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11. 发明授权

US07803778B2 Glucose transport inhibitors and methods of use 有权
标题翻译：葡萄糖转运抑制剂和使用方法
公开(公告)号：US07803778B2
公开(公告)日：2010-09-28
申请号：US11752226
申请日：2007-05-22
申请人： Yuanwei Chen , Yan Feng , Baihua Xu , Binhua Lv , Jiajia Dong , Brian Seed , Michael J. Hadd
发明人： Yuanwei Chen , Yan Feng , Baihua Xu , Binhua Lv , Jiajia Dong , Brian Seed , Michael J. Hadd
IPC分类号： A01N43/04 , C07H1/00 , C07H3/00 , C08B37/00
CPC分类号： C07D311/96 , C07D407/12 , C07H7/04 , C07H19/00
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译：提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。

12. 发明授权

US08129434B2 Benzylphenyl cyclohexane derivatives and methods of use 有权
标题翻译：苄基苯基环己烷衍生物和使用方法
公开(公告)号：US08129434B2
公开(公告)日：2012-03-06
申请号：US12333190
申请日：2008-12-11
申请人： Yuanwei Chen , Kun Peng , Lili Zhang , Binhua Lv , Baihua Xu , Jiajia Dong , Jiyan Du , Yan Feng , Ge Xu , Vasanthakumar Rajappan , Brian Seed
发明人： Yuanwei Chen , Kun Peng , Lili Zhang , Binhua Lv , Baihua Xu , Jiajia Dong , Jiyan Du , Yan Feng , Ge Xu , Vasanthakumar Rajappan , Brian Seed
IPC分类号： A61K31/015 , C07C15/12
CPC分类号： C07H7/04
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译：提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。

13. 发明申请

US20090156516A1 BENZYLPHENYL CYCLOHEXANE DERIVATIVES AND METHODS OF USE 有权
标题翻译：苯并噻吩衍生物及其使用方法
公开(公告)号：US20090156516A1
公开(公告)日：2009-06-18
申请号：US12333190
申请日：2008-12-11
申请人： Yuanwei Chen , Kun Peng , Lili Zhang , Binhua Lv , Baihua Xu , Jiajia Dong , Jiyan Du , Yan Feng , Ge Xu , Vasanthakumar Rajappan , Brian Seed
发明人： Yuanwei Chen , Kun Peng , Lili Zhang , Binhua Lv , Baihua Xu , Jiajia Dong , Jiyan Du , Yan Feng , Ge Xu , Vasanthakumar Rajappan , Brian Seed
IPC分类号： A61K31/7034 , C07H7/04 , A61P3/10
CPC分类号： C07H7/04
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译：提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。

14. 发明申请

US20070275907A1 GLUCOSE TRANSPORT INHIBITORS AND METHODS OF USE 有权
标题翻译：葡萄糖运输抑制剂及其使用方法
公开(公告)号：US20070275907A1
公开(公告)日：2007-11-29
申请号：US11752226
申请日：2007-05-22
申请人： Yuanwei Chen , Yan Feng , Baihua Xu , Binhua Lv , Jiajia Dong , Brian Seed , Michael Hadd
发明人： Yuanwei Chen , Yan Feng , Baihua Xu , Binhua Lv , Jiajia Dong , Brian Seed , Michael Hadd
IPC分类号： A61K31/70 , A61K31/5377 , A61K31/496 , A61K31/453 , A61K31/452 , A61K31/382 , A61K31/35
CPC分类号： C07D311/96 , C07D407/12 , C07H7/04 , C07H19/00
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译：提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。

15. 发明授权

US07795228B2 Spiroheterocyclic glycosides and methods of use 有权
标题翻译：螺杂环苷及其使用方法
公开(公告)号：US07795228B2
公开(公告)日：2010-09-14
申请号：US11964493
申请日：2007-12-26
申请人： Michael J. Hadd , Yuanwei Chen , Yan Feng , Sengen Sen , Brian Seed
发明人： Michael J. Hadd , Yuanwei Chen , Yan Feng , Sengen Sen , Brian Seed
IPC分类号： A01N43/04 , C07H1/00 , C07H3/00 , C08B37/00
CPC分类号： C07H17/04
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译：提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。

16. 发明申请

US20080182802A1 SPIROHETEROCYCLIC GLYCOSIDES AND MEHTODS OF USE 有权
标题翻译：螺旋藻糖苷和使用的MEHTODS
公开(公告)号：US20080182802A1
公开(公告)日：2008-07-31
申请号：US11964493
申请日：2007-12-26
申请人： Michael J. Hadd , Yuanwei Chen , Yan Feng , Sengen Sen , Brian Seed
发明人： Michael J. Hadd , Yuanwei Chen , Yan Feng , Sengen Sen , Brian Seed
IPC分类号： A61K31/7048 , C07H17/04 , A61P3/10 , A61P3/04
CPC分类号： C07H17/04
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译：提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。

17. 发明授权

US10640457B2 Histone acetyltransferase activators and uses thereof 有权
公开(公告)号：US10640457B2
公开(公告)日：2020-05-05
申请号：US13493490
申请日：2012-06-11
申请人： Yan Feng , Mauro Fa , Ottavio Arancio , Shixian Deng , Donald W. Landry , Yitshak Francis
发明人： Yan Feng , Mauro Fa , Ottavio Arancio , Shixian Deng , Donald W. Landry , Yitshak Francis
IPC分类号： A61K49/00 , C07C235/64 , C07C323/67 , C07C323/42 , C07D213/82 , C07D213/75 , C07C235/56 , C07C237/40 , C07D239/52 , C07D333/38 , C12Q1/48 , C07C323/44 , C07C323/60
CPC分类号： C07C235/64 , C07C235/56 , C07C237/40 , C07C323/42 , C07C323/44 , C07C323/60 , C07C323/67 , C07D213/75 , C07D213/82 , C07D239/52 , C07D333/38 , C12Q1/48 , C07C2601/08 , G01N2500/04 , G01N2800/2814
摘要： The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject.

18. 发明授权

US08773752B2 Narrow band fiber Raman optical amplifier 有权
标题翻译：窄带光纤拉曼光放大器
公开(公告)号：US08773752B2
公开(公告)日：2014-07-08
申请号：US12812370
申请日：2009-01-16
申请人： Luke R. Taylor , Yan Feng , Wolfgang Hackenberg , Ronald Holzlöhner , Domenico Bonaccini Calia
发明人： Luke R. Taylor , Yan Feng , Wolfgang Hackenberg , Ronald Holzlöhner , Domenico Bonaccini Calia
IPC分类号： H04B10/17 , H01S3/30
CPC分类号： H01S3/302
摘要： Optical Raman fiber amplifier (20), with an amplification fiber, wherein at least one section thereof has a ratio of Raman gain coefficient gR to Brillouin gB gain coefficient of gR/gB larger than 0.001 at the fiber operating temperature and a vacuum wavelength of 1064 nm. The invention further refers to a corresponding light source, the use of a fiber and a method of amplifying light.
摘要翻译：具有放大光纤的光拉曼光纤放大器（20），其中至少一个部分在光纤工作温度下的拉曼增益系数gR与布里渊gB增益系数gR / gB大于0.001，真空波长为1064 nm。本发明还涉及相应的光源，光纤的使用和放大光的方法。

19. 发明授权

US08618145B2 Small molecular compounds capable of accelerating proliferation of stem cells and use thereof 有权
标题翻译：能够促进干细胞增殖的小分子化合物及其用途
公开(公告)号：US08618145B2
公开(公告)日：2013-12-31
申请号：US13320203
申请日：2009-05-12
申请人： Mei Han , Yan Feng , Yuanyuan Sun
发明人： Mei Han , Yan Feng , Yuanyuan Sun
IPC分类号： A61K31/4245 , C07D271/113
CPC分类号： C07D271/07
摘要： The invention provides small molecule compounds capable of accelerating proliferation of stem cells and uses thereof. The compounds play an important role in the research of stem cell proliferation mechanism. The invention further relates to the uses of the compounds and relevant compounds thereof in the preparation of stem cell proliferation accelerators and the preparation of medicines accelerating stem cell proliferation. The invention also relates to the uses of the compounds in the preparation of medicines for the treatment of various diseases arising from functional cells loss or damage. The diseases arising from stem cell trauma comprise diseases related to the degeneration or damage of nervous system cells, blood system diseases, diseases related to the loss or damage of cardiovascular cells, skin burn and the like.
摘要翻译：本发明提供能够促进干细胞增殖的小分子化合物及其用途。该化合物在干细胞增殖机制研究中起着重要作用。本发明还涉及化合物及其相关化合物在制备干细胞增殖促进剂中的用途以及加速干细胞增殖的药物的制备。本发明还涉及该化合物在制备用于治疗由功能性细胞损失或损伤引起的各种疾病的药物中的用途。由干细胞创伤引起的疾病包括与神经系统细胞的退化或损伤相关的疾病，血液系统疾病，与心血管细胞的损失或损伤有关的疾病，皮肤灼伤等。

20. 外观设计

USD638688S1 Electrical receptacle and inlet valve cover plate 有权
标题翻译：电气插座和进口阀盖板
公开(公告)号：USD638688S1
公开(公告)日：2011-05-31
申请号：US29347207
申请日：2009-10-23
申请人： James George Sheremeta , Daniel David Richard Mika , Yan Feng
设计人： James George Sheremeta , Daniel David Richard Mika , Yan Feng

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