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21. 发明授权

US4756201A Apparatus and method for combined closed and open tube sampling 失效
标题翻译：用于组合封闭和开放管取样的装置和方法
公开(公告)号：US4756201A
公开(公告)日：1988-07-12
申请号：US49905
申请日：1987-05-11
申请人： Kenneth F. Uffenheimer
发明人： Kenneth F. Uffenheimer
IPC分类号： G01N1/00 , G01N35/10 , G01N1/10
CPC分类号： G01N35/1097 , G01N35/1004
摘要： Sampler apparatus and method are provided and include both closed and open tube samplers, and selector valve operable to select therebetween for sample supply to automated sample analysis apparatus. A shear valve divides the samples into separate sample quantities for independent sample quantity analysis by multi-channel sample analysis apparatus. A pressure equilibration chamber prevents vacuum bulid-up in the closed tube sampler to insure the supply of consistent sample quantities therefrom. A source of a pressurized rinse solution is provided; and is operatively connected to the sampler apparatus in such manner as to insure the particularly thorough rinsing and cleansing of all relevant sample components to remove sample residue therefrom between sampling operations, thereby reducing sample carryover to levels below those of clinical significance.
摘要翻译：提供了采样器装置和方法，包括封闭和开放管取样器，以及可操作以在其间选择供自动化样品分析装置供样的选择阀。剪切阀将样品分成不同的样品量，用于通过多通道样品分析仪器进行独立样品量分析。压力平衡室防止密闭管取样器中的真空膨胀，以确保从其中提供一致的样品量。提供加压冲洗溶液的来源; 并且以这样的方式可操作地连接到取样器装置，以便确保所有相关样品组分的特别彻底的漂洗和清洁以在取样操作之间从其中除去样品残余物，从而将样品携带量降低到低于临床意义的水平。

22. 发明授权

US3954341A Liquid sample analyzer with improved optical characteristics 失效
标题翻译：具有改善光学特性的液体样品分析仪
公开(公告)号：US3954341A
公开(公告)日：1976-05-04
申请号：US510829
申请日：1974-09-30
申请人： Kenneth F. Uffenheimer
发明人： Kenneth F. Uffenheimer
IPC分类号： G01N21/05 , G01N1/10
CPC分类号： G01N21/05 , G01N2021/0346
摘要： A quantitative liquid sample analysis system exhibiting improved light transmission along the sight path of a flowcell and greater optical stability for significantly more accuracy of analytical results. There is provided in such a system a source of treated liquid having a first index of refraction, means for flowing the liquid along a conduit, the conduit including a flowcell having a tubular wall structure with a second index of refraction, the second index of refraction being less than the first index of refraction.
摘要翻译：定量液体样品分析系统显示沿着流动池的视线的改善的光透射和更大的光学稳定性，以显着提高分析结果的准确度。在这种系统中提供具有第一折射率的处理液体源，用于沿着导管流动液体的装置，该导管包括具有第二折射率的管状壁结构的流动池，第二折射率小于第一折射率。

23. 发明授权

US08524489B2 Particle or cell analyzer and method 有权
公开(公告)号：US08524489B2
公开(公告)日：2013-09-03
申请号：US13118831
申请日：2011-05-31
申请人： Philippe J. Goix , Paul J. Lingane , Janette T. Phi-Wilson , Kenneth F. Uffenheimer
发明人： Philippe J. Goix , Paul J. Lingane , Janette T. Phi-Wilson , Kenneth F. Uffenheimer
IPC分类号： C12M1/34
CPC分类号： G01N15/1404 , G01N21/64
摘要： A particle analyzer in which tagged particles to be analyzed are drawn through a suspended capillary tube where a predetermined volume in the capillary tube is illuminated. The illumination scattered by said particles is detected by a detector to count all particles. The fluorescent illumination emitted by tagged particles is detected and the output signals from the fluorescent detectors and scatter detector are processed to provide an analysis of the particles.

24. 发明授权

US08241571B2 Particle or cell analyzer and method 有权
标题翻译：粒子或细胞分析仪和方法
公开(公告)号：US08241571B2
公开(公告)日：2012-08-14
申请号：US13118838
申请日：2011-05-31
申请人： Philippe J. Goix , Paul J. Lingane , Janette T. Phil-Wilson , Kenneth F. Uffenheimer
发明人： Philippe J. Goix , Paul J. Lingane , Janette T. Phil-Wilson , Kenneth F. Uffenheimer
IPC分类号： G01N33/00
CPC分类号： G01N15/1404 , G01N21/64
摘要： A particle analyzer in which tagged particles to be analyzed are drawn through a suspended capillary tube where a predetermined volume in the capillary tube is illuminated. The illumination scattered by said particles is detected by a detector to count all particles. The fluorescent illumination emitted by tagged particles is detected and the output signals from the fluorescent detectors and scatter detector are processed to provide an analysis of the particles.
摘要翻译：其中待分析的标记颗粒通过毛细管中的预定体积被照亮的悬浮毛细管吸取的颗粒分析仪。由所述颗粒散射的照明由检测器检测以计数所有颗粒。检测由标记的颗粒发射的荧光照明，并且处理来自荧光检测器和散射检测器的输出信号以提供颗粒的分析。

25. 发明申请

US20110226964A1 PARTICLE OR CELL ANALYZER AND METHOD 有权
标题翻译：颗粒或细胞分析仪和方法
公开(公告)号：US20110226964A1
公开(公告)日：2011-09-22
申请号：US13118831
申请日：2011-05-31
申请人： Philippe J. Goix , Paul J. Lingane , Janette T. Phil-Wilson , Kenneth F. Uffenheimer
发明人： Philippe J. Goix , Paul J. Lingane , Janette T. Phil-Wilson , Kenneth F. Uffenheimer
IPC分类号： G01N21/64
CPC分类号： G01N15/1404 , G01N21/64
摘要： A particle analyzer in which tagged particles to be analyzed are drawn through a suspended capillary tube where a predetermined volume in the capillary tube is illuminated. The illumination scattered by said particles is detected by a detector to count all particles. The fluorescent illumination emitted by tagged particles is detected and the output signals from the fluorescent detectors and scatter detector are processed to provide an analysis of the particles.
摘要翻译：其中待分析的标记颗粒通过毛细管中的预定体积被照亮的悬浮毛细管吸取的颗粒分析仪。由所述颗粒散射的照明由检测器检测以计数所有颗粒。检测由标记的颗粒发射的荧光照明，并且处理来自荧光检测器和散射检测器的输出信号以提供颗粒的分析。

26. 发明授权

US07198956B2 Automated fluid handling system and method 有权
标题翻译：自动流体处理系统和方法
公开(公告)号：US07198956B2
公开(公告)日：2007-04-03
申请号：US10172546
申请日：2002-06-13
申请人： Kenneth F. Uffenheimer , Arthur Hunt
发明人： Kenneth F. Uffenheimer , Arthur Hunt
IPC分类号： G01N1/10 , G01N35/10
CPC分类号： G01N35/1002 , G01N15/1404 , G01N35/109 , G01N2001/383 , G01N2015/1409 , G01N2015/1411 , G01N2015/149 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/119163 , Y10T436/2575
摘要： An automated fluid handling system configured to prepare fluid samples and to introduce them into an analytical instrument, such as a particle analyzer, flow cytometer or sorter flow cell, and that is capable of analyzing both accurately and quickly.
摘要翻译：一种自动化流体处理系统，其被配置为制备流体样品并将其引入分析仪器，例如粒子分析仪，流式细胞仪或分选器流动池，并且能够准确和快速地分析两者。

27. 发明授权

US5841039A Apparatus and method for integrated sampling from closed and open sample containers 失效
公开(公告)号：US5841039A
公开(公告)日：1998-11-24
申请号：US988074
申请日：1992-12-09
申请人： Kenneth F. Uffenheimer
发明人： Kenneth F. Uffenheimer
IPC分类号： G01N1/00 , G01N30/24
CPC分类号： G01N35/1079
摘要： Integrated sampler apparatus and method are provided and include a sample liquid container support component which is operable to support both closed and open sample liquid containers thereon on a random basis. Sample liquids from the open sample liquid containers are presented directly to a sample liquid analysis system probe for access thereby; while sample liquids from the closed sample liquid containers, which take the form of sample liquid containers closed by sample needle-pierced stoppers, are transferred by virtue of a sampling needle assembly and connected sample liquid transfer conduits and transfer valve, to a sample liquid dispensing well for access by the same sample liquid analysis system probe. Air segmented rinse liquid is provided for the sampling needle, transfer conduits, transfer valve, and dispensing well to minimize sample liquid carryover with regard to the sample liquids from the closed containers; and a surfactant is included with the rinse to lubricate the sampling needle to facilitate the piercing thereby of the closed sample liquid container stoppers and minimize the generation of sample liquid-contaminating stopper particles to use with aqueous sample and rinse liquids, hydrophobic sample liquid transfer conduits, transfer valve, and dispensing well surfaces are provided; and an isolation liquid which selectively wets those surfaces to the substantial exclusion of the aqueous sample and rinse liquids, is utilized in conjunction with the rinse liquid to further minimize sample liquid carryover. The open sample liquid containers and the dispensing well are supported at essentially the same level relative to the probe to maximize sampling accuracy thereby. A detector is provided to detect sample liquid identification as supported from the sample liquid container support component, and to differentiate between open and closed sample liquid containers for operation of the sample liquid analysis system probe in accordance therewith.

28. 发明授权

US5201232A Integrated sampler for closed and open sample containers 失效
公开(公告)号：US5201232A
公开(公告)日：1993-04-13
申请号：US671713
申请日：1991-04-04
申请人： Kenneth F. Uffenheimer
发明人： Kenneth F. Uffenheimer
IPC分类号： G01N1/00 , G01N35/10
CPC分类号： G01N35/1079 , G01N35/1004 , G01N35/1095
摘要： Integrated sampler apparatus and method are provided and include a sample liquid container support component which is operable to support both closed and open sample liquid containers thereon on a random basis. Sample liquids from the open sample liquid containers are presented directly to a sample liquid analysis system probe for access thereby; while sample liquids from the closed sample liquid containers, which take the form of sample liquid containers closed by sample needle-pierced stoppers, are transferred by virtue of a sampling needle assembly and connected sample liquid transfer conduits and transfer valve, to a sample liquid dispensing well for access by the same sample liquid analysis system probe. Air segmented rinse liquid is provided for the sampling needle, transfer conduits, transfer valve, and dispensing well to minimize sample liquid carryover with regard to the sample liquids from the closed containers; and a surfactant is included with the rinse to lubricate the sampling needle to facilitate the piercing thereby of the closed sample liquid container stoppers and minimize the generation of sample liquid-contaminating stopper particles to use with aqueous sample and rinse liquids, hydrophobic sample liquid transfer conduits, transfer valve, and dispensing well surfaces are provided; and an isolation liquid which selectively wets those surfaces to the substantial exclusion of the aqueous sample and rinse liquids, is utilized in conjunction with the rinse liquid to further minimize sample liquid carryover. The open sample liquid containers and the dispensing well are supported at essentially the same level relative to the probe to maximize sampling accuracy thereby. A detector is provided to detect sample liquid identification as supported from the sample liquid container support component, and to differentiate between open and closed sample liquid containers for operation of the sample liquid analysis system probe in accordance therewith.

29. 发明授权

US4863066A System for dispensing precisely metered quantities of a fluid and method of utilizing the system 失效
标题翻译：用于分配精确计量的流体的系统和利用该系统的方法
公开(公告)号：US4863066A
公开(公告)日：1989-09-05
申请号：US277274
申请日：1988-11-29
申请人： Kenneth F. Uffenheimer , Kent M. Negersmith
发明人： Kenneth F. Uffenheimer , Kent M. Negersmith
IPC分类号： G01F11/08
CPC分类号： G01F11/08
摘要： A fluid delivery system for dispensing precisely metered quantities of a fluid, and more particularly, a fluid delivery system incorporating a diaphragm pump for effectuation of the precise control over the dispensing of a metered quantity of the fluid through the formation of a fluid flow-occluding air bubble at the point of discharge inhibiting the formation of droplets tending to adversely influence the accuracy of the system. Also disclosed is a method for delivering and dispensing precisely metered quantities of a fluid through the utilization of the system.
摘要翻译：用于分配精确计量的流体的流体递送系统，更具体地，包括隔膜泵的流体输送系统，用于通过形成流体阻塞的流体来实现对计量量的流体的分配的精确控制在放电点处的气泡抑制液滴的形成倾向于不利地影响系统的精度。还公开了一种通过利用该系统来精确计量的流体的输送和分配的方法。

30. 发明授权

US4602995A Liquid level adjusting and filtering device 失效
标题翻译：液位调节和过滤装置
公开(公告)号：US4602995A
公开(公告)日：1986-07-29
申请号：US735847
申请日：1985-05-20
申请人： Michael M. Cassaday , Rand Herron , Kenneth F. Uffenheimer , John L. Smith
发明人： Michael M. Cassaday , Rand Herron , Kenneth F. Uffenheimer , John L. Smith
IPC分类号： G01N33/48 , G01N1/00 , G01N33/49 , G01N35/10 , B01D33/00
CPC分类号： G01N33/491
摘要： New and improved, liquid level adjusting and filtering device is provided, and is operable upon insertion into a container to automatically adjust the level of a liquid as contained in the container to a predetermined, precisely repeatable location, and to filter the thusly level-adjusted liquid. The device is particularly adapted for use in conjunction with test tube-like devices, in the nature of those marketed under the Trademark "Vacutainer" by the Becton-Dickinson Company of East Rutherford, NJ, containing whole blood samples which have been separated as by centrifugation into respective blood cell, buffy and blood serum layers; and is operable in that context to present blood serum samples to automated sample analysis systems at the same predetermined and precisely repeatable location relative to the aspirating probe means of such systems.
摘要翻译：提供了新的和改进的液位调节和过滤装置，并且在插入到容器中以便将包含在容器中的液体的水平自动调节到预定的，精确可重复的位置时可操作，并且将因此被调节的水平液体。该装置特别适合与试管类装置一起使用，其性质是由新泽西州东卢瑟福的Becton-Dickinson公司在“Vacutainer”商标范围内销售的，其中包含已经被分离的全血样本离心分离到各自的血细胞，血沉棕质和血清层; 并且在该上下文中可操作地将相对于这种系统的抽吸探针装置的血清样品呈现在相同的预定和精确可重复的位置处的自动化样品分析系统。

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