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21. 发明授权

US06615061B1 Optical sensor having a selectable sampling distance for determination of analytes 有权
标题翻译：具有用于测定分析物的可选取样距离的光学传感器
公开(公告)号：US06615061B1
公开(公告)日：2003-09-02
申请号：US09366084
申请日：1999-08-03
申请人： Omar S. Khalil , Xiaomao Wu , Shu-jen Yeh , Charles F. Hanna , Stanislaw Kantor , Tzyy-Wen Jeng
发明人： Omar S. Khalil , Xiaomao Wu , Shu-jen Yeh , Charles F. Hanna , Stanislaw Kantor , Tzyy-Wen Jeng
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , G01N21/49
摘要： A method and apparatus for the measurement of trans-cutaneous diffuse reflectance at a single sampling distance for determining the concentration of an analyte in a biological sample, such as, for example, human tissue. The determination of the concentration of the analyte has been found to depend on the sampling distance and reaches an optimal result at a defined sampling distance for a given analyte and a given sample. The method involves measuring the light re-emitted from the sample at a distance from a light introduction site and correlating the intensity of the re-emitted light to the concentration of an analyte. For a given sample, the distance between the light collection site and a light introduction site (i.e., the sampling distance) corresponds to the depth from the surface into the sample at which scattering and absorption events significantly affect the intensity of re-emitted light (i.e., the sampling depth). Prior knowledge about the sample determines the optimal sampling depth for performing a measurement for a specific analyte and the corresponding sampling distance needed to reach that optimal sampling depth. Optimization of the sampling distance, as well as the correlation relationship, can be established in a calibration procedure.
摘要翻译：一种用于在单个采样距离处测量透皮漫反射率以确定生物样品（例如人体组织）中的分析物的浓度的方法和装置。已经发现分析物浓度的确定取决于采样距离，并且在给定分析物和给定样品的定义的采样距离处达到最佳结果。该方法包括测量从光引入位置一段距离处从样品再发射的光并将再发射的光的强度与分析物的浓度相关联。对于给定的样品，光采集位置和光引入位点之间的距离（即采样距离）对应于从表面到样品的深度，其中散射和吸收事件显着影响再发射光的强度（即采样深度）。关于样品的现有知识决定了对特定分析物进行测量的最佳采样深度以及达到该最佳采样深度所需的相应采样距离。可以在校准过程中建立采样距离的优化以及相关关系。

22. 发明授权

US6067463A Method and apparatus for non-invasively measuring the amount of glucose in blood 有权
标题翻译：用于非侵入性测量血液中葡萄糖量的方法和装置
公开(公告)号：US6067463A
公开(公告)日：2000-05-23
申请号：US225430
申请日：1999-01-05
申请人： Tzyy-Wen Jeng , Shu-Jen Yeh , John M. Lindberg , Joseph Larry Pezzaniti , Omar S. Khalil , Gary M. Oosta , Charles F. Hanna , Arnold F. Stalder , Ete Z. Szuts
发明人： Tzyy-Wen Jeng , Shu-Jen Yeh , John M. Lindberg , Joseph Larry Pezzaniti , Omar S. Khalil , Gary M. Oosta , Charles F. Hanna , Arnold F. Stalder , Ete Z. Szuts
IPC分类号： G01N21/35 , A61B5/00 , A61B5/145 , A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532
摘要： A method and apparatus for measuring the concentration of an analyte of interest, e.g. glucose, in blood non-invasively, i.e., without penetrating the skin or obtaining a biological sample from the body of a patient. The method and apparatus uses a plurality of measurement channels with appropriate wavelengths of interest to control variations of signal and to separate the contribution of the analyte of interest from those of interfering compounds. The method and apparatus of this invention can also be adapted to allow a portion of a body part to be engorged with blood to bring about greater accuracy in optical measurements. In the method of this invention, at least two similar, but not identical, measurements are made concurrently. For example, at least two measurements can be made with similar, but not identical, wavelengths of electromagnetic radiation. The two wavelengths should not be overlapping to allow maximum non-identity. By making measurements concurrently, each measurement channel in the system experiences variations as they occur substantially simultaneously in all channels. By selecting one of the channels as a reference channel and by normalizing the optical measurements of the other channels to this reference channel, the variations common to all channels are eliminated. Removing these common variations from the optical measurements by normalization, such as by calculating ratios of the measurement of each of the measuring channels to that of the reference channel, will allow the actual changes of the signal for a specific analyte of interest to be measured.
摘要翻译：用于测量所关注的分析物的浓度的方法和装置，例如，葡萄糖在血液中非侵入性地，即不渗透皮肤或从患者的身体获得生物样品。该方法和装置使用具有适当的感兴趣波长的多个测量通道来控制信号的变化并分离感兴趣分析物对干扰化合物的贡献。本发明的方法和装置还可以适于允许身体部分的一部分被血液吸收以在光学测量中带来更高的精度。在本发明的方法中，同时进行至少两个相似但不相同的测量。例如，可以用类似但不相同的电磁辐射波长进行至少两次测量。两个波长不应重叠，以允许最大的非身份。通过同时进行测量，系统中的每个测量通道在所有通道中基本上同时发生变化。通过选择一个通道作为参考通道，并将其他通道的光学测量标准化到该参考通道，可以消除所有通道共用的变化。通过归一化从光学测量中去除这些常见的变化，例如通过计算每个测量通道的测量与参考通道的测量的比率，将允许测量特定分析物的信号的实际变化。

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