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21. 发明授权

US4805747A Arrangement for supplying cooling air to a brake disk 失效
标题翻译：将制冷空气供给到制动盘的配置
公开(公告)号：US4805747A
公开(公告)日：1989-02-21
申请号：US76859
申请日：1987-07-23
申请人： Wolfgang Moedinger , Michael Preiss , Reinhard Lechner
发明人： Wolfgang Moedinger , Michael Preiss , Reinhard Lechner
IPC分类号： B60T5/00 , F16D65/847 , F16D65/84
CPC分类号： B60T5/00 , F16D65/847
摘要： An arrangement for supplying cooling air to a brake disk of a front wheel brake comprises an air guiding duct that is developed to be partially flexible and, on the inlet side, has an air opening in the front end of a motor vehicle and, on the outlet side, has another air opening that is directed at the brake disk. Two air inlet openings in a brake disk guard plate are opposite said air opening and form a separate transversely directed air guiding system to the brake disk. The air guiding duct is provided with several rigid duct portions that are held so that they are be fixed at the vehicle, namely at the vehicle body, as well as at the wheel, namely at the wishbone, as well as adjacent to the brake disk at a guard plate. They are each connected with one another via flexible intermediate duct portions, in which case the rigid duct portions can be moved relative to one another together with their assorted vehicle components.
摘要翻译：用于向前轮制动器的制动盘供给冷却空气的装置包括：空气引导管，其被形成为部分柔性的，并且在入口侧具有在机动车辆的前端中的空气开口，并且在出口侧具有指向制动盘的另一个空气开口。制动盘保护板中的两个空气入口开口与所述空气开口相对，并且形成单独的横向导向系统到制动盘。空气引导管设置有几个刚性的管道部分，其被固定成使得它们被固定在车辆上，即在车体处，以及在车轮处，即在叉骨处，以及相邻于制动盘在守卫板上。它们各自通过柔性中间管道部分彼此连接，在这种情况下，刚性管道部分可以与其各种车辆部件一起相对于彼此移动。

22. 发明授权

US4235774A Penicillin derivatives 失效
标题翻译：青霉素衍生物
公开(公告)号：US4235774A
公开(公告)日：1980-11-25
申请号：US11347
申请日：1979-02-12
申请人： Michael Preiss , Hans-Bodo Konig , Karl G. Metzger , Gunter Schmidt
发明人： Michael Preiss , Hans-Bodo Konig , Karl G. Metzger , Gunter Schmidt
IPC分类号： A61K31/43 , A61P31/04 , C07D499/00 , C07D499/64 , C07D499/70
CPC分类号： C07D499/00
摘要： New penicillin derivatives, or esters or salts thereof, of the formula ##STR1## in which R is H or alkoxy,B is a heterocyclic radical,A is an ethylene, trimethylene or o-phenylene radical,D is --co-- or a direct bond, andZ is a hydrogen atom, an optionally substituted alkyl or alkenyl group, an optionally substituted cycloalkyl, cycloalkenyl or cycloalkadienyl group, an optionally substituted aryl group, an optionally substituted hetercyclyl group or an acyl radical.
摘要翻译：新颖的青霉素衍生物或其酯或其盐，其中R为H或烷氧基，B为杂环基，A为乙烯，三亚甲基或邻亚苯基，D为 - 或直接键，Z是氢原子，任选取代的烷基或烯基，任选取代的环烷基，环烯基或环二烯基，任选取代的芳基，任选取代的杂环基或酰基。

23. 发明授权

US4147693A .beta.Lactam antibiotics and process for their use 失效
标题翻译： {62内酰胺抗生素及其使用过程
公开(公告)号：US4147693A
公开(公告)日：1979-04-03
申请号：US631515
申请日：1975-11-13
申请人： Hans-Bodo Konig , Karl G. Metzger , Michael Preiss , Wilfried Schrock
发明人： Hans-Bodo Konig , Karl G. Metzger , Michael Preiss , Wilfried Schrock
IPC分类号： A61K31/43 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/545 , A61K31/546 , A61P31/04 , C07D233/34 , C07D233/38 , C07D333/00 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D499/00 , C07D499/04 , C07D499/64 , C07D499/66 , C07D499/68 , C07D501/20 , C07D503/00 , C07D505/00 , A61K31/54 , C07D499/46 , C07D501/34
CPC分类号： C07D505/00 , C07D233/38 , C07D499/00 , C07D503/00
摘要： 6-[.alpha.-(Imidazolidin-2-on-1-ylcarbonylamino)-substutited acetamido]penicillanic acids, and the correspondingly 7-substituted ceph-3-em-4-carboxylic acids, characterized by the presence of a methyleneamino or substituted methyleneamino group on the 3-nitrogen atom of the imidazolidine ring are antibacterial agents. The compounds, of which 6-[.alpha.-(3-benzaliminoimidazolidin-2-on-1-ylcarbonylamino)cyclohexa-1,4-dien-1-ylacetamido]penicillanic acid and 7-[.alpha.-(3-furylideneaminoimidazolidin-2-on-1-ylcarbonylamino)phenylacetamido]-3-(3-methylthiadiazol-5-ylthiomethyl)ceph-3-em-4-carboxylic acid are typical examples, are prepared through acylation of an 6-[.alpha.-(amino)substituted acetamido]penicillanic acid or the corresponding 7-[.alpha.-(amino)substituted acetamido]ceph-3-em-4-carboxylic acid with a reactive nucleofugic derivative of a 3-methyleneaminoimidazolidin-2-on-1-carboxylic acid.
摘要翻译： 6- [α-（咪唑烷-2-酮-1-基羰基氨基） - 亚氨基乙酰氨基]青霉烷酸和相应的7-取代的头孢-3-烯-4-羧酸，其特征在于存在亚甲基氨基或取代的亚甲基氨基咪唑烷环的3-氮原子上的基团是抗菌剂。其中6-（α-（3-亚苄基亚氨基咪唑烷-2-酮-1-基羰基氨基）环己-1,4-二烯-1-基乙酰胺基]青霉烷酸和7- [3-（3-亚芳基氨基咪唑烷-2-基） 1-基羰基氨基）苯乙酰氨基] -3-（3-甲基噻二唑-5-基硫甲基）头孢-3-烯-4-羧酸是典型的实例，通过酰化6- [α-（氨基）取代的乙酰氨基 ]青霉烷酸或相应的7- [α-（氨基）取代的乙酰氨基]头孢-3-烯-4-羧酸与3-亚甲基氨基咪唑烷-2-酮-1-羧酸的反应性核苷衍生物。

24. 发明授权

US4093722A Sulfonylimidazolidone substituted cephalosporins, antibacterial compositions containing them, and methods of combatting bacteria employing them 失效
标题翻译：磺酰基咪唑烷酮取代的头孢菌素，含有它们的抗菌组合物，以及使用它们的抗菌药物的方法
公开(公告)号：US4093722A
公开(公告)日：1978-06-06
申请号：US686103
申请日：1976-05-13
申请人： Wilfried Schrock , Hans-Bodo Konig , Michael Preiss , Karl Georg Metzger , Michael Walkowiak
发明人： Wilfried Schrock , Hans-Bodo Konig , Michael Preiss , Karl Georg Metzger , Michael Walkowiak
IPC分类号： A61K31/545 , C07D501/20 , C07D501/24 , C07D501/34
CPC分类号： C07D501/20
摘要： Cephalosporins of the formula ##STR1## their pharmaceutically-acceptable, nontoxic salts, and hydrates thereof are produced, whereinA is hydrogen; unsubstituted or substituted alkyl; aryl; or R.sub.1 --X--, whereinX is -CO- or -SO.sub.2 -, andR.sub.1 is hydrogen, unsubstituted or substituted alkyl; aryl; thienyl; furyl; amino; alkylamino; dialkylamino; pyrrolidyl; or piperidyl;Or whenX is -CO-,R.sub.1 can also be alkoxy;B is phenyl, methylphenyl, chlorophenyl, hydroxyphenyl or the moiety ##STR2## E is hydrogen, hydroxyl or acetoxy; and C is a center of chirality.These compounds are particularly useful for their antimicrobial and, particularly, antibacterial effects.
摘要翻译：生产下式的头孢菌素：其药学上可接受的无毒盐及其水合物，其中A是氢; 未取代或取代的烷基; 芳基; 或R 1 -X-，其中X是-CO-或-SO 2 - ，并且R 1是氢，未取代或取代的烷基; 芳基; 噻吩基呋喃氨基; 烷基氨基; 二烷基氨基; 吡咯烷基或哌啶基; 或当X为-CO-时，R 1也可为烷氧基; B是苯基，甲基苯基，氯苯基，羟基苯基或部分E是氢，羟基或乙酰氧基; C是手性的中心。

25. 发明授权

US4086341A Cephalosporin derivatives 失效
标题翻译：头孢菌素衍生物
公开(公告)号：US4086341A
公开(公告)日：1978-04-25
申请号：US707853
申请日：1976-07-22
申请人： Wolfgang Krohn , Karl Georg Metzger , Michael Preiss , Michael Walkowiak
发明人： Wolfgang Krohn , Karl Georg Metzger , Michael Preiss , Michael Walkowiak
IPC分类号： C07D499/00 , C07D501/20 , A61K31/545
CPC分类号： C07D499/00 , C10M2219/10 , C10M2219/102 , C10M2219/104 , C10M2219/106
摘要： Penicillin and cephalosporin derivatives characterized by the presence of a nitroalkyl, nitrocycloalkyl, nitrophenylalkyl or nitroanilinoalkyl group in the side chain are antibacterial agents. The compounds, of which 6-(2-nitro-3,3-dimethylbutyrylamido)-penicillanic acid, 7-nitroacetamido-3-methyl-ceph-3-em-4-carboxylic acid, and 6-[D-.alpha.-(2-nitro-2-methylpropionylamido)phenylacetamido]-penicillanic acid are typical embodiments, are prepared by reacting 6-amino-penicillanic acid, 7-amino-cephalosporanic acid (or derivative thereof) or an .alpha.-substituted-.alpha.-amino-acetamido-penicillanic acid with an appropriate nitrated carboxylic acid or an equivalent nitrated acylating agent.
摘要翻译：特征在于在侧链中存在硝基烷基，硝基环烷基，硝基苯基烷基或硝基苯胺基烷基的青霉素和头孢菌素衍生物是抗菌剂。其中6-（2-硝基-3,3-二甲基丁酰氨基） - 青霉烷酸，7-硝基乙酰胺基-3-甲基 - 头孢-3-烯-4-羧酸和6- [D-α - （ 2-硝基-2-甲基丙酰胺基）苯乙酰氨基] - 青霉烷酸是典型的实施方案，通过6-氨基 - 青霉烷酸，7-氨基 - 头孢烷酸（或其衍生物）或α-取代-α-氨基 - 乙酰氨基 - 适当的硝酸羧酸或等同的硝化酰化剂。

26. 发明授权

US4012518A Nitro-.beta.-lactam antibiotics and processes for their preparation and use 失效
标题翻译：硝基 - {62-内酰胺抗生素及其制备和使用的方法
公开(公告)号：US4012518A
公开(公告)日：1977-03-15
申请号：US602969
申请日：1975-08-08
申请人： Wolfgang Krohn , Karl Georg Metzger , Michael Preiss , Michael Walkowiak
发明人： Wolfgang Krohn , Karl Georg Metzger , Michael Preiss , Michael Walkowiak
IPC分类号： C07D499/10 , C07D499/00 , C07D499/04 , C07D499/44 , C07D499/46 , C07D499/48 , C07D499/54 , C07D499/64 , C07D499/66 , C07D499/68 , C07D499/70 , C07D499/74 , C07D501/20
CPC分类号： C07D499/00 , C10M2219/10 , C10M2219/102 , C10M2219/104 , C10M2219/106
摘要： Penicillin and cephalosporin derivatives characterized by the presence of a nitroalkyl, nitrocycloalkyl, nitrophenylalkyl or nitroanilinoalkyl group in the side chain are antibacterial agents. The compounds, of which 6-(2-nitro-3,3-dimethylbutyrylamido)-penicillanic acid, 7-nitroacetamido-3-methyl-ceph-3-em-4-carboxylic acid, and 6-[D-.alpha.-(2-nitro-2-methylpropionylamido)phenylacetamido]-penicillanic acid are typical embodiments, are prepared by reacting 6-amino-penicillanic acid, 7-amino-cephalosporanic acid (or derivative thereof) or an .alpha.-substituted-.alpha. -aminoacetamido-penicillanic acid with an appropriate nitrated carboxylic acid or an equivalent nitrated acylating agent.
摘要翻译：特征在于在侧链中存在硝基烷基，硝基环烷基，硝基苯基烷基或硝基苯胺基烷基的青霉素和头孢菌素衍生物是抗菌剂。其中6-（2-硝基-3,3-二甲基丁酰氨基） - 青霉烷酸，7-硝基乙酰胺基-3-甲基 - 头孢-3-烯-4-羧酸和6- [D-α - （ 2-硝基-2-甲基丙酰胺基）苯基乙酰氨基] - 青霉烷酸是典型的实施方案，通过6-氨基 - 青霉烷酸，7-氨基 - 头孢烷酸（或其衍生物）或α-取代-α-氨基乙酰氨基 - 青霉烷酸与适当的硝化羧酸或等同的硝化酰化剂反应。

27. 发明申请

US20090266312A1 Cooling Device 有权
标题翻译：冷却装置
公开(公告)号：US20090266312A1
公开(公告)日：2009-10-29
申请号：US12428505
申请日：2009-04-23
申请人： MICHAEL PREISS
发明人： MICHAEL PREISS
IPC分类号： F01P7/02
CPC分类号： F01P11/10 , B60K11/04 , B60K11/085 , F01P7/10 , Y02T10/88
摘要： A cooling device in an engine bay of a motor vehicle has a radiator and a radiator louver with at least one lamella that controls the passage of a gas flow through the radiator. At least one bypass duct bypasses the radiator and can be closed off by an associated closing element which is operatively connected to the radiator louver in such a way that an opening of the radiator louver generates a closing of the closing element, and therefore of the associated bypass duct, and vice versa. The radiator louver and the at least one closing element are coupled to one another in such a way that, regardless of the position of the lamellae of the radiator louver and the position of the at least one closing element, an at least approximately uniform lift force, or an at least approximately uniform pitching moment, is imparted to the vehicle.
摘要翻译：机动车辆的发动机舱中的冷却装置具有散热器和具有至少一个薄片的散热器百叶窗，其控制通过散热器的气流的通过。至少一个旁路管道绕过散热器并且可以由相关联的关闭元件封闭，闭合元件可操作地连接到散热器百叶窗，使得散热器百叶窗的开口产生关闭元件的关闭，并且因此相关联旁路管道，反之亦然。散热器百叶窗和至少一个关闭元件彼此联接，使得不管散热器百叶窗的薄片的位置和至少一个关闭元件的位置如何，至少大致均匀的提升力或至少近似均匀的俯仰时刻被赋予车辆。

28. 发明授权

US5052745A Wind deflector for sliding roofs, removable roof sections or the like of motor vehicles 失效
标题翻译：用于滑行车，可拆卸车顶部分或电动车类似的风力发电机
公开(公告)号：US5052745A
公开(公告)日：1991-10-01
申请号：US448860
申请日：1989-12-12
申请人： Michael Preiss
发明人： Michael Preiss
IPC分类号： B60J7/22
CPC分类号： B60J7/22
摘要： In a motor vehicle equipped with a sliding roof, a wind deflector is provided to avoid disturbing vibrations in the vehicle interior. The wind deflector is movable between a retracted position and an extended, operative position. An additional air guiding element of narrower width than the wind deflector is mounted locally of the wind deflector. The air guiding element is movable between a first position in a depression of the wind deflector and a second operative position in which the air guiding element projects beyond the wind deflector in an upward direction. The air guiding element moves into the second position coincidentally with movement of the wind deflector into the operative position.
摘要翻译：在配备有滑动车顶的机动车辆中，设有导风板以避免车辆内部的扰动。挡风板可在缩回位置和延伸的操作位置之间移动。与挡风板相比，宽度窄的附加导风元件局部安装在导风板上。空气引导元件可在导风板的凹部中的第一位置和第二操作位置之间移动，在第二操作位置，空气引导元件沿着向上的方向突出超过挡风板。空气引导元件与导风板的运动巧妙地进入第二位置进入操作位置。

29. 发明授权

US4901826A Vehicle equipped with air-cooled wheel brakes 失效
标题翻译：车辆配有风冷轮胎制动器
公开(公告)号：US4901826A
公开(公告)日：1990-02-20
申请号：US307956
申请日：1989-02-09
申请人： Michael Preiss
发明人： Michael Preiss
IPC分类号： B60T5/00
CPC分类号： B60T5/00
摘要： An air guiding arrangement for wheel brakes of a motor vehicle comprises a profiled deflecting element which is adjusted against the arriving air current. The arrangement is constructed with an air deflecting element held at the vehicle and extending in transverse direction of the vehicle which is arranged below an adjacent dome-shaped air catching and guiding element. It faces the deflecting element with its air inlet area and is located opposite an opening in the brake protection plate with its air outlet area.
摘要翻译：用于机动车辆的车轮制动器的空气引导装置包括相对于到达的气流调节的异型偏转元件。该装置由保持在车辆处的空气偏转元件构成，并且在车辆的横向方向上延伸，该横向方向布置在相邻的圆顶形空气捕获和引导元件的下方。它面向具有其进气区域的偏转元件，并且与其空气出口区域相对于制动保护板中的开口相对。

30. 发明授权

US4633007A Preparation of benzylidene compounds 失效
标题翻译：亚苄基化合物的制备
公开(公告)号：US4633007A
公开(公告)日：1986-12-30
申请号：US832503
申请日：1986-02-21
申请人： Michael Preiss
发明人： Michael Preiss
IPC分类号： C07C69/738 , B01J31/00 , C07B61/00 , C07C67/00 , C07C201/00 , C07C205/56 , C07C213/00 , C07C219/10 , C07C253/00 , C07C255/57 , C07C301/00 , C07C303/22 , C07C309/58 , C07C143/525 , C07C79/38 , C07C121/76
CPC分类号： C07C201/12
摘要： A process for the preparation of a benzylidene compound of the formula ##STR1## in which R.sup.1 is hydrogen or one or two substituents independently selected from the group consisting of nitro, cyano, halogen, SO.sub.3 H, alkyl, alkoxy and fluorinated alkyl, each with 1 to 4 C atoms and two or three fluorine substituents, andR.sup.3 is alkyl with 1 to 10 C atoms, which is optionally interrupted by an oxygen in the chain or is optionally substituted by fluorine, chlorine, hydroxyl or a methylbenzylamine group, comprising reacting an acetal of the formula ##STR2## in which R.sup.2 each independently is alkyl with 1 to 6 C atoms, which is optionally substituted by phenyl, or the two radicals R.sup.2 conjointly form an alkylene radical with 1-6 C atoms,with a .beta.-ketocarboxylic acid ester of the formulaCH.sub.3 CO--CH.sub.2 --COOR.sup.3in the presence of an acid at a temperature between about 40.degree. and 120.degree..
摘要翻译：制备式“IMAGE”的亚苄基化合物的方法，其中R 1是氢或一个或两个独立地选自硝基，氰基，卤素，SO 3 H，烷基，烷氧基和氟化烷基的取代基，各自具有1 至4个C原子和两个或三个氟取代基，R3是具有1至10个C原子的烷基，其任选被链中的氧中断或任选被氟，氯，羟基或甲基苄胺基取代，包括使其中R 2各自独立地为具有1至6个C原子的烷基，其任选被苯基取代，或两个基团R 2与1-6个C原子一起形成亚烷基，与β-酮羧酸在酸存在下，在约40至120℃的温度下，式CH 3 CO-CH 2 -COOR 3的酸酯。

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