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11. 发明授权

US08702941B2 Method of analyzing hemoglobin by electrophoresis 有权
标题翻译：电泳分析血红蛋白的方法
公开(公告)号：US08702941B2
公开(公告)日：2014-04-22
申请号：US12978280
申请日：2010-12-23
申请人： Yusuke Nakayama , Satoshi Yonehara
发明人： Yusuke Nakayama , Satoshi Yonehara
IPC分类号： G01N27/26 , G01N27/447
CPC分类号： G01N27/44747 , G01N27/44791 , G01N33/721
摘要： A method for analyzing hemoglobin by electrophoresis, capable of analyzing hemoglobin A1c (HbA1c) and modified hemoglobin with improved accuracy in a shortened analysis time is provided. The method for analyzing hemoglobin by electrophoresis includes performing electrophoresis under conditions in which an acidic substance having two or more carboxyl groups is present in an electrophoresis solution. At least two of the carboxyl groups of the acidic substance each have an acid dissociation constant (pKa) lower than the pH of the electrophoresis solution at the time of analysis.
摘要翻译：提供了一种通过电泳分析血红蛋白的方法，其能够在缩短的分析时间内以更高的精度分析血红蛋白A1c（HbA1c）和改良的血红蛋白。通过电泳分析血红蛋白的方法包括在电泳液中存在具有两个以上羧基的酸性物质的条件下进行电泳。酸性物质的至少两个羧基在分析时各自具有低于电泳溶液pH值的酸解离常数（pKa）。

12. 发明申请

US20110174621A1 Method for Analyzing Sample by Electrophoresis and Use of the Same 审中-公开
标题翻译：通过电泳分析样品的方法及其应用
公开(公告)号：US20110174621A1
公开(公告)日：2011-07-21
申请号：US13006197
申请日：2011-01-13
申请人： Satoshi Yonehara , Yusuke Nakayama
发明人： Satoshi Yonehara , Yusuke Nakayama
IPC分类号： G01N27/447 , C25B7/00
CPC分类号： G01N27/44747 , G01N27/44791
摘要： A sample analysis method with improved separation accuracy is provided. The method relates to a method for analyzing a sample by electrophoresis using an electrophoresis apparatus provided with a channel and a sample reservoir formed in the channel. The method includes: placing the sample in the sample reservoir of the electrophoresis apparatus with the channel being filled with an electrophoresis running buffer; and performing electrophoresis by applying a voltage to both ends of the channel. The concentration of at least one of a) and b) is set to be approximately the same between the sample and the electrophoresis running buffer; wherein a) and b) are defined as follows: a) an ion that moves in the same direction as an analyte in the sample by the electrophoresis and has a smaller degree of mobility than the analyte, and b) an ion that moves in the opposite direction to the analyte.
摘要翻译：提供了一种提高分离精度的样品分析方法。该方法涉及一种使用电泳装置进行电泳分析样品的方法，所述电泳装置设置有形成在通道中的通道和样品储存器。该方法包括：将样品放置在电泳装置的样品容器中，其中通道充满电泳缓冲液; 并通过向通道的两端施加电压来进行电泳。 a）和b）中的至少一个的浓度被设置为在样品和电泳运行缓冲液之间大致相同; 其中a）和b）定义如下：a）通过电泳在与样品中的分析物相同的方向上移动并且具有比分析物更低的迁移率的离子，以及b）在与分析物相反的方向。

13. 发明申请

US20110155573A1 METHOD OF ANALYZING HEMOGLOBIN BY ELECTROPHORESIS 有权
标题翻译：通过电泳分析HEMOGLOBIN的方法
公开(公告)号：US20110155573A1
公开(公告)日：2011-06-30
申请号：US12978280
申请日：2010-12-23
申请人： Yusuke Nakayama , Satoshi Yonehara
发明人： Yusuke Nakayama , Satoshi Yonehara
IPC分类号： G01N27/447
CPC分类号： G01N27/44747 , G01N27/44791 , G01N33/721
摘要： A method for analyzing hemoglobin by electrophoresis, capable of analyzing hemoglobin A1c (HbA1c) and modified hemoglobin with improved accuracy in a shortened analysis time is provided. The method for analyzing hemoglobin by electrophoresis includes performing electrophoresis under conditions in which an acidic substance having two or more carboxyl groups is present in an electrophoresis solution. At least two of the carboxyl groups of the acidic substance each have an acid dissociation constant (pKa) lower than the pH of the electrophoresis solution at the time of analysis.
摘要翻译：提供了一种通过电泳分析血红蛋白的方法，其能够在缩短的分析时间内以更高的精度分析血红蛋白A1c（HbA1c）和改良的血红蛋白。通过电泳分析血红蛋白的方法包括在电泳液中存在具有两个以上羧基的酸性物质的条件下进行电泳。酸性物质的至少两个羧基在分析时各自具有低于电泳溶液pH值的酸解离常数（pKa）。

14. 发明申请

US20100032294A1 METHOD FOR ANALYZING HEMOGLOBIN BY CAPILLARY ELECTROPHORESIS AND ADDITIVE USED THEREIN 有权
标题翻译：通过毛细管电泳分析HEMOGLOBIN的方法及其使用的添加剂
公开(公告)号：US20100032294A1
公开(公告)日：2010-02-11
申请号：US12514293
申请日：2008-04-23
申请人： Yusuke Nakayama , Satoshi Yonehara
发明人： Yusuke Nakayama , Satoshi Yonehara
IPC分类号： G01N27/447 , C09K3/00
CPC分类号： G01N27/44747
摘要： The present invention provides a method for analyzing hemoglobin by capillary electrophoresis, that allows the apparatus to be smaller in size, allows a highly precise analysis to be obtained, and allows the analysis to be performed in a short period of time. The analytical method of the present invention are methods for analyzing hemoglobin by capillary electrophoresis, comprising: a sample-providing step of providing a sample containing hemoglobin; a capillary tube-providing step of providing a capillary tube containing a buffer solution; and an electrophoresis step of carrying out electrophoresis of the sample, by introducing the sample into the buffer solution in the capillary tube, and applying a voltage across both ends of the capillary tube; wherein the electrophoresis is carried out following at least one of modes (A) and (B) below: (A) the electrophoresis is carried out with a surfactant (a) added to the buffer solution, the surfactant (a) being a non-ionic surfactant having an alkyl group as a hydrophobic portion and a sugar as a hydrophilic portion; and (B) the electrophoresis is carried out with a surfactant (b) added to the sample, the surfactant (b) being a betaine-type amphoteric surfactant.
摘要翻译：本发明提供了一种通过毛细管电泳分析血红蛋白的方法，其允许装置尺寸更小，可以获得高精度分析，并允许在短时间内进行分析。本发明的分析方法是通过毛细管电泳分析血红蛋白的方法，包括：提供含有血红蛋白的样品的样品提供步骤; 毛细管提供步骤，提供含有缓冲溶液的毛细管; 以及电泳步骤，通过将样品引入毛细管中的缓冲溶液中并在毛细管的两端施加电压，进行样品的电泳; 其中所述电泳按照以下模式（A）和（B）中的至少一种进行：（A）用添加到缓冲溶液中的表面活性剂（a）进行电泳，所述表面活性剂（a）具有作为疏水部分的烷基和作为亲水部分的糖的离子表面活性剂; （B）用表面活性剂（b）进行电泳，表面活性剂（b）为甜菜碱型两性表面活性剂。

15. 发明申请

US20120125773A1 Analysis Chip and Analysis Apparatus 审中-公开
公开(公告)号：US20120125773A1
公开(公告)日：2012-05-24
申请号：US13364129
申请日：2012-02-01
申请人： Yusuke Nakayama , Koji Sugiyama
发明人： Yusuke Nakayama , Koji Sugiyama
IPC分类号： G01N33/72 , G01N33/66 , G01N27/26
CPC分类号： G01N27/44791 , B01D57/02 , G01N27/44704
摘要： An analysis chip that enables an apparatus to be small, analysis to be simple, analysis time to be short and analysis of both glycosylated hemoglobin and glucose to be highly accurate is provided. The electrophoresis chip includes an upper substrate 4, a lower substrate 1, a first introduction reservoir 2a, a first recovery reservoir 2b and a capillary channel for sample analysis 3x; the first introduction reservoir 2a and the first recovery reservoir 2b are formed in the lower substrate 1; and the first introduction reservoir 2a and the first recovery reservoir 2b are in communication with each other via the capillary channel for sample analysis 3x.

16. 发明授权

US08252163B2 Analysis apparatus for capillary electrophoresis 有权
标题翻译：毛细管电泳分析仪
公开(公告)号：US08252163B2
公开(公告)日：2012-08-28
申请号：US12506940
申请日：2009-07-21
申请人： Koji Sugiyama , Yukio Higashiisokawa , Yusuke Nakayama
发明人： Koji Sugiyama , Yukio Higashiisokawa , Yusuke Nakayama
IPC分类号： G01N27/453
CPC分类号： G01N27/44791 , C07K1/26 , G01N27/44721
摘要： A capillary electrophoresis analysis apparatus is provided for analyzing samples by a capillary electrophoresis method that allows for rapid and highly accurate separation and detection.
摘要翻译：提供毛细管电泳分析装置，用于通过毛细管电泳方法分析样品，其允许快速和高精度的分离和检测。

17. 发明申请

US20100181199A1 ANALYSIS APPARATUS FOR CAPILLARY ELECTROPHORESIS 有权
标题翻译：毛细管电泳分析仪
公开(公告)号：US20100181199A1
公开(公告)日：2010-07-22
申请号：US12506940
申请日：2009-07-21
申请人： Koji Sugiyama , Yukio Higashiisokawa , Yusuke Nakayama
发明人： Koji Sugiyama , Yukio Higashiisokawa , Yusuke Nakayama
IPC分类号： G01N27/453
CPC分类号： G01N27/44791 , C07K1/26 , G01N27/44721
摘要： A capillary electrophoresis analysis apparatus is provided for analyzing samples by a capillary electrophoresis method that allows for rapid and highly accurate separation and detection.
摘要翻译：提供毛细管电泳分析装置，用于通过毛细管电泳方法分析样品，其允许快速和高精度的分离和检测。

18. 发明申请

US20100051464A1 ANALYSIS CHIP AND ANALYSIS APPARATUS 审中-公开
标题翻译：分析芯片和分析仪器
公开(公告)号：US20100051464A1
公开(公告)日：2010-03-04
申请号：US12515990
申请日：2008-04-23
申请人： Yusuke Nakayama , Koji Sugiyama
发明人： Yusuke Nakayama , Koji Sugiyama
IPC分类号： G01N27/447
CPC分类号： G01N27/44791 , B01D57/02 , G01N27/44704
摘要： An analysis chip that enables an apparatus to be small, analysis to be simple, analysis time to be short and analysis of both glycosylated hemoglobin and glucose to be highly accurate is provided. The electrophoresis chip includes an upper substrate 4, a lower substrate 1, a first introduction reservoir 2a, a first recovery reservoir 2b and a capillary channel for sample analysis 3x; the first introduction reservoir 2a and the first recovery reservoir 2b are formed in the lower substrate 1; and the first introduction reservoir 2a and the first recovery reservoir 2b are in communication with each other via the capillary channel for sample analysis 3x.
摘要翻译：提供一种使装置小型化，分析简单，分析时间短，糖基化血红蛋白和葡萄糖分析高精度的分析芯片。电泳芯片包括上基板4，下基板1，第一引入槽2a，第一回收槽2b和用于样品分析的毛细通道3x; 第一引入槽2a和第一回收槽2b形成在下基板1中; 并且第一引入槽2a和第一回收槽2b经由用于样品分析3x的毛细通道彼此连通。

19. 发明申请

US20090200166A1 Method of Analyzing Hemoglobin by Capillary Eletrophoresis 审中-公开
标题翻译：毛细管电泳分析血红蛋白的方法
公开(公告)号：US20090200166A1
公开(公告)日：2009-08-13
申请号：US12367260
申请日：2009-02-06
申请人： Yusuke Nakayama , Koji Sugiyama
发明人： Yusuke Nakayama , Koji Sugiyama
IPC分类号： G01N27/447
CPC分类号： G01N27/44747 , C07K1/16
摘要： The present invention is directed to methods of analyzing hemoglobin by capillary electrophoresis involving electrophoresing a hemoglobin-containing sample in the presence of chaotropic anion.
摘要翻译：本发明涉及通过毛细管电泳分析血红蛋白的方法，包括在存在离液序的阴离子的情况下电泳含有血红蛋白的样品。

20. 发明授权

US08888980B2 Electrophoresis apparatus and control method thereof 有权
标题翻译：电泳装置及其控制方法
公开(公告)号：US08888980B2
公开(公告)日：2014-11-18
申请号：US13206263
申请日：2011-08-09
申请人： Yasunori Shiraki , Genki Adachi , Rina Matsumi , Toru Odagaki , Yusuke Nakayama
发明人： Yasunori Shiraki , Genki Adachi , Rina Matsumi , Toru Odagaki , Yusuke Nakayama
IPC分类号： G01N27/453 , G01N27/447
CPC分类号： G01N27/44713 , G01N2030/889
摘要： An electrophoresis apparatus that applies voltage from electrodes that are provided in a capillary flow channel and causes component separation by performing electrophoresis on a specimen that is injected into the capillary flow channel comprises: a physical quantity acquisition unit and a physical quantity determination unit. The physical quantity acquisition unit, with migration solution and specimen injected inside the capillary flow channel, acquires an electrical quantity that occurs in the capillary flow channel at a specified time when voltage is being applied to the electrodes. The physical quantity determination unit determines whether or not the electrical quantity that the physical acquisition unit acquires is within a specified range.
摘要翻译：一种电泳装置，其从设置在毛细管流路中的电极施加电压，并且通过对注入到所述毛细管流路的试样进行电泳而使成分分离，包括物理量取得部和物理量判定部。物理量获取单元，具有在毛细管流动通道内注入的迁移溶液和样品，在电压施加到电极的特定时间获取在毛细管流动通道中发生的电量。物理量确定单元确定物理获取单元获取的电量是否在指定范围内。

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