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11. 发明申请

US20170355756A1 TDP-43-Binding Polypeptides Useful for the Treatment of Neurodegenerative Diseases 审中-公开
公开(公告)号：US20170355756A1
公开(公告)日：2017-12-14
申请号：US15532909
申请日：2015-12-07
申请人： UNIVERSITÉ LAVAL
发明人： Jean-Pierre Julien , Claude Gravel , Silvia Pozzi
IPC分类号： C07K16/18 , C12N15/86 , A61K48/00
CPC分类号： C07K16/18 , A61K48/00 , C07K2317/24 , C07K2317/35 , C07K2317/52 , C07K2317/54 , C07K2317/55 , C07K2317/569 , C07K2317/622 , C07K2317/76 , C07K2317/82 , C12N15/86 , C12N2750/14143
摘要： Provided herein are antigen-binding constructs such as antibodies that bind to the RRM-1 domain of TDP-43. The antigen-binding constructs are capable of blocking the interaction of TDP-43 with NF-κB in cells. Also provided herein are method of using the antigen-binding constructs in the treatment of diseases associated with TPD-43 proteinopathy, such as amyotrophic lateral sclerosis (ALS), frontotemperal lobar degeneration (FTLD), Lewy body disease and motor neuron disease.

12. 发明申请

US20170073429A1 CELL PENETRATING ANTI-GUANOSINE ANTIBODY BASED THERAPY FOR CANCERS WITH RAS MUTATIONS 审中-公开
标题翻译：基于RAS MUTATIONS的癌细胞基于抗细胞因子抗体的治疗方法
公开(公告)号：US20170073429A1
公开(公告)日：2017-03-16
申请号：US15123195
申请日：2015-03-04
申请人： Yale University , The United States Govemment as represented by The Department of Veterans Affairs
发明人： James E. Hansen , Richard H. Weisbart , Melissa Young , Philip W. Noble
IPC分类号： C07K16/40 , A61K45/06 , A61K39/395
CPC分类号： C07K16/40 , A61K39/39558 , A61K45/06 , C07K16/30 , C07K16/44 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/77 , C07K2317/82
摘要： It has been established that cancer cells with oncogenic mutants in the small GTPase K-Ras are susceptible to antibodies that bind intracellular guanosine, but delivery of antibodies into cells can be challenging. A subset of lupus autoantibodies is associated with anti-guanosine activity, and is capable of cellular penetration. These antibodies have potential as therapeutic agents targeted towards K-Ras associated malignancies.
摘要翻译：已经确定，在小GTP酶K-Ras中具有致癌突变体的癌细胞对结合细胞内鸟嘌呤的抗体敏感，但将抗体递送到细胞中可能是具有挑战性的。狼疮自身抗体的一个子集与抗鸟苷活性相关，并且能够进行细胞穿透。这些抗体具有针对K-Ras相关恶性肿瘤的治疗剂的潜力。

13. 发明授权

US09541551B2 Anti-GAP43 antibody 有权
标题翻译：抗GAP43抗体
公开(公告)号：US09541551B2
公开(公告)日：2017-01-10
申请号：US14352808
申请日：2012-10-19
申请人： Niigata University
发明人： Kosei Takeuchi , Michihiro Igarashi , Motohiro Nozumi , Asami Kawasaki
IPC分类号： G01N33/566 , C07K16/18 , C07K16/44 , G01N33/68
CPC分类号： G01N33/566 , C07K16/18 , C07K16/44 , C07K2317/33 , C07K2317/82 , G01N33/6854 , G01N2440/14
摘要： An anti-GAP43 antibody which is capable of distinguishing a non-phosphorylated threonine residue at position 89 (T89) from a phosphorylated threonine residue at position 89 (pT89) of mouse GAP43 set forth in SEQ ID NO: 13, and which is capable of specifically detecting a growth cone; an anti-GAP43 antibody which is capable of distinguishing a non-phosphorylated serine residue at position 96 (S96) from a phosphorylated serine residue at position 96 (pS96) of mouse GAP43, and which is capable of specifically detecting a growth cone; an anti-GAP43 antibody which is capable of distinguishing a non-phosphorylated threonine residue at position 172 (T172) from a phosphorylated threonine residue at position 172 (pT172) of mouse GAP43, and which is capable of specifically detecting a growth cone; and an immunological analysis method using these anti-GAP43 antibodies.
摘要翻译：能够区分第89位（T89）的非磷酸化苏氨酸残基与SEQ ID NO：13所示的小鼠GAP43位置89（pT89）上的磷酸化苏氨酸残基的抗GAP43抗体，其能够特异性检测生长锥; 能够区分96位非磷酸化丝氨酸残基（S96）与小鼠GAP43位置96（pS96）的磷酸化丝氨酸残基，能够特异性检测生长锥的抗GAP43抗体; 能够区分172位的非磷酸化苏氨酸残基（T172）与小鼠GAP43第172位的磷酸化苏氨酸残基（pT172）并能够特异性检测生长锥的抗GAP43抗体; 以及使用这些抗GAP43抗体的免疫学分析方法。

14. 发明授权

US09518108B2 Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same 有权
标题翻译：表现出在细胞内环境中增强的稳定性的免疫球蛋白框架及鉴定其的方法
公开(公告)号：US09518108B2
公开(公告)日：2016-12-13
申请号：US14469276
申请日：2014-08-26
申请人： ESBATech, an Alcon Biomedical Research Unit LLC
发明人： Kathrin Tissot , Stefan Ewert , Adrian Auf Der Maur , Alcide Barberis , Dominik Escher
IPC分类号： C07K16/00 , A61K48/00
CPC分类号： C07K16/00 , A61K48/00 , C07K2317/21 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/80 , C07K2317/82 , C07K2317/94 , G01N33/6857
摘要： Compositions are provided, which can be used as frameworks for the creation of very stable and soluble single-chain Fv antibody fragments. These frameworks have been selected for intracellular performance and are thus ideally suited for the creation of scFv antibody fragments or scFv antibody libraries for applications where stability and solubility are limiting factors for the performance of antibody fragments, such as in the reducing environment of a cell. Such frameworks can also be used to identify highly conserved residues and consensus sequences which demonstrate enhanced solubility and stability.
摘要翻译：提供组合物，其可用作产生非常稳定和可溶性单链Fv抗体片段的框架。这些框架已经被选择用于细胞内性能，因此理想地适用于产生scFv抗体片段或scFv抗体文库，用于其中稳定性和溶解度是抗体片段表现的限制因素，例如在细胞的还原环境中。此类框架还可用于鉴定高度保守的残基和共有序列，这些序列表现出增强的溶解度和稳定性。

15. 发明授权

US09404123B2 Nucleic acid assembly, vector, cell, methods and kit thereof 有权
标题翻译：核酸组装，载体，细胞，方法和试剂盒
公开(公告)号：US09404123B2
公开(公告)日：2016-08-02
申请号：US14351400
申请日：2012-10-11
申请人： NATIONAL CENTRE FOR BIOLOGICAL SCIENCES
发明人： Yamuna Krishnan , Souvik Modi
IPC分类号： C07H21/02 , C07H21/04 , A61K48/00 , C12N15/85 , C07K16/44 , C12N15/113
CPC分类号： C12N15/85 , C07K16/44 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/82 , C07K2317/92 , C07K2319/00 , C12N15/113 , C12N2810/85 , C12N2810/859
摘要： The present disclosure relates to a nucleic acid assembly (NAA), comprising sensor domain and handle domain; an assembly interfaceable motif (AIM) sequence optionally along with intracellular targeting motif (ITM) sequence; and an AIM-NAA complex. It also relates to a vector comprising assembly interfaceable motif sequence optionally along with intracellular targeting motif sequence and a cell comprising the vector. Further, the instant disclosure also provides a method to obtain the nucleic acid assembly, method of intracellular targeting and kit thereof.
摘要翻译：本公开涉及包含传感器域和手柄结构域的核酸组装（NAA）; 任选地连同细胞内靶向基序（ITM）序列的组装接口基序（AIM）序列; 和AIM-NAA复合体。它还涉及包含任选地与细胞内靶向基序序列的组装可接合基序序列的载体和包含载体的细胞。此外，本公开还提供了获得核酸组装，细胞内靶向方法及其试剂盒的方法。

16. 发明申请

US20150057191A1 IMMUNOGLOBULIN FRAMEWORKS WHICH DEMONSTRATE ENHANCED STABILITY IN THE INTRACELLULAR ENVIRONMENT AND METHODS OF IDENTIFYING SAME 有权
标题翻译：阐明细胞内环境中增强稳定性的免疫球蛋白框架及其鉴别方法
公开(公告)号：US20150057191A1
公开(公告)日：2015-02-26
申请号：US14469276
申请日：2014-08-26
申请人： ESBATech, an Alcon Biomedical Research Unit LLC
发明人： Kathrin Tissot , Stefan Ewert , Adrian Auf Der Maur , Alcide Barberis , Dominik Escher
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , A61K48/00 , C07K2317/21 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/80 , C07K2317/82 , C07K2317/94 , G01N33/6857
摘要： Compositions are provided, which can be used as frameworks for the creation of very stable and soluble single-chain Fv antibody fragments. These frameworks have been selected for intracellular performance and are thus ideally suited for the creation of scFv antibody fragments or scFv antibody libraries for applications where stability and solubility are limiting factors for the performance of antibody fragments, such as in the reducing environment of a cell. Such frameworks can also be used to identify highly conserved residues and consensus sequences which demonstrate enhanced solubility and stability.
摘要翻译：提供组合物，其可用作产生非常稳定和可溶性单链Fv抗体片段的框架。这些框架已经被选择用于细胞内性能，因此理想地适用于产生scFv抗体片段或scFv抗体文库，用于其中稳定性和溶解度是抗体片段表现的限制因素，例如在细胞的还原环境中。此类框架还可用于鉴定高度保守的残基和共有序列，这些序列表现出增强的溶解度和稳定性。

17. 发明申请

US20150023979A1 Antibodies Against E7 Protein of Human Papilloma Virus (HPV) 审中-公开
标题翻译：针对人乳头状瘤病毒（HPV）的E7蛋白的抗体
公开(公告)号：US20150023979A1
公开(公告)日：2015-01-22
申请号：US14344525
申请日：2012-09-06
申请人： Christian Kuhne
发明人： Christian Kuhne
IPC分类号： C07K16/08 , C12N7/00 , C07K14/005
CPC分类号： C07K16/084 , C07K14/005 , C07K2317/33 , C07K2317/82 , C07K2317/92 , C12N7/00 , C12N2710/20034 , C12N2710/20051 , G01N33/56983 , G01N2333/025
摘要： The invention discloses a method for preparing Human Papilloma Virus protein E7 antigen (HPV E7 antigen) comprising the following steps: —providing a purified preparation of HPV protein E7; —phosphorylating the HPV protein E7 in the preparation; —purifying the phosphorylated E7 protein with an anion exchange chromatography, wherein the phosphorylated E7 protein is separated from the non-phosphorylated E7 protein by a step wherein the non-phosphorylated E7 protein stays bound to an anion exchanger during the anion exchange chromatography whereas the phosphorylated E7 protein is obtained in the eluate of the anion exchange chromatography, thereby—obtaining a purified preparation of a phosphorylated HPV protein E7 antigen. The invention further discloses antibodies specific to this antigen, a kit and method for using such antibodies in clinical diagnostics and methods for generation of such antibodies.
摘要翻译：本发明公开了一种制备人乳头状瘤病毒蛋白E7抗原（HPV E7抗原）的方法，包括以下步骤：提供HPV蛋白E7纯化制剂; 在制备中磷酸化HPV蛋白E7; 用阴离子交换层析纯化磷酸化的E7蛋白质，其中通过一个步骤将磷酸化的E7蛋白与非磷酸化的E7蛋白分离，其中非磷酸化的E7蛋白在阴离子交换层析期间与阴离子交换剂结合，而磷酸化的在阴离子交换层析的洗脱液中获得E7蛋白质，从而获得磷酸化的HPV蛋白E7抗原的纯化制剂。本发明还公开了对该抗原特异性的抗体，在临床诊断中使用这些抗体的试剂盒和方法以及用于产生这种抗体的方法。

18. 发明授权

US08853362B2 Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same 有权
标题翻译：表现出在细胞内环境中增强的稳定性的免疫球蛋白框架及鉴定其的方法
公开(公告)号：US08853362B2
公开(公告)日：2014-10-07
申请号：US10515241
申请日：2003-05-21
申请人： Kathrin Tissot , Stefan Ewert , Adrian Auf Der Maur , Alcide Barberis , Dominik Escher
发明人： Kathrin Tissot , Stefan Ewert , Adrian Auf Der Maur , Alcide Barberis , Dominik Escher
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , A61K48/00 , C07K2317/21 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/80 , C07K2317/82 , C07K2317/94 , G01N33/6857
摘要： Compositions are provided, which can be used as frameworks for the creation of very stable and soluble single-chain Fv antibody fragments. These frameworks have been selected for intracellular performance and are thus ideally suited for the creation of scFv antibody fragments or scFv antibody libraries for applications where stability and solubility are limiting factors for the performance of antibody fragments, such as in the reducing environment of a cell. Such frameworks can also be used to identify highly conserved residues and consensus sequences which demonstrate enhanced solubility and stability.
摘要翻译：提供组合物，其可用作产生非常稳定和可溶性单链Fv抗体片段的框架。这些框架已经被选择用于细胞内性能，因此理想地适用于产生scFv抗体片段或scFv抗体文库，用于其中稳定性和溶解度是抗体片段表现的限制因素，例如在细胞的还原环境中。此类框架还可用于鉴定高度保守的残基和共有序列，这些序列表现出增强的溶解度和稳定性。

19. 发明申请

US20140051586A1 HIGH-THROUGHPUT METHODS TO PRODUCE, VALIDATE AND CHARACTERIZE MMABS 审中-公开
标题翻译：用于生产，验证和表征MMABS的高通量方法
公开(公告)号：US20140051586A1
公开(公告)日：2014-02-20
申请号：US13981308
申请日：2012-01-25
申请人： Ignacio Pino
发明人： Ignacio Pino
IPC分类号： G01N33/543
CPC分类号： G01N33/54306 , C07K16/00 , C07K16/18 , C07K2317/82 , G01N33/6854
摘要： Provided herein is a system and method for identifying a biomarker and producing a reagent for detecting the biomarker. The system and method comprises administering to an animal a biological sample and comparing the immune response of the animal to the immune response of another animal.
摘要翻译：本文提供了用于鉴定生物标志物并产生用于检测生物标志物的试剂的系统和方法。该系统和方法包括向动物施用生物样品并将动物的免疫应答与另一动物的免疫应答进行比较。

20. 发明授权

US08652467B2 Dek protein compositions and methods of using the same 有权
标题翻译： Dek蛋白质组合物及其使用方法
公开(公告)号：US08652467B2
公开(公告)日：2014-02-18
申请号：US12090164
申请日：2006-10-16
申请人： David M. Markovitz , Nirit Mor-Vaknin , Michael Khodadoust , Barbara S. Adams
发明人： David M. Markovitz , Nirit Mor-Vaknin , Michael Khodadoust , Barbara S. Adams
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K48/00 , C07K2317/82 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2310/53 , G01N33/564
摘要： The present invention relates to DEK protein compositions (e.g., antibodies, small molecule inhibitors, siRNAs) and methods of using the same. In particular, the present invention provides compositions and methods for treating autoimmune disease (e.g., juvenile rheumatoid arthritis, lupus, etc.) and for inhibiting inflammation (e.g., associated with autoimmune disease) and cellular chemotaxis (e.g., of neutrophils, NK cells and T cells). The present invention further provides a diagnostic marker (e.g., DEK antigen) for autoimmune disease.
摘要翻译：本发明涉及DEK蛋白质组合物（例如，抗体，小分子抑制剂，siRNA）及其使用方法。特别地，本发明提供了用于治疗自身免疫性疾病（例如，幼年型类风湿性关节炎，狼疮等）和用于抑制炎症（例如，与自身免疫疾病相关）和细胞趋化性（例如嗜中性粒细胞，NK细胞和 T细胞）。本发明还提供了用于自身免疫疾病的诊断标记物（例如DEK抗原）。

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