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21. 发明授权

US08956643B2 Porous biodegradable polymer scaffolds for in situ tissue regeneration and method for the preparation thereof 有权
标题翻译：用于原位组织再生的多孔可生物降解聚合物支架及其制备方法
公开(公告)号：US08956643B2
公开(公告)日：2015-02-17
申请号：US12473850
申请日：2009-05-28
申请人： Dong Keun Han , Kwideok Park , Jae-Jin Kim , Soon Eon Bae
发明人： Dong Keun Han , Kwideok Park , Jae-Jin Kim , Soon Eon Bae
IPC分类号： A61F2/00 , A61F13/00 , A61L27/50 , A61L27/18 , A61L27/54 , A61L27/56
CPC分类号： A61L27/50 , A61L27/18 , A61L27/54 , A61L27/56 , A61L2300/25 , A61L2300/414 , A61L2300/428 , A61L2300/43 , A61L2300/45 , A61L2300/604 , A61L2400/18 , C08L67/04
摘要： The present invention relates to an intelligent porous biodegradable polymer scaffold for in situ tissue regeneration in which two kinds of physiologically active substances having high differentiation potential and biocompatibility are introduced into the polymer scaffold and conjugated to the surface thereof, respectively, and a method for the preparation thereof. Since the intelligent porous biodegradable polymer scaffold exhibits improved biocompatibility and differentiation potential due to the introduction of physiologically active substances capable of efficiently inducing cell proliferation and differentiation into both the surface and the inside thereof, it can directly induce in situ tissue regeneration of the musculoskeletal system from stem cells in a living tissue after transplanting the polymer scaffold and stem cells into a human body without additional in vitro cultivation. Therefore, the intelligent porous biodegradable polymer scaffold according to the present invention can be effectively used in the regeneration of various kinds of tissues and organs including the musculoskeletal system.
摘要翻译：本发明涉及一种用于原位组织再生的智能多孔可生物降解聚合物支架，其中将具有高分化潜能和生物相容性的两种生理活性物质分别引入聚合物支架并与其表面共轭，的制备。由于智能多孔生物可降解聚合物支架由于引入能够有效诱导细胞增殖和分化至其表面和内部的生理活性物质而显示出改善的生物相容性和分化潜能，因此可直接诱导肌肉骨骼系统的原位组织再生从移植聚合物支架和干细胞到人体中的生物体组织中的干细胞，而不需要额外的体外培养。因此，根据本发明的智能多孔生物可降解聚合物支架可以有效地用于包括肌肉骨骼系统在内的各种组织和器官的再生。

22. 发明授权

US07842305B2 Method of preparing biodegradable dual pore polymer scaffolds for tissue engineering 有权
标题翻译：制备用于组织工程的可生物降解双孔聚合物支架的方法
公开(公告)号：US07842305B2
公开(公告)日：2010-11-30
申请号：US11526280
申请日：2006-09-21
申请人： Dong Keun Han , Kwang-Duk Ahn , Hyun Jung Jung , Kwideok Park
发明人： Dong Keun Han , Kwang-Duk Ahn , Hyun Jung Jung , Kwideok Park
IPC分类号： A61F2/00
CPC分类号： A61L27/56 , A61L27/18 , A61L27/58 , C08L67/04
摘要： There is provided a method of preparing biodegradable dual pore polymer scaffolds, comprising the steps of: maintaining a polymer solution containing a biodegradable polymer, an effervescent mixture of carbonate and organic acid, and solvent at a temperature range of −196° C. to ambient temperature so as to evaporate the solvent and produce a polymer sample; and foaming the polymer sample in a mixed solution of water and alcohol.According to the present invention, the pore size of the polymer scaffolds can be easily controlled, and biodegradable polymer scaffolds can be more simply prepared compared to conventional methods such as salt leaching technique, phase separation technique or gas foaming technique. Further, since the biodegradable polymer scaffolds prepared according to the present invention have a high surface area and porosity without formation of skin layer, secretion of toxic substances and remnant phenomenon, they can be advantageously used for regenerating almost all living tissues and organs in tissue engineering.
摘要翻译：提供了一种制备可生物降解的双孔聚合物支架的方法，包括以下步骤：将含有可生物降解的聚合物，碳酸盐和有机酸的泡腾混合物和溶剂的聚合物溶液在-196℃的温度范围内保持至环境温度温度以蒸发溶剂并产生聚合物样品; 并将聚合物样品在水和酒精的混合溶液中发泡。根据本发明，与常规方法如盐浸技术，相分离技术或气体发泡技术相比，可以容易地控制聚合物支架的孔径，并且可以更简单地制备可生物降解的聚合物支架。此外，由于根据本发明制备的可生物降解的聚合物支架具有高的表面积和孔隙率，而没有形成皮肤层，有毒物质的分泌和残留现象，因此它们可有利地用于组织工程中几乎所有活组织和器官的再生。

23. 发明申请

US20100168506A1 Method For Preparing Drug-Eluting Stent Having Nano-Structured Pattern 审中-公开
标题翻译：制备具有纳米结构图案的药物洗脱支架的方法
公开(公告)号：US20100168506A1
公开(公告)日：2010-07-01
申请号：US12368537
申请日：2009-02-10
申请人： Myoung-Woon Moon , Kwang Ryeol Lee , Dong Keun Han , Kwi- Deok Park
发明人： Myoung-Woon Moon , Kwang Ryeol Lee , Dong Keun Han , Kwi- Deok Park
IPC分类号： A61F2/04 , A61F2/06
CPC分类号： A61L31/16 , A61L31/10 , A61L31/14 , A61L31/148 , A61L2300/61 , A61L2400/12 , A61L2400/18
摘要： This invention relates to a method for preparing a drug-eluting stent using a chemical vapor deposition, the method comprising modifying the surface of a biodegradable polymer with nanostructures through a plasma-assisted chemical vapor deposition so as to improve drug-loading capability and drug elution rate.
摘要翻译：本发明涉及一种使用化学气相沉积制备药物洗脱支架的方法，所述方法包括通过等离子体辅助化学气相沉积来改变具有纳米结构的可生物降解的聚合物的表面，以改善药物负载能力和药物洗脱率。

24. 发明授权

US07304096B2 Highly functional dental adhesive composition 失效
标题翻译：高功能牙科粘合剂组合物
公开(公告)号：US07304096B2
公开(公告)日：2007-12-04
申请号：US11025337
申请日：2004-12-29
申请人： Dong Keun Han , Kyu Hyun Baek , Min Sung Kim , Sang Soon Park , Hyun Chul Goo , Choong Ho Kim
发明人： Dong Keun Han , Kyu Hyun Baek , Min Sung Kim , Sang Soon Park , Hyun Chul Goo , Choong Ho Kim
IPC分类号： C08F2/46 , C08F2/50 , A61K6/083
CPC分类号： A61K6/0023 , Y10S522/908 , C08L33/00
摘要： There is provided a highly functional one-step light-curing dental adhesive composition i) based on a multifunctional prepolymer mixture of 2,2-bis-[4-(2-hydroxy-3-methacryloyloxypropoxy)phenyl]propane (“Bis-GMA”) and a multifunctional prepolymer formed by substitiuting hydrogen atoms of hydroxyl groups present in Bis-GMA molecules with methacrylate groups, in which the Bis-GMA is used as a base prepolymer of conventional dental adhesive compositions; and ii) comprising and acidic monomer for removing a portion of smear layer, which is allowed to be bonded without separate treatment of acid etchant, an adhesive monomer having both hydrophobic and hydrophilic properties, a hydrophilic monomer which is allowed to be bonded in the present of moisture, an inorganic filler for improving mechanical properties, diluent, water for demineralization, a photoinitiation system and other additives.
摘要翻译：提供了基于2,2-双 - [4-（2-羟基-3-甲基丙烯酰氧基丙氧基）苯基]丙烷（“Bis-GMA”）的多官能预聚物混合物的高功能性一步光固化牙科粘合剂组合物 “）和通过将Bis-GMA分子中存在的羟基的氢原子与甲基丙烯酸酯基团取代形成的多官能预聚物，其中Bis-GMA用作常规牙科粘合剂组合物的基础预聚物; 和ii）包含和酸性单体，用于除去涂覆层的一部分，其在酸性蚀刻剂单独处理的情况下允许粘合，具有疏水性和亲水性两者的粘合剂单体，在本发明中允许结合的亲水性单体的水分，用于改善机械性能的无机填料，稀释剂，用于脱矿质的水，光引发体系和其它添加剂。

25. 发明授权

US07115674B2 Dental self-curing resin cement compositions 有权
标题翻译：牙科自固化树脂水泥组合物
公开(公告)号：US07115674B2
公开(公告)日：2006-10-03
申请号：US10699117
申请日：2003-10-31
申请人： Kwang Soo Park , Sang Soon Park , Kyu Hyun Baek , Min Sung Kim , Dong Keun Han
发明人： Kwang Soo Park , Sang Soon Park , Kyu Hyun Baek , Min Sung Kim , Dong Keun Han
IPC分类号： A61K6/083 , C08K3/22
CPC分类号： A61K6/083 , C08L33/00
摘要： The present invention refers to dental self-curing resin compositions having enhanced mechanical and physical properties. In particular, the present invention relates to dental self-curing resin compositions consisting of (i) a Paste A composition containing the multifunctional prepolymer mixture of 2,2-bis-[4-(2-hydroxy-3-methacryloxypropoxy)phenyl]propane (“Bis-GMA”) and multifunctional prepolymer formed by substituting hydrogen atoms in hydroxyl group with methacrylate groups in the Bis-GMA molecules, and further containing a diluent, an adhesive monomer, a polymerization initiator, a polymerization inhibitor, a light stabilizer, an antioxidant, an inorganic pigment and an inorganic filler; and ii) a Paste B composition containing the same prepolymer mixture in the Paste A composition, and further containing a diluent, an adhesive monomer, a reductant, a polymerization inhibitor, a light stabilizer, an antioxidant, an inorganic pigment and an inorganic filler. The composition according to the present invention has better physical and mechanical properties than that of conventional compositions and is an ointment-ointment system able to be conveniently used.
摘要翻译：本发明涉及具有增强的机械和物理性质的牙科自固化树脂组合物。特别地，本发明涉及牙科自固化树脂组合物，其由（i）含有2,2-双 - [4-（2-羟基-3-甲基丙烯酰氧基丙氧基）苯基]丙烷的多官能预聚物混合物的糊剂A组合物（“Bis-GMA”）和通过在Bis-GMA分子中用甲基丙烯酸酯基取代羟基中的氢原子形成的多官能预聚物，还含有稀释剂，粘合剂单体，聚合引发剂，阻聚剂，光稳定剂，抗氧化剂，无机颜料和无机填料; 和ii）在糊剂A组合物中含有相同的预聚物混合物的糊剂B组合物，并且还含有稀释剂，粘合剂单体，还原剂，阻聚剂，光稳定剂，抗氧化剂，无机颜料和无机填料。根据本发明的组合物具有比常规组合物更好的物理和机械性能，并且是能够方便使用的软膏剂系统。

26. 发明授权

US06573312B2 Photo-cured dental pit and fissure sealant composition for caries prevention 失效
公开(公告)号：US06573312B2
公开(公告)日：2003-06-03
申请号：US09749878
申请日：2000-12-29
申请人： Dong-Keun Han , Kwang-Duk Ahn , Jin-Hee Jeong
发明人： Dong-Keun Han , Kwang-Duk Ahn , Jin-Hee Jeong
IPC分类号： A61K6083
CPC分类号： C09D4/00 , A61K6/0017 , C08K5/08 , C08K5/175 , C08F222/20 , C08F222/1006 , C08L33/00
摘要： The invention relates to a photo-cured dental pit and fissure sealant composition for caries prevention: i) based on the multifunctional prepolymer mixture of 2,2-bis-(4-(2-hydroxy-3-methacryloyloxypropoxy)phenyl)propane (“Bis-GMA”), which has conventionally been used as dental pit and fissure sealant for caries prevention, and a multifunctional prepolymer formed by substituting hydrogen atoms in hydroxyl group with methacrylate groups in the Bis-GMA molecules; and ii) comprising a diluent, an inorganic filler, a photoinitiation system, and other additives. The dental pit and fissure sealant composition of the present invention is based on a multifunctional prepolymer mixture and has better physical and mechanical properties and biocompatibility than a conventional composition based on Bis-GMA only.

27. 发明授权

US5697972A Bioprosthetic heart valves having high calcification resistance 失效
标题翻译：具有高钙化阻力的生物假体心脏瓣膜
公开(公告)号：US5697972A
公开(公告)日：1997-12-16
申请号：US480318
申请日：1995-06-07
申请人： Young Ha Kim , Ki Dong Park , Dong Keun Han , Hack Joo Kim
发明人： Young Ha Kim , Ki Dong Park , Dong Keun Han , Hack Joo Kim
IPC分类号： A61L27/00 , A61F2/24 , A61L27/34 , A61L27/36
CPC分类号： A61L27/3687 , A61L27/34 , A61L27/3604 , A61L27/3625 , A61L27/3645 , A61L27/507 , A61F2/24 , A61L2400/02 , Y10S623/901 , Y10S623/918
摘要： The specification describes an invention of calcification resistant bioprosthetic heart valves which can be used for a long term, and have good blood compatibility and in vivo stability, and have high calcification resistance. The bioprosthetic heart valves of the invention can be prepared by binding sulfonated polyethylene oxide (PEO) derivatives covalently to the tissue. The valves have an anionic effect equal to that of chondroitin sulfate, space filling effect, and blocking effect of the carboxyl group of collagen which has been known as one factor of the calcium deposition,. In particular, the present method has better advantages in view of calcification resistance than any other conventional methods, because it suppresses thrombosis and embolism and decreases incidence of infection.
摘要翻译：该说明书是能够长期使用且具有良好的血液相容性和体内稳定性，耐钙化性高的生物假体心脏瓣膜的发明。本发明的生物假体心脏瓣膜可以通过将磺化聚环氧乙烷（PEO）衍生物共价结合到组织来制备。这些阀具有与硫酸软骨素相当的阴离子效应，空间填充效应和被称为钙沉积的一个因素的胶原羧基的阻断作用。特别地，本方法考虑到耐钙化性优于任何其它常规方法，因为其抑制血栓形成和栓塞并降低感染发生率。

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