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21. 发明申请

WO2002083188A2 DENSE/POROUS STRUCTURES FOR USE AS BONE SUBSTITUTES 审中-公开
标题翻译： DENSE /多孔结构用作骨髓替代品
公开(公告)号：WO2002083188A2
公开(公告)日：2002-10-24
申请号：PCT/US2002/011909
申请日：2002-04-16
申请人： CASSIDY, James, J. , NORBERG, Brian, L. , HECKENDORF, Bradley, R. , KO, Ying
发明人： CASSIDY, James, J. , NORBERG, Brian, L. , HECKENDORF, Bradley, R. , KO, Ying
IPC分类号： A61L
CPC分类号： A61L27/425 , A61F2/28 , A61F2/2803 , A61F2/30767 , A61F2/3094 , A61F2/4225 , A61F2/4241 , A61F2/4465 , A61F2002/2817 , A61F2002/2825 , A61F2002/2892 , A61F2002/30011 , A61F2002/30013 , A61F2002/30057 , A61F2002/30092 , A61F2002/30225 , A61F2002/3023 , A61F2002/30576 , A61F2002/30578 , A61F2002/30622 , A61F2002/30677 , A61F2002/30678 , A61F2002/30785 , A61F2002/30841 , A61F2002/30878 , A61F2002/3092 , A61F2002/30929 , A61F2002/30957 , A61F2002/30958 , A61F2002/30968 , A61F2002/30981 , A61F2002/4212 , A61F2002/4271 , A61F2002/4648 , A61F2210/0014 , A61F2230/0069 , A61F2250/0023 , A61F2250/0024 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00131 , A61F2310/00203 , A61F2310/00239 , A61F2310/00293 , A61F2310/00329 , A61F2310/00353 , A61F2310/00365 , A61L27/427 , A61L27/56 , A61L2430/02 , B22F7/004 , B22F2998/00 , B28B1/24 , B28B1/26 , B28B19/00 , B28B23/0068 , B29C45/14795 , B22F3/225
摘要： A combination dense/porous structure includes a porous element having an outer surface defining a shape having a bulk volume, the element includes a continuous framework having struts defining a plurality of interconnecting interstices throughout the bulk volume. The porous element has interconnecting interstices extending throughout the volume and opening through the surface. The combination dens/porous structure also includes a dense element formed from a material and having a sintered density of at least 95%, contacting at least a portion of the porous element; and an interconnection zone formed by the inter-penetration of the material forming the dense element into the porous element. The combination dense/porous structures are particularly useful as bone substitute materials and extended release delivery systems, preferable sustained release, for physiologically active agents. The interconnection zone can also be formed by a bonding phase that may or may not be the same material as the dense and/or porous element. A process for producing a combination dense/porous structure includes: providing a porous element; providing a dispersion comprising a ceramic or metal powder and a binder; contacting the dispersion with the porous element whereby the slip at least partially penetrates into at least a portion of the porous element to form an interconnection zone and a dense element formed from the dispersion and adjacent to the interconnection zone to form a dense/porous structure; treating the dense/porous structure to form a green dens/porous structure; and curing, drying, and/or heating the green dense/porous structure to form the combination dense/porous structure.
摘要翻译：组合致密/多孔结构包括具有限定具有本体体积的形状的外表面的多孔元件，所述元件包括具有在整个体积中限定多个互连间隙的支柱的连续框架。多孔元件具有延伸贯穿整个体积并通过表面打开的互连间隙。组合密度/多孔结构还包括由材料形成并且具有至少95％的烧结密度的致密元件，与多孔元件的至少一部分接触; 以及通过将形成致密元件的材料相互渗入多孔元件而形成的互连区。组合致密/多孔结构特别可用作生物活性剂的骨替代材料和延长释放递送系统，优选持续释放。互连区域也可以通过粘结相形成，所述粘合相可以是或可以不是与致密和/或多孔元件相同的材料。用于生产组合致密/多孔结构的方法包括：提供多孔元件; 提供包含陶瓷或金属粉末和粘合剂的分散体; 使所述分散体与所述多孔元件接触，由此所述滑移部至少部分地渗入所述多孔元件的至少一部分，以形成互连区域和由所述分散体形成并且邻近所述互连区域形成致密/多孔结构的致密元件; 处理致密/多孔结构以形成绿色/多孔结构; 并固化，干燥和/或加热绿色致密/多孔结构以形成组合致密/多孔结构。

22. 发明申请

WO1997022076A1 VIRTUAL DNA SEQUENCER 审中-公开
标题翻译：虚拟DNA序列
公开(公告)号：WO1997022076A1
公开(公告)日：1997-06-19
申请号：PCT/CA1996000834
申请日：1996-12-12
申请人： VISIBLE GENETICS INC. , STEVENS, John, K. , DUNN, James, M. , DEE, Gregory , CASSIDY, James, W.
发明人： VISIBLE GENETICS INC.
IPC分类号： G06F19/00
CPC分类号： G01N27/44782
摘要： A virtual DNA sequencer combines a plurality of individual DNA sequencers. Samples of DNA or other nucleic acid from subjects are prepared and allocated in real time to particular lanes or sets of lanes in electrophoresis plates of the individual sequencers, with records kept of the allocations. The data resulting from the electrophoresis runs is collected and collated according to the identities of the subjects. The individual sequencers are networked, and each individual sequencer is preferably equipped with a data buffer large enough to accommodate all or substantially all of a data run, thus protecting the virtual sequencer from loss of valuable data in the event that the network is disrupted for some portion of the time of the data run. In this way, a plurality of sequencers is virtually the same as a single sequencer with a very large number of tracks each of which can run for a much longer sequencing run than an individual sequencer.
摘要翻译：虚拟DNA测序仪组合了多个单独的DNA测序仪。来自受试者的DNA或其他核酸的样品被制备并实时分配到各个定序器的电泳板中的特定泳道或泳道组，并保存有分配记录。根据受试者的身份收集和整理电泳运行产生的数据。各个顺控程序被联网，并且每个单独的顺控程序优选地配备有足够大的数据缓冲器以容纳所有或基本上所有的数据运行，从而在网络被中断的情况下保护虚拟定序器免于丢失有价值的数据部分时间的数据运行。以这种方式，多个定序器与具有非常大数量的轨道的单个定序器几乎相同，每个轨道可以运行比单个定序器更长的排序运行。

23. 发明申请

WO2011107799A3 IMPROVED TIDAL STREAM TURBINE 审中-公开
公开(公告)号：WO2011107799A3
公开(公告)日：2011-09-09
申请号：PCT/GB2011/050415
申请日：2011-03-02
申请人： SILVINE CORPORATION , FRENCH, Matthew , RUST, Robert W , CASSIDY, James
发明人： FRENCH, Matthew , RUST, Robert W , CASSIDY, James
IPC分类号： F03B13/26 , F03B17/06
摘要： The invention relates to a tidal stream turbine (10) arranged to be located underwater in a tidal stream flow to generate a hydraulic head. The turbine comprises a nacelle (12) pivotally coupled to a support such that the nacelle (12) can rotate about a substantially vertical pivot axis A; a rotor (22) having a plurality of circumferentially spaced blades (26) radially extending from a hub (24); a plurality of circumferentially spaced guide vanes (30) radially extending from the nacelle (12) and positioned upstream of the rotor; and a pump (34) arranged to be driven by the rotor (22) and having a water inlet (40) and a water outlet (42). In use the tidal stream causes the rotor (22) to rotate, thereby driving the pump (34) which draws in water through the water inlet (40), increases the hydraulic head of the water, and delivers the water from the outlet (42).

24. 发明申请

WO03070191A8 TAMPER-RESISTANT TRANSDERMAL OPIOID DELIVERY DEVICES 审中-公开
标题翻译：防篡改透明阿片类物质递送装置
公开(公告)号：WO03070191A8
公开(公告)日：2004-06-10
申请号：PCT/US0304999
申请日：2003-02-19
申请人： EURO CELTIQUE SA , SHEVCHUK IHOR , CASSIDY JAMES P , REIDENBERG BRUCE , SHARP DALE E , KUPPER ROBERT J
发明人： SHEVCHUK IHOR , CASSIDY JAMES P , REIDENBERG BRUCE , SHARP DALE E , KUPPER ROBERT J
IPC分类号： A61K9/70 , A61K31/485 , A61K45/06 , A61P25/04 , A61P25/36 , C07D489/08
CPC分类号： A61K9/7084 , A61K31/485 , A61K45/06 , C07D489/08 , A61K2300/00
摘要： This invention relates to a tamper-resistant transdermal-delivery device comprising an opioid, or a pharmaceutically acceptable salt thereof, and an acyl opiod antagonist, or a pharmaceutically acceptable salt thereof. The transdermal-delivery device allows an analgesically effective amount of the opioid, or a pharmaceutically acceptable salt thereof, to be transdermally administered to a patient. The invention further relates to methods for treating or preventing pain in a patient comprising contacting the skin of a patient in need thereof with the transdermal-delivery device of the invention for an amount of time sufficient to treat or prevent pain. The invention further relates to acyl opioid antagonists.
摘要翻译：本发明涉及抗篡改透皮递送装置，其包含阿片样物质或其药学上可接受的盐和酰基阿片类拮抗剂或其药学上可接受的盐。透皮递送装置允许镇痛有效量的阿片样物质或其药学上可接受的盐透皮施用于患者。本发明进一步涉及治疗或预防患者疼痛的方法，其包括使有需要的患者的皮肤与本发明的透皮递送装置接触足以治疗或预防疼痛的时间量。本发明进一步涉及酰基阿片样物质拮抗剂。

25. 发明申请

WO9830141A3 DEVICES FOR TISSUE REPAIR AND METHODS FOR PREPARATION AND USE THEREOF 审中-公开
标题翻译：用于组织修复的装置及其制备和使用方法
公开(公告)号：WO9830141A3
公开(公告)日：1998-11-26
申请号：PCT/US9800414
申请日：1998-01-08
申请人： COHESION TECH INC , CHU GEORGE H , YEUNG JEFFREY E , CASSIDY JAMES J , SCHROEDER JACQUELINE A , BROWN MELISSA K C , SHENOY VIVEK N , RICE JOHN
发明人： CHU GEORGE H , YEUNG JEFFREY E , CASSIDY JAMES J , SCHROEDER JACQUELINE A , BROWN MELISSA K C , SHENOY VIVEK N , RICE JOHN
IPC分类号： A61F2/00 , A61F2/08 , A61L27/24 , A61L27/46 , A61L27/48 , A61L31/04 , A61L31/12 , B29C47/70 , A61B1/07
CPC分类号： B29C47/702 , A61B17/0401 , A61B2017/00526 , A61B2017/00898 , A61B2017/0404 , A61B2017/0409 , A61B2017/0414 , A61B2017/0445 , A61F2/0811 , A61F2310/00365 , A61L27/24 , A61L27/46 , A61L27/48 , A61L31/044 , A61L31/127 , A61L31/129 , A61L2430/02 , B29C47/0023 , B29C47/003 , C08L89/06
摘要： Disclosed herein are uniformly shaped swellable devices comprising polymeric materials, as well as apparatuses and processes for their manufacture. In one embodiment, the present invention relates to load bearing implant devices for use in tissue repair. The implants consist of a resorbable, swellable implant body which is formed from a dehydrated cross-linked biocompatible polymer. As such, the implants are capable of swelling after insertion to become anchored in place. The implants function to enhance the structural integrity of the hard tissue into which they are placed, and thereby improve the load bearing capacity of such tissues. The implants are particularly well suited for use in attaching a second (hard or soft) tissue to the first (hard) tissue into which the implant is inserted. They may also be used as a site for attachment of a surgical device such as a screw, rod or pin.

26. 发明申请

WO03070191A3 TAMPER-RESISTANT TRANSDERMAL OPIOID DELIVERY DEVICES 审中-公开
标题翻译：防篡改传感器输送装置
公开(公告)号：WO03070191A3
公开(公告)日：2004-09-10
申请号：PCT/US0304999
申请日：2003-02-19
申请人： EURO CELTIQUE SA , SHEVCHUK IHOR , CASSIDY JAMES P , REIDENBERG BRUCE , SHARP DALE E , KUPPER ROBERT J
发明人： SHEVCHUK IHOR , CASSIDY JAMES P , REIDENBERG BRUCE , SHARP DALE E , KUPPER ROBERT J
IPC分类号： A61K9/70 , A61K31/485 , A61K45/06 , A61P25/04 , A61P25/36 , C07D489/08 , A61K31/4468 , A61K31/55 , C07D221/26 , C07D221/28
CPC分类号： A61K9/7084 , A61K31/485 , A61K45/06 , C07D489/08 , A61K2300/00
摘要： This invention relates to a tamper-resistant transdermal-delivery device comprising an opioid, or a pharmaceutically acceptable salt thereof, and an acyl opiod antagonist, or a pharmaceutically acceptable salt thereof. The transdermal-delivery device allows an analgesically effective amount of the opioid, or a pharmaceutically acceptable salt thereof, to be transdermally administered to a patient. The invention further relates to methods for treating or preventing pain in a patient comprising contacting the skin of a patient in need thereof with the transdermal-delivery device of the invention for an amount of time sufficient to treat or prevent pain. The invention further relates to acyl opioid antagonists.
摘要翻译：本发明涉及包含阿片样物质或其药学上可接受的盐和酰基阿片剂拮抗剂或其药学上可接受的盐的抗篡改透皮递送装置。透皮递送装置允许将止痛有效量的阿片样物质或其药学上可接受的盐透皮给药给患者。本发明还涉及用于治疗或预防患者疼痛的方法，包括将有需要的患者的皮肤与本发明的透皮递送装置接触足以治疗或预防疼痛的时间量。本发明还涉及酰基阿片样物质拮抗剂。

27. 发明申请

WO2003070191A1 TAMPER-RESISTANT TRANSDERMAL OPIOID DELIVERY DEVICES 审中-公开
标题翻译：防篡改透明阿片类物质递送装置
公开(公告)号：WO2003070191A1
公开(公告)日：2003-08-28
申请号：PCT/US2003/004999
申请日：2003-02-19
申请人： EURO-CELTIQUE, S.A. , SHEVCHUK, Ihor , CASSIDY, James, P. , REIDENBERG, Bruce , SHARP, Dale, E. , KUPPER, Robert, J.
发明人： SHEVCHUK, Ihor , CASSIDY, James, P. , REIDENBERG, Bruce , SHARP, Dale, E. , KUPPER, Robert, J.
IPC分类号： A61K
摘要： This invention relates to a tamper-resistant transdermal-delivery device comprising an opioid, or a pharmaceutically acceptable salt thereof, and an acyl opiod antagonist, or a pharmaceutically acceptable salt thereof. The transdermal-delivery device allows an analgesically effective amount of the opioid, or a pharmaceutically acceptable salt thereof, to be transdermally administered to a patient. The invention further relates to methods for treating or preventing pain in a patient comprising contacting the skin of a patient in need thereof with the transdermal-delivery device of the invention for an amount of time sufficient to treat or prevent pain. The invention further relates to acyl opioid antagonists.
摘要翻译：本发明涉及包含阿片样物质或其药学上可接受的盐和酰基阿片类拮抗剂或其药学上可接受的盐的抗篡改透皮递送装置。透皮递送装置允许镇痛有效量的阿片样物质或其药学上可接受的盐透皮施用于患者。本发明进一步涉及治疗或预防患者疼痛的方法，其包括使有需要的患者的皮肤与本发明的透皮递送装置接触足以治疗或预防疼痛的时间量。本发明进一步涉及酰基阿片样物质拮抗剂。

28. 发明申请

WO1996001598A1 PROSTHETIC DEVICES 审中-公开
标题翻译：前置设备
公开(公告)号：WO1996001598A1
公开(公告)日：1996-01-25
申请号：PCT/GB1995001550
申请日：1995-07-03
申请人： SMITH & NEPHEW PLC , CASSIDY, James, Joseph , PIGG, William
发明人： SMITH & NEPHEW PLC
IPC分类号： A61F02/02
CPC分类号： A61F2/441 , A61F2/30965 , A61F2/442 , A61F2002/444
摘要： Prostheses, e.g. disc nucleus prostheses comprising a resiliently deformable material are reinforced with physically discrete structures to form a composite. The resiliently deformable material may be a hydrophilic polymer such as a hydrogel.
摘要翻译：假肢，例如包括可弹性变形材料的椎间盘假体由物理上离散的结构增强以形成复合体。可弹性变形材料可以是亲水性聚合物，例如水凝胶。

29. 发明授权

US3136031A Tool holder 失效
标题翻译：工具托架
公开(公告)号：US3136031A
公开(公告)日：1964-06-09
申请号：US12318461
申请日：1961-07-11
申请人： CASSIDY JAMES P
发明人： CASSIDY JAMES P
IPC分类号： B23B27/16
CPC分类号： B23B27/1674 , Y10T407/112 , Y10T407/2206 , Y10T407/227 , Y10T407/23

30. 发明授权

US1301103A Track-sanding device. 失效
公开(公告)号：US1301103A
公开(公告)日：1919-04-22
申请号：US23900518
申请日：1918-06-08
申请人： CASSIDY JAMES
发明人： CASSIDY JAMES
CPC分类号： B60B39/04

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