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21. 发明授权

US08409272B2 Sustained drug-releasing stent 失效
标题翻译：持续放药支架
公开(公告)号：US08409272B2
公开(公告)日：2013-04-02
申请号：US12733460
申请日：2008-09-03
申请人： Ikuo Omura , Zhen Yu Jin , Shuzo Yamashita , Hiroo Iwata , Akira Mochizuki
发明人： Ikuo Omura , Zhen Yu Jin , Shuzo Yamashita , Hiroo Iwata , Akira Mochizuki
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0067 , A61K9/0024 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/608 , A61L2420/08
摘要： A stent includes a stent body of a cylindrical configuration having outer and inner surfaces, a first coated layer coating at least the outer surface, and a second coated layer coating substantially completely over the first coated layer. The first coated layer is prepared of a first composition comprising a polymer and a vascular intimal hyperplasia inhibitor (preferably argatroban) of a kind, which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the inhibitor being within the range of 8:2 to 3:7. On the other hand, the second coated layer is prepared of a polymer alone or a second composition comprising a polymer and a drug, the weight compositional ratio of the drug to 80% by weight of the polymer being less than 20% by weight.
摘要翻译：支架包括具有外表面和内表面的圆柱形构造的支架体，至少涂覆外表面的第一涂层，以及基本上完全覆盖在第一涂层上的第二涂层涂层。第一涂层由包含不抑制内皮细胞增殖的聚合物和血管内膜增生抑制剂（优选阿加曲班）的第一组合物制备，聚合物与抑制剂的重量组成比在该范围内 8：2到3：7。另一方面，第二涂层由单独的聚合物或包含聚合物和药物的第二组合物制备，所述药物与所述聚合物的80重量％的重量组成比小于20重量％。

22. 发明申请

US20100198344A1 SUSTAINED DRUG-RELEASING STENT 失效
标题翻译：持续的药物释放
公开(公告)号：US20100198344A1
公开(公告)日：2010-08-05
申请号：US12733460
申请日：2008-09-03
申请人： Ikuo Omura , Zhen Yu Jin , Shuzo Yamashita , Hiroo Iwata , Akira Mochizuki
发明人： Ikuo Omura , Zhen Yu Jin , Shuzo Yamashita , Hiroo Iwata , Akira Mochizuki
IPC分类号： A61F2/82 , B05D3/00 , A61K31/4709 , A61P7/00
CPC分类号： A61F2/82 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0067 , A61K9/0024 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/608 , A61L2420/08
摘要： A stent includes a stent body of a cylindrical configuration having outer and inner surfaces, a first coated layer coating at least the outer surface, and a second coated layer coating substantially completely over the first coated layer. The first coated layer is prepared of a first composition comprising a polymer and a vascular intimal hyperplasia inhibitor (preferably argatroban) of a kind, which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the inhibitor being within the range of 8:2 to 3:7. On the other hand, the second coated layer is prepared of a polymer alone or a second composition comprising a polymer and a drug, the weight compositional ratio of the drug to 80% by weight of the polymer being less than 20% by weight.
摘要翻译：支架包括具有外表面和内表面的圆柱形构造的支架体，至少涂覆外表面的第一涂层，以及基本上完全覆盖在第一涂层上的第二涂层涂层。第一涂层由包含不抑制内皮细胞增殖的聚合物和血管内膜增生抑制剂（优选阿加曲班）的第一组合物制备，聚合物与抑制剂的重量组成比在该范围内 8：2到3：7。另一方面，第二涂层由单独的聚合物或包含聚合物和药物的第二组合物制备，所述药物与所述聚合物的80重量％的重量组成比小于20重量％。

23. 发明申请

US20090131271A1 METHOD FOR DELIVERING NUCLEIC ACID AND DEVICE FOR DELIVERING NUCLEIC ACID 审中-公开
标题翻译：用于递送核酸的方法和用于递送核酸的装置
公开(公告)号：US20090131271A1
公开(公告)日：2009-05-21
申请号：US11914702
申请日：2006-05-16
申请人： Takuro Niidome , Fumio Wada , Yoshiki Katayama , Kosuke Yakumaru , Takahito Kawano , Shuzo Yamashita
发明人： Takuro Niidome , Fumio Wada , Yoshiki Katayama , Kosuke Yakumaru , Takahito Kawano , Shuzo Yamashita
IPC分类号： C40B30/06 , C12N15/87 , C40B60/12 , C12M1/00
CPC分类号： C12N15/87
摘要： In a method for delivering a nucleic acid of the invention, a nucleic acid is introduced into a cell by pressing the nucleic acid supported on a surface of a solid substrate against the cell. According to the method, the nucleic acid can be delivered into the cell simply at a low cost without placing a heavy burden on the cell at a high nucleic acid delivery efficiency. By allowing the surface of the solid substrate to support the nucleic acid in the form of a complex with a polyamine or a cationic lipid and pressing it against the cell, the introduction efficiency into the cell can be further improved. In the invention, by using a nucleic acid useful for gene therapy as the nucleic acid, a high-efficiency device for gene therapy can be obtained.
摘要翻译：在递送本发明的核酸的方法中，通过将负载在固体基质表面上的核酸压在细胞上，将核酸引入细胞。根据该方法，可以简单地以低成本将核酸递送到细胞中，而不会以高核酸输送效率对细胞施加沉重的负担。通过使固体基质的表面以与多胺或阳离子脂质的复合物的形式支持核酸并将其压在细胞上，可以进一步提高进入细胞的引入效率。在本发明中，通过使用用于基因治疗的核酸作为核酸，可以获得用于基因治疗的高效装置。

24. 发明授权

US4317729A Ethylene-vinyl alcohol copolymer hollow fiber membranes and method of producing same 失效
标题翻译：乙烯 - 乙烯醇共聚物中空纤维膜及其制备方法
公开(公告)号：US4317729A
公开(公告)日：1982-03-02
申请号：US142227
申请日：1980-04-21
申请人： Shuzo Yamashita , Taku Tanaka , Hirokuni Tanii , Akira Kubotsu , Syuji Kawai
发明人： Shuzo Yamashita , Taku Tanaka , Hirokuni Tanii , Akira Kubotsu , Syuji Kawai
IPC分类号： D01F6/04 , B01D69/08 , B01D71/38 , D01D5/24 , D01F6/30 , D01F6/34 , B29D27/04 , D02G3/00
CPC分类号： D01F6/30 , B01D69/08 , B01D71/38 , D01D5/24 , D01F6/34 , Y10T428/2935 , Y10T428/2975
摘要： A hollow fiber membrane made of an ethylene-vinyl alcohol copolymer is provided, which is characterized in that, when observed in a dry state with an electron microscope, the hollow fiber membrane has at least one dense, active layer (or skin layer) on the inside and/or outside surface thereof and further a three-layered structure comprising two layers respectively contacting the inside and outside surfaces and each consisting of a plurality of particles bonded together and having particle sizes of 0.01 to 2 microns and a substantially particle-free homogeneous layer lying between the two layers.A method of producing such hollow fiber membranes is also provided comprising spinning a spinning solution prepared by dissolving an ethylene-vinyl alcohol copolymer in a solvent mainly consisting of dimethyl sulfoxide, dimethylacetamide, pyrrolidone, N-methylpyrrolidone or a mixture of these through a spinneret for hollow fiber production while simultaneously introducing a coagulating liquid through the central aperture of said spinneret, passing the spun fiber through a gaseous atmosphere such that the fiber is drawn to 3 to 30 times its extrusion rate, and coagulating the fiber in a coagulation bath at a temperature within the range specified below:When 15.ltoreq.C.ltoreq.40, -15.ltoreq.T.ltoreq.1/4C+10where C is polymer concentration (weight %) and T is coagulation temperature (.degree.C.).
摘要翻译：提供一种由乙烯 - 乙烯醇共聚物制成的中空纤维膜，其特征在于，当用电子显微镜在干燥状态下观察时，中空纤维膜具有至少一个致密的有源层（或表层）其内部和/或外部表面，并且还包括三层结构，其包括分别接触内表面和外表面的两层，并且各自由粘合在一起并具有0.01至2微米的颗粒尺寸和基本上无颗粒的多个颗粒组成均匀层位于两层之间。还提供了制造这种中空纤维膜的方法，包括将通过将乙烯 - 乙烯醇共聚物溶解在主要由二甲基亚砜，二甲基乙酰胺，吡咯烷酮，N-甲基吡咯烷酮或它们的混合物的溶剂中制备的纺丝溶液通过喷丝头纺丝，中空纤维生产，同时通过所述喷丝头的中心孔引入凝固液，使纺丝纤维通过气态气氛，使得纤维被拉伸至其挤出速率的3至30倍，并将纤维在凝固浴中凝固温度在下面规定的范围内：当15℃/ 40℃时，-15℃= 1 / 4C + 10其中C是聚合物浓度（重量％），T是凝固温度（℃））。

25. 发明授权

US4269713A Ethylene-vinyl alcohol copolymer membrane and a method for producing the same 失效
标题翻译：乙烯 - 乙烯醇共聚物膜及其制备方法
公开(公告)号：US4269713A
公开(公告)日：1981-05-26
申请号：US71671
申请日：1979-08-31
申请人： Shuzo Yamashita , Syuji Kawai , Hirokuni Tanii , Koichi Takakura
发明人： Shuzo Yamashita , Syuji Kawai , Hirokuni Tanii , Koichi Takakura
IPC分类号： B01D67/00 , B01D69/02 , B01D69/08 , B01D71/38 , B01D39/18 , B01D13/00 , B01D31/00
CPC分类号： B01D71/38 , B01D67/0009 , B01D69/02 , B01D69/08 , B01D2323/12 , B01D2325/02 , Y10T428/2975
摘要： There is described an ethylene-vinyl alcohol copolymer membrane comprising at least a skin layer on its surface and a porous layer supporting the skin layer. The porous layer, when the membrane is observed in the dry state with an electron microscope, contains vacuoles or voids, which present a mono- or multi-layer structure and have straight-line lengths corresponding to 20-99% of the whole thickness of the membrane. In addition, the polymer portion of the porous layer has micropores with an average pore diameter of 0.1-5 microns and the membrane has a porosity of 60-90%.
摘要翻译：描述了在其表面上至少包含表层的乙烯 - 乙烯醇共聚物膜和支撑表皮层的多孔层。当用电子显微镜在干燥状态下观察膜时，多孔层包含空泡或空隙，其呈现单层或多层结构，并且具有对应于整个厚度的20-99％的直线长度膜。此外，多孔层的聚合物部分具有平均孔径为0.1-5微米的微孔，并且膜具有60-90％的孔隙率。

26. 发明授权

US08435287B2 Stent and method for fabricating the same 失效
标题翻译：支架及其制造方法
公开(公告)号：US08435287B2
公开(公告)日：2013-05-07
申请号：US12088000
申请日：2007-01-15
申请人： Tatsuyuki Nakatani , Keishi Okamoto , Shuzo Yamashita , Ikuo Komura , Koji Mori
发明人： Tatsuyuki Nakatani , Keishi Okamoto , Shuzo Yamashita , Ikuo Komura , Koji Mori
IPC分类号： A61F2/06
CPC分类号： A61L31/084 , A61F2/91 , A61F2250/0067 , A61L31/10 , A61L31/16 , A61L33/025 , A61L2300/416 , A61L2300/606 , A61L2420/08
摘要： A stent includes a tubular stent body 11, a diamond-like carbon film 12 formed on the surface of the stent body 11 and having an activated surface, and a polymer layer 13 immobilized on the surface of the diamond-like carbon film. The polymer layer 13 contains a drug 14 having an effect to prevent restenosis, and the drug 14 is gradually released from the polymer layer 13.
摘要翻译：支架包括管状支架体11，形成在支架主体11的表面上并具有活化表面的类金刚石碳膜12和固定在金刚石状碳膜表面上的聚合物层13。聚合物层13含有具有防止再狭窄作用的药物14，药物14从聚合物层13逐渐释放。

27. 发明申请

US20090209942A1 MEDICAL DEVICE HAVING DIAMOND-LIKE THIN FILM AND METHOD FOR MANUFACTURING THEREOF 有权
标题翻译：具有类似金刚石薄膜的医疗装置及其制造方法
公开(公告)号：US20090209942A1
公开(公告)日：2009-08-20
申请号：US12301003
申请日：2007-01-15
申请人： Tatsuyuki Nakatani , Keishi Okamoto , Shuzo Yamashita , Koji Mori , Ikuo Komura
发明人： Tatsuyuki Nakatani , Keishi Okamoto , Shuzo Yamashita , Koji Mori , Ikuo Komura
IPC分类号： A61L27/30 , A61L29/10
CPC分类号： A61L31/088 , A61F2/0077 , A61L31/10 , A61M25/0045 , C08L43/04
摘要： A medical device includes a medial device body, and a diamond-like thin film covering the medical device body and containing silicon. The diamond-like thin film has a concentration of silicon which is lower in a surface thereof than in an interface thereof with the medical device body mentioned above, and continuously varies.
摘要翻译：医疗装置包括中间装置主体和覆盖医疗装置主体并且含有硅的金刚石状薄膜。菱形薄膜的表面的硅浓度比上述医疗装置体的界面低，连续变化。

28. 发明授权

US08968392B2 Method of inhibiting vascular intimal hyperplasia using stent 有权
标题翻译：使用支架抑制血管内膜增生的方法
公开(公告)号：US08968392B2
公开(公告)日：2015-03-03
申请号：US13561828
申请日：2012-07-30
申请人： Ikuo Omura , Zhen Yu Jin , Shuzo Yamashita , Hiroo Iwata , Akira Mochizuki
发明人： Ikuo Omura , Zhen Yu Jin , Shuzo Yamashita , Hiroo Iwata , Akira Mochizuki
IPC分类号： A61F2/82 , A61F2/00 , A61L33/00 , A61F2/915 , A61K9/00 , A61L31/10 , A61L31/16 , A61F2/91
CPC分类号： A61F2/82 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0067 , A61K9/0024 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/608 , A61L2420/08
摘要： A method of inhibiting vascular intimal hyperplasia including: placing a stent within a blood vessel, the stent having a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces, a first coated layer coating at least the outer surface of the stent body, the first coated layer being prepared of a first composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, comprising argatroban, which does not inhibit proliferation of endothelial cells, the weight composition ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 7:3, and a second coated layer; and causing argatroban to be released from the stent to thereby inhibit the vascular intimal hyperplasia without inhibiting proliferation of endothelial cells.
摘要翻译：一种抑制血管内膜增生的方法，包括：将支架放置在血管内，所述支架具有圆柱形构造的支架主体，其外表面和内表面具有涂覆在其上的金刚石状薄膜，第一涂层涂层至少支架体的外表面，第一涂层由包含生物可降解聚合物和一种血管内膜增生抑制剂的第一组合物制成，其包含不抑制内皮细胞增殖的阿加曲班，其重量组成比血管内膜增生抑制剂的聚合物在8:2至7:3的范围内，以及第二涂层; 并使阿加曲班从支架释放，从而抑制血管内膜增生而不抑制内皮细胞的增殖。

29. 发明申请

US20130018455A1 METHOD OF INHIBITING VASCULAR INTIMAL HYPERPLASIA USING STENT 审中-公开
标题翻译：使用静脉阻塞血管紧张素血症的方法
公开(公告)号：US20130018455A1
公开(公告)日：2013-01-17
申请号：US13561828
申请日：2012-07-30
申请人： Ikuo Omura , Zhen Yu Jin , Shuzo Yamashita , Hiroo Iwata , Akira Mochizuki
发明人： Ikuo Omura , Zhen Yu Jin , Shuzo Yamashita , Hiroo Iwata , Akira Mochizuki
IPC分类号： A61F2/82 , A61K9/00
CPC分类号： A61F2/82 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0067 , A61K9/0024 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/608 , A61L2420/08
摘要： A method of inhibiting vascular intimal hyperplasia including: placing a stent within a blood vessel, the stent having a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces, a first coated layer coating at least the outer surface of the stent body, the first coated layer being prepared of a first composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, comprising argatroban, which does not inhibit proliferation of endothelial cells, the weight composition ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 7:3, and a second coated layer; and causing argatroban to be released from the stent to thereby inhibit the vascular intimal hyperplasia without inhibiting proliferation of endothelial cells.
摘要翻译：一种抑制血管内膜增生的方法，包括：将支架放置在血管内，所述支架具有圆柱形构造的支架主体，其外表面和内表面具有涂覆在其上的金刚石状薄膜，第一涂层涂层至少支架体的外表面，第一涂层由包含生物可降解聚合物和一种血管内膜增生抑制剂的第一组合物制成，其包含不抑制内皮细胞增殖的阿加曲班，其重量组成比血管内膜增生抑制剂的聚合物在8:2至7:3的范围内，以及第二涂层; 并使阿加曲班从支架释放，从而抑制血管内膜增生而不抑制内皮细胞的增殖。

30. 发明授权

US07931934B2 Medical device having diamond-like thin film and method for manufacturing thereof 有权
标题翻译：具有类金刚石薄膜的医疗装置及其制造方法
公开(公告)号：US07931934B2
公开(公告)日：2011-04-26
申请号：US12301003
申请日：2007-01-15
申请人： Tatsuyuki Nakatani , Keishi Okamoto , Shuzo Yamashita , Koji Mori , Ikuo Komura
发明人： Tatsuyuki Nakatani , Keishi Okamoto , Shuzo Yamashita , Koji Mori , Ikuo Komura
IPC分类号： B05D3/00 , H01L29/15 , A61F2/06
CPC分类号： A61L31/088 , A61F2/0077 , A61L31/10 , A61M25/0045 , C08L43/04
摘要： A medical device includes a medial device body, and a diamond-like thin film covering the medical device body and containing silicon. The diamond-like thin film has a concentration of silicon which is lower in a surface thereof than in an interface thereof with the medical device body mentioned above, and continuously varies.
摘要翻译：医疗装置包括中间装置主体和覆盖医疗装置主体并且含有硅的金刚石状薄膜。菱形薄膜的表面的硅浓度比上述医疗装置体的界面低，连续变化。

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