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11. 发明授权

US10561679B2 Double-stranded nucleic acid molecule, DNA, vector, cancer cell growth inhibitor, cancer cell migration inhibitor, and drug 有权
公开(公告)号：US10561679B2
公开(公告)日：2020-02-18
申请号：US15318576
申请日：2015-06-12
申请人： SAITAMA MEDICAL UNIVERSITY
发明人： Satoshi Inoue , Kazuhiro Ikeda , Kuniko Inoue
IPC分类号： C12N15/113 , A61K31/713 , A61P35/04 , A61K31/7105 , A61K31/711
摘要： A double-stranded nucleic acid molecule for suppressing expression of non-coding RNA, the double-stranded nucleic acid molecule including: (a) a sense strand containing a nucleotide sequence corresponding to a target sequence set forth in any one of SEQ ID NOs: 5 to 11 and 26 to 31; and (b) an antisense strand containing a nucleotide sequence which is complementary to the sense strand in the (a) to form a double strand with the sense strand, wherein the non-coding RNA contains a base sequence set forth in any one of SEQ ID NOs: 1 to 4, a part of the base sequence, or both of the base sequence and the part.

12. 发明授权

US10413559B2 Method for treating demyelinating disease 有权
公开(公告)号：US10413559B2
公开(公告)日：2019-09-17
申请号：US14763618
申请日：2014-01-28
申请人： OCHANOMIZU UNIVERSITY , SAITAMA MEDICAL UNIVERSITY
发明人： Kimiko Murofushi , Mari Gotoh , Kei Maruyama , Keisuke Yoshikawa , Shinji Yamamoto
IPC分类号： A61K31/665 , A61K31/67 , A61K31/66 , A61K31/662
摘要： It is an object of the present invention to provide a novel therapeutic agent for demyelinating disease which has an action to suppress demyelination of nerve axons. According to the present invention, a therapeutic agent for demyelinating disease which comprises cyclic phosphatidic acids, carba-cyclic phosphatidic acids, thia-cyclic phosphatidic acids, or a salt thereof is provided.

13. 发明授权

US09873920B2 Method for evaluating side-effect onset risk in anticancer drug treatment, including detecting MUC4 gene polymorphism 有权
公开(公告)号：US09873920B2
公开(公告)日：2018-01-23
申请号：US14771465
申请日：2014-02-27
申请人： SAITAMA MEDICAL UNIVERSITY
发明人： Koichi Hagiwara , Hitoshi Miyazawa , Jun Shiihara , Tomoaki Tanaka , Yoshiaki Inoue
IPC分类号： C12Q1/68 , A61K31/5377 , A61K31/519 , A61K31/4545 , A61K31/7068 , A61K31/4745 , A61K31/337 , A61K31/517
CPC分类号： C12Q1/6886 , A61K31/337 , A61K31/4545 , A61K31/4745 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/7068 , C12Q2600/106 , C12Q2600/142 , C12Q2600/156
摘要： The purpose of the present invention is to provide an evaluation method kit for evaluating the risk of onset of diffuse alveolar damage due to such factors as anticancer drug administration. The purpose of the present invention is also to provide a method for evaluating the risk of onset of side effects in anticancer drug treatment. An evaluation method and evaluation kit for evaluating the risk of onset of diffuse alveolar damage, including detecting gene polymorphism present in the MUC4 gene. A method for evaluating the risk of onset of side effect in anticancer drug treatment, including detecting gene polymorphism present in the MUC4 gene of a patient scheduled for anticancer drug administration.

14. 发明申请

US20170182157A1 IMMUNOSTIMULATOR AND METHOD FOR PRODUCING THE SAME 审中-公开
公开(公告)号：US20170182157A1
公开(公告)日：2017-06-29
申请号：US15387951
申请日：2016-12-22
申请人： Saitama Medical University , Sysmex Corporation
发明人： Hiroshi HANDA , Masaaki KAWANO , Masahiko KATO
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K39/00 , A61K2039/5258 , A61K2039/555 , C12N2710/14043 , C12N2710/22023
摘要： Disclosed is an immunostimulator containing virus-like particles, in which the virus-like particles contain an outer coat protein containing an amino acid sequence selected from the group consisting of SEQ ID No. 1, SEQ ID No. 26, SEQ ID No. 33, SEQ ID No. 35, SEQ ID No. 37, SEQ ID No. 39, SEQ ID No. 41, SEQ ID No. 43 and SEQ ID No. 45; the outer coat protein constitutes an outer coat of the virus-like particles; and the virus-like particles do not substantially contain a genome DNA of SV40.

15. 发明授权

US09284557B2 Double-stranded nucleic acid molecule, cancer cell proliferation inhibitor and pharmaceutical agent suitable for prevention or treatment of cancer 有权
标题翻译：双链核酸分子，癌细胞增殖抑制剂和适合于预防或治疗癌症的药剂
公开(公告)号：US09284557B2
公开(公告)日：2016-03-15
申请号：US14324803
申请日：2014-07-07
申请人： Saitama Medical University , RNAi Co., Ltd.
发明人： Satoshi Inoue , Kazuhiro Ikeda
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12N15/113 , A61K31/713 , A01K67/027 , C12N15/11 , C12Q1/68
CPC分类号： C12N15/1135 , A01K67/0271 , A01K2207/12 , A01K2227/105 , A01K2267/0331 , A61K31/713 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2320/30
摘要： A double-stranded nucleic acid molecule including (a) a sense strand which includes a nucleotide sequence corresponding to a target sequence indicated by any one of SEQ ID Nos.: 1 to 21, and (b) an antisense strand which includes a nucleotide sequence complementary to that of the sense strand specified in (a), wherein the double-stranded nucleic acid molecule is for suppressing the expression of at least one of APP and EBAG9 genes.
摘要翻译：一种双链核酸分子，其包含（a）有义链，其包含对应于由SEQ ID NO：1至21中任一个表示的靶序列的核苷酸序列，和（b）含有核苷酸序列的反义链与（a）中规定的有义链的互补序列互补，其中双链核酸分子用于抑制APP和EBAG9基因中的至少一个的表达。

16. 发明授权

US08809289B2 Double-stranded nucleic acid molecule, cancer cell proliferation inhibitor and pharmaceutical agent suitable for prevention or treatment of cancer 有权
标题翻译：双链核酸分子，癌细胞增殖抑制剂和适合于预防或治疗癌症的药剂
公开(公告)号：US08809289B2
公开(公告)日：2014-08-19
申请号：US12879305
申请日：2010-09-10
申请人： Satoshi Inoue , Ikeda Kazuhiro
发明人： Satoshi Inoue , Ikeda Kazuhiro
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12N15/113 , C12N15/11 , C12Q1/68
CPC分类号： C12N15/1135 , A01K67/0271 , A01K2207/12 , A01K2227/105 , A01K2267/0331 , A61K31/713 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2320/30
摘要： A double-stranded nucleic acid molecule including (a) a sense strand which includes a nucleotide sequence corresponding to a target sequence indicated by any one of SEQ ID Nos.: 1 to 21, and (b) an antisense strand which includes a nucleotide sequence complementary to that of the sense strand specified in (a), wherein the double-stranded nucleic acid molecule is for suppressing the expression of at least one of APP and EBAG9 genes.
摘要翻译：一种双链核酸分子，其包含（a）有义链，其包含对应于由SEQ ID NO：1至21中任一个表示的靶序列的核苷酸序列，和（b）含有核苷酸序列的反义链与（a）中规定的有义链的互补序列互补，其中双链核酸分子用于抑制APP和EBAG9基因中的至少一个的表达。

17. 发明申请

US20140030742A1 ANTIBODY REACTING WITH NATIVE COCHLIN-TOMOPROTEIN (CTP) AND METHOD FOR MEASURING CTP USING SAME 有权
标题翻译：使用本发明的苯丙氨酸蛋白酶（CTP）的抗体反应和用于测量CTP的方法
公开(公告)号：US20140030742A1
公开(公告)日：2014-01-30
申请号：US14008677
申请日：2012-04-02
申请人： Tetsuo Ikezono , Satomi Shikaze
发明人： Tetsuo Ikezono , Satomi Shikaze
IPC分类号： C07K14/47 , G01N33/68
CPC分类号： C07K14/47 , C07K16/18 , C07K2317/33 , C07K2317/34 , G01N33/6893 , G01N2800/14
摘要： An immunological measurement is performed using anti-CTP antibody characterized by recognizing an antigenic determinant included in the polypeptide represented by amino acid numbers 118-132 of SEQ ID NO: 1, and reacting with native Cochlin-tomoprotein (CTP).
摘要翻译：使用抗CTP抗体进行免疫学测定，其特征在于识别包含在由SEQ ID NO：1的氨基酸编号118-132表示的多肽中的抗原决定簇，并与天然的Cochlin-tomoprotein（CTP）反应。

18. 发明申请

US20120281816A1 PHASE CONTROLLER 有权
标题翻译：相控制器
公开(公告)号：US20120281816A1
公开(公告)日：2012-11-08
申请号：US13520593
申请日：2010-12-28
申请人： Hiroto Kuroda , Motoyoshi Baba , Shin Yoneya
发明人： Hiroto Kuroda , Motoyoshi Baba , Shin Yoneya
IPC分类号： G21K1/16
CPC分类号： G21K1/06
摘要： A reflection surface 12 constituted by a transition metal having a core level absorption edge in the vicinity of a wavelength of a soft X-ray is formed on an inside of a vacuum vessel 14, and furthermore, there is provided a permanent magnet 13 for generating a magnetic field in a perpendicular direction to a longitudinal direction of the vacuum vessel 14 in a position of the reflection surface 12 by which the soft X-ray is to be reflected, and the soft X-ray to be linearly polarized light incident on the vacuum vessel 14 is reflected at plural times over the reflection surface 12 in a position where the magnetic field is applied in such a manner that magnetic scattering is increased by a resonant effect of a magnetic circular dichroism when the soft X-ray is reflected by the reflection surface 12. Thus, a great difference in a refractive index is made between circularly polarized counterclockwise light and circularly polarized clockwise light which constitute the linearly polarized light, and a phase difference between the circularly polarized counterclockwise light and the circularly polarized clockwise light is obtained at a time. Consequently, it is possible to reversibly convert the soft X-ray from the linearly polarized light into the circularly polarized light or from the circularly polarized light into the linearly polarized light by a reflection to be carried out at only several times.
摘要翻译：在真空容器14的内部形成有由具有在软X射线的波长附近的芯层吸收边缘的过渡金属构成的反射面12，此外，设置有用于产生在反射表面12的位置上与真空容器14的纵向方向垂直的方向上的磁场，软X射线将通过该磁场反射，并且软X射线成为入射在该X射线上的线性偏振光真空容器14在反射面12上被反射多次，位于施加磁场的位置，使得当软X射线被反射时，通过磁性圆二色性的共振效应使磁散射增加因此，构成线偏振光的圆偏振逆时针光和圆偏振顺时针光之间产生很大的折射率差异并且一次获得圆偏振的逆时针光和圆偏振的顺时针光之间的相位差。因此，可以通过仅进行几次的反射将来自线偏振光的软X射线可逆地转换成圆偏振光或从圆偏振光转换为线偏振光。

19. 发明公开

US20240108275A1 ANALYSIS SYSTEM, ANALYSIS METHOD, ANALYTICAL DATA ACQUISITION DEVICE, AND ANALYSIS PROGRAM 审中-公开
公开(公告)号：US20240108275A1
公开(公告)日：2024-04-04
申请号：US18257144
申请日：2021-12-22
申请人： Saitama Medical University
发明人： Susumu SHINDO
IPC分类号： A61B5/00 , A61B3/113 , A61B5/11
CPC分类号： A61B5/4023 , A61B3/113 , A61B5/1114 , A61B5/746
摘要： To provide an analysis system for analysis of semicircular canal functions with rotational stimuli. The analysis system includes a vestibulo ocular reflex data-acquiring unit configured to acquire first vestibulo ocular reflex data and second vestibulo ocular reflex data. The first vestibulo ocular reflex data is acquired by dividing a rotation angle owing to a vestibulo ocular reflex with a rotation angle of a head position. The second vestibulo ocular reflex data is acquired by subtracting at least a rotation angle owing to catch-up saccades (CUS) from the rotation angle of the head position to determine a residual rotation angle, followed by dividing the residual rotation angle with the rotation angle of the head position. The analysis system is configured to analyze semicircular canal functions based on the second vestibulo ocular reflex data, or based on both the first vestibulo ocular reflex data and the second vestibulo ocular reflex data.

20. 发明申请

US20220223239A1 DETERMINATION DEVICE, DETERMINATION METHOD, AND DETERMINATION PROGRAM 有权
公开(公告)号：US20220223239A1
公开(公告)日：2022-07-14
申请号：US17609865
申请日：2020-05-07
申请人： SAITAMA MEDICAL UNIVERSITY
发明人： Koshiro NISHIMOTO
IPC分类号： G16H10/40 , A61B6/03 , G06T7/00
摘要： A determination device includes a factor information acquisition unit configured to acquire information on one or more predetermined factors for a subject with a primary aldosteronism, a tumor diameter acquisition unit configured to acquire a tumor diameter, the tumor diameter being a size of a largest tumor among tumors included in an image of an adrenal gland of the subject obtained through computed tomography, and a calculation unit configured to calculate a probability of an aldosterone-producing adenoma of the adrenal gland of the subject being smaller than a predetermined size on the basis of the information of one or more predetermined factors acquired by the factor information acquisition unit, and determine that adrenalectomy is indicated for the subject on the basis of the tumor diameter and the probability.

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