of cardiogenic shock (severe decompensation after acute myocardial infarct).

30. 发明专利

DE29512719U1 未知
公开(公告)号：DE29512719U1
公开(公告)日：1996-08-29
申请号：DE29512719
申请日：1995-07-28
申请人： SABAT ROBERT , SEIFERT MARTINA DR RER NAT , MARX UWE DR MED , GLASER RALF DR RER NAT , VOLK HANS DIETER PROF DR MED
IPC分类号： A61K38/00 , C07K16/24 , C12N5/18 , G01N33/68 , C07K16/00 , A61K39/395 , G01N33/577

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