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21. 发明授权

US4931546A Process for the treatment of collagen, notably for facilitating its cross-linking, and the collagen obtained by the application of the said process 失效
标题翻译：用于治疗胶原的方法，特别是用于促进其交联，以及通过应用所述方法获得的胶原
公开(公告)号：US4931546A
公开(公告)日：1990-06-05
申请号：US72368
申请日：1987-07-13
申请人： Michel Tardy , Jean-Louis Tayot
发明人： Michel Tardy , Jean-Louis Tayot
IPC分类号： A61L27/00 , A61F2/00 , A61L27/24 , C07K1/107 , C07K1/113 , C07K1/14 , C07K14/78 , C08H1/00 , C08H1/06 , C12N9/96 , C12N11/02
CPC分类号： A61L27/24 , C08H1/06 , C12N11/02 , C12N9/96 , A61F2310/00365
摘要： Collagen is submitted to a controlled oxidation by treatment with a solution of periodic acid or of a periodate, notably of sodium. Application to gels, implants, lenses, films, spheres, etc., of collagen.
摘要翻译：通过用高碘酸或高碘酸盐，特别是钠的溶液处理，将胶原蛋白进行受控氧化。适用于胶原蛋白的凝胶，植入物，镜片，胶片，球体等。

22. 发明授权

US08853361B2 Preparation, for use, in particular, for tissue augmentation and healing 有权
标题翻译：准备使用，特别是用于组织增生和愈合
公开(公告)号：US08853361B2
公开(公告)日：2014-10-07
申请号：US12375705
申请日：2007-01-24
申请人： Jean-Louis Tayot
发明人： Jean-Louis Tayot
IPC分类号： A61K38/02 , A61K38/17 , C07K14/47 , C07K17/02 , A61K31/715 , A61P19/00 , A61P17/00 , A61L15/32 , A61L31/04 , A61L24/10 , A61L26/00 , A61L27/46 , A61K38/42 , A61L27/20 , A61L27/22 , A61K38/39
CPC分类号： A61K38/42 , A61K38/39 , A61L15/32 , A61L24/108 , A61L26/0047 , A61L27/20 , A61L27/227 , A61L27/46 , A61L31/047 , C08L5/08
摘要： The invention relates to a sterile preparation which can be implanted on or in organic tissues, comprising: a natural or modified globin material which is insoluble at physiological pH and/or a material obtainable from globin which has been modified to be soluble at physiological pH, the said materials being biocompatible and biodegradable in the organism; an agent selected from natural or synthetic polymeric adhesive agents, polymeric tissue enhancement or filling agents, more particularly an agent based on crosslinked hyaluronic acid or on polylactic acid, and a polymeric wound cicatrization agent, specifically oxidized cellulose; with the provisos that, if the preparation comprises the said material obtainable from globin modified so as to be at least partly soluble, the said polymeric adhesive agent, if present, is not hyaluronic acid or carboxymethylcellulose and the said polymeric enhancement or filling agent, if present, is an agent based on crosslinked hyaluronic acid, and that, if the preparation comprises oxidized cellulose, the latter is present in a proportion greater than that of the said globin material, which in that case is a natural or modified globin material which is insoluble at physiological pH; and the use of this preparation, more particularly for filling or cicatrization.
摘要翻译：本发明涉及可以植入有机组织上或在有机组织中的无菌制剂，其包括：在生理pH下不溶的天然或改性球蛋白材料和/或可从球蛋白获得的材料，其已经被修饰以在生理pH下可溶，所述材料在生物体内是生物相容的和可生物降解的; 选自天然或合成聚合物粘合剂，聚合物组织增强剂或填充剂，更特别是基于交联透明质酸或聚乳酸的试剂，以及聚合物缠绕瘢痕形成剂，特别是氧化纤维素; 条件是，如果制剂包含可从球形蛋白得到的至少部分可溶的所述材料，则所述聚合物粘合剂（如果存在的话）不是透明质酸或羧甲基纤维素，并且所述聚合物增强剂或填充剂如果存在的是基于交联透明质酸的试剂，并且如果制剂包含氧化纤维素，则后者的比例大于所述珠蛋白材料的比例，其在这种情况下是天然或改性的珠蛋白材料，其为不溶于生理pH; 和这种制剂的使用，更特别是用于填充或瘢痕形成。

23. 发明申请

US20090312239A1 PREPARATION, FOR USE, IN PARTICULAR, FOR TISSUE AUGMENTATION AND HEALING 有权
标题翻译：准备，特别用于组织治疗和治疗
公开(公告)号：US20090312239A1
公开(公告)日：2009-12-17
申请号：US12375705
申请日：2007-01-24
申请人： Jean-Louis Tayot
发明人： Jean-Louis Tayot
IPC分类号： A61K38/16
CPC分类号： A61K38/42 , A61K38/39 , A61L15/32 , A61L24/108 , A61L26/0047 , A61L27/20 , A61L27/227 , A61L27/46 , A61L31/047 , C08L5/08
摘要： The invention relates to a sterile preparation which can be implanted on or in organic tissues, comprising: a natural or modified globin material which is insoluble at physiological pH and/or a material obtainable from globin which has been modified to be soluble at physiological pH, the said materials being biocompatible and biodegradable in the organism; an agent selected from natural or synthetic polymeric adhesive agents, polymeric tissue enhancement or filling agents, more particularly an agent based on crosslinked hyaluronic acid or on polylactic acid, and a polymeric wound cicatrisation agent, specifically oxidized cellulose; with the provisos that, if the preparation comprises the said material obtainable from globin modified so as to be at least partly soluble, the said polymeric adhesive agent, if present, is not hyaluronic acid or carboxymethylcellulose and the said polymeric enhancement or filling agent, if present, is an agent based on crosslinked hyaluronic acid, and that, if the preparation comprises oxidized cellulose, the latter is present in a proportion greater than that of the said globin material, which in that case is a natural or modified globin material which is insoluble at physiological pH; and the use of this preparation, more particularly for filling or cicatrisation.
摘要翻译：本发明涉及可以植入有机组织上或在有机组织中的无菌制剂，其包括：在生理pH下不溶的天然或改性球蛋白材料和/或可从球蛋白获得的材料，其已经被修饰以在生理pH下可溶，所述材料在生物体内是生物相容的和可生物降解的; 选自天然或合成聚合物粘合剂，聚合物组织增强剂或填充剂，更特别是基于交联透明质酸或聚乳酸的试剂，以及聚合物缠绕瘢痕剂，特别是氧化纤维素; 条件是，如果制剂包含可从球状蛋白得到的至少部分可溶性的所述材料，所述聚合物粘合剂（如果存在的话）不是透明质酸或羧甲基纤维素，并且所述聚合物增强剂或填充剂如果存在的是基于交联透明质酸的试剂，并且如果制剂包含氧化纤维素，则后者的比例大于所述珠蛋白材料的比例，其在这种情况下是天然或改性的珠蛋白材料，其为不溶于生理pH; 以及使用这种制剂，特别是用于填充或c。。

24. 发明申请

US20070032805A1 Oxydized cellulose prosthesis 审中-公开
标题翻译：氧化纤维素假体
公开(公告)号：US20070032805A1
公开(公告)日：2007-02-08
申请号：US11494635
申请日：2006-07-28
申请人： Michel Therin , Alfred Meneghin , Jean-Louis Tayot , Suzelei Montanari
发明人： Michel Therin , Alfred Meneghin , Jean-Louis Tayot , Suzelei Montanari
IPC分类号： A61F2/02
CPC分类号： A61F2/0077 , A61F2/0063 , A61F2002/0068 , A61F2210/0004 , A61L31/10 , A61L31/129 , A61L31/14 , A61L31/146 , A61L31/148 , C08L67/04 , D04B21/12 , D10B2403/0213 , D10B2509/08 , C08L1/26 , C08L5/08
摘要： The present invention relates to a three-dimensional prosthetic fabric comprising a first face and a second face, the said first face and the said second face being opposite each other and separated by the thickness of the said fabric, the said first face being porous, characterized in that the said second face is dense and made of at least one first resorbable yarn. The invention also relates to a process for preparing such a fabric and to a prosthesis obtained using such a fabric.
摘要翻译：本发明涉及一种三维假体织物，其包括第一面和第二面，所述第一面和所述第二面彼此相对并分隔所述织物的厚度，所述第一面是多孔的，其特征在于，所述第二面是致密的并且由至少一个第一可再吸收纱线制成。本发明还涉及制备这种织物的方法和使用这种织物获得的假体。

25. 发明授权

US06605066B1 Device for forming and delivering a mixture 有权
标题翻译：用于形成和输送混合物的装置
公开(公告)号：US06605066B1
公开(公告)日：2003-08-12
申请号：US09554577
申请日：2000-08-29
申请人： Philippe Gravagna , Jean-Louis Tayot
发明人： Philippe Gravagna , Jean-Louis Tayot
IPC分类号： A61M500
CPC分类号： A61B17/00491 , A61B2017/00004 , A61B2017/00084 , A61B2017/00495 , A61M2205/3653
摘要： A device for the formation and delivery of a mixture, notably a surgical adhesive, consisting of a receptacle adapted for easy handling by the surgeon, and including the means of receiving two syringe barrels containing the constituents of the mixture, the means of simultaneously expelling the contents, the means of maintaining the contents of syringe containing the first constituent, at a predetermined temperature setting which is higher than body temperature, and a mixer simultaneously receiving the contents of the two syringes, and the mixer also being used for cooling.
摘要翻译：用于形成和输送混合物的装置，特别是手术粘合剂，其由适于外科医生容易处理的容器组成，并且包括容纳包含混合物成分的两个注射器筒的装置，同时排出内容物，将含有第一成分的注射器的内容物保持在比体温高的预定温度设定的装置以及同时接收两个注射器的内容物的混合器，并且混合器也用于冷却。

26. 发明授权

US6165488A Adhesive composition with macromolecular polyaldehyde base and method for cross-linking collagen 失效
标题翻译：胶体组合物与大分子多醛基和交联胶原蛋白的方法
公开(公告)号：US6165488A
公开(公告)日：2000-12-26
申请号：US91050
申请日：1998-06-08
申请人： Michel Tardy , Herve Volckmann , Jerome Tiollier , Philippe Gravagna , Jean-Louis Tayot
发明人： Michel Tardy , Herve Volckmann , Jerome Tiollier , Philippe Gravagna , Jean-Louis Tayot
IPC分类号： A61L24/00 , A61L24/04 , A61L24/08 , C08H1/06 , C09J103/10 , C09J189/06 , A61F2/02
CPC分类号： A61L24/08 , A61L24/0042 , A61L24/043 , A61L24/046 , C08H1/06 , C08L2666/02 , C09J189/06 , C08L1/04 , C08L89/06 , C08L61/00
摘要： A biocompatible, bioresorbable and nontoxic adhesive composition for surgical and/or therapeutic use, especially for the bonding of biological tissues to one another or to an implanted biomaterial, is provided which comprises at least one biodegradable macromolecular polyaldehyde of natural origin in aqueous solution and a collagen-based component dissolved in aqueous medium. A process for preparing this composition is also provided wherein these aqueous components are mixed together (e.g., at neutral, physiological pH) to give a gel which is rapidly applied to tissues and/or biomaterial to achieve binding. The present invention is advantageous in that it provides biodegradable macromolecular polyaldehydes with adhesive properties and the ability to be extremely well tolerated by the recipient while retaining their adhesive properties during their retention in the body. The invention thus makes it possible to rapidly bind biological tissues to one another or to implanted biological material without tissue lesions in a manner which also retains the quality and the mechanical strength of the adhesion.
摘要翻译： PCT No.PCT / FR97 / 01787第 371日期1998年6月8日第 102（e）日期1998年6月8日PCT 1997年10月7日提交PCT公布。第WO98 / 15299号公报日期1998年04月16日提供了用于手术和/或治疗用途的生物相容性，生物可再吸收和无毒性粘合剂组合物，特别是用于将生物组织彼此粘附或植入的生物材料结合，其包含至少一种天然来源的可生物降解的大分子多醛水溶液和溶于水性介质中的基于胶原的组分。还提供了一种制备该组合物的方法，其中将这些水性成分混合在一起（例如，在中性，生理pH），得到快速施用于组织和/或生物材料以实现结合的凝胶。本发明的优点在于它提供具有粘合性质的生物可降解的大分子多醛，并且其能够在接受者中保持极好的耐受性，同时保持其在体内的粘合性能。因此，本发明使得可以以同样保持粘附的质量和机械强度的方式将生物组织彼此快速结合或植入生物材料而无组织损伤。

27. 发明授权

US5496872A Adhesive compositions for surgical use 失效
标题翻译：用于外科用途的粘合剂组合物
公开(公告)号：US5496872A
公开(公告)日：1996-03-05
申请号：US277069
申请日：1994-07-19
申请人： Alain Constancis , Ge/ rard Soula , Jean-Louis Tayot , Je/ ro/ me Tiollier
发明人： Alain Constancis , Ge/ rard Soula , Jean-Louis Tayot , Je/ ro/ me Tiollier
IPC分类号： A61L26/00 , A61K6/00 , A61L24/04 , A61L27/18 , A61L27/26 , A61L31/04 , A61L31/06 , C08G75/14 , C09J159/00 , C09J181/04 , A61K38/00 , A61L25/00 , C08G69/10 , C08L1/00
CPC分类号： A61L31/041 , A61L24/043 , A61L24/046 , A61L27/18 , A61L27/26 , A61L31/06
摘要： The invention relates to an adhesive, biocompatible, biodegradable and non-toxic composition for surgical use, in particular for binding tissues, which composition is of the following general formula: ##STR1## in which: R is a hydrocarbon chain containing from 1 to 50 carbon atoms,R.sub.1 and R.sub.2 are identical or different and are chosen from the following groups: ##STR2## R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 independently represent hydrogen or an aliphatic and/or alicyclic and/or aromatic group, ##STR3##
摘要翻译：本发明涉及用于外科用途，特别是结合组织的粘合剂，生物相容性，可生物降解和无毒组合物，该组合物具有以下通式：含有1至50个碳原子，R 1和R 2相同或不同并且选自以下组： R3，R4，R5，R6和R7独立地表示氢或脂族和/或脂环族和/或芳族基团，

28. 发明授权

US5436135A New preparation of placenta collagen, their extraction method and their applications 失效
标题翻译：胎盘胶原蛋白的新制备及其提取方法及应用
公开(公告)号：US5436135A
公开(公告)日：1995-07-25
申请号：US638022
申请日：1991-01-07
申请人： Jean-Louis Tayot , Michel Tardy
发明人： Jean-Louis Tayot , Michel Tardy
IPC分类号： A61L27/36 , C08H1/06 , C07K14/78
CPC分类号： A61L27/3604 , A61L27/3683 , C08H1/06 , A61L2430/40
摘要： Human or animal placenta is subjected to moderate enzymatic digestion, in particular with pepsin at an acid pH, then, after separation of the residual tissue the impurities are separated at a moderately acid pH, the collagen is precipitated at a neutral pH, redissolved and the residual impurities precipitated at an acid pH. The collagen obtained can be brought back to a neutral pH and dried in the form of fibres. Completely transparent, physiological and hemocompatible gels and solutions can be prepared. Applications for the fabrication of contact lenses and implants.
摘要翻译：对人或动物胎盘进行适度的酶消化，特别是在酸性pH下用胃蛋白酶消化，然后在残留组织分离后，在中等酸性pH下分离杂质，胶原蛋白在中性pH下沉淀，再溶解，残余杂质在酸性pH下沉淀。所获得的胶原可以恢复到中性pH并以纤维的形式干燥。可以制备完全透明的生理和血液相容性凝胶和溶液。用于制造隐形眼镜和植入物的应用。

29. 发明授权

US5108908A Process for the treatment of proteinic solutions containing pigments such as heminic groups or chlorophylls in view of their decolorization and products thus obtained 失效
标题翻译：考虑到它们的脱色以及由此获得的产物，用于处理含有染料如堇青组或叶绿素的蛋白质溶液的方法
公开(公告)号：US5108908A
公开(公告)日：1992-04-28
申请号：US582643
申请日：1990-09-14
申请人： Jacques Coves , Jean-Louis Tayot
发明人： Jacques Coves , Jean-Louis Tayot
IPC分类号： A23J3/34 , C12P21/06
CPC分类号： C12P21/06 , A23J3/345 , A23J3/346 , A23V2002/00 , Y10S435/80
摘要： A process for pigments such as the treatment of proteinic solutions containing heminic groups or chlorophylls in view of their decolorization, and products thus obtained.The proteinic solution is subjected in a first step, to a slight enzymatic hydrolysis, preferably with acid pH pepsin, and the partially hydrolyzed solution is then brought to a temperature above 60.degree. C., at an acid pH between 2 and 4.
摘要翻译：考虑到它们的脱色，颜料的处理方法，例如处理含有热敏基团或叶绿素的蛋白质溶液，以及由此获得的产物。将蛋白质溶液在第一步骤中进行轻微的酶水解，优选用酸性pH胃蛋白酶进行，然后将部分水解的溶液温度高于60℃，酸性pH在2和4之间。

30. 发明授权

US4415733A Ganglioside derivatives, their preparation and their application 失效
标题翻译：神经节苷脂衍生物，其制备及应用
公开(公告)号：US4415733A
公开(公告)日：1983-11-15
申请号：US244312
申请日：1981-03-16
申请人： Jean-Louis Tayot
发明人： Jean-Louis Tayot
IPC分类号： A61K35/30 , A61K35/74 , A61K39/08 , A61K39/106 , A61K39/385 , C07G99/00 , C07H15/10 , C08B37/00
CPC分类号： C07H15/10 , A61K39/08 , A61K39/107 , B01D15/3804 , B01J20/286 , B01J20/3219 , B01J20/3255
摘要： This invention has for its object new ganglioside derivatives, their preparation and their application.
摘要翻译：本发明的目的是提供新的神经节苷脂衍生物，其制备及应用。

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