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21. 发明申请

WO2008028133A3 SURGICAL FASTENER AND METHOD OF USE 审中-公开
标题翻译：手术紧固件和使用方法
公开(公告)号：WO2008028133A3
公开(公告)日：2008-08-14
申请号：PCT/US2007077392
申请日：2007-08-31
申请人： UNIV CREIGHTON , FILIPI CHARLES J
发明人： FILIPI CHARLES J
IPC分类号： A61B17/08
CPC分类号： A61B17/0682 , A61B17/0644 , A61B2017/00004
摘要： A surgical fastener and applicator for positioning the same are provided for subcuticular incision closure. The fastener 10 is provided with a pair of arcuately shaped arms 12, 14 that extend outwardly from a pair of foot plates 16, 18 that form a hinge 20, which is selectively movable between open and closed positions to draw the arms toward one another. The hinge is secure in the closed position by one of various mechanical fastening mechanisms. The fastener is comprised of a bio-absorbable material to facilitate subcuticular use. The applicator is shaped to position fasteners in subcuticular fashion without impairment of the user's view of the incision.
摘要翻译：提供用于定位其的外科紧固件和敷贴器用于下面的角膜切口闭合。紧固件10设置有一对弓形形状的臂12,14，弓形形状的臂12,14从形成铰链20的一对脚板16,18向外延伸，铰链20可在打开位置和闭合位置之间选择性地移动以将臂朝向彼此拉动。铰链通过各种机械紧固机构之一固定在关闭位置。紧固件由生物可吸收材料组成以促进皮下使用。涂药器成形为将紧固件定位在皮下方式，而不损害使用者对切口的观察。

22. 发明申请

WO2008061230A3 MOBILE REGISTRATION SYSTEM 审中-公开
标题翻译：移动注册系统
公开(公告)号：WO2008061230A3
公开(公告)日：2008-07-10
申请号：PCT/US2007084982
申请日：2007-11-16
申请人： UNIV CREIGHTON , CORRITORE CINDY , REMPE NATE
发明人： CORRITORE CINDY , REMPE NATE
IPC分类号： G06Q10/00
CPC分类号： G06Q10/02 , G06Q50/20 , H04L67/04 , H04L67/306
摘要： A method and system for registering for a course of an educational institution with a telecommunication device (104) via a mobile registration system (10) being executed on a server (102) is disclosed. The server (102) sends registration notifications (116) to the telecommunication devices (104) of a student eligible to participate the mobile registration system (10). A student operates their telecommunication device (104) to send a registration request (116) to the server (102) to receive registration data (126). The mobile registration system (10) then retrieves the requested registration data (126), and based on an infinite number of business rules, performs a smart interpretation convenient when accessing the information via a mobile telecommunications device.
摘要翻译：公开了一种通过在服务器（102）上执行的移动登记系统（10）向具有电信设备（104）注册教育机构课程的方法和系统。服务器（102）向有资格参与移动注册系统（10）的学生的电信设备（104）发送注册通知（116）。学生操作其电信设备（104）向服务器（102）发送注册请求（116）以接收注册数据（126）。然后，移动登记系统（10）检索所请求的登记数据（126），并且基于无限数量的业务规则，当通过移动电信设备访问信息时执行智能解释。

23. 发明申请

WO2005087811A3 ESTROGEN RECEPTORS AND METHODS OF USE 审中-公开
标题翻译：雌激素受体和使用方法
公开(公告)号：WO2005087811A3
公开(公告)日：2006-03-30
申请号：PCT/US2005007857
申请日：2005-03-10
申请人： UNIV CREIGHTON , WANG ZHAO YI
发明人： WANG ZHAO YI
IPC分类号： C07K16/00 , C07K16/28 , A61K39/395 , C07K14/72 , C12N5/10 , G01N33/53
CPC分类号： C07K14/721 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/2869 , G01N33/743 , G01N2500/04
摘要： The present invention provides isolated polypeptides having an amino acid sequence having at least 70 % identity to SEQ ID N0:20, wherein the polypeptide has ER-a36 activity. The invention further provides methods for identifying agents that bind to such polypeptides, methods for detecting such polypeptides, and methods for altering the activity of such polypeptides. Also provided are antibodies that specifically bind to an amino acid sequence depicted at SEQ ID NO:1, or an immunogenic fragment thereof, and methods for making and using such antibodies.
摘要翻译：本发明提供具有与SEQ ID NO：20具有至少70％同一性的氨基酸序列的分离的多肽，其中所述多肽具有ER-a36活性。本发明还提供了用于鉴定与这些多肽结合的试剂的方法，用于检测这些多肽的方法，以及改变这些多肽的活性的方法。还提供了特异性结合SEQ ID NO：1所示氨基酸序列的抗体或其免疫原性片段，以及制备和使用该抗体的方法。

24. 发明申请

WO2006031936A2 DEVICE AND METHOD FOR DETECTING ANTIBIOTIC-INACTIVATING ENZYMES 审中-公开
标题翻译：用于检测抗生素消化酶的装置和方法
公开(公告)号：WO2006031936A2
公开(公告)日：2006-03-23
申请号：PCT/US2005032857
申请日：2005-09-15
申请人： UNIV CREIGHTON , BLACK JENNIFER A , THOMSON KENNETH S
发明人： BLACK JENNIFER A , THOMSON KENNETH S
IPC分类号： C12Q1/18
CPC分类号： C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/34 , G01N2333/986
摘要： A method for determining whether a microorganism produces an AmpC ßlactamase is disclosed in which a culture of a microorganism suspected of producing a ß-lactamase that inactivates a ß-lactam-containing antibiotic is admixed with an effective amount of each of i) a ß-lactam-containing antibiotic, ii) a ß-lactamase inhibitor to which AmpC ß-lactamase is resistant, and iii) a permeabilizing agent for the microorganism present in a non-growth-inhibiting microorganism-permeabilizing amount to form an assay culture. That assay culture in maintained under appropriate culture conditions and for a time period sufficient to determine the interaction of the microorganism with the AmpC ß-lactamase resistant inhibitor and antibacterial compound, and thereby determine the presence of an AmpC ß-lactamase, wherein a positive test indicates the presence of an AmpC ß-lactamase.
摘要翻译：公开了一种确定微生物是否产生AmpCβ-内酰胺酶的方法，其中将怀疑产生β-内酰胺酶的微生物的培养物与含有β-内酰胺的抗生素失活，将其与有效量的i）a- 含内酰胺的抗生素，ii）AmpCβ-内酰胺酶耐受的β-内酰胺酶抑制剂，和iii）用于存在非生长抑制微生物透化量的微生物的透化剂以形成测定培养物。该测定培养物在合适的培养条件下维持足够的时间以确定微生物与AmpCβ-内酰胺酶抗性抑制剂和抗细菌化合物的相互作用，从而确定AmpCβ-内酰胺酶的存在，其中阳性测试表明存在AmpCβ-内酰胺酶。

25. 发明申请

WO2005020802A2 SUTURING DEVICES AND METHODS 审中-公开
标题翻译：缝合装置和方法
公开(公告)号：WO2005020802A2
公开(公告)日：2005-03-10
申请号：PCT/US2004028516
申请日：2004-09-02
申请人： UNIV CREIGHTON , FILIPI CHARLES J , CORNET DOUGLAS A , ZAINIEV GAFUR , ZAINIEVA INLIK , GERASIMOV VLADIMIR , PRUSHINSKIY VALERIY , PRUSHINSKAYA MARINA
发明人： FILIPI CHARLES J , CORNET DOUGLAS A , ZAINIEV GAFUR , ZAINIEVA INLIK , GERASIMOV VLADIMIR , PRUSHINSKIY VALERIY , PRUSHINSKAYA MARINA
IPC分类号： A61B20060101 , A61B17/04 , A61B17/10 , A61B17/11 , A61B
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0487 , A61B17/0491 , A61B17/1114 , A61B2017/00296 , A61B2017/0409 , A61B2017/0416 , A61B2017/0417 , A61B2017/0458 , A61B2017/0464 , A61B2017/0496
摘要： Disclosed is a T-fastener delivery device. The device includes a belt and a pusher rod. The belt includes a plurality of slots for holding a plurality of T-bars substantially parallel to one another in a sideby-side arrangement; and the belt is moveable such that the slots can be sequentially aligned with the pusher rod. Also disclosed are methods for creating a gastric pouch in the stomach of an obese patient and methods for reducing lower esophageal sphincter distraction with gastric filling in a subject. Suturing systems are also disclosed. One suturing system includes a plurality of T-fasteners and a continuous suture connecting the plurality of T-fasteners. The T-fastener comprises a cylindrical bar having a filament loop attached thereto substantially at the cylindrical bar's axial midpoint, and the continuous suture slidably passes through the T-fasteners' filament loops. Another suturing system includes a plurality of T-fasteners; and a continuous suture connecting the plurality of T-fasteners. The T-fastener comprises two cylindrical bars connected by a filament, and the continuous suture slidably passes through a loop formed by the T-fasteners' filaments.
摘要翻译：公开了一种T形紧固件输送装置。该装置包括一个皮带和一个推杆。该带包括多个槽，用于以并排布置方式基本上彼此平行地保持多个T形条; 并且带是可移动的，使得槽可以顺序地与推杆对齐。还公开了用于在肥胖患者的胃中产生胃囊的方法以及用于减少受试者中胃充填的下食道括约肌分离的方法。还披露了缝合系统。一个缝合系统包括多个T形紧固件和连接多个T形紧固件的连续缝合线。该T型紧固件包括圆柱形杆，该圆柱形杆具有基本上在圆柱杆的轴向中点附接到其上的细丝环，并且连续缝合线可滑动地穿过T形紧固件的细丝环。另一种缝合系统包括多个T形紧固件; 以及连接多个T形紧固件的连续缝合线。该T形紧固件包括两根通过细丝连接的圆柱形杆，并且连续缝合线可滑动地穿过由T形紧固件的细丝形成的环。

26. 发明申请

WO0170130A3 COMPOSITIONS DERIVED FROM MODIOLUS MODIOLUS AND METHODS FOR MAKING AND USING SAME 审中-公开
标题翻译：从MODIOLUS MODIOLUS衍生的组合物及其制备和使用方法
公开(公告)号：WO0170130A3
公开(公告)日：2002-02-07
申请号：PCT/US0109192
申请日：2001-03-22
申请人： UNIV CREIGHTON , SFS INC , ADRIAN THOMAS E , COLLIN PETER D
发明人： ADRIAN THOMAS E , COLLIN PETER D
IPC分类号： A61K35/56 , A61K35/60 , A61P3/10 , A61P9/00 , A61P19/02 , A61P29/00
CPC分类号： A61K35/618
摘要： Disclosed are compositions which include an isolated soft tissue from Modiolus modiolus ("MM") and compositions which include an oil isolated from MM or a portion thereof. Also disclosed are methods of treating adenocarcinoma in a subject; methods of decreasing proliferation of adenocarcinoma cells, or of inducing apoptosis of adenocarcinoma cells, or of inducing differentiation of adenocarcinoma cells into non-cancerous cells; methods of inhibiting the activity of 5-lipoxygenase or 12-lipoxygenase or both in cells; and methods of treating a subject suffering from a disease or condition associated with excessive 5-lipoxygenase activity or 12-lipoxygenase activity or both. A process for preparing an MM extract by contacting MM or a portion thereof with a solvent under conditions effective to extract one or more materials from the MM or portion thereof is also described.
摘要翻译：公开了包括来自Modiolus modiolus（“MM”）的分离的软组织的组合物和包含从MM或其一部分分离的油的组合物。还公开了在受试者中治疗腺癌的方法; 降低腺癌细胞增殖或诱导腺癌细胞凋亡或诱导腺癌细胞分化为非癌细胞的方法; 抑制5-脂氧合酶或12-脂氧合酶或两者在细胞中的活性的方法; 以及治疗患有与过量的5-脂氧合酶活性或12-脂肪氧合酶活性或两者有关的疾病或病症的受试者的方法。还描述了在有效从MM或其部分提取一种或多种材料的条件下使MM或其一部分与溶剂接触来制备MM提取物的方法。

27. 发明申请

WO2012151464A3 USE OF RADIOGRAPHIC CONTRAST AGENTS FOR DETECTING DENTAL CARIES 审中-公开
标题翻译：用于检测牙科用途的无线电对比剂
公开(公告)号：WO2012151464A3
公开(公告)日：2012-12-27
申请号：PCT/US2012036444
申请日：2012-05-04
申请人： UNIV CREIGHTON , BENN DOUGLAS K
发明人： BENN DOUGLAS K
IPC分类号： A61C5/00
CPC分类号： A61K49/04 , A61K49/0404 , A61K49/0409 , A61K49/0438 , A61K49/0495
摘要： The present invention provides methods of imaging dental tissue. More particularly, the invention relates to a method of imaging dental caries by administering a topical intra-oral composition that provides enhanced radiographic imaging.
摘要翻译：本发明提供牙科组织成像的方法。更具体地，本发明涉及一种通过施用提供增强的放射照相成像的局部口腔内组合物来成像龋齿的方法。

28. 发明申请

WO2010120323A3 CALENDAR SYSTEM 审中-公开
标题翻译：日历系统
公开(公告)号：WO2010120323A3
公开(公告)日：2012-06-14
申请号：PCT/US2009053155
申请日：2009-08-07
申请人： UNIV CREIGHTON , HOLZAPFEL DAMIEN , ZIMMERMAN STUART , MARTIN TADD
发明人： HOLZAPFEL DAMIEN , ZIMMERMAN STUART , MARTIN TADD
IPC分类号： G06F15/16
CPC分类号： G06Q10/109
摘要： A calendar system (10) displays event data via an electronic calendar form that is accessible over a network by a user of a client computer (102). The system (10) stores event data for multiple events and selectively displays event data based on whether a calendar access request (1 1 1 ) is received from a guest user or an authenticated user. The system (10) displays event data via a default calendar to guest users and displays event data via a customized calendar to authenticated users. The default calendar displays event data for related events based on a contextual relationship that is derived by examining event data for each the multiple events to determine a position separation and/or a frequency of a user supplied keyword in the event data. The customized calendar displays events based on contextual relationships and based on the viewing history of the user and other input data from user.
摘要翻译：日历系统（10）经由电子日历表格显示事件数据，电子日历表格可由客户端计算机（102）的用户通过网络访问。系统（10）存储多个事件的事件数据，并且基于是否从访客用户或认证用户接收到日历访问请求（111）来选择性地显示事件数据。系统（10）通过默认日历向访客用户显示事件数据，并通过自定义日历向经过身份验证的用户显示事件数据。默认日历基于通过检查每个多个事件的事件数据而导出的上下文关系来显示相关事件的事件数据，以确定事件数据中的用户提供的关键字的位置间隔和/或频率。自定义日历根据上下文关系并根据用户的查看历史记录和来自用户的其他输入数据来显示事件。

29. 发明申请

WO2007137210A3 SYSTEM AND TECHNIQUES FOR MAGNETIC MANIPULATION OF INTERNAL ORGANS DURING MINIMALLY INVASIVE SURGERY 审中-公开
标题翻译：微创外科手术中内脏手术的系统与技术
公开(公告)号：WO2007137210A3
公开(公告)日：2008-05-02
申请号：PCT/US2007069317
申请日：2007-05-19
申请人： UNIV CREIGHTON , FILIPI CHARLES J
发明人： FILIPI CHARLES J
IPC分类号： A61N2/10
CPC分类号： A61B17/122 , A61B17/1227 , A61B17/1285 , A61B34/70 , A61B34/73 , A61B2017/00278 , A61B2017/00411 , A61B2017/00867 , A61B2017/00876 , A61B2090/3954 , A61N2/06
摘要： Systems and techniques for manipulating organs during minimally invasive surgery are disclosed. Magnetic material is delivered to an organ (10) of interest and the organ (10) is manipulated during the procedure via a magnet (30) external to the patient (25). The magnetic material may be delivered in fluidized form by filing a balloon (22).
摘要翻译：公开了在微创手术中操纵器官的系统和技术。将磁性材料输送到感兴趣的器官（10），并且在手术期间通过患者（25）外部的磁体（30）操纵器官（10）。磁性材料可以通过填充气球（22）以流化形式递送。

30. 发明申请

WO2005048946A3 TREATMENT FOR BURN VICTIMS AND ANIMAL CARCASSES 审中-公开
标题翻译：烧伤和动物卡车的治疗
公开(公告)号：WO2005048946A3
公开(公告)日：2006-03-30
申请号：PCT/US2004038094
申请日：2004-11-15
申请人： UNIV CREIGHTON , DASH ALEKHA K
发明人： DASH ALEKHA K
IPC分类号： A61K31/506 , A61K20060101 , A61K31/14 , A61K31/18 , A61K31/722 , A61K45/06 , A61L2/00
CPC分类号： A61L2/0088 , A61K45/06
摘要： Disclosed is a method for applying a medicament to a surface of a burn victim. The method includes providing a medicament formulation that includes a medicament, a foaming agent, and a film-forming agent. The method further includes applying the medicament formulation as a collapsible foam to the surface of the burn victim. Also disclosed is a method for reducing bacterial contamination in animal carcasses. The method includes providing a foam formulation that includes a foaming agent and a film-forming agent; and applying the foam formulation as a collapsible foam to a surface of the animal carcasses.
摘要翻译：公开了一种将药物施用于烧伤受害者的表面的方法。该方法包括提供包含药物，发泡剂和成膜剂的药物制剂。该方法还包括将药物制剂作为可收缩的泡沫施用于烧伤受害者的表面。还公开了一种减少动物尸体细菌污染的方法。该方法包括提供包含发泡剂和成膜剂的泡沫制剂; 并将泡沫制剂作为可收缩的泡沫施用于动物屠体的表面。

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