专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

US20100099660A1 METHOD FOR TREATING THROMBOSIS OR EMBOLISM AND RELATED DISEASES 审中-公开
标题翻译：治疗肝硬化或相关疾病的方法
公开(公告)号：US20100099660A1
公开(公告)日：2010-04-22
申请号：US12639986
申请日：2009-12-16
申请人： Toshiharu Ohta , Satoshi Komoriya , Toshiharu Yoshino , Kouichi Uoto , Yumi Nakamoto , Hiroyuki Naito , Akiyoshi Mochizuki , Tsutomu Nagata , Hideyuki Kanno , Noriyasu Haginoya , Kenji Yoshikawa , Masatoshi Nagamochi , Syozo Kobayashi , Makoto Ono
发明人： Toshiharu Ohta , Satoshi Komoriya , Toshiharu Yoshino , Kouichi Uoto , Yumi Nakamoto , Hiroyuki Naito , Akiyoshi Mochizuki , Tsutomu Nagata , Hideyuki Kanno , Noriyasu Haginoya , Kenji Yoshikawa , Masatoshi Nagamochi , Syozo Kobayashi , Makoto Ono
IPC分类号： A61K31/397 , A61K31/437 , A61K31/502 , A61K31/5377 , A61K31/55
CPC分类号： C07D498/04 , C07D213/75 , C07D401/12 , C07D401/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/14 , C07D519/00
摘要： A method for treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after artificial valve or joint replacement, thrombus formation and reocclusion after angioplasty, multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing is provided. The method includes administration of an effective amount of a compound represented by formula (1):
摘要翻译：一种治疗脑梗死，脑栓塞，心肌梗塞，心绞痛，肺梗塞，肺栓塞，Buerger病，深静脉血栓形成，弥散性血管内凝血综合征，人工瓣膜或关节置换后血栓形成，血管成形术后血栓形成和再闭塞的方法，提供多器官功能障碍综合征（MODS），体外循环期间的血栓形成或血液抽血时的凝血。该方法包括施用有效量的由式（1）表示的化合物：

12. 发明申请

US20090270446A1 DIAMINE DERIVATIVES 审中-公开
标题翻译： DIAMINE衍生物
公开(公告)号：US20090270446A1
公开(公告)日：2009-10-29
申请号：US12399702
申请日：2009-03-06
申请人： Toshiharu Ohta , Satoshi Komoriya , Toshiharu Yoshino , Kouichi Uoto , Yumi Nakamoto , Hiroyuki Naito , Akiyoshi Mochizuki , Tsutomu Nagata , Hideyuki Kanno , Noriyasu Haginoya , Kenji Yoshikawa , Masatoshi Nagamochi , Syozo Kobayashi , Makoto Ono
发明人： Toshiharu Ohta , Satoshi Komoriya , Toshiharu Yoshino , Kouichi Uoto , Yumi Nakamoto , Hiroyuki Naito , Akiyoshi Mochizuki , Tsutomu Nagata , Hideyuki Kanno , Noriyasu Haginoya , Kenji Yoshikawa , Masatoshi Nagamochi , Syozo Kobayashi , Makoto Ono
IPC分类号： A61K31/437
CPC分类号： C07D487/04 , A61K31/428 , A61K31/429 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , C07D209/42 , C07D401/12 , C07D401/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D513/04 , C07D513/14 , C07K5/06191 , C07K5/0827
摘要： The present invention relates to diamine compounds which inhibit activated blood coagulation factor X and exhibit an anticoagulant effect and there uses for treating various diseases based on thromboembolism.
摘要翻译：本发明涉及抑制活化凝血因子X并表现出抗凝血作用的二胺化合物，其用于治疗基于血栓栓塞的各种疾病。

13. 发明申请

US20060252837A1 Diamine derivatives 有权
标题翻译：二胺衍生物
公开(公告)号：US20060252837A1
公开(公告)日：2006-11-09
申请号：US10540259
申请日：2003-12-25
申请人： Toshiharu Ohta , Satoshi Komoriya , Toshiharu Yoshino , Kouichi Uoto , Yumi Nakamoto , Hiroyuki Naito , Akiyoshi Mochizuki , Hideyuki Kanno , Noriyasu Haginoya , Kenji Yoshikawa , Masatoshi Nagamochi , Syozo Kobayashi , Makoto Ono
发明人： Toshiharu Ohta , Satoshi Komoriya , Toshiharu Yoshino , Kouichi Uoto , Yumi Nakamoto , Hiroyuki Naito , Akiyoshi Mochizuki , Hideyuki Kanno , Noriyasu Haginoya , Kenji Yoshikawa , Masatoshi Nagamochi , Syozo Kobayashi , Makoto Ono
IPC分类号： A61K31/13
CPC分类号： C07D498/04 , C07D213/75 , C07D401/12 , C07D401/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/14 , C07D519/00
摘要： A compound represented by formula (1): Q1-Q2-To-N(R1)-Q3-N(R2)-T1-Q4 (1) [wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 represents the following group: (wherein Q5 is an alkylene group having 1 to 8 carbon atoms, or the like); and T0 and T1 are carbonyl groups or the like], a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after artificial valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.
摘要翻译：由式（1）表示的化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？> Q ^{1 -N（R 1） - Q 3 -N（R 2） - T SUP （1）<？in-line-formula description =“In-line Formulas”end =“tail”？> [其中R <1> 和R 2是氢原子等; Q 1是可被取代的饱和或不饱和的5或6元环烃基，等等; Q 2是单键等; Q 3表示以下基团：（其中Q 5是具有1〜8个碳原子的亚烷基等）; 并且T 0和T 1是羰基等，其盐，其溶剂化物或其N-氧化物。该化合物可用作预防和/或治疗脑梗塞，脑栓塞，心肌梗死，心绞痛，肺梗塞，肺栓塞，Buerger病，深静脉血栓形成，弥散性血管内凝血综合征，人工瓣膜或关节后血栓形成血管成形术后的替代，血栓形成和再闭塞，全身炎症反应综合征（SIRS），多器官功能障碍综合征（MODS），体外循环期间的血栓形成或血液抽血时的凝血。}

14. 发明授权

US07935824B2 Ethylenediamine derivatives 失效
标题翻译：乙二胺衍生物
公开(公告)号：US07935824B2
公开(公告)日：2011-05-03
申请号：US12465329
申请日：2009-05-13
申请人： Toshiharu Yoshino , Tsutomu Nagata , Noriyasu Haginoya , Kenji Yoshikawa , Hideyuki Kanno , Masatoshi Nagamochi
发明人： Toshiharu Yoshino , Tsutomu Nagata , Noriyasu Haginoya , Kenji Yoshikawa , Hideyuki Kanno , Masatoshi Nagamochi
IPC分类号： C07D513/04
CPC分类号： C07D513/04 , C07D213/56 , C07D487/04 , C07D495/04 , C07D498/04
摘要： The invention relates a compound represented by the formula (1): Q1-Q2-C(═O)—N(R1)-Q3-N(R2)-T1-Q4 (1) wherein R1 and R2 represent H or the like; Q1 represents an aromatic ring, heterocyclic ring or the like; Q2 represents a single bond, aromatic ring, heterocyclic ring or the like; Q3 represents a group or the like, Q4 represents an aromatic ring, heterocyclic ring or the like; and T1 represents —CO— or —SO2—, and a medicine which comprises the compound and is useful for thrombosis and embolism.
摘要翻译：本发明涉及式（1）表示的化合物：其中R1和R2表示H等的Q1-Q2-C（= O）-N（R1）-Q3-N（R2）-T1-Q4（1） ; Q1表示芳环，杂环等; Q2表示单键，芳香环，杂环等; Q 3表示基团等，Q 4表示芳香环，杂环等; 并且T1表示-CO-或-SO2-，以及包含该化合物并用于血栓形成和栓塞的药物。

15. 发明申请

US20060004009A1 Ethylenediamine derivatives 审中-公开
标题翻译：乙二胺衍生物
公开(公告)号：US20060004009A1
公开(公告)日：2006-01-05
申请号：US11217837
申请日：2005-09-02
申请人： Toshiharu Yoshino , Tsutomu Nagata , Noriyasu Haginoya , Kenji Yoshikawa , Hideyuki Kanno , Masatoshi Nagamochi
发明人： Toshiharu Yoshino , Tsutomu Nagata , Noriyasu Haginoya , Kenji Yoshikawa , Hideyuki Kanno , Masatoshi Nagamochi
IPC分类号： A61K31/519 , C07D498/02 , C07D491/02 , A61K31/50
CPC分类号： C07D513/04 , C07D213/56 , C07D487/04 , C07D495/04 , C07D498/04
摘要： The invention relates a compound represented by the formula (1): Q1-Q2-C(═O)—N(R1)-Q3-N(R2)-T1-Q4 (1) wherein R1 and R2 represent H or the like; Q1 represents an aromatic ring, heterocyclic ring or the like; Q2 represents a single bond, aromatic ring, heterocyclic ring or the like; Q3 represents a group or the like, Q4 represents an aromatic ring, heterocyclic ring or the like; and T1 represents —CO— or —SO2—, and a medicine which comprises the compound and is useful for thrombosis and embolism.
摘要翻译：本发明涉及由式（1）表示的化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？> Q-1 -Q2 -C（-O）-N（R 1） - Q 3 -N（R 2） - T O （1）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R 1 和R 2代表H等; Q 1表示芳环，杂环等; Q 2表示单键，芳环，杂环等; Q 3表示一个或多个基团，Q 4表示芳环，杂环等; 和T 1表示-CO - 或-SO 2 - ，以及包含该化合物并用于血栓形成和栓塞的药物。

16. 发明授权

US07192968B2 Ethylenediamine derivatives 失效
标题翻译：乙二胺衍生物
公开(公告)号：US07192968B2
公开(公告)日：2007-03-20
申请号：US10240725
申请日：2001-04-05
申请人： Toshiharu Yoshino , Tsutomu Nagata , Noriyasu Haginoya , Kenji Yoshikawa , Hideyuki Kanno , Masatoshi Nagamochi
发明人： Toshiharu Yoshino , Tsutomu Nagata , Noriyasu Haginoya , Kenji Yoshikawa , Hideyuki Kanno , Masatoshi Nagamochi
IPC分类号： C07D237/26 , C07D471/02 , C07D209/02 , A61K31/495 , A61K31/44
CPC分类号： C07D513/04 , C07D213/56 , C07D487/04 , C07D495/04 , C07D498/04
摘要： The invention relates a compound represented by the formula (1): Q1-Q2-C(═O)—N(R1)-Q3-N(R2)-T1-Q4 (1) wherein R1 and R2 represent H or the like; Q1 represents an aromatic ring, heterocyclic ring or the like; Q2 represents a single bond, aromatic ring, heterocyclic ring or the like; Q3 represents a group or the like, Q4 represents an aromatic ring, heterocyclic ring or the like; and T1 represents —CO— or —SO2—, and a medicine which comprises the compound and is useful for thrombosis and embolism.
摘要翻译：本发明涉及由式（1）表示的化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？> Q-1 -Q2 -C（-O）-N（R 1） - Q 3 -N（R 2） - T O （1）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R 1 和R 2代表H等; Q 1表示芳环，杂环等; Q 2表示单键，芳环，杂环等; Q 3表示一个或多个基团，Q 4表示芳环，杂环等; 和T 1表示-CO - 或-SO 2 - ，以及包含该化合物并用于血栓形成和栓塞的药物。

17. 发明申请

US20070129371A1 Novel ethylenediamine derivatives 审中-公开
公开(公告)号：US20070129371A1
公开(公告)日：2007-06-07
申请号：US10539995
申请日：2003-12-24
申请人： Yumi Nakamoto , Toshiharu Yoshino , Hiroyuki Naito , Tsutomu Nagata , Kenji Yoshikawa , Makoto Suzuki
发明人： Yumi Nakamoto , Toshiharu Yoshino , Hiroyuki Naito , Tsutomu Nagata , Kenji Yoshikawa , Makoto Suzuki
IPC分类号： A61K31/519 , A61K31/503 , A61K31/501 , A61K31/517 , A61K31/497 , A61K31/498
CPC分类号： C07D417/12 , C07D213/75
摘要： A compound represented by the following formula (1): Q1—Q2—To—N(R1)—Q3—N(R2)—T1—Q4 (1) [wherein, R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may have a substituent, or the like; Q2 is a single bond or the like; Q3 represents the following group: —C(R3a)(R4a)—{C(R3b)(R4b)}m1—{C(R3c)(R4c)}m2—{C(R3d)(R4d)}m3—{C(R3e)(R4e)}m4—C (R3f)(R4f)— (in which, R3a to R4e represent hydrogen or the like); T0 represents a carbonyl group or the like; and T1 represents —COCONR— or the like]; or salt thereof, solvate thereof, or N-oxide thereof. The compound is useful as a preventive and/or therapeutic agent for cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

18. 发明申请

US20130029964A1 [5, 6] HETEROCYCLIC COMPOUND 审中-公开
标题翻译： [5,6]杂环化合物
公开(公告)号：US20130029964A1
公开(公告)日：2013-01-31
申请号：US13595608
申请日：2012-08-27
申请人： Kazumasa Aoki , Satoshi Matsui , Kenji Yoshikawa , Hiroki Shimizu , Junko Sasaki , Katsuyoshi Nakajima , Osamu Kanno , Kiyoshi Oizumi
发明人： Kazumasa Aoki , Satoshi Matsui , Kenji Yoshikawa , Hiroki Shimizu , Junko Sasaki , Katsuyoshi Nakajima , Osamu Kanno , Kiyoshi Oizumi
IPC分类号： A61K31/4184 , C07D471/04 , A61K31/437 , C07D235/14 , C07D401/10 , C07D413/10 , A61K31/5377 , C07D405/12 , C07D491/056 , A61K31/4188 , C07D403/10 , A61K31/496 , A61K31/506 , A61K31/454 , A61K31/4439 , A61P19/08 , A61P19/10 , C07D235/12
CPC分类号： C07D235/06 , A61K31/4184 , A61K31/4188 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , C07D401/04 , C07D403/04 , C07D405/12 , C07D405/14 , C07D417/04 , C07D471/04 , C07D491/056
摘要： An object of the present invention is to provide a novel low molecular weight compound exhibiting an osteogenesis-promoting action. This object is achieved by a compound having the general formula (I) or a pharmacologically acceptable salt thereof. In the general formula (I), R1 and R2 represent hydrogen atoms, and the like; R3 represents a hydrogen atom, and the like; X, Y, and Z represent nitrogen atoms, and the like; A represents a phenylene group, and the like; n represents 1 or 2, and the like; and V and W represent oxygen atoms, and the like.
摘要翻译：本发明的目的是提供一种表现出成骨促进作用的新型低分子量化合物。该目的通过具有通式（I）的化合物或其药理学上可接受的盐来实现。在通式（I）中，R 1和R 2表示氢原子等; R3表示氢原子等; X，Y和Z表示氮原子等; A表示亚苯基等; n表示1或2，等等; V和W表示氧原子等。

19. 发明授权

US08131434B2 Engine speed control system for work vehicle 有权
标题翻译：工作车辆发动机转速控制系统
公开(公告)号：US08131434B2
公开(公告)日：2012-03-06
申请号：US12212202
申请日：2008-09-17
申请人： Eiji Nishi , Nobuyuki Okabe , Kenji Yoshikawa
发明人： Eiji Nishi , Nobuyuki Okabe , Kenji Yoshikawa
IPC分类号： G06F7/70 , F02D41/08
CPC分类号： F02D31/009 , F02D11/105
摘要： An engine speed control system for a work vehicle comprises a pedal sensor (32) for detecting an operative position of an accelerator pedal (31); a foot accelerator controller for carrying out foot accelerator control in which the engine speed that corresponds to an output of the pedal sensor (32) is used as a target rotational speed; and upper limit setting device (35) for setting the upper limit of the engine speed. The upper limit rotation control in which the upper limit rotational speed is used as the target rotational speed is carried out when the target engine speed is greater than the upper limit rotational speed set by the upper limit setting device (35).
摘要翻译：一种用于工作车辆的发动机速度控制系统包括用于检测加速器踏板（31）的操作位置的踏板传感器（32）; 用于执行脚踏加速器控制的脚踏加速器控制器，其中将与踏板传感器（32）的输出相对应的发动机速度用作目标转速; 以及用于设定发动机转速的上限的上限设定装置（35）。当目标发动机转速大于由上限设定装置（35）设定的上限转速时，进行上限转速用作目标转速的上限转动控制。

20. 发明授权

US07930084B2 Engine speed control system for work vehicle 有权
标题翻译：工作车辆发动机转速控制系统
公开(公告)号：US07930084B2
公开(公告)日：2011-04-19
申请号：US12212325
申请日：2008-09-17
申请人： Eiji Nishi , Nobuyuki Okabe , Kenji Yoshikawa
发明人： Eiji Nishi , Nobuyuki Okabe , Kenji Yoshikawa
IPC分类号： G06F7/70 , F02D41/08
CPC分类号： B60W10/06 , B60W30/188 , B60W2540/10 , B60W2540/16 , B60W2710/0644 , E02F9/2066 , F02D31/001 , F02D2200/602 , F02D2200/604
摘要： The engine speed control system for a work vehicle has a foot accelerator controller for carrying out foot accelerator control based on a pedal sensor, a hand accelerator controller for carrying out hand accelerator control based on a lever sensor, a manually operated input device, storage means for storing a predetermined engine speed, and a constant rotation controller for carrying out constant rotation control in which the engine speed stored in the storage means is used as the target rotational speed on the basis of an input to the input device. The constant rotation control is carried out when the input device has been operated in the case that the engine speed that corresponds to the output of the lever sensor is greater than an idling speed, and the constant rotation control is terminated when the input device is operated in the case that the engine speed that corresponds to the output of the lever sensor is equal to or less than the idling speed.
摘要翻译：工作车辆的发动机转速控制系统具有脚踏加速器控制器，用于基于踏板传感器执行脚踏加速器控制，用于执行基于杠杆传感器的手加速器控制的手加速器控制器，手动操作的输入装置，存储装置以及用于进行恒定旋转控制的恒定旋转控制器，所述恒定旋转控制器根据对所述输入装置的输入，将存储在所述存储装置中的发动机转速用作所述目标转速。在对应于杠杆传感器的输出的发动机转速大于空转速度的情况下，当输入装置被操作时，执行恒定旋转控制，并且当输入装置被操作时终止恒定旋转控制在与传感器的输出对应的发动机转速等于或小于空转速度的情况下。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式