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11. 发明授权

US06491896B1 Polybutene containing denture cleanser compositions 失效
标题翻译：含丁烯的义齿清洁剂组合物
公开(公告)号：US06491896B1
公开(公告)日：2002-12-10
申请号：US10084870
申请日：2002-02-28
申请人： Jayanth Rajaiah , Lisa Catron Ernst , Ann Maria Case , Thinh Nguyen Ha , William Michael Glandorf , Christopher Robert Mayer
发明人： Jayanth Rajaiah , Lisa Catron Ernst , Ann Maria Case , Thinh Nguyen Ha , William Michael Glandorf , Christopher Robert Mayer
IPC分类号： A61K946
CPC分类号： A61K8/894 , A61K8/02 , A61K8/0216 , A61K8/046 , A61K8/19 , A61K8/22 , A61K8/23 , A61K8/365 , A61K8/37 , A61K8/38 , A61K8/41 , A61K8/42 , A61K8/8111 , A61K8/922 , A61K2800/222 , A61Q11/02
摘要： A denture cleanser composition comprising polybutene, with a molecular weight of about 300 to about 3000, an effervescence generator and a bleaching agent. Optionally, denture cleanser compositions may further comprise tablet binders, organic peroxyacid bleach precursors, surfactants including a dimethicone copolyol, lipophilic compounds such as flavorants and coolants, chelating agents, and other therapeutic and cosmetic active agents.
摘要翻译：一种义齿清洁剂组合物，其包含分子量为约300至约3000的聚丁烯，泡腾发生剂和漂白剂。任选地，义齿清洁剂组合物还可以包含片剂粘合剂，有机过氧酸漂白剂前体，包含二甲聚硅氧烷共聚多元醇的表面活性剂，亲脂性化合物如调味剂和冷却剂，螯合剂和其它治疗和美容活性剂。

12. 发明授权

US06391335B1 Effervescent drug delivery system for oral administration 有权
公开(公告)号：US06391335B1
公开(公告)日：2002-05-21
申请号：US09613270
申请日：2000-07-10
申请人： S. Indiran Pather , Joseph R. Robinson , Jonathan D. Eichman , Rajendra K. Khankari , John Hontz , Sangeeta V. Gupte
发明人： S. Indiran Pather , Joseph R. Robinson , Jonathan D. Eichman , Rajendra K. Khankari , John Hontz , Sangeeta V. Gupte
IPC分类号： A61K946
CPC分类号： A61K9/2886 , A61K9/0007 , A61K9/2072 , A61K9/2866 , A61K9/5084 , Y10S514/96
摘要： The pharmaceutical compositions of the present invention comprise orally administerable dosage forms that use effervescence as a penetration enhancer for drugs known, or suspected, of having poor bioavailability. Effervescence can occur in the stomach, once the tablet or other dosage form is ingested. In addition to effervescence in the stomach, or as alternative technique, by the use of appropriate coatings and other techniques, the effervescence can occur in other parts of the gastrointestinal tract, including, but not limited to, the esophagus, duodenum, and colon. The site of effervescence and drug release is chosen to correspond with the segment of the gastrointestinal tract displaying maximal absorption of the formulated drug, or to gain some other therapeutic advantage.

13. 发明授权

US06365182B1 Organoleptically pleasant in-mouth rapidly disintegrable potassium chloride tablet 有权
标题翻译：感官愉悦的口腔快速崩解的氯化钾片
公开(公告)号：US06365182B1
公开(公告)日：2002-04-02
申请号：US09132837
申请日：1998-08-12
申请人： Rajendra K. Khankari , John Hontz , Sara J. Chastain
发明人： Rajendra K. Khankari , John Hontz , Sara J. Chastain
IPC分类号： A61K946
CPC分类号： A61K33/14 , A61K9/0007 , A61K9/0056 , A61K9/2018 , A61K9/2081
摘要： The present invention relates to a potassium containing dosage form which is capable of rapidly disintegrating in a patient's mouth to form an easy to swallow slurry.
摘要翻译：本发明涉及一种含钾剂型，其能够在患者口中快速崩解以形成容易吞咽的浆液。

14. 发明授权

US06284272B1 Pharmaceutical compositions containing an effervescent acid-base couple 有权
标题翻译：含有泡腾酸碱的药物组合物
公开(公告)号：US06284272B1
公开(公告)日：2001-09-04
申请号：US09463224
申请日：2000-03-21
申请人： Paolo Chiesi , Paolo Ventura , Rosa Mezzadri , Gaetano Brambilla , Daniela Acerbi
发明人： Paolo Chiesi , Paolo Ventura , Rosa Mezzadri , Gaetano Brambilla , Daniela Acerbi
IPC分类号： A61K946
CPC分类号： A61K9/0007
摘要： A pharmaceutical composition in the form of effervescent tablets comprising an active ingredient and an effervescent blend, wherein the effervescent blend comprises an acidic component and sodium glycine carbonate as alkaline components. Preferred acid components are fumaric acid, maleic acid, and their salts. Tablets are prepared in normal thermo-hygrometric conditions and with standard tabletting equipment.
摘要翻译：泡腾片剂形式的药物组合物，其包含活性成分和泡腾混合物，其中所述泡腾混合物包含作为碱性组分的酸性组分和甘氨酸钠。优选的酸组分是富马酸，马来酸及其盐。在正常的热湿度条件和标准压片设备中制备片剂。

15. 发明授权

US06261600B1 Folic acid supplement 有权
标题翻译：叶酸补充
公开(公告)号：US06261600B1
公开(公告)日：2001-07-17
申请号：US09303000
申请日：1999-04-30
申请人： Mitchell I. Kirschner , George Paradissis , R. Saul Levinson
发明人： Mitchell I. Kirschner , George Paradissis , R. Saul Levinson
IPC分类号： A61K946
CPC分类号： A61K9/0056 , A23K20/174 , A23L33/15 , A23V2002/00 , A61K9/2009 , A23V2250/7056 , A23V2250/1564 , A23V2250/1578 , A23V2250/628
摘要： The present invention is directed to novel chewable or dissolvable nutritional supplements for improving the absorption of folic acid in humans and other animals and methods of using said supplements. The nutritional supplements contain folic acid and non-toxic acid neutralizing alkaline compounds in chewable or dissolvable forms.
摘要翻译：本发明涉及用于改善人类和其他动物中叶酸吸收的新型可咀嚼或可溶解的营养补充剂以及使用所述补充剂的方法。营养补充剂含有叶酸和无毒酸中和碱性化合物，其咀嚼或溶解形式。

16. 发明授权

US06190697B1 Effervescent formulation containing plant extract 有权
标题翻译：含有植物提取物的泡腾制剂
公开(公告)号：US06190697B1
公开(公告)日：2001-02-20
申请号：US09178639
申请日：1998-10-26
申请人： Gerhard Gergely , Irmgard Gergely , Thomas Gergely , Stefan Gergely
发明人： Gerhard Gergely , Irmgard Gergely , Thomas Gergely , Stefan Gergely
IPC分类号： A61K946
CPC分类号： A61K9/0007 , A61K36/00 , A61K2300/00
摘要： The effervescent formulation elation in the form of granules or of a tablet contains, in addition to the effervescent base, at least one water-soluble or at least suspendable plant extract whose particles are coated with at least one oily, fatty or waxy substance. At least one emulsifier and/or at least one antifoam may be present in the coating and/or as a further component of the mixture, in particular applied as a further component of the mixture to a pharmaceutically permissible filler as carrier. The individual phases are prepared by a procedure in which the plant extract or the filler is heated—preferably in a granulator, in particular in a vacuum granulator—and wet or mixed with a melt or solution of the oily, fatty or waxy substance or at least one emulsifier and/or at least one antifoam and then dried—preferably in a vacuum—and sieved to the desired particle size.
摘要翻译：颗粒或片剂形式的泡腾剂配方除了泡腾基质之外还含有至少一种水溶性或至少可悬浮的植物提取物，其颗粒被至少一种油性，脂肪或蜡状物质包被。至少一种乳化剂和/或至少一种消泡剂可以存在于涂层和/或作为混合物的另外的组分中，特别是作为混合物的另外的组分被用作药学上允许的填料作为载体。各个阶段通过其中植物提取物或填料加热的方法制备，优选在造粒机中，特别是在真空制粒机中，并且与油，脂肪或蜡质物质的熔体或溶液一起湿润或混合，或在至少一种乳化剂和/或至少一种消泡剂，然后干燥，优选在真空中并筛分至所需粒度。

17. 发明授权

US06811793B2 Effervescent composition including stevia 有权
标题翻译：泡腾成分包括甜叶菊
公开(公告)号：US06811793B2
公开(公告)日：2004-11-02
申请号：US10096417
申请日：2002-03-11
申请人： Fred Wehling
发明人： Fred Wehling
IPC分类号： A61K946
CPC分类号： A61K9/2068 , A23L2/40 , A23L33/15 , A23L33/175 , A23V2002/00 , A61K9/0007 , Y10S514/96 , A23V2250/262 , A23V2250/642 , A23V2200/222 , A23V2250/032 , A23V2250/708 , A23V2250/0652
摘要： A tablet that includes stevia, water soluble binder, water soluble lubricant, active agent, and effervescent agent.
摘要翻译：包含甜叶菊，水溶性粘合剂，水溶性润滑剂，活性剂和泡腾剂的片剂。

18. 发明授权

US06689339B1 Viscous compositions containing carbon dioxide 有权
标题翻译：含二氧化碳的粘性组合物
公开(公告)号：US06689339B1
公开(公告)日：2004-02-10
申请号：US09530731
申请日：2000-08-17
申请人： Masaya Tanaka , Masato Hiki
发明人： Masaya Tanaka , Masato Hiki
IPC分类号： A61K946
CPC分类号： A61Q17/00 , A61K8/0204 , A61K8/046 , A61K8/19 , A61K9/122 , A61K33/00 , A61K2800/222 , A61K2800/75 , A61Q7/02 , A61Q11/00 , A61Q19/00 , A61Q19/007 , A61Q19/02 , A61Q19/06 , Y10S514/817 , Y10S514/828 , Y10S514/858 , Y10S514/887 , Y10S514/944 , Y10S514/945 , Y10S514/947 , Y10S514/96
摘要： A carbon dioxide-containing viscous composition wherein carbon dioxide bubbles are retained in an aqueous viscous composition. Use of the composition makes it possible to treat or ameliorate itching accompanying mucocutaneous diseases or mucocutaneous disorders, mucocutaneous injury, dental diseases, skin ulcer, cryesthesia and numbness caused by peripheral circulatory disorders, musculoskeletal diseases, nervous system diseases, keratosis, constipation, unwanted hair re-growing after depilation, cosmetic troubles in the skin or hair, partial obesity, etc. while exerting little side effects.
摘要翻译：含二氧化碳的粘性组合物，其中二氧化碳气泡保留在含水粘性组合物中。组合物的使用使得可以治疗或改善伴随的皮肤疾病或粘膜皮肤病，粘膜皮肤损伤，牙齿疾病，皮肤溃疡，由周围循环障碍引起的麻醉和麻木，肌肉骨骼疾病，神经系统疾病，角化病，便秘，不需要的头发脱毛后再生长，皮肤或毛发上的化妆品麻烦，部分肥胖等，同时施加少量副作用。

19. 发明授权

US06620433B2 Dispersible and soluble galenic paracetamol formulation, method for its preparation and its applications 失效
公开(公告)号：US06620433B2
公开(公告)日：2003-09-16
申请号：US10188680
申请日：2002-07-03
申请人： Luis Carvajal Martín , Juan Carlos Asensio Asensio , Francisco Javier Sevilla Tirado
发明人： Luis Carvajal Martín , Juan Carlos Asensio Asensio , Francisco Javier Sevilla Tirado
IPC分类号： A61K946
CPC分类号： A61K47/12 , A61K9/0007 , A61K9/0056 , A61K31/167 , A61K31/375 , A61K2300/00
摘要： The new galenic formulation of paracetamol is comprised of a base mixture of paracetamol and citric acid in a proportion of 85:15 to 90:10 w/w among other pharmaceutically acceptable components, in an exsiccation state corresponding to a water activity of less than 0.6 and it is in the form of a powder, granulate or tablet. The process comprises obtaining said exsiccated base mixture up to a water activity of less than 0.6 in order to obtain a powder, that can be granulated in order to obtain a granulate dispersible and soluble in water, whose granulate can also be compressed in order to obtain a tablet dispersible and soluble in water. Said new formulation is useful in human and veterinary medicine.

20. 发明授权

US06602520B1 Method for producing quickly decomposable solid pharmaceutical preparations 有权
标题翻译：快速分解固体药物制剂的制备方法
公开(公告)号：US06602520B1
公开(公告)日：2003-08-05
申请号：US10030456
申请日：2002-01-03
申请人： Marco Schroeder , Klaus-Jürgen Steffens
发明人： Marco Schroeder , Klaus-Jürgen Steffens
IPC分类号： A61K946
CPC分类号： A61K9/0056 , A61K9/0007 , A61K9/2095
摘要： Rapidly disintegrating preparations containing at least one active pharmaceutical ingredient and at least one excipient can be obtained by a simple process in which at least the predominant part of the complete composition of the ingredients for the preparation to be produced is granulated, the resulting granules and, where appropriate, the remainder of the ingredients are shaped in the presence of liquid virtually without pressure, and the resulting shaped articles are dried.
摘要翻译：含有至少一种活性药物成分和至少一种赋形剂的快速崩解制剂可以通过简单的方法获得，其中制备制剂的成分的完整组合物的主要部分至少是造粒的，在适当的情况下，剩余的成分在几乎没有压力的液体存在下成型，并将所得的成型制品干燥。

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