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21. 发明授权

US07697978B1 Systems and methods for detecting alternans in intrinsic rhythms to monitor myocardial stability 有权
标题翻译：用于检测内在节律交替的监测心肌稳定性的系统和方法
公开(公告)号：US07697978B1
公开(公告)日：2010-04-13
申请号：US11561259
申请日：2006-11-17
申请人： Taraneh Ghaffari Farazi
发明人： Taraneh Ghaffari Farazi
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/0215 , A61B5/026 , A61B5/0535 , A61B5/1107 , A61B5/1459 , A61B5/6852 , A61B5/686 , A61B2562/0219 , A61N1/3627 , A61N1/3702
摘要： Implantable systems, and methods for use therewith, are provided for monitoring myocardial stability based on a signal that is indicative of functioning of a patient's heart for a plurality of consecutive beats. Sample data is obtained that is representative of functioning of a patient's heart for a plurality of consecutive beats, wherein each beat has a corresponding cycle length that may differ from cycle lengths of other beats. Such sample data is adjusted so that cycle lengths of consecutive beats represented in the adjusted sample data are substantially equal. Myocardial stability is then monitored based on the adjusted sample data. Where the obtained sample data is representative of electrical functioning of the patient's heart, electrical stability can be monitored, e.g., by monitoring for electrical alternations. Where the obtained sample data is representative of mechanical functioning of the patient's heart, mechanical stability can be monitored, e.g., by monitoring for mechanical alternans.
摘要翻译：提供了可植入系统及其使用方法，用于基于指示患者心脏对于多个连续搏动的功能的信号来监测心肌稳定性。获得代表多个连续节拍的患者心脏的功能的样本数据，其中每个节拍具有可能与其他节拍的周期长度不同的相应周期长度。调整这样的样本数据，使得在经调整的样本数据中表示的连续节拍的周期长度基本相等。然后基于经调整的样本数据监测心肌稳定性。在获得的样本数据代表患者心脏的电功能的情况下，可以例如通过监测电气变化来监测电稳定性。在获得的样品数据代表患者心脏的机械功能的情况下，可以例如通过监测机械交替物来监测机械稳定性。

22. 发明授权

US07627374B1 System and method for evaluating and optimizing the contribution of particular heart chambers to the overall efficacy of cardiac pacing therapy 有权
标题翻译：用于评估和优化特定心室对心脏起搏治疗总体疗效的贡献的系统和方法
公开(公告)号：US07627374B1
公开(公告)日：2009-12-01
申请号：US11421936
申请日：2006-06-02
申请人： Taraneh Ghaffari Farazi , Euljoon Park
发明人： Taraneh Ghaffari Farazi , Euljoon Park
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3688
摘要： Techniques are provided for evaluating and optimizing the contribution of particular heart chambers to pacing efficacy. Briefly, a pacemaker temporarily alters the mode with which pacing therapy is delivered so as to selectively alter the heart chambers that are paced. The pacemaker detects any transient changes in pacing efficacy following the alteration in pacing mode. The pacemaker then assesses the contribution of particular heart chambers to pacing efficacy based on the alteration in the pacing mode and on any transient changes in the pacing efficacy. Additionally, techniques are provided herein for automatically adjusting pacing parameters to optimize the contribution of particular chambers to pacing efficacy.
摘要翻译：提供技术来评估和优化特定心室对起搏功效的贡献。简而言之，起搏器暂时改变了起搏治疗的方式，以便选择性地改变起搏的心室。心脏起搏器检测起搏模式改变后起搏功效的任何瞬时变化。起搏器然后根据起搏模式的改变以及起搏功效的任何暂时变化来评估特定心室对起搏功效的贡献。此外，本文提供了用于自动调整起搏参数以优化特定腔室对起搏功效的贡献的技术。

23. 发明申请

US20090036788A1 SYSTEMS AND METHODS FOR DETECTION OF VT AND VF FROM REMOTE SENSING ELECTRODES 有权
标题翻译：用于从远程感测电极检测VT和VF的系统和方法
公开(公告)号：US20090036788A1
公开(公告)日：2009-02-05
申请号：US12244607
申请日：2008-10-02
申请人： Yelena Nabutovsky , Taraneh Ghaffari Farazi , Anders Bjorling , Kjell Noren , Gene A. Bornzin
发明人： Yelena Nabutovsky , Taraneh Ghaffari Farazi , Anders Bjorling , Kjell Noren , Gene A. Bornzin
IPC分类号： A61B5/0456
CPC分类号： A61B5/046 , A61B5/04011 , A61B5/0464 , A61N1/3702 , A61N1/3956
摘要： Methods and systems are provided for performing ventricular arrhythmia monitoring using at least two sensing channels that are each associated with different sensing vectors, for example by different pairs of extracardiac remote sensing electrodes. Myopotential associated with each of the sensing channels in monitored, and a ventricular arrhythmia monitoring mode is selected based thereon (e.g., based on determined myopotential levels). Ventricular arrhythmia monitoring is then performed using the selected monitoring mode.
摘要翻译：提供的方法和系统用于使用至少两个感测通道进行心室心律失常监测，每个感测通道各自与不同的感测向量相关联，例如通过不同的心外感测电极对。与监测的每个感测通道相关联的神经电位和基于（例如，基于确定的电位电平）来选择心室心律失常监测模式。然后使用所选择的监测模式进行室性心律失常监测。

24. 发明授权

US08934963B1 Method and apparatus for monitoring arrythmogenic effects of medications using an implantable device 有权
标题翻译：用于使用可植入装置监测药物的致汗作用的方法和装置
公开(公告)号：US08934963B1
公开(公告)日：2015-01-13
申请号：US11623613
申请日：2007-01-16
申请人： Taraneh Ghaffari Farazi
发明人： Taraneh Ghaffari Farazi
IPC分类号： A61B5/0452 , A61B5/00
CPC分类号： A61B5/0452 , A61B5/04525 , A61B5/4839 , A61B5/4848 , A61N1/0563 , A61N1/3622 , A61N1/36507 , A61N1/36592 , A61N1/3684 , A61N1/37211
摘要： An implantable device and method for monitoring changes in the risk of arrhythmia induced by medications. The implantable device monitors risk of arrhythmia by analyzing an aspect of T-wave morphology to generate a metric of transmural dispersion of repolarization (“TDR”) as a proxy for the risk of arrhythmia. The implantable device generates an index of change in the risk of arrhythmia by comparing values of the metric of TDR obtained for different time periods. The implantable device generates a warning if the change in risk of arrhythmia is outside acceptable limits. The implantable device can also communicate with other devices to correlate changes in risk of arrhythmia with medications taken by the patient.
摘要翻译：用于监测由药物引起的心律失常风险变化的可植入装置和方法。可植入装置通过分析T波形态的一个方面来监测心律不齐的风险，以产生一种度量的复极化的透壁性分散（“TDR”）作为心律失常风险的代表。通过比较不同时间段获得的TDR的度量值，可植入装置产生心律失常风险的变化指标。如果心律失常风险的变化超出了可接受的限度，植入式装置会产生警告。可植入装置还可以与其他装置通信，以将心律不齐的风险变化与患者所采取的药物相关联。

25. 发明授权

US08874213B2 System and method for monitoring diastolic function using an implantable medical device 有权
标题翻译：使用可植入医疗装置监测舒张功能的系统和方法
公开(公告)号：US08874213B2
公开(公告)日：2014-10-28
申请号：US13601569
申请日：2012-08-31
申请人： Allen Keel , Steve Koh , Taraneh Ghaffari Farazi
发明人： Allen Keel , Steve Koh , Taraneh Ghaffari Farazi
IPC分类号： A61N1/362 , A61N1/37 , A61N1/368 , A61N1/365
CPC分类号： A61N1/3702 , A61N1/3627 , A61N1/36507 , A61N1/368 , A61N1/3712
摘要： Diastolic function is monitored within a patient using a pacemaker or other implantable medical device. In one example, the implantable device uses morphological parameters derived from the T-wave evoked response waveform as proxies for ventricular relaxation rate and ventricular compliance. In particular, the magnitude of the peak of the T-wave evoked response is employed as a proxy for ventricular compliance. The maximum slew rate of the T-wave evoked response following its peak is employed as a proxy for ventricular relaxation. A metric is derived from these proxy values to represent diastolic function. The metric is tracked over time to evaluate changes in diastolic function. In other examples, specific values for ventricular compliance and ventricular relaxation are derived for the patient based on the T-wave evoked response parameters.
摘要翻译：使用起搏器或其他可植入医疗器械在患者体内监测舒张功能。在一个示例中，可植入装置使用从T波诱发反应波形导出的形态参数作为心室松弛率和心室顺应性的代理。特别地，T波诱发反应的峰值的大小被用作心室顺应性的代表。其峰值后的T波诱发反应的最大压摆率被用作心室松弛的代用品。来自这些代理值的度量来表示舒张功能。随着时间的推移跟踪度量以评估舒张功能的变化。在其他实例中，基于T波诱发反应参数为患者导出心室顺应性和心室松弛的具体值。

26. 发明授权

US08473068B2 Subcardiac threshold vagal nerve stimulation 有权
标题翻译：子心脏门槛迷走神经刺激
公开(公告)号：US08473068B2
公开(公告)日：2013-06-25
申请号：US12873868
申请日：2010-09-01
申请人： Taraneh Ghaffari Farazi
发明人： Taraneh Ghaffari Farazi
IPC分类号： A61N1/36 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3684 , A61N1/3688
摘要： In one embodiment, an implantable stimulation apparatus includes a vagal nerve stimulator configured to generate electrical pulses below a cardiac threshold of a heart, and an electrode coupled to the vagal nerve stimulator which is configured to transmit the electrical pulses below the cardiac threshold, to a vagal nerve so as to inhibit injury resulting from an ischemia and/or reduce injury resulting from an ischemia. In another embodiment, an implantable stimulation apparatus includes a vagal nerve stimulator configured to generate electrical pulses below a cardiac threshold, and includes an electrode, which is coupled to the vagal nerve stimulator and configured transmit electrical pulses to a vagal nerve so as to reduce a defibrillation threshold of the heart.
摘要翻译：在一个实施例中，植入式刺激装置包括迷走神经刺激器，其被配置为产生低于心脏心脏阈值的电脉冲，以及耦合到迷走神经刺激器的电极，其被配置为将低于心脏阈值的电脉冲传输到迷走神经刺激器迷走神经，以抑制由缺血引起的损伤和/或减少由局部缺血引起的损伤。在另一个实施例中，可植入刺激装置包括迷走神经刺激器，其被配置为产生低于心脏阈值的电脉冲，并且包括耦合到迷走神经刺激器的电极，并配置为迷走神经的传输电脉冲，以减少心脏除颤阈值。

27. 发明授权

US08449472B2 Neurostimulation and neurosensing techniques to optimize atrial anti-tachycardia pacing for prevention of atrial tachyarrhythmias 有权
标题翻译：神经刺激和神经感应技术优化房性心动过速起搏预防房性快速性心律失常
公开(公告)号：US08449472B2
公开(公告)日：2013-05-28
申请号：US12891429
申请日：2010-09-27
申请人： Kyungmoo Ryu , Jong Gill , Taraneh Ghaffari Farazi , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Taraneh Ghaffari Farazi , Gene A. Bornzin
IPC分类号： A61B5/02 , A61N1/00
CPC分类号： A61N1/3621 , A61N1/36114 , A61N1/3624
摘要： Implantable systems and method for use therewith are provided that take advantage of various neuromodulation and neurosensing techniques for either preventing atrial fibrillation (AF) or terminating AF. Specific embodiments are for use with an implantable device that includes one or more atrial electrode for sensing atrial fibrillation (AF) and/or delivering Atrial Anti-Tachycardia Pacing (AATP) and one or more electrode for monitoring and/or stimulating atrial vagal fat pads.
摘要翻译：提供了可植入系统及其使用的方法，其利用各种神经调节和神经感应技术来预防心房颤动（AF）或终止AF。具体实施方案用于可植入装置，其包括一个或多个心房电极，用于感测心房颤动（AF）和/或递送心房抗心动过速起搏（AATP）和用于监测和/或刺激心房迷走神经脂肪垫的一个或多个电极。

28. 发明授权

US08401627B1 Methods and systems for monitoring heart instabilities 有权
标题翻译：监测心脏不稳定的方法和系统
公开(公告)号：US08401627B1
公开(公告)日：2013-03-19
申请号：US11848631
申请日：2007-08-31
申请人： Taraneh Ghaffari Farazi , Fujian Qu
发明人： Taraneh Ghaffari Farazi , Fujian Qu
IPC分类号： A61N1/362
CPC分类号： A61N1/3702 , A61N1/36592
摘要： Systems and method for assessing a patient's myocardial electrical stability by pacing a patient's heart using a pacing sequence that includes at least two different types of pacing pulses. The pacing rate used is preferably only slightly above the patient's intrinsic heart rate. A degree of alternans, in a signal (e.g., IEGM or ECG) that is indicative of cardiac activity in response to the pacing sequence, is determined. The degree of alternans can be determined by comparing portions of the signal that are indicative of cardiac activity in response to the first type of pacing pulses to portions of the signal that are indicative of cardiac activity in response to the second type of pacing pulses. The patient's myocardial electrical stability is assessed based on the determined degree of alternans.
摘要翻译：通过使用包括至少两种不同类型的起搏脉冲的起搏序列来对患者的心脏进行起搏来评估患者的心肌电稳定性的系统和方法。起搏率优选仅略高于患者的内在心率。确定在响应于起搏序列指示心脏活动的信号（例如，IEGM或ECG）中的交替量的程度。可以通过将响应于第一类型的起搏脉冲的指示心脏活动的部分的信号的部分与响应于第二类型的起搏脉冲的指示心脏活动的信号的部分进行比较来确定交替的程度。基于确定的交替量程度评估患者的心肌电稳定性。

29. 发明授权

US08385999B1 Processing venous oxygen saturation and hematocrit information in an implantable sensor 有权
标题翻译：在植入式传感器中处理静脉血氧饱和度和血细胞比容信息
公开(公告)号：US08385999B1
公开(公告)日：2013-02-26
申请号：US12028261
申请日：2008-02-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
IPC分类号： A61B5/00
CPC分类号： A61N1/39 , A61B5/0031 , A61B5/14535 , A61B5/14551 , A61B5/4836 , A61N1/362
摘要： Methods of processing venous oxygen saturation and hematrocrit information in an implantable sensor are provided. In an embodiment a method for collecting data from an implantable multi-wavelength SvO2 sensor having multiple light sources is provided. The method includes receiving a frame signal that indicates a beginning of the light sources being turned on and receiving a light source signal that indicates a light source is on. The output of a photodetector is sampled to measure the intensity of the transmitted light. The process is repeated for each light source to gather intensity measurements that then can be used to generate venous oxygen saturation and hematocrit measurements.
摘要翻译：提供了在可植入传感器中处理静脉血氧饱和度和血细胞信息的方法。在一个实施例中，提供了一种用于从具有多个光源的可植入多波长SvO2传感器收集数据的方法。该方法包括接收指示光源开始接通的帧信号，并接收指示光源所接通的光源信号。对光检测器的输出进行采样以测量透射光的强度。对于每个光源重复该过程以收集强度测量，然后可以使用该测量来产生静脉血氧饱和度和血细胞比容测量。

30. 发明授权

US08326429B2 Acquiring nerve activity from carotid body and/or sinus 有权
公开(公告)号：US08326429B2
公开(公告)日：2012-12-04
申请号：US13088223
申请日：2011-04-15
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
IPC分类号： A61N1/08
CPC分类号： A61B5/04001 , A61B5/4047 , A61B5/4818 , A61B5/4866 , A61B5/7264 , A61N1/36117 , A61N1/365 , A61N1/3702
摘要： An exemplary includes acquiring an electroneurogram of the right carotid sinus nerve or the left carotid sinus nerve, analyzing the electroneurogram for at least one of chemosensory information and barosensory information and calling for one or more therapeutic actions based at least in part on the analyzing. Therapeutic actions may aim to treat conditions such as sleep apnea, an increase in metabolic demand, hypoglycemia, hypertension, renal failure, and congestive heart failure. Other exemplary methods, devices, systems, etc., are also disclosed.

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