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21. 发明申请

US20170216402A1 SYNERGISTIC TUMOR TREATMENT WITH IL-2 AND INTEGRIN-BINDING-FC-FUSION PROTEIN 审中-公开
公开(公告)号：US20170216402A1
公开(公告)日：2017-08-03
申请号：US15501028
申请日：2015-08-12
申请人： Massacusetts Institute of Technology , STANFORD UNIVERSITY
发明人： Karl Dane WITTRUP , Jennifer R. COCHRAN , Byron Hua KWAN
IPC分类号： A61K38/20 , A61K38/16 , C07K16/22 , C07K16/28 , C07K16/40 , C07K16/30 , A61K38/38 , A61K39/395
CPC分类号： A61K38/2013 , A61K38/16 , A61K38/179 , A61K38/385 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K14/55 , C07K16/22 , C07K16/249 , C07K16/28 , C07K16/2803 , C07K16/2812 , C07K16/2815 , C07K16/2818 , C07K16/30 , C07K16/3053 , C07K16/40 , C07K2317/52 , C07K2317/71 , C07K2317/76 , C07K2319/30 , C07K2319/31 , C07K2319/70 , A61K2300/00
摘要： The present invention provides a method of treating cancer with a combination of IL-2 and an integrin-binding-Fc fusion protein. The methods of the invention can be applied to a broad range of cancer types.

22. 发明申请

US20160253466A1 SYSTEMS AND METHODS FOR QUANTITATIVE ANALYSIS OF HISTOPATHOLOGY IMAGES USING MULTICLASSIFIER ENSEMBLE SCHEMES 有权
标题翻译：使用多分类器方案对组织病理学图像进行定量分析的系统和方法
公开(公告)号：US20160253466A1
公开(公告)日：2016-09-01
申请号：US15028314
申请日：2014-10-10
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , STANFORD UNIVERSITY
发明人： Sos Agaian , Clara M. Mosquera-Lopez , Aaron Greenblatt
IPC分类号： G06F19/00 , G06K9/46 , G06K9/66 , G06T7/20 , G06K9/34 , G06T7/00 , G06K9/62
CPC分类号： G16H50/20 , G06F19/00 , G06F19/345 , G06K9/0014 , G06K9/34 , G06K9/4652 , G06K9/6212 , G06K9/628 , G06K9/629 , G06K9/66 , G06K2009/4666 , G06N3/0427 , G06N5/043 , G06N99/005 , G06T7/0012 , G06T7/0014 , G06T7/246 , G06T2207/10024 , G06T2207/10056 , G06T2207/20036 , G06T2207/20064 , G06T2207/20081 , G06T2207/20084 , G06T2207/30024 , G06T2207/30096
摘要： Described herein are systems and methods for performing multi-stage detection and classification of cancer regions from digitized images of biopsy slides. Novel methods for processing the digitized images to improve feature extraction and structure identification are disclosed, including but not limited to the use of quaternions, logarithmic mappings of color channels, and application of wavelets to logarithmic color channel mappings. The extracted features are utilized in improved machine learning algorithms that are further optimized to analyze multiple color channels in multiple dimensions. The improved machine learning algorithms include techniques for accelerating the training of the algorithms, making their application to biopsy detection and classification practical for the first time. The performance of the described systems and methods are further improved by the disclosure of a novel multistage machine learning scheme, in which additional classifiers are utilized to choose among the classes proposed by other classifiers in close cases.
摘要翻译：本文描述了用于从活检片的数字化图像执行癌症区域的多级检测和分类的系统和方法。公开了用于处理数字化图像以改进特征提取和结构识别的新颖方法，包括但不限于使用四元数，颜色通道的对数映射以及将小波应用于对数色彩通道映射。提取的特征被用于改进的机器学习算法中，其被进一步优化以分析多个维度中的多个颜色通道。改进的机器学习算法包括加速算法训练的技术，使其应用于活检检测和分类首次实用。所描述的系统和方法的性能通过公开新颖的多级机器学习方案进一步改进，其中使用附加分类器在紧密情况下由其他分类器提出的类别中选择。

23. 发明申请

US20140280224A1 Systems and Methods for Recommending Relationships within a Graph Database 审中-公开
标题翻译：在图表数据库中推荐关系的系统和方法
公开(公告)号：US20140280224A1
公开(公告)日：2014-09-18
申请号：US14212222
申请日：2014-03-14
申请人： STANFORD UNIVERSITY
发明人： Evan Feinberg , Julien Clancy
IPC分类号： G06F17/30
CPC分类号： G06F17/30958
摘要： Systems and methods for relationship recommendations systems in accordance with embodiments of the invention are illustrated. In one embodiment, a relationship recommendation server system includes a processor wherein a relationship recommendation program configures the processor to obtain a graph database including a set of nodes including node attribute data and a set of edges including edge attribute data and describing relationships between nodes in the set of nodes, determine a set of motif data, where the motif data describes at least one subgraph including a subset of the nodes and a subset of the edges within the graph database, obtain a search node, generate additional edges between the search node and a subset of the nodes within the graph database, where the additional edges form subgraphs including the search node that are isomorphic to a subset of the motif data, and recommend relationships based on the generated additional edges.
摘要翻译：示出了根据本发明的实施例的关系建议系统的系统和方法。在一个实施例中，关系推荐服务器系统包括处理器，其中关系推荐程序配置处理器以获得图形数据库，其包括包括节点属性数据的一组节点和包括边缘属性数据的一组边缘，以及描述在确定一组主题数据，其中主题数据描述包括节点的子集和图形数据库内的边缘的子集的至少一个子图，获得搜索节点，在搜索节点和图形数据库中的节点的子集，其中附加边缘形成包括与图案数据的子集同构的搜索节点的子图，以及基于所生成的附加边缘推荐关系。

24. 发明申请

US20140277666A1 SYSTEMS AND METHODS FOR GENERATING SCHEDULING OPTIONS IN CONSIDERATION OF SPECIFIC SPACE CONSTRAINTS WITHIN A CONSTRUCTION SITE 审中-公开
标题翻译：用于在施工现场考虑特定空间限制的时间安排选项的系统和方法
公开(公告)号：US20140277666A1
公开(公告)日：2014-09-18
申请号：US13831946
申请日：2013-03-15
申请人： STANFORD UNIVERSITY
发明人： Rene Morkos
IPC分类号： G05B19/418
摘要： Systems and methods for generating scheduling options in consideration of space and resource constraints in accordance with embodiments of the invention are disclosed. One embodiment of the invention includes a scheduling application that configures the processor to generate a project schedule from a TODO list comprising a plurality of construction operations, where the construction operations comprise at least one specific space requirements within a construction site, resource requirements, and a duration time.
摘要翻译：公开了考虑到根据本发明的实施例的空间和资源约束产生调度选项的系统和方法。本发明的一个实施例包括调度应用，其配置处理器以从包括多个施工操作的TODO列表生成项目进度，其中施工操作包括施工现场内的至少一个特定空间要求，资源要求和持续时间

25. 发明申请

US20040259102A1 DETECTION OF CHEMICAL LIGATION USING FLUORESCENCE QUENCHING LEAVING GROUPS 有权
标题翻译：使用荧光猝灭组检测化学物质
公开(公告)号：US20040259102A1
公开(公告)日：2004-12-23
申请号：US10604400
申请日：2003-07-17
申请人： Stanford University
发明人： Eric T. KOOL
IPC分类号： C12Q001/68 , G01N033/53 , C07H021/04 , C07K014/00
CPC分类号： G01N33/533 , C12Q1/6818 , C12Q1/6823 , C12Q1/6827 , G01N33/542 , C12Q2561/125 , C12Q2565/101
摘要： Novel compounds having a fluorescence quencher as a leaving group are disclosed. Nucleic acids and other molecules containing a fluorophore and a fluorescence quencher are disclosed as an embodiment of this invention. The use of the oligonucleotides in enzyme-free oligonucleotide ligation reactions results in an increase in fluorescence when the oligonucleotide also contains a nearby fluorophore. The ligation reactions can be performed in solution, on surfaces, or in cells.
摘要翻译：公开了具有荧光猝灭剂作为离去基团的新型化合物。公开了含有荧光团和荧光猝灭剂的核酸和其它分子作为本发明的实施方案。当寡核苷酸还含有附近的荧光团时，在无酶寡核苷酸连接反应中使用寡核苷酸导致荧光增加。连接反应可以在溶液，表面或细胞中进行。

26. 发明申请

US20040126797A1 Micro-array system for micro amount reaction 审中-公开
标题翻译：用于微量反应的微阵列系统
公开(公告)号：US20040126797A1
公开(公告)日：2004-07-01
申请号：US10690971
申请日：2003-10-21
申请人： NATIONAL TSING-HUA UNIVERSITY , STANFORD UNIVERSITY
发明人： Chih-Ying Hsu , Tzong-Hsiung Hseu , Ruey-Shing Huang , David R. Cox , Chien-ming Wu , Jiann Heng Chen , Min-Lung Tsai , Ming-Tsong Lai , Yong-Li Pan , Tai-ching Fan
IPC分类号： C12Q001/68 , C12M001/34
CPC分类号： B01L7/52 , B01F11/00 , B01F13/0059 , B01L3/50851 , B01L2200/0647 , B01L2300/0819 , B01L2300/1822 , B01L2300/1827 , B01L2400/0439
摘要： The present invention relates to a micro-array system and the uses thereof. Particularly, the micro-array system is for a micro amount of biomolecules carrying on a bioreaction in a reaction solution, which comprises a substrate comprising a plurality of micro-wells for receiving the reaction solution; a plurality of micro-beads placing in the reaction solution for the biomolecules attached on surfaces thereon; and a vibrating module for vibrating the substrate, which makes the biomolecules attached on the micro-beads react evenly. Optionally, the micro-array system further comprises a temperature control module for controlling the temperature of the reaction solution. The bioreaction performed in the micro-array system according to the invention has the advantages of having a high sensitivity, being easily post-manipulated, being easily operated, having a high reliability and being reusable.
摘要翻译：本发明涉及一种微阵列系统及其应用。特别地，微阵列系统用于在反应溶液中进行生物反应的微量生物分子，其包含含有多个用于接收反应溶液的微孔的底物; 将多个微珠放置在附着在其上的生物分子的反应溶液中; 以及用于使基板振动的振动模块，这使得附着在微珠上的生物分子反应均匀。任选地，微阵列系统还包括用于控制反应溶液的温度的温度控制模块。在根据本发明的微阵列中进行的生物反应具有高灵敏度，易于后操作，易于操作，具有高可靠性和可重复使用的优点。

27. 发明申请

US20020096690A1 Manufacture of semiconductor capacitively-coupled NDR device for applications such as high-density high-speed memories and power switches 失效
标题翻译：制造用于诸如高密度高速存储器和电源开关等应用的半导体电容耦合NDR器件
公开(公告)号：US20020096690A1
公开(公告)日：2002-07-25
申请号：US10103240
申请日：2002-03-20
申请人： Stanford University
发明人： Farid Nemati , James D. Plummer
IPC分类号： H01L029/74
CPC分类号： H01L29/74 , G11C11/39 , H01L27/0617 , H01L27/0688 , H01L27/1023 , H01L27/1027 , H01L27/11 , H01L27/1104 , H01L29/41716 , H01L29/42308 , H01L29/749 , H01L29/87
摘要： A novel capacitively coupled NDR device can be used to implement a variety of semiconductor circuits, including high-density SRAM cells and power thyristor structures. In one example embodiment, the NDR device is used as a thin vertical PNPN structure with capacitively-coupled gate-assisted turn-off and turn-on mechanisms. An SRAM based on this new device is comparable in cell area, standby current, architecture, speed, and fabrication process to a DRAM of the same capacity. In one embodiment, an NDR-based SRAM cell consists of only two elements, has an 8 F2 footprint, can operate at high speeds and low voltages, has a good noise-margin, and is compatible in fabrication process with main-stream CMOS. This cell significantly reduces standby power consumption compared to other types of NDR-based SRAMs.
摘要翻译：可以使用新颖的电容耦合NDR器件来实现各种半导体电路，包括高密度SRAM单元和功率晶闸管结构。在一个示例实施例中，NDR设备用作具有电容耦合门辅助关断和导通机制的薄垂直PNPN结构。基于这种新器件的SRAM在单元面积，待机电流，架构，速度和制造工艺方面相当于相同容量的DRAM。在一个实施例中，基于NDR的SRAM单元仅由两个元件组成，具有8F2封装，可以在高速和低电压下工作，具有良好的噪声余量，并且与主流CMOS的制造工艺兼容。与其他类型的基于NDR的SRAM相比，该单元显着降低了待机功耗。

28. 发明公开

US20230303990A1 PYRUVATE KINASE DEFICIENCY (PKD) GENE EDITING TREATMENT METHOD 审中-公开
公开(公告)号：US20230303990A1
公开(公告)日：2023-09-28
申请号：US18012894
申请日：2021-06-28
申请人： CENTRO DE INVESTIGACIONES ENERGÉTICAS, MEDIOAMBIENTALES Y TECNOLÓGICAS O.A., M.P. (CIEMAT) , CONSORCIO CENTRO DE INVESTIGACTIGACIÓN BIOMÉDICA EN RED , FUNDACIÓN INSTITUTO DE INVESTIGACIÓN SANITARIA FUNDACIÓN JIMÉNEZ DÍAZ , THE BOARD OF TRUSTEES OF THE LELAND STANFORD UNIVERSITY
发明人： José Carlos SEGOVIA SANZ , Oscar QUINTANA BUSTAMANTE , Sara FAÑANAS BAQUERO , Mathew PORTEUS
IPC分类号： C12N9/22 , C12N15/86
CPC分类号： C12N9/22 , C12N15/86 , C12N2310/20 , C12N2750/14143
摘要： The present invention relates to the treatment of Pyruvate Kinase Deficiency (PKD) using the Clustered- Regularly Interspaced Short Palindromic Repeats (CRISPR) system. This technology offers the possibility to design an improved single guide RNA (sgRNA), in particular, an improved crRNA to be associated with tracrRNA, which is incorporated into a CRISPR-associated protein (Cas9) to recognize and induce DNA double-strand breaks at a specific target location. DNA double-strand breaks will be repaired by homologous recombination (HR) in the presence of a donor sequence for PKLR gene repair.

29. 发明申请

US20220354893A1 BIOLOGICALLY RELEVANT ORTHOGONAL CYTOKINE/RECEPTOR PAIRS 有权
公开(公告)号：US20220354893A1
公开(公告)日：2022-11-10
申请号：US17815092
申请日：2022-07-26
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD UNIVERSITY , UNIVERSITY OF WASHINGTON
发明人： Kenan Christopher Garcia , Jonathan Sockolosky , David Baker , Chris King
IPC分类号： A61K35/17 , A61K38/17 , A61K38/20 , C07K14/55 , C12N5/0783 , C12N15/10
摘要： Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.

30. 发明申请

US20220190842A1 EMBEDDED DEEP COMPRESSION FOR TIME-SERIES DATA 有权
公开(公告)号：US20220190842A1
公开(公告)日：2022-06-16
申请号：US17439836
申请日：2019-03-22
申请人： Siemens Corporation , Stanford University
发明人： Chengtao Wen , Lingyun Wang , Juan L. Aparicio Ojea , Shubham Chandak , Kedar Shriram Tatwawadi , Tsachy Weissman
IPC分类号： H03M7/30 , G06N3/08
摘要： A lossy compression algorithm is described for performing data compression of high-frequency floating point time-series data, for example. The compression algorithm utilizes a prediction engine that employs at least one of a linear prediction model or a non-linear prediction model to calculate one-step-ahead prediction of a current data value at current sampling time t using N previous quantized data values, where N is the model order. A prediction error is determined between the predicted value and an actual value, and the prediction error is quantized. A quantized current data value is determined from the predicted value and the quantized prediction error. The quantized prediction error is sent from an edge device to a data decompressor on a cloud device. The decompressor reconstructs the quantized current data value using the received quantized prediction error and by generating the same predicted value as the compressor.

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