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1. 发明授权

US06617027B2 Biocompatible metallic materials grafted with biologically active compounds and preparation thereof 失效
标题翻译：用生物活性化合物接枝的生物相容性金属材料及其制备方法
公开(公告)号：US06617027B2
公开(公告)日：2003-09-09
申请号：US09816446
申请日：2001-03-26
申请人： Young Ha Kim , Ki Dong Park , Soo Hyun Kim , Won Kyu Lee , Hyun Chul Goo
发明人： Young Ha Kim , Ki Dong Park , Soo Hyun Kim , Won Kyu Lee , Hyun Chul Goo
IPC分类号： B32B2736
CPC分类号： B82Y30/00 , A61L31/088 , A61L33/0011 , A61L33/0076 , A61L33/0082 , Y10T428/31504
摘要： Disclosed are surface-modified medical metallic materials and preparation thereof. The medical metallic material is prepared by coating a gold or silver thin layer onto a base metal, adsorbing a polyfunctional sulfur compound onto the gold or silver thin layer, and chemically bonding a biologically active material such as heparin or estradiol to the functional group of the sulfur compound. The biologically active material is firmly bonded to the base metal via the sulfur compound. Being significantly improved in antithrombogenicity and biocompatibility, the metallic materials are suitable for use in various implants, including stents, artificial cardiac valves and catheters.
摘要翻译：公开了表面改性的医用金属材料及其制备方法。通过将金或银薄层涂覆在母体金属上，将多官能硫化合物吸附到金或银薄层上，并将生物活性物质如肝素或雌二醇化学键合到所述金属或金属的官能团上来制备医用金属材料硫化合物。生物活性物质通过硫化合物牢固地结合到贱金属。抗凝血性和生物相容性显着提高，金属材料适用于各种植入物，包括支架，人造心脏瓣膜和导管。

2. 发明授权

US07304096B2 Highly functional dental adhesive composition 失效
标题翻译：高功能牙科粘合剂组合物
公开(公告)号：US07304096B2
公开(公告)日：2007-12-04
申请号：US11025337
申请日：2004-12-29
申请人： Dong Keun Han , Kyu Hyun Baek , Min Sung Kim , Sang Soon Park , Hyun Chul Goo , Choong Ho Kim
发明人： Dong Keun Han , Kyu Hyun Baek , Min Sung Kim , Sang Soon Park , Hyun Chul Goo , Choong Ho Kim
IPC分类号： C08F2/46 , C08F2/50 , A61K6/083
CPC分类号： A61K6/0023 , Y10S522/908 , C08L33/00
摘要： There is provided a highly functional one-step light-curing dental adhesive composition i) based on a multifunctional prepolymer mixture of 2,2-bis-[4-(2-hydroxy-3-methacryloyloxypropoxy)phenyl]propane (“Bis-GMA”) and a multifunctional prepolymer formed by substitiuting hydrogen atoms of hydroxyl groups present in Bis-GMA molecules with methacrylate groups, in which the Bis-GMA is used as a base prepolymer of conventional dental adhesive compositions; and ii) comprising and acidic monomer for removing a portion of smear layer, which is allowed to be bonded without separate treatment of acid etchant, an adhesive monomer having both hydrophobic and hydrophilic properties, a hydrophilic monomer which is allowed to be bonded in the present of moisture, an inorganic filler for improving mechanical properties, diluent, water for demineralization, a photoinitiation system and other additives.
摘要翻译：提供了基于2,2-双 - [4-（2-羟基-3-甲基丙烯酰氧基丙氧基）苯基]丙烷（“Bis-GMA”）的多官能预聚物混合物的高功能性一步光固化牙科粘合剂组合物 “）和通过将Bis-GMA分子中存在的羟基的氢原子与甲基丙烯酸酯基团取代形成的多官能预聚物，其中Bis-GMA用作常规牙科粘合剂组合物的基础预聚物; 和ii）包含和酸性单体，用于除去涂覆层的一部分，其在酸性蚀刻剂单独处理的情况下允许粘合，具有疏水性和亲水性两者的粘合剂单体，在本发明中允许结合的亲水性单体的水分，用于改善机械性能的无机填料，稀释剂，用于脱矿质的水，光引发体系和其它添加剂。

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