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21. 发明授权

US06348449B1 Methods of inducing mucosal immunity 失效
标题翻译：诱导粘膜免疫的方法
公开(公告)号：US06348449B1
公开(公告)日：2002-02-19
申请号：US08357398
申请日：1994-12-16
申请人： David B. Weiner , Bin Wang , Kenneth E. Ugen
发明人： David B. Weiner , Bin Wang , Kenneth E. Ugen
IPC分类号： A01N4304
CPC分类号： A61K31/7052 , A61K31/711 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/292 , A61K48/00 , A61K2039/53 , A61K2039/541 , C07K14/005 , C12N15/87 , C12N2730/10122 , C12N2730/10134 , C12N2740/13022 , C12N2740/13034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2770/24222
摘要： Methods of inducing mucosal immunity in individuals against proteins and peptides are disclosed. The methods comprise the step of administering topically or by lavage into mucosal tissue selected from the group consisting of rectal, vaginal, urethral, sublingual and buccal, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein or peptide that comprises an epitope against which mucosal immunity is desired. The methods may be used to immunize an individual against a pathogen infection, hyperproliferative diseases or autoimmune diseases using nucleic acid molecules which encode proteins and peptides that share an epitope with a pathogen antigen or protein associated with cells involved in hyperproliferative diseases or autoimmune diseases, respectively.
摘要翻译：公开了在个体中针对蛋白质和肽诱导粘膜免疫的方法。所述方法包括向局部或通过灌洗施用选自直肠，阴道，尿道，舌下和颊部的粘膜组织的步骤，所述核酸分子包含编码蛋白质或肽的核苷酸序列，所述核苷酸序列包含针对需要哪种粘膜免疫。可以使用这些方法来免疫个体免受病原体感染，过度增殖性疾病或自身免疫性疾病的使用，该核酸分子编码分别与参与过度增殖性疾病或自身免疫性疾病的细胞相关的病原体抗原或蛋白质共享表位的蛋白质和肽。

22. 发明授权

US5962428A Compositions and methods for delivery of genetic material 失效
标题翻译：用于遗传物质传递的组合物和方法
公开(公告)号：US5962428A
公开(公告)日：1999-10-05
申请号：US704701
申请日：1996-09-16
申请人： Richard A. Carrano , Bin Wang , David B. Weiner
发明人： Richard A. Carrano , Bin Wang , David B. Weiner
IPC分类号： A61K39/00 , A61K39/12 , A61K39/205 , A61K39/21 , A61K39/29 , C07K14/16 , A61K31/70 , A61K45/05
CPC分类号： C07K14/005 , A61K39/00 , A61K39/0008 , A61K39/0011 , A61K39/12 , A61K39/205 , A61K39/21 , A61K39/29 , A61K39/292 , A61K2039/53 , A61K2039/55511 , A61K2039/55522 , C12N2730/10134 , C12N2740/16134 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , C12N2770/24234
摘要： Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an individual with a genetic vaccine facilitator and administering to the cells a nucleic acid molecule that is free of retroviral particles. The nucleic acid molecule comprises a nucleotide sequence that encodes a protein that comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen or an antigen associated with a hyperproliferative or autoimmune disease, a protein otherwise missing from the individual due to a missing, non-functional or partially functioning gene, or a protein that produces a therapeutic effect on an individual. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
摘要翻译： PCT No.PCT / US95 / 04071 Sec。 371日期1996年9月16日 102（e）1996年9月16日PCT 1995年3月30日PCT PCT。 WO95 / 26718 PCT公开号 1995年10月12日的日期公开了将遗传物质引入个体细胞的方法和用于实施其的组合物和试剂盒。所述方法包括使个体的细胞与基因疫苗促进剂接触并向细胞施用不含逆转录病毒颗粒的核酸分子的步骤。核酸分子包含编码蛋白质的核苷酸序列，该蛋白质包含与病原体抗原或与过度增殖或自身免疫疾病相关的抗原的表位相同或基本相似的至少一个表位，涉及缺失的，非功能的或部分功能的基因或对个体产生治疗作用的蛋白质。公开了预防和治疗个体免受HIV感染的方法。公开了用于本发明的实践方法的药物组合物和试剂盒。

23. 发明授权

US5780220A Methods and compositions for inhibiting HIV replication 失效
标题翻译：用于抑制HIV复制的方法和组合物
公开(公告)号：US5780220A
公开(公告)日：1998-07-14
申请号：US382873
申请日：1995-02-03
申请人： David B. Weiner , Yosef Refaeli , David N. Levy
发明人： David B. Weiner , Yosef Refaeli , David N. Levy
IPC分类号： A61K38/00 , C07K14/16 , C07K16/10 , C12P21/08 , G01N33/569 , C12Q1/70 , A01N43/04 , A61K31/56 , G01N33/53
CPC分类号： C07K14/005 , C07K16/1072 , G01N33/56988 , A61K38/00 , C12N2740/16322 , Y10S514/01
摘要： A method for treating an individual exposed to or infected with HIV is disclosed which comprises administering to said individual a therapeutically effective amount of one or more compounds which inhibit or prevent replication of said HIV by interfering with the replicative or other essential functions of Vpr expressed by said HIV, by interactively blocking the Vpr target in human cells, and thereby preventing translocation of the Vpr/target complex from the cytosol of said human cells to the nuclei of said cells, where Vpr carries on activities essential to replication of HIV. In preferred embodiments, the compound or compounds which interactively block the target are steroid hormone receptor antagonists, glucocorticoid receptor antagonists, or glucocorticoid receptor Type II antagonists, especially mifepristone (RU-486). Pharmaceutical compositions comprising these compounds, as well as a method for identifying them and a kit for use therein, are also disclosed.
摘要翻译：公开了一种用于治疗暴露于或感染HIV的个体的方法，其包括向所述个体施用治疗有效量的一种或多种化合物，所述一种或多种化合物通过干扰由Vpr表达的Vpr的复制或其它基本功能来抑制或阻止所述HIV的复制所述HIV通过交互阻断人细胞中的Vpr靶，从而防止Vpr /靶复合物从所述人细胞的胞质溶胶转移到所述细胞的细胞核，其中Vpr进行HIV复制必需的活性。在优选的实施方案中，交互地阻断靶标的化合物或类似物是类固醇激素受体拮抗剂，糖皮质激素受体拮抗剂或糖皮质激素受体II型拮抗剂，特别是米非司酮（RU-486）。还公开了包含这些化合物的药物组合物，以及用于鉴定它们的方法和用于其中的试剂盒。

24. 发明授权

US5637677A Biologically active compounds and methods of constructing and using the same 失效
标题翻译：生物活性化合物及其使用方法
公开(公告)号：US5637677A
公开(公告)日：1997-06-10
申请号：US940654
申请日：1992-09-03
申请人： Mark I. Greene , William V. Williams , David B. Weiner , Jeffrey A. Cohen , Thomas Kieber-Emmons , Robert M. Williams
发明人： Mark I. Greene , William V. Williams , David B. Weiner , Jeffrey A. Cohen , Thomas Kieber-Emmons , Robert M. Williams
IPC分类号： A61K39/00 , C07K14/005 , C07K14/14 , C07K14/16 , C07K14/725 , C07K14/73 , C07K14/74 , C07K16/10 , C07K7/00
CPC分类号： C07K14/005 , C07K14/7051 , C07K14/70514 , C07K14/70539 , C07K16/10 , C07K16/1063 , A61K39/00 , C12N2720/12022 , C12N2740/16122
摘要： A method of constructing biologically active compounds which mimic the biological activity of the biologically active protein or which block the activity of the biologically active protein is disclosed. A method of identifying specific and discrete portions of pathogen antigens which either serve as epitopes for neutralizing antibodies or which are involved in pathogen binding to host cell receptors is disclosed. A method of constructing biologically active compounds which compete with cellular receptors for binding to either biologically active proteins or pathogen antigens is disclosed.
摘要翻译：公开了一种构建模拟生物活性蛋白的生物活性或阻断生物活性蛋白的活性的生物活性化合物的方法。公开了鉴定作为中和抗体或参与病原体与宿主细胞受体结合的表位的病原体抗原的特异性和离散部分的方法。公开了一种构建与细胞受体竞争结合生物活性蛋白或病原体抗原的生物活性化合物的方法。

25. 发明授权

US5556744A Methods and compositions for diagnosing and treating certain HIV infected patients 失效
标题翻译：用于诊断和治疗某些HIV感染患者的方法和组合物
公开(公告)号：US5556744A
公开(公告)日：1996-09-17
申请号：US218025
申请日：1994-03-24
申请人： David B. Weiner , Kenneth E. Ugen , William V. Williams
发明人： David B. Weiner , Kenneth E. Ugen , William V. Williams
IPC分类号： C07K14/16 , C12Q1/70
CPC分类号： C07K14/005 , C12N2740/16122 , Y10S435/974 , Y10S435/975 , Y10S530/826
摘要： The present invention provides a panel of HIV peptides useful in diagnosing whether or not a patient is of vertical HIV transmission status, methods for diagnosing same, methods for identifying epitopes and peptides associated with non-transmission status, and pharmaceutical and vaccine compositions containing same.
摘要翻译：本发明提供了一组可用于诊断患者是否具有垂直HIV传播状态的HIV肽组，用于诊断其的方法，用于鉴定与非传染状态相关的表位和肽的方法，以及含有其的药物和疫苗组合物。

26. 外观设计

USD275732S Liquid dispensing container 失效
公开(公告)号：USD275732S
公开(公告)日：1984-10-02
申请号：US380924
申请日：1982-05-21
申请人： Joseph A. Bauwens , David B. Weiner
设计人： Joseph A. Bauwens , David B. Weiner

27. 发明授权

US10226528B2 Vaccines with biomolecular adjuvants 有权
公开(公告)号：US10226528B2
公开(公告)日：2019-03-12
申请号：US14774428
申请日：2014-03-14
申请人： David B. Weiner , Karuppiah Muthumani
发明人： David B. Weiner , Karuppiah Muthumani
IPC分类号： A61K39/39 , A61K39/12 , A61K39/21 , C07K14/52 , C12N7/00 , A61K41/00 , C07K14/47 , A61K39/00
摘要： Disclosed herein is a vaccine comprising an antigen and one or more bimolecular adjuvant. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.

28. 发明授权

US10071154B2 Vaccines and immunotherapeutics using IL-28 and compositions and methods of using the same 有权
公开(公告)号：US10071154B2
公开(公告)日：2018-09-11
申请号：US12936192
申请日：2009-04-06
申请人： David B Weiner , Matthew P Morrow
发明人： David B Weiner , Matthew P Morrow
IPC分类号： A61K39/395 , A61K38/21 , C07K16/28 , C07K14/56 , C12N7/00 , A61K39/285 , C07K14/54 , A61K38/20
CPC分类号： A61K39/285 , A61K38/20 , C07K14/54 , C12N7/00 , Y02A50/393
摘要： Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes IL-28 or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.

29. 发明授权

US10022434B2 Influenza nucleic acid molecules and vaccines made therefrom 有权
公开(公告)号：US10022434B2
公开(公告)日：2018-07-17
申请号：US14774241
申请日：2014-03-12
申请人： David B. Weiner , Jian Yan , Matthew Morrow
发明人： David B. Weiner , Jian Yan , Matthew Morrow
IPC分类号： A61K39/145 , A61K39/12 , C07K14/005 , C12N7/00 , A61K39/00
摘要： Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin and/or influenza B hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more influenza A serotypes and/or influenza B serotypes, or combinations thereof, using the vaccines that are provided.

30. 发明授权

US09987347B2 Vaccines against multiple subtypes of dengue virus 有权
公开(公告)号：US09987347B2
公开(公告)日：2018-06-05
申请号：US14775069
申请日：2014-03-14
申请人： INOVIO PHARMACEUTICALS, INC. , David B. Weiner , Jian Yan , Niranjan Sardesai
发明人： David B. Weiner , Jian Yan , Niranjan Sardesai
IPC分类号： C07H21/04 , A61K31/70 , A61K39/12 , A61K31/7088 , A61N1/04 , A61N1/32 , C07K14/005 , C12N7/00 , A01K67/00 , A61K39/00
CPC分类号： A61K39/12 , A61K31/7088 , A61K2039/53 , A61K2039/54 , A61K2039/55527 , A61K2039/55538 , A61K2039/575 , A61N1/0412 , A61N1/0476 , A61N1/327 , C07K14/005 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24141 , Y02A50/386 , Y02A50/394
摘要： An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide, such as a consensus dengue prME that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal that is cross reactive against all 4 dengue subtypes.

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