专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US4343736A Process for recovering interferon 失效
标题翻译：干扰素回收方法
公开(公告)号：US4343736A
公开(公告)日：1982-08-10
申请号：US280687
申请日：1981-07-06
申请人： Yahiro Uemura , Hirofumi Arimura , Hiroshi Morise , Satoshi Funakoshi , Tadakazu Suyama
发明人： Yahiro Uemura , Hirofumi Arimura , Hiroshi Morise , Satoshi Funakoshi , Tadakazu Suyama
IPC分类号： C12P21/00 , A61K38/21 , C07K1/22 , C07K14/52 , C07K14/555 , C07K14/56 , C07K14/57 , A61K45/02 , C07G7/00
CPC分类号： C07K14/555 , Y10S435/811 , Y10S530/829 , Y10S530/837 , Y10S530/838 , Y10S530/848
摘要： A process for recovering interferon which comprises contacting a solution containing an interferon produced by the induced cells of human origin with a water-insolubilized sulfated polysaccharide to allow the interferon to be adsorbed on the water-insolubilized sulfated polysaccharide and then selectively eluting the interferon with an aqueous solution of an inorganic salt.

12. 发明授权

US4526782A Process for recovering interferon 失效
标题翻译：干扰素回收方法
公开(公告)号：US4526782A
公开(公告)日：1985-07-02
申请号：US432909
申请日：1982-09-27
申请人： Yahiro Uemura , Hirofumi Arimura , Hiroshi Morise , Satoshi Funakoshi , Tadakazu Suyama
发明人： Yahiro Uemura , Hirofumi Arimura , Hiroshi Morise , Satoshi Funakoshi , Tadakazu Suyama
IPC分类号： C07K14/56 , A61K45/02 , C07G7/00 , C12P21/00
CPC分类号： C07K14/56
摘要： Interferon can be recovered simply by contacting an aqueous solution containing interferon which is induced and produced from cells of human origin capable of producing interferon, with a siliceous substance to adsorb interferon on it and eluting the adsorbed interferon with an aqueous solution containing a nonionic surfactant, preferably further containing an acriflavine such as acrinol.
摘要翻译： PCT No.PCT / JP81 / 00030 Sec。 371日期1982年9月27日 102（e）日期1982年9月27日PCT提交1981年2月17日PCT公布。出版物WO82 / 02834 日本1982年9月2日。通过将含有可产生干扰素的人源细胞诱导和产生的含有干扰素的水溶液与硅质物质接触，可以简单地回收地塞米松，以吸附干扰素并用吸附的干扰素含有非离子表面活性剂的水溶液，优选还含有吖啶如Acrinol。

13. 发明授权

US4442037A Water-soluble cholesterol derivative 失效
标题翻译：水溶性胆固醇衍生物
公开(公告)号：US4442037A
公开(公告)日：1984-04-10
申请号：US432938
申请日：1982-09-28
申请人： Yoshio Arakawa , Atsuyuki Takanabe , Yahiro Uemura , Satoshi Funakoshi , Tadakazu Suyama
发明人： Yoshio Arakawa , Atsuyuki Takanabe , Yahiro Uemura , Satoshi Funakoshi , Tadakazu Suyama
IPC分类号： C07J9/00 , C07J41/00
CPC分类号： C07J9/00 , C07J41/0055
摘要： Complexes of albumin combined with organic dibasic acid half esters, such as those of succinic acid and phthalic acid, of 7-hydroxycholesterol are soluble in water and have excellent immunosuppressive and anti-inflammatory action.
摘要翻译： PCT No.PCT / JP81 / 00056 Sec。 371日期1982年9月28日 102（e）日期1982年9月28日PCT提交1981年3月13日PCT公布。公开号WO82 / 03175 日期为1982年9月30日。与7-羟基胆固醇的琥珀酸和邻苯二甲酸的有机二元酸半酯结合的复合物可溶于水，具有优异的免疫抑制和抗炎作用。

14. 发明授权

US4694074A Process for the purification of HBsAg 失效
标题翻译： HBsAg纯化方法
公开(公告)号：US4694074A
公开(公告)日：1987-09-15
申请号：US792081
申请日：1985-10-28
申请人： Yahiro Uemura , Takao Ohmura , Akimasa Ohmizu , Akinori Sumi , Wataru Ohtani , Yoshitaka Sakanishi , Hiroshi Morise , Hirofumi Arimura , Tadakazu Suyama
发明人： Yahiro Uemura , Takao Ohmura , Akimasa Ohmizu , Akinori Sumi , Wataru Ohtani , Yoshitaka Sakanishi , Hiroshi Morise , Hirofumi Arimura , Tadakazu Suyama
IPC分类号： C12N15/09 , A61K39/29 , A61P1/16 , C07K1/16 , C07K1/22 , C07K14/005 , C07K14/02 , C07K14/195 , C07K14/435 , C12N5/00 , C12N15/00 , C12P21/00 , C12P21/08 , C07K3/18 , C07K3/28
CPC分类号： C07K14/005 , C12N2730/10122 , Y10S530/806 , Y10S530/808
摘要： A process for the purification of HBsAg is disclosed, which comprises adsorbing specifically on a carrier, in the presence of an inorganic salt in an amount of 5 to 25 W/V %, an HBsAg obtained by gene engineering.
摘要翻译：公开了一种用于纯化HBsAg的方法，其包括在载体上以5至25W / V％的无机盐存在下特异性吸附通过基因工程获得的HBsAg。

15. 发明授权

US4371520A Process for preparing immunoglobulin suitable for intravenous injection 失效
标题翻译：制备适合静脉注射的免疫球蛋白的方法
公开(公告)号：US4371520A
公开(公告)日：1983-02-01
申请号：US316042
申请日：1981-10-28
申请人： Yahiro Uemura , Takashi Goto , Yoshiaki Kano , Satoshi Funakoshi
发明人： Yahiro Uemura , Takashi Goto , Yoshiaki Kano , Satoshi Funakoshi
IPC分类号： A61K38/00 , C07K16/06 , A61K39/00
CPC分类号： C07K16/065 , A61K38/00 , Y10S530/83 , Y10S530/831
摘要： A process for preparing immunoglobulin suitable for intravenous injection, comprising treating with an acid a plasma or fraction I+II+III, fraction II+III, fraction II, or fraction III (hereinafter these are sometimes referred collectively to as starting material) obtained from plasma by Cohn's cold alcohol fractionation method, and subjecting to fractionation using an alkylene oxide polymer or copolymer having a molecular weight of 2,000 to 20,000.
摘要翻译：一种制备适用于静脉注射的免疫球蛋白的方法，包括用酸将血浆或级分I + II + III，级分II + III，级分II或级分III（以下有时统称为原料）等离子体，并使用分子量为2,000〜20,000的烯化氧聚合物或共聚物进行分馏。

16. 发明授权

US5219995A Plasma fraction purification 失效
$Plasma fraction purification$
标题翻译：血浆级分纯化
公开(公告)号：US5219995A
公开(公告)日：1993-06-15
申请号：US913590
申请日：1992-07-14
申请人： Steven W. Herring , Yahiro Uemura , Munehiro Noda , Kenneth T. Shitanishi
发明人： Steven W. Herring , Yahiro Uemura , Munehiro Noda , Kenneth T. Shitanishi
IPC分类号： A61K38/43 , C07K1/18 , C07K1/22 , C07K1/30 , C07K14/435 , C07K14/745 , C12N9/64 , C12N9/74
CPC分类号： C12N9/6429 , C07K14/745 , C12N9/6432 , C12Y304/21005 , C12Y304/21006
摘要： The present invention describes a process for activating Factor II to Factor II.sub.a by incubating Factor II in the presence of Factor V, Factor X.sub.a, phospholipids, and calcium ions. Each of the factors is prepared from a single impure protein fraction which includes Factors II, V and X. The Factor II, V and X purification procedure comprises the steps of DEAE ligand chromatography and precipitation by the addition of barium chloride. Factor V is recovered from the barium chloride supernatant, and Factors II and X are contained in the barium chloride precipitate. The barium chloride precipitate is dissolved in an aqueous solution and is applied to a chromatographic resin coupled with a ligand which binds Factor X and Factor II weakly or not at all. Factor II is recovered from the fraction, which remains unbound or weakly bound to the Factor X binding ligand. Factor X.sub.a is prepared by recovering Factor X from the ligand during the Factor II preparation procedure and activating the Factor X to Factor X.sub.a by specific proteolytic cleavage.
摘要翻译：本发明描述了通过在因子V，因子Xa，磷脂和钙离子的存在下孵育因子II来激活因子II至因子IIa的方法。因子II，V和X的纯化程序包括DEAE配体层析和加入氯化钡沉淀的步骤。因子V从氯化钡上清液中回收，因子II和X包含在氯化钡沉淀中。将氯化钡沉淀物溶解在水溶液中，并施加到与限制因子X和因子II的配体偶联的色谱树脂上或完全不结合。因子II从部分回收，其保持未结合或弱结合于因子X结合配体。因子Xa通过在因子II制备过程中从配体中回收因子X并通过特异性蛋白水解切割活化因子X至因子Xa来制备。

17. 发明授权

US5151499A Production method for protein-containing composition 失效
标题翻译：含蛋白质组合物的生产方法
公开(公告)号：US5151499A
公开(公告)日：1992-09-29
申请号：US464077
申请日：1990-01-12
申请人： Shoju Kameyama , Kenmi Miyano , Motonori Hashimoto , Kazuo Takechi , Takao Ohmura , Yutaka Hirao , Yahiro Uemura , Kazumasa Yokoyama
发明人： Shoju Kameyama , Kenmi Miyano , Motonori Hashimoto , Kazuo Takechi , Takao Ohmura , Yutaka Hirao , Yahiro Uemura , Kazumasa Yokoyama
IPC分类号： A61K38/16 , A61K35/16 , A61K38/00 , A61K38/21 , A61K38/43 , A61K38/46 , A61K38/48 , A61K38/55 , A61K47/24 , A61L2/00 , C12N7/06
CPC分类号： C12N7/00 , A61K35/16 , A61L2/0023 , A61L2/0088 , C12N2760/20263
摘要： A method of producing a virus-inactivated protein-containing composition from a protein-containing composition which may be contaminated with virus. The method according to the present invention permits production of pharmaceutically safer virus-inactivated protein preparations without spoiling the protein activity.

18. 发明授权

US5989593A Method for producing antithrombin-III, method for purifying it, and preparation containing it 失效
标题翻译：抗凝血酶III的制备方法，纯化方法及其制备方法
公开(公告)号：US5989593A
公开(公告)日：1999-11-23
申请号：US974191
申请日：1997-11-19
申请人： Shouji Ideno , Katsuhiro Uriyu , Yahiro Uemura
发明人： Shouji Ideno , Katsuhiro Uriyu , Yahiro Uemura
IPC分类号： A61K38/00 , C07K14/81 , A61K35/14 , A61K38/16
CPC分类号： C07K14/8128 , A61K38/00
摘要： A method for producing antithrombin-III from an antithrombin-III-containing aqueous solution, comprising at least one of the following steps (a) and (b): (a) heating the antithrombin-III-containing aqueous solution in the presence of a stabilizing agent so that 85% or more of the activity of antithrombin-III before the heating is maintained after the heating, and that the ratio of an antithrombin-III monomer after the heating is maintained at 95% or more; and (b) treating the antithrombin-III-containing aqueous solution with a metal chelate resin and recovering a purified antithrombin-III.
摘要翻译：一种含抗凝血酶III的水溶液制备抗凝血酶III的方法，包括以下步骤（a）和（b）中的至少一个：（a）在含有抗凝血酶III的水溶液存在下，使加热后保持加热前的抗凝血酶III的85％以上的活性，加热后的抗凝血酶III单体的比例保持在95％以上; 和（b）用金属螯合树脂处理含有抗凝血酶III的水溶液并回收纯化的抗凝血酶III。

19. 发明授权

US5138034A Method of fractionating plasma proteins 失效
$Method of fractionating plasma proteins$
标题翻译：分离血浆蛋白的方法
公开(公告)号：US5138034A
公开(公告)日：1992-08-11
申请号：US537651
申请日：1990-06-14
申请人： Yahiro Uemura , Kazuo Takechi , Kenji Tanaka
发明人： Yahiro Uemura , Kazuo Takechi , Kenji Tanaka
IPC分类号： A61K38/16 , A61K35/14 , C07K1/22 , C07K14/435 , C07K14/745 , C07K14/755 , C07K14/76 , C07K16/00
CPC分类号： C07K1/22
摘要： A method of fractionating plasma protein which comprises treating a plasma protein-containing material in the following sequence of steps, provided that steps (ii) through (v) may be performed in an optional order: (i) freeze-thaw treatment, (ii) treatment at 5 to 10% ethanol concentration, (iii) treatment with an anion exchanger, (iv) affinity chromatography with immobilized lysine, (v) affinity chromatography with immobilized heparin, (vi) treatment at 18 to 30% ethanol concentration, (vii) treatment at 35 to 45% ethanol concentration.

20. 发明授权

US4555401A Live mumps vaccine and method of stabilizing the same 失效
标题翻译：活腮腺炎疫苗及其稳定方法
公开(公告)号：US4555401A
公开(公告)日：1985-11-26
申请号：US589863
申请日：1984-03-19
申请人： Hirofumi Arimura , Yahiro Uemura , Yoshiomi Okuno
发明人： Hirofumi Arimura , Yahiro Uemura , Yoshiomi Okuno
IPC分类号： A61K39/165 , A61K47/42
CPC分类号： A61K47/42 , A61K39/12 , A61K39/165 , A61K2039/5254 , C12N2760/18734
摘要： A live mumps vaccine can be stabilized to a great extent by adding in an amount, effective for stabilizing said vaccine, at least one stabilizer selected from the group consisting of albumin and gelatin.
摘要翻译：活腮腺炎疫苗可以在很大程度上通过加入有效稳定所述疫苗，至少一种选自白蛋白和明胶的稳定剂的量来稳定。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式