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21. 发明授权

US07092765B2 Non-sheath based medical device delivery system 失效
标题翻译：非护套型医疗器械输送系统
公开(公告)号：US07092765B2
公开(公告)日：2006-08-15
申请号：US10252243
申请日：2002-09-23
申请人： Jeff B. Geske , Steven L. Waldhauser , Bruce E. Chivers , James F. Kelley
发明人： Jeff B. Geske , Steven L. Waldhauser , Bruce E. Chivers , James F. Kelley
IPC分类号： A61N1/372
CPC分类号： A61N1/0587 , A61B17/22031 , A61B17/221 , A61B17/3421 , A61B17/3439 , A61B17/3468 , A61B2017/00247 , A61B2017/00469 , A61B2017/00867 , A61B2017/2215 , A61B2017/347 , A61B2018/00392 , A61N1/056 , A61N2001/0578
摘要： A non-sheath based medical device delivery system is provided including an elongated tubular guide body having a distal end fixedly attached to a resilient collet with a longitudinal opening to receive a medical lead or other device. The collet may be opened by actuating a retraction member to cause the closing member to slide proximally along the collet shaft, allowing the collet to maintain a normally open position. With the collet closed, the device may be advanced to a desired internal body location by advancing the guide body. The majority of the device body will be exposed, running alongside the guide body, allowing any sensors or electrodes located on the device body to be fully operational during the implantation procedure. The delivery system may be removed by opening the collet, to slidably disengage from the device body.
摘要翻译：提供了一种非护套型医疗装置递送系统，其包括细长管状引导体，其具有固定地附接到弹性夹头的远端，纵向开口以接收医疗引线或其它装置。夹头可以通过致动回缩构件来打开，以使封闭构件沿夹头轴向近侧滑动，从而允许夹头保持常开位置。在夹头关闭的情况下，通过推进引导体，装置可以前进到期望的内部身体位置。装置主体的大部分将被暴露，与引导体一起运行，允许位于装置主体上的任何传感器或电极在植入过程中完全可操作。输送系统可以通过打开夹头而与装置主体滑动脱离。

22. 发明授权

US07065394B2 Guide catheter 失效
公开(公告)号：US07065394B2
公开(公告)日：2006-06-20
申请号：US10016114
申请日：2001-12-12
申请人： Christopher M. Hobot , Stanten C. Spear , James F. Kelley , Jennifer L. Braunschweig , Kiem Dang , Kenneth C. Gardeski
发明人： Christopher M. Hobot , Stanten C. Spear , James F. Kelley , Jennifer L. Braunschweig , Kiem Dang , Kenneth C. Gardeski
IPC分类号： A61B5/05
CPC分类号： A61M25/0108 , A61L29/02 , A61L29/18 , A61M25/005
摘要： A guide catheter has properties that promote enhanced visibility of the guide catheter using fluoroscopic or ultrasonic imaging techniques. The tip of the guide catheter may incorporate a material that is both fluoro and echo visible. The first material also may be provided in various amounts along the length of the guide catheter. In addition, the guide catheter may incorporate a reinforcing braid that includes one or more strands of a second material that is radio-opaque. As a result, the result guide catheter achieves improved radio-opacity and echogenicity.

23. 发明授权

US06939338B2 Methods and apparatus for imparting curves in elongated medical catheters 失效
标题翻译：在细长的医用导管中赋予曲线的方法和装置
公开(公告)号：US06939338B2
公开(公告)日：2005-09-06
申请号：US10125365
申请日：2002-04-19
申请人： Steven L. Waldhauser , Timothy G. Laske , James F. Kelley , Kenneth C. Gardeski , Gregory P. Shipe
发明人： Steven L. Waldhauser , Timothy G. Laske , James F. Kelley , Kenneth C. Gardeski , Gregory P. Shipe
IPC分类号： A61B1/005 , A61M25/00 , A61M25/01 , A61M25/092
CPC分类号： A61M25/0158 , A61B1/0058 , A61M25/0041 , A61M25/0054 , A61M2025/0064
摘要： Curves and dynamic shapes are imparted in distal segments of medical instruments e.g., catheters, through use of a temperature-activated actuator coupled to distal segment of the instrument body. The actuator comprises includes members extending side-by-side in substantially a common plane and configured to move in opposite directions when independently activated. A first heating device is coupled to a first actuator member and configured to deliver thermal energy to the first actuator member to activate the first actuator member and cause the first actuator member to move the distal segment in a first direction. A second heating device is coupled to a second actuator member and configured to deliver thermal energy to the second actuator member to activate the second actuator member and cause the second actuator member to move the distal segment in a second direction opposed to the first direction.
摘要翻译：曲线和动态形状通过使用耦合到仪器主体的远端部分的温度激活的致动器，在医疗器械的远端部分（例如导管）中被施加。致动器包括在基本上共同的平面中并排延伸的构件，并且构造成当独立地启动时沿相反的方向移动。第一加热装置联接到第一致动器构件并且构造成将热能传递到第一致动器构件以启动第一致动器构件并使第一致动器构件沿第一方向移动远侧段。第二加热装置联接到第二致动器构件并且被配置为将热能传递到第二致动器构件以致动第二致动器构件并使第二致动器构件沿与第一方向相反的第二方向移动远侧段。

24. 发明授权

US06832478B2 Shape memory alloy actuators 有权
标题翻译：形状记忆合金执行器
公开(公告)号：US06832478B2
公开(公告)日：2004-12-21
申请号：US10410545
申请日：2003-04-09
申请人： David A. Anderson , James F. Kelley , Naim S. Istephanous , Steven L. Waldhauser
发明人： David A. Anderson , James F. Kelley , Naim S. Istephanous , Steven L. Waldhauser
IPC分类号： F03G706
CPC分类号： F03G7/065 , A61B1/0058
摘要： An electrically insulative layer of a shape memory alloy (SMA) actuator includes an inorganic material formed upon a portion of an SMA substrate. A conductive material formed upon a portion of the electrically insulative layer in a trace pattern includes a first end, a second end, and a heating element disposed between the first and second ends. The SMA substrate is trained to deform at a transition temperature achieved when electricity is conducted through the conductive material via first and second interconnect pads terminating the first and second ends of the trace pattern.
摘要翻译：形状记忆合金（SMA）致动器的电绝缘层包括形成在SMA基底的一部分上的无机材料。形成在电绝缘层的痕迹图案的一部分上的导电材料包括第一端，第二端和设置在第一端和第二端之间的加热元件。训练SMA基底，以在通过导电材料通过终止迹线图案的第一和第二端的第一和第二互连焊盘传导电导时实现的转变温度下变形。

25. 发明授权

US06743227B2 Intraluminal visualization system with deflectable mechanism 有权
标题翻译：具有偏转机制的管腔内可视化系统
公开(公告)号：US06743227B2
公开(公告)日：2004-06-01
申请号：US09822678
申请日：2001-03-30
申请人： Mahmoud K. Seraj , Eric Chan , James F. Kelley
发明人： Mahmoud K. Seraj , Eric Chan , James F. Kelley
IPC分类号： A61B1818
CPC分类号： A61M25/0668 , A61B18/1492 , A61B2017/22038 , A61M25/0051 , A61M25/0054 , A61M25/0138 , A61M25/0147 , A61M2025/0042 , A61M2025/0047 , A61M2025/0081 , A61M2025/0161 , A61M2025/0681 , A61M2025/1052 , A61M2025/1079 , A61N1/056 , A61N2001/0578 , A61N2001/0585
摘要： This is a combination method and system for intravascularly accessing and visualizing a body structure. A system is disclosed comprising a sheath, a balloon catheter, and a catheter deflection mechanism. A micro-deflection mechanism, which may be placed into the lumen of devices such as cardiac leads or electrophysiology catheters, is also provided for accurate guidance and placement of such devices to their target location. In one embodiment, a procedure for a lead or catheter placement is described in which a combination deflection mechanism, balloon catheter, and sheath assembly access the coronary sinus ostium via a superior approach. A distal balloon on the catheter is inflated and an occlusive venogram is obtained under fluoroscopic guidance to visualize the coronary veins. The sheath is advanced into the coronary sinus ostium and the balloon is deflated. The catheter and deflection mechanism are then removed. Next, a micro-deflection mechanism that has been inserted into the lumen of a cardiac lead is deployed through the sheath, allowing the lead to deflect with a high degree of accuracy and control as it is placed in the selected location.
摘要翻译：这是用于血管内访问和可视化身体结构的组合方法和系统。公开了一种包括护套，球囊导管和导管偏转机构的系统。还可以提供可以放置在诸如心脏引线或电生理学导管的装置的内腔中的微偏转机构，用于将这些装置精确地引导和放置到其目标位置。在一个实施例中，描述了用于引导或导管放置的过程，其中组合偏转机构，球囊导管和护套组件通过优异的方法进入冠状窦口。导管上的远端气球被充气，并且在荧光镜引导下获得闭塞静脉图以使冠状静脉可视化。鞘进入冠状窦口，气囊放气。然后取出导管和偏转机构。接下来，已经插入到心脏引线的内腔中的微偏转机构通过护套展开，从而允许引线在被放置在所选择的位置时以高度的精度和控制偏转。

26. 发明授权

US06733500B2 Method and system for delivering a medical electrical lead within a venous system 有权
标题翻译：用于在静脉系统内递送医用电线的方法和系统
公开(公告)号：US06733500B2
公开(公告)日：2004-05-11
申请号：US10131672
申请日：2002-04-24
申请人： James F. Kelley , James H. Vaughn , Stanten C. Spear , Douglas S. Hine , Kenneth C. Gardeski , Vicki L. Bjorklund , Pedro A. Meregotte , John L. Sommer , John J. Maier
发明人： James F. Kelley , James H. Vaughn , Stanten C. Spear , Douglas S. Hine , Kenneth C. Gardeski , Vicki L. Bjorklund , Pedro A. Meregotte , John L. Sommer , John J. Maier
IPC分类号： A61B1818
CPC分类号： A61M25/0138 , A61B18/1492 , A61B2017/22038 , A61M25/005 , A61M25/0054 , A61M25/0141 , A61M25/0147 , A61M25/0668 , A61M25/09 , A61M25/09041 , A61M2025/0042 , A61M2025/0047 , A61M2025/0081 , A61M2025/0161 , A61M2025/0681 , A61M2025/1052 , A61M2025/1079 , A61N1/056 , A61N1/06 , A61N1/372 , A61N2001/0578 , A61N2001/0585
摘要： A loading device for loading a guide wire within a medical electrical lead that includes a navigation portion, having an outer portion, and extending from a front end to a back end, and having an opening formed at the back end. An engagement cavity receives and properly orientates the lead distal tip to align the lumen of the lead with the opening of the navigation portion during the loading of the guide wire within the lead. A first side wall is spaced from a second side wall to form a slot extending along the outer portion from the front end to the back end of the navigation portion, and the guide wire is advanced through the slot as the lead having the guide wire loaded therein is removed from the loading device.
摘要翻译：一种用于将导丝装载在医疗用电线内的装载装置，其包括具有外部的导航部，并且从前端延伸到后端，并且具有形成在后端的开口。接合腔容纳并适当地定向引线远侧末端，以在引导线在引线内的加载期间使引线的内腔与引导部分的开口对准。第一侧壁与第二侧壁间隔开以形成沿着导引部分的前端到后端的外部部分延伸的狭槽，并且当导线加载有引导线时，引导线前进通过狭槽其中的装载装置被移除。

27. 发明授权

US5897578A Attachment apparatus and method for an implantable medical device employing ultrasonic energy 有权
标题翻译：使用超声波能量的可植入医疗装置的附件装置和方法
公开(公告)号：US5897578A
公开(公告)日：1999-04-27
申请号：US140499
申请日：1998-08-27
申请人： Craig L. Wiklund , Daniel C. Haeg , James F. Kelley
发明人： Craig L. Wiklund , Daniel C. Haeg , James F. Kelley
IPC分类号： A61N1/375
CPC分类号： A61N1/3752 , Y10T29/49925
摘要： A method and apparatus for attaching a pre-formed header module, e.g. a connector header module or an electrode bearing header module, etc., to a hermetically sealed enclosure of the implantable medical device, typically including electronic integrated circuits, batteries, electromechanical pumps, or the like, are disclosed. A plurality of upstanding tabs that are fixed to the hermetically sealed enclosure, e.g. to the enclosure attachment surface, extend into a like plurality of tab channels formed in the header module housing. The upstanding tab(s) are inserted into the respective tab channel(s) during seating of the module and enclosure attachment surfaces and effects an initial alignment of the header module with the hermetically sealed enclosure. Each attachment tab has a retention feature formed on or in the tab that is designed to accommodate the flow of the thermoplastic material during the application of ultrasonic energy in the region of the tab channel and to cooperate with the solidified mass of thermoplastic material. During application of the ultrasonic energy, the thermoplastic material melts and flows into the remaining space of the tab channel and encapsulate the attachment tab including the retention feature. Upon termination of the ultrasonic energy, the thermoplastic housing material cools and solidifies and forms a continuous mass that encapsulates the surface of the attachment tab and the retention feature.
摘要翻译：一种用于附接预成形头部模块的方法和装置，例如，公开了通常包括电子集成电路，电池，机电泵等的可植入医疗装置的气密密封外壳中的连接器插头模块或电极支承插头模块等。多个直立突出部，固定在密封的外壳上，例如。到壳体附接表面，延伸到形成在头部模块壳体中的相似的多个突片通道。在模块和机壳连接表面的座位期间，将直立的插片插入到相应的标签通道中，并且实现了头部模块与密封外壳的初始对准。每个附接翼片具有形成在翼片上或翼片中的保持特征，该保持特征被设计成在翼片通道的区域中施加超声波能量期间适应热塑性材料的流动并且与固化的热塑性材料块配合。在施加超声波能量期间，热塑性材料熔化并流入突片通道的剩余空间并且封装包括保持特征的连接片。在超声波能量终止时，热塑性外壳材料冷却并固化并形成包封附着突片的表面和保持特征的连续质量。

28. 发明授权

US5341804A System for disabling oximeter in presence of ambient light 失效
标题翻译：存在环境光时禁用血氧计的系统
公开(公告)号：US5341804A
公开(公告)日：1994-08-30
申请号：US977978
申请日：1992-11-18
申请人： Eric J. Fogt , James F. Kelley , Ralph M. Kerns , Timothy J. Duffy , David J. Draska
发明人： Eric J. Fogt , James F. Kelley , Ralph M. Kerns , Timothy J. Duffy , David J. Draska
IPC分类号： A61B5/00 , G01N21/27
CPC分类号： A61B5/14535 , A61B5/14557 , A61B5/1495 , G01N21/274 , A61B2560/0233 , G01N2201/1244 , G01N2201/1281
摘要： A system for disabling an oximetric device when radiation-carrying channels are exposed to excess ambient radiation is disclosed. It includes a transmitter channel adjacent the sample to be measured, means for isolating the channel from the sample so that it does not carry radiation reflected from or transmitted through the sample, a detector for receiving the transmitted signal, if any, and means for disabling the output in response to the transmitted signal. Preferably, the transmitter channel runs parallel to other transmitter channels in the device, and is isolated from undue ambient light. The system preferably includes means for determining when the second transmitted signal exceeds background noise and the output is disabled when the second transmitted signal exceeds background noise. In general, the sample is a fluid, usually blood, passing through a cuvette adjacent the fiber-optic channels, the cuvette defining an area of radiation absorption adjacent the transmitter channel so that the transmitter does not carry reflected or transmitted radiation from the sample. Also disclosed is a fiber-optic sensor for measuring components of a composition by detecting transmitted or reflected, usually reflected, radiation including such a system, and the cuvette therefore. Finally, a method of disabling the output of an oximetric device when the fiber-optic channels are exposed to undue ambient radiation is disclosed.
摘要翻译：公开了一种当辐射承载通道暴露于过量环境辐射时使得血压测定装置失效的系统。它包括与要测量的样本相邻的发射机信道，用于将信道与样本隔离的装置，使得其不携带从样本反射或透射的辐射，用于接收发射信号的检测器（如果有的话）以及用于禁用的装置响应于所发送的信号的输出。优选地，发射机信道平行于设备中的其他发射机信道，并且与不适当的环境光隔离。系统优选地包括用于确定第二发射信号何时超过背景噪声的装置，并且当第二发射信号超过背景噪声时输出被禁用。通常，样品是流体，通常为血液，通过与光纤通道相邻的比色杯，比色皿限定了邻近发射器通道的辐射吸收区域，使得发射器不携带来自样品的反射或透射的辐射。还公开了一种用于通过检测包括这种系统的透射或反射的，通常被反射的辐射来测量组合物的组分的光纤传感器，以及因此的比色皿。最后，公开了当光纤通道暴露于不适当的环境辐射时禁用血压计的输出的方法。

29. 发明授权

US08409219B2 Method and system for placement of electrical lead inside heart 有权
标题翻译：电线内置心脏的方法和系统
公开(公告)号：US08409219B2
公开(公告)日：2013-04-02
申请号：US12570390
申请日：2009-09-30
申请人： James F. Kelley , Zhongping C. Yang , Mark T. Stewart
发明人： James F. Kelley , Zhongping C. Yang , Mark T. Stewart
IPC分类号： A61B19/00
CPC分类号： A61N1/059 , A61B17/12 , A61B17/12009 , A61B17/128 , A61B17/3468 , A61B2017/00247 , A61B2017/12018 , A61B2018/00392
摘要： A method of placing an electrical lead of an implantable cardiac device inside a heart of a patient. The method includes securing a tool to an atrial appendage of the heart to hold onto the atrial appendage, piercing the atrial appendage, and creating an aperture in the atrial appendage while holding the atrial appendage with the tool. The method also includes moving a distal end of the electrical lead into the heart through the aperture in the atrial appendage and into a ventricle of the heart. Furthermore, the method includes coupling the distal end of the electrical lead to cardiac tissue in the ventricle and delivering an electrical signal to the cardiac tissue in the ventricle of the heart to maintain a predetermined heartbeat of the heart.
摘要翻译：将可植入心脏装置的电引线放置在患者心脏内的方法。该方法包括将工具固定到心脏的心房附着物，以固定在心房附近，刺穿心房附件，以及在用该工具持有心房附件的同时创建心房附近的孔。该方法还包括通过心耳中的孔将电引线的远端移动到心脏中并进入心脏的心室。此外，该方法包括将电导线的远端耦合到心室中的心脏组织，并将电信号传送到心脏心室的心脏组织以维持心脏的预定心跳。

30. 发明授权

US06836687B2 Method and system for delivery of a medical electrical lead within a venous system 有权
标题翻译：用于在静脉系统内递送医用电线的方法和系统
公开(公告)号：US06836687B2
公开(公告)日：2004-12-28
申请号：US10131388
申请日：2002-04-25
申请人： James F. Kelley , James H. Vaughn , Stanten C. Spear , Douglas S. Hine , Kenneth C. Gardeski , Vicki L. Bjorklund , Pedro A. Meregotte , John L. Sommer , John J. Maier
发明人： James F. Kelley , James H. Vaughn , Stanten C. Spear , Douglas S. Hine , Kenneth C. Gardeski , Vicki L. Bjorklund , Pedro A. Meregotte , John L. Sommer , John J. Maier
IPC分类号： A61N105
CPC分类号： A61M25/0138 , A61B18/1492 , A61B2017/22038 , A61M25/005 , A61M25/0054 , A61M25/0141 , A61M25/0147 , A61M25/0668 , A61M39/0613 , A61M2025/0042 , A61M2025/0047 , A61M2025/0081 , A61M2025/0161 , A61M2025/0681 , A61M2025/1052 , A61M2025/1079 , A61N1/05 , A61N1/056 , A61N2001/0578 , A61N2001/0585
摘要： A system for delivering a medical electrical lead within a coronary venous system that includes an introducer kit for establishing venous access to the coronary venous system and a plurality of delivery sheaths, each corresponding to a desired approach to a coronary sinus of the coronary venous system and insertable within the coronary venous system through the navigation pathway. A hemostasis valve is coupled to a delivery sheath of the plurality of delivery sheaths, and a guide wire is inserted within the lead lumen, guiding delivery of the distal tip of the medical electrical lead to a target site within the coronary venous system through the hemostasis valve and the delivery sheath. Subsequent to the distal tip being delivered to the target sight, the hemostasis valve is advanced over the connector of the medical electrical lead to remove the hemostasis valve from the medical electrical lead.
摘要翻译：一种用于在冠状静脉系统内递送医用电线的系统，其包括用于建立对冠状静脉系统的静脉通路的引导器套件和多个输送护套，每个输送护套对应于冠状静脉系统的冠状窦所需的方法，通过导航路径插入冠状静脉系统内。止血阀联接到多个输送护套的输送护套，并且引导线插入引导腔内，通过止血将医用电导线的远端引导到冠状静脉系统内的靶位点阀门和输送护套。在远端尖端被传送到目标瞄准器之后，止血阀在医用电线的连接器上前进，以从医用电引线上除去止血阀。

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