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    • 3. 发明专利
    • DENSE/POROUS STRUCTURES FOR USE AS BONE SUBSTITUTES
    • CA2447683A1
    • 2002-10-24
    • CA2447683
    • 2002-04-16
    • CASSIDY JAMES
    • CASSIDY JAMES JKO YINGNORBERG BRIAN LHECKENDORF BRADLEY R
    • A61F2/00A61F2/28A61F2/30A61F2/42A61F2/44A61F2/46A61L27/10A61L27/56B22F7/00B28B1/24B28B1/26B28B19/00B28B23/00B29C45/14C12N5/08B29C45/00A61K9/00A61L27/54
    • A combination dense/porous structure includes a porous element having an out er surface defining a shape having a bulk volume, the element includes a continuous framework having struts defining a plurality of interconnecting interstices throughout the bulk volume. The porous element has interconnecti ng interstices extending throughout the volume and opening through the surface. The combination dens/porous structure also includes a dense element formed from a material and having a sintered density of at least 95%, contacting at least a portion of the porous element; and an interconnection zone formed by the inter-penetration of the material forming the dense element into the porous element. The combination dense/porous structures are particularly useful as bone substitute materials and extended release delivery systems, preferable sustained release, for physiologically active agents. The interconnection zone can also be formed by a bonding phase that may or may n ot be the same material as the dense and/or porous element. A process for producing a combination dense/porous structure includes: providing a porous element; providing a dispersion comprising a ceramic or metal powder and a binder; contacting the dispersion with the porous element whereby the slip a t least partially penetrates intoat least a portion of the porous element to form an interconnection zone and a dense element formed from the dispersion and adjacent to the interconnection zone to form a dense/porous structure; treating the dense/porous structure to form a green dens/porous structure; a nd curing, drying, and/or heating the green dense/porous structure to form the combination dense/porous structure.