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21. 发明授权

US09382226B2 Aldosterone synthase inhibitors 有权
标题翻译：醛固酮合酶抑制剂
公开(公告)号：US09382226B2
公开(公告)日：2016-07-05
申请号：US13811059
申请日：2011-07-20
申请人： Scott B. Hoyt , Min K. Park , Clare London , Yusheng Xiong , D. Jonathan Bennett , Jiaqiang Cai , Paul Ratcliffe , Andrew Cooke , Emma Carswell , John MacLean , Rohit Saxena , Bheemashankar A. Kulkarni , Archana Gupta
发明人： Scott B. Hoyt , Min K. Park , Clare London , Yusheng Xiong , D. Jonathan Bennett , Jiaqiang Cai , Paul Ratcliffe , Andrew Cooke , Emma Carswell , John MacLean , Rohit Saxena , Bheemashankar A. Kulkarni , Archana Gupta
IPC分类号： C07D401/04 , C07D413/14 , C07D471/04 , A61K31/4375 , A61K31/4439 , A61K31/4184 , A61K31/4709
CPC分类号： C07D401/04 , A61K31/4184 , A61K31/4375 , A61K31/4439 , A61K31/4709 , C07D413/14 , C07D471/04
摘要： The invention involves compounds of structural Formula (I) and the pharmaceutically acceptable salts thereof. The compounds of the invention are effective at selectively inhibiting CYP11B2, and are therefore useful for the treatment or prophylaxis of disorders that are associated with elevated aldosterone levels, including, but not limited to, hypertension and heart failure.
摘要翻译：本发明涉及结构式（I）的化合物及其药学上可接受的盐。本发明的化合物对选择性抑制CYP11B2有效，因此可用于治疗或预防与升高的醛固酮水平相关的病症，包括但不限于高血压和心力衰竭。

22. 发明申请

US20150322074A1 4-FLUOROPIPERIDINE OREXIN RECEPTOR ANTAGONISTS 有权
标题翻译： 4氟氟哌啶异黄酮受体拮抗剂
公开(公告)号：US20150322074A1
公开(公告)日：2015-11-12
申请号：US14761170
申请日：2014-01-13
申请人： Scott KUDUK , Andrew COOKE , Craig STUMP , Peter WILLIAMS , MERCK SHARP & DOHME CORP.
发明人： Andrew Cooke , Scott D. Kuduk , Craig Stump , Peter WILLIAMS
IPC分类号： C07D487/04 , C07D471/04 , C07D401/14 , C07D413/14 , C07D401/12 , C07D417/14
CPC分类号： C07D487/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The present invention is directed to 4-fluoropiperidine compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译：本发明涉及作为食欲素受体的拮抗剂的4-氟哌啶化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。

23. 发明申请

US20110307833A1 Control Selection Approximation 审中-公开
标题翻译：控制选择近似
公开(公告)号：US20110307833A1
公开(公告)日：2011-12-15
申请号：US12892851
申请日：2010-09-28
申请人： Thomas Andrew Cooke Dale , Christopher Brian Fleizach
发明人： Thomas Andrew Cooke Dale , Christopher Brian Fleizach
IPC分类号： G06F3/048
CPC分类号： G06F3/04886 , G06F3/0488
摘要： A method includes displaying a user interface of an application on a device's touch-sensitive display. The user interface includes a plurality of regions, including a respective region at a respective hierarchy level. The respective region has two or more child regions at a hierarchy level below the respective hierarchy level. The method includes detecting a first contact at a location that corresponds to the respective region and that does not correspond to any of the two or more child regions. When the application is configured to process the first contact, not in conjunction with the respective region, but in conjunction with at least one child region of the two or more child regions, the method includes identifying a respective child region in accordance with positions of the child regions relative to the location, and processing the first contact in conjunction with the identified respective child region using the application.
摘要翻译：一种方法包括在设备的触敏显示器上显示应用的用户界面。用户界面包括多个区域，包括相应层级的相应区域。相应的区域具有在相应层级下面的层级下的两个或更多个子区域。该方法包括在对应于相应区域并且不对应于两个或更多个子区域中的任一个的位置处检测第一联系人。当所述应用被配置为处理所述第一联系人时，不与所述相应区域结合，而是与所述两个或更多个子区域的至少一个子区域结合，所述方法包括根据所述第二联系人的位置识别相应的子区域子区域，并且使用应用程序结合所识别的相应子区域处理第一联系人。

24. 发明授权

US06469014B1 Thieno[2,3-d] pyrimidinediones, their preparation and use in therapy 失效
标题翻译：噻吩并[2,3-d]嘧啶，其制备和用于治疗
公开(公告)号：US06469014B1
公开(公告)日：2002-10-22
申请号：US09977944
申请日：2001-10-17
申请人： David Cheshire , Andrew Cooke , Martin Cooper , David Donald , Mark Furber , Matthew Perry , Philip Thorne
发明人： David Cheshire , Andrew Cooke , Martin Cooper , David Donald , Mark Furber , Matthew Perry , Philip Thorne
IPC分类号： C07D49504
CPC分类号： C07D495/04
摘要： The invention provides pharmaceutically useful thieno[2,3-d]pyrimidinediones, processes for their production, pharmaceutical compositions containing them and methods of treatment involving their use.
摘要翻译：本发明提供药学上有用的噻吩并[2,3-d]嘧啶并二酮，其制备方法，含有它们的药物组合物和涉及其用途的治疗方法。

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