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1. 发明授权

US07549752B2 Method of detecting glaucoma 有权
标题翻译：检测青光眼的方法
公开(公告)号：US07549752B2
公开(公告)日：2009-06-23
申请号：US11840675
申请日：2007-08-17
申请人： Gholam A. Peyman , Shin Yoneya
发明人： Gholam A. Peyman , Shin Yoneya
IPC分类号： A61B3/00 , A61B3/10 , A61B3/14
CPC分类号： A61B3/12 , A61B5/14555 , G01N21/31 , G01N2021/3144
摘要： The present invention relates to a method, including the steps of mapping at least a portion of the fundus of the eye by forming a plurality of pixels, estimating the oxygen saturation level at each of the plurality of pixels, superimposing the fundus maps on maps of anatomic borderlines, and comparing portions of the superimposed fundus maps to predetermined fundus maps.
摘要翻译：本发明涉及一种方法，包括以下步骤：通过形成多个像素来映射眼睛的至少一部分眼睛，估计多个像素中的每个像素处的氧饱和度水平，将眼底图叠加在解剖边界线，以及将叠加的眼底图的部分与预定的眼底图进行比较。

2. 发明申请

US20070088206A1 Photoacoustic measurement of analyte concentration in the eye 审中-公开
标题翻译：眼睛中分析物浓度的光声测量
公开(公告)号：US20070088206A1
公开(公告)日：2007-04-19
申请号：US11323232
申请日：2005-12-30
申请人： Gholam Peyman , Shin Yoneya
发明人： Gholam Peyman , Shin Yoneya
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0095 , A61B5/14532
摘要： In one aspect, the invention features a method and device for measuring blood concentration of a substance such as glucose in the aqueous humor by illuminating the aqueous humor with a light source at a frequency that is absorbed by the substance to the measured, and then sensing photoacoustically generated sound waves originated within the aqueous humor as a consequence of illumination by the light source. The blood concentration can be estimated from the amplitude of the sound waves received. The method may be combined with other optical techniques for glucose measurement and/or with optical or ultrasonic techniques for topographic mapping of eye structures.
摘要翻译：在一个方面，本发明的特征在于一种用于通过用被测物质吸收的频率的光源照射房水来测量房水中的物质的血液浓度的方法和装置，然后感测光声产生的声波起因于光源的照明而在房水内产生。可以从收到的声波的幅度估计血液浓度。该方法可以与用于葡萄糖测量的其它光学技术和/或与用于眼睛结构的地形图的光学或超声波技术组合。

3. 发明授权

US08781076B2 Phase controller 有权
标题翻译：相位控制器
公开(公告)号：US08781076B2
公开(公告)日：2014-07-15
申请号：US13520593
申请日：2010-12-28
申请人： Hiroto Kuroda , Motoyoshi Baba , Shin Yoneya
发明人： Hiroto Kuroda , Motoyoshi Baba , Shin Yoneya
IPC分类号： G21K1/16 , G21K1/06
CPC分类号： G21K1/06
摘要： A reflection surface 12 constituted by a transition metal having a core level absorption edge in the vicinity of a wavelength of a soft X-ray is formed on an inside of a vacuum vessel 14, and furthermore, there is provided a permanent magnet 13 for generating a magnetic field in a perpendicular direction to a longitudinal direction of the vacuum vessel 14 in a position of the reflection surface 12 by which the soft X-ray is to be reflected, and the soft X-ray to be linearly polarized light incident on the vacuum vessel 14 is reflected at plural times over the reflection surface 12 in a position where the magnetic field is applied in such a manner that magnetic scattering is increased by a resonant effect of a magnetic circular dichroism when the soft X-ray is reflected by the reflection surface 12. Thus, a great difference in a refractive index is made between circularly polarized counterclockwise light and circularly polarized clockwise light which constitute the linearly polarized light, and a phase difference between the circularly polarized counterclockwise light and the circularly polarized clockwise light is obtained at a time. Consequently, it is possible to reversibly convert the soft X-ray from the linearly polarized light into the circularly polarized light or from the circularly polarized light into the linearly polarized light by a reflection to be carried out at only several times.
摘要翻译：在真空容器14的内部形成有由具有在软X射线的波长附近的芯层吸收边缘的过渡金属构成的反射面12，此外，设置有用于产生在反射表面12的位置上与真空容器14的纵向方向垂直的方向上的磁场，软X射线将通过该磁场反射，并且软X射线成为入射在该X射线上的线性偏振光真空容器14在反射面12上被反射多次，位于施加磁场的位置，当软X射线被反射时，以磁性圆二色性的共振效应使磁散射增加因此，构成线偏振光的圆偏振逆时针光和圆偏振顺时针光之间产生很大的折射率差异并且一次获得圆偏振的逆时针光和圆偏振的顺时针光之间的相位差。因此，可以通过仅进行几次的反射将来自线偏振光的软X射线可逆地转换成圆偏振光或从圆偏振光转换为线偏振光。

4. 发明申请

US20130087724A1 Observation Device and Method of Observing 有权
标题翻译：观察装置及观察方法
公开(公告)号：US20130087724A1
公开(公告)日：2013-04-11
申请号：US13639786
申请日：2011-04-04
申请人： Hiroto Kuroda , Shin Yoneya , Motoyoshi Baba , Masayuki Takasu
发明人： Hiroto Kuroda , Shin Yoneya , Motoyoshi Baba , Masayuki Takasu
IPC分类号： G01N21/59 , G01B9/02
CPC分类号： G01N21/59 , G01B9/02024 , G01B9/02091 , G01N21/4795
摘要： Provided is an observation device and a method of observing capable of clearly obtaining information relating to a boundary part where a medium inside an observation object changes. An observation device (1) is a device for observing an observation object (2) including a sensitivity factor in which a dipole moment changes by sensing an electromagnetic wave (31). An output part (11) outputs the electromagnetic wave (31) and the dipole moment of the sensitivity factor included in the observation object (2) is changed by the electromagnetic wave (31). A detector part (12) detects, of the electromagnetic wave (31) outputted from the output part (11), a signal electromagnetic wave (33) which comes through the observation object (2) and a reference electromagnetic wave (32) which bypasses the observation object (2). A control part (13) analyzes the structure of the observation object (2) based on the detection results of the detection part (12). The electromagnetic wave (31) is pulse laser light which is intermittently outputted in pulse waveform. The wavelength of the electromagnetic wave (31) is arranged within the wavelength absorption band of the sensitivity factor.
摘要翻译：提供了一种观察装置和观察方法，其能够清楚地获得与观察对象内的介质变化的边界部分有关的信息。观察装置（1）是通过感测电磁波（31）来观察包括偶极矩变化的灵敏度因素的观察对象物（2）的装置。输出部（11）输出电磁波（31），由电磁波（31）改变观察对象物（2）所包含的灵敏度因子的偶极矩。检测器部分（12）检测从输出部分（11）输出的电磁波（31）中通过观察对象（2）的信号电磁波（33）和旁路的参考电磁波（32）观察对象（2）。控制部（13）基于检测部（12）的检测结果来分析观察对象（2）的结构。电磁波（31）是以脉冲波形间歇输出的脉冲激光。电磁波（31）的波长被布置在灵敏度因子的波长吸收带内。

5. 发明授权

US08121663B2 Photoacoustic measurement of analyte concentration in the eye 有权
标题翻译：眼睛中分析物浓度的光声测量
公开(公告)号：US08121663B2
公开(公告)日：2012-02-21
申请号：US11870935
申请日：2007-10-11
申请人： Gholam A. Peyman , Shin Yoneya
发明人： Gholam A. Peyman , Shin Yoneya
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/0095 , A61B5/14532
摘要： In one aspect, the invention features a method and device for measuring blood concentration of a substance such as glucose in the aqueous humor by illuminating the aqueous humor with a light source at a frequency that is absorbed by the substance to the measured, and then sensing photoacoustically generated sound waves originated within the aqueous humor as a consequence of illumination by the light source. The blood concentration can be estimated from the amplitude of the sound waves received. The method may be combined with other optical techniques for glucose measurement and/or with optical or ultrasonic techniques for topographic mapping of eye structures.
摘要翻译：在一个方面，本发明的特征在于一种用于通过用被测物质吸收的频率的光源照射房水来测量房水中的物质的血液浓度的方法和装置，然后感测光声产生的声波起因于光源的照明而在房水内产生。可以从收到的声波的幅度估计血液浓度。该方法可以与用于葡萄糖测量的其它光学技术和/或与用于眼睛结构的地形图的光学或超声波技术组合。

6. 再颁专利

USRE37180E1 Photochemotherapeutical obstruction of newly-formed blood vessels 有权
标题翻译：新形成的血管的光化学治疗性阻塞
公开(公告)号：USRE37180E1
公开(公告)日：2001-05-15
申请号：US09301320
申请日：1999-04-29
申请人： Keisuke Mori , Masataka Ohta , Shigeru Mori , Shin Yoneya , Naoki Hayashi , Masaru Sonoda
发明人： Keisuke Mori , Masataka Ohta , Shigeru Mori , Shin Yoneya , Naoki Hayashi , Masaru Sonoda
IPC分类号： A61K3140
CPC分类号： A61K41/0071 , A61K31/409
摘要： A photosensitive tetrapyrrole derivative having formula (I) where n stands for 1 or 2 or a pharmaceutically acceptable salt thereof is useful as an effective ingredient in an obstruent composition for photochemotherapeutically obstructing neovascular vessels. The photosensitive tetrapyrroles of the formula (I) may be administered in a photochemotherapeutic method for obstructing neovascular vessels, particularly choroidal and retinal neovascularizations.
摘要翻译：其中n表示1或2的式（I）的光敏四吡咯衍生物或其药学上可接受的盐可用作用于光化学治疗性阻塞新血管血管的组合物中的有效成分。式（I）的光敏四吡咯可以以光化学治疗方法施用，用于阻塞新血管血管，特别是脉络膜和视网膜新血管形成。

7. 发明申请

US20120281816A1 PHASE CONTROLLER 有权
标题翻译：相控制器
公开(公告)号：US20120281816A1
公开(公告)日：2012-11-08
申请号：US13520593
申请日：2010-12-28
申请人： Hiroto Kuroda , Motoyoshi Baba , Shin Yoneya
发明人： Hiroto Kuroda , Motoyoshi Baba , Shin Yoneya
IPC分类号： G21K1/16
CPC分类号： G21K1/06
摘要： A reflection surface 12 constituted by a transition metal having a core level absorption edge in the vicinity of a wavelength of a soft X-ray is formed on an inside of a vacuum vessel 14, and furthermore, there is provided a permanent magnet 13 for generating a magnetic field in a perpendicular direction to a longitudinal direction of the vacuum vessel 14 in a position of the reflection surface 12 by which the soft X-ray is to be reflected, and the soft X-ray to be linearly polarized light incident on the vacuum vessel 14 is reflected at plural times over the reflection surface 12 in a position where the magnetic field is applied in such a manner that magnetic scattering is increased by a resonant effect of a magnetic circular dichroism when the soft X-ray is reflected by the reflection surface 12. Thus, a great difference in a refractive index is made between circularly polarized counterclockwise light and circularly polarized clockwise light which constitute the linearly polarized light, and a phase difference between the circularly polarized counterclockwise light and the circularly polarized clockwise light is obtained at a time. Consequently, it is possible to reversibly convert the soft X-ray from the linearly polarized light into the circularly polarized light or from the circularly polarized light into the linearly polarized light by a reflection to be carried out at only several times.
摘要翻译：在真空容器14的内部形成有由具有在软X射线的波长附近的芯层吸收边缘的过渡金属构成的反射面12，此外，设置有用于产生在反射表面12的位置上与真空容器14的纵向方向垂直的方向上的磁场，软X射线将通过该磁场反射，并且软X射线成为入射在该X射线上的线性偏振光真空容器14在反射面12上被反射多次，位于施加磁场的位置，使得当软X射线被反射时，通过磁性圆二色性的共振效应使磁散射增加因此，构成线偏振光的圆偏振逆时针光和圆偏振顺时针光之间产生很大的折射率差异并且一次获得圆偏振的逆时针光和圆偏振的顺时针光之间的相位差。因此，可以通过仅进行几次的反射将来自线偏振光的软X射线可逆地转换成圆偏振光或从圆偏振光转换为线偏振光。

8. 再颁专利

USRE39357E1 Medicine for clogging blood vessels of eye fundus 失效
标题翻译：用于堵塞眼底血管的药物
公开(公告)号：USRE39357E1
公开(公告)日：2006-10-17
申请号：US10262880
申请日：2002-10-03
申请人： Shin Yoneya , Yutaka Yoneda , Masayuki Takasu
发明人： Shin Yoneya , Yutaka Yoneda , Masayuki Takasu
IPC分类号： A61N5/06
CPC分类号： A61F9/008 , A61B3/145 , A61F9/00821 , A61F2009/00863
摘要： An apparatus for clogging blood vessels of an eye fundus includes an illuminating optical system (1) for illuminating an eye fundus of a subject, who has been given an injection of an infrared fluorescent agent, with infrared rays of light and exciting the infrared fluorescent agent so as to generate infrared fluorescence, a photographic optical system (2) for observing and photographing the eye fundus, and a projecting optical system (21) for projecting a laser beam of light having a specific wavelength onto the subject who has been also given an injection of a photosensitive substance which undergoes a photochemical change by the laser beam. In the apparatus, while a region which emits infrared fluorescence is being observed, the laser beam is projected onto the photosensitive substance so as to clog blood vessels of a diseased part in the depth of the eye fundus.
摘要翻译：用于堵塞眼底血管的装置包括照射光学系统（1），用于照射已经被注射了红外线荧光剂的受试者的眼底，用红外光照射并激发红外荧光剂以产生红外荧光，用于观察和拍摄眼底的摄影光学系统（2），以及投影光学系统（21），用于将具有特定波长的激光束投射到已经被给予注射由激光束发生光化学变化的感光物质。在该装置中，当观察到发射红外荧光的区域时，将激光束投影到感光物质上，从而堵塞眼底深部的病变部位的血管。

9. 发明授权

US09080974B2 Observation device and method of observing 有权
标题翻译：观察装置及观察方法
公开(公告)号：US09080974B2
公开(公告)日：2015-07-14
申请号：US13639786
申请日：2011-04-04
申请人： Hiroto Kuroda , Shin Yoneya , Motoyoshi Baba , Masayuki Takasu
发明人： Hiroto Kuroda , Shin Yoneya , Motoyoshi Baba , Masayuki Takasu
IPC分类号： G01B9/02 , G01N21/59 , G01N21/47
CPC分类号： G01N21/59 , G01B9/02024 , G01B9/02091 , G01N21/4795
摘要： Provided is an observation device and a method of observing capable of clearly obtaining information relating to a boundary part where a medium inside an observation object changes. An observation device (1) is a device for observing an observation object (2) including a sensitivity factor in which a dipole moment changes by sensing an electromagnetic wave (31). An output part (11) outputs the electromagnetic wave (31) and the dipole moment of the sensitivity factor included in the observation object (2) is changed by the electromagnetic wave (31). A detector part (12) detects, of the electromagnetic wave (31) outputted from the output part (11), a signal electromagnetic wave (33) which comes through the observation object (2) and a reference electromagnetic wave (32) which bypasses the observation object (2). A control part (13) analyzes the structure of the observation object (2) based on the detection results of the detection part (12). The electromagnetic wave (31) is pulse laser light which is intermittently outputted in pulse waveform. The wavelength of the electromagnetic wave (31) is arranged within the wavelength absorption band of the sensitivity factor.
摘要翻译：提供了一种观察装置和观察方法，其能够清楚地获得与观察对象内的介质变化的边界部分有关的信息。观察装置（1）是通过感测电磁波（31）来观察包括偶极矩变化的灵敏度因素的观察对象物（2）的装置。输出部（11）输出电磁波（31），由电磁波（31）改变观察对象物（2）所包含的灵敏度因子的偶极矩。检测器部分（12）检测从输出部分（11）输出的电磁波（31）中通过观察对象（2）的信号电磁波（33）和旁路的参考电磁波（32）观察对象（2）。控制部（13）基于检测部（12）的检测结果来分析观察对象（2）的结构。电磁波（31）是以脉冲波形间歇输出的脉冲激光。电磁波（31）的波长被布置在灵敏度因子的波长吸收带内。

10. 发明授权

US5633275A Photochemotherapeutical obstruction of newly-formed blood vessels 失效
标题翻译：新形成的血管的光化学治疗性阻塞
公开(公告)号：US5633275A
公开(公告)日：1997-05-27
申请号：US616177
申请日：1996-03-15
申请人： Keisuke Mori , Masataka Ohta , Shigeru Mori , Shin Yoneya , Naoki Hayashi , Masaru Sonoda
发明人： Keisuke Mori , Masataka Ohta , Shigeru Mori , Shin Yoneya , Naoki Hayashi , Masaru Sonoda
IPC分类号： C07D487/22 , A61K31/00 , A61K31/40 , A61K31/409 , A61K41/00 , A61P27/00 , A61P27/02 , A61P27/04 , A61P43/00
CPC分类号： A61K41/0071 , A61K31/409
摘要： A photosensitive tetrapyrrole derivative having formula (I) ##STR1## where n stands for 1 or 2 or a pharmaceutically acceptable salt thereof is useful as an effective ingredient in an obstruent composition for photochemotherapeutically obstructing neovascular vessels. The photosensitive tetrapyrroles of the formula (I) may be administered in a photochemotherapeutic method for obstructing neovascular vessels, particularly choroidal and retinal neovascularizations.
摘要翻译：具有式（I）的光敏四吡咯衍生物（I）其中n代表1或2或其药学上可接受的盐可用作用于光化学治疗性阻塞新生血管血管的组合物中的有效成分。式（I）的光敏四吡咯可以以光化学治疗方法施用，用于阻塞新血管血管，特别是脉络膜和视网膜新血管形成。

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