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11. 发明申请

US20120077827A1 ZAP-70 ACTIVE COMPOUNDS 有权
标题翻译： ZAP-70活性化合物
公开(公告)号：US20120077827A1
公开(公告)日：2012-03-29
申请号：US13244071
申请日：2011-09-23
申请人： Prabha N. Ibrahim , Chao Zhang
发明人： Prabha N. Ibrahim , Chao Zhang
IPC分类号： A61K31/519 , C12N9/99 , A61P37/08 , A61P35/00 , A61P29/00 , C07D487/04 , A61P35/02
CPC分类号： C07D487/04
摘要： Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on one or more protein kinases, including a Zeta-chain-associated protein kinase 70 (ZAP-70), and any mutations thereof.
摘要翻译：其化合物及其盐，其制剂，其缀合物，其衍生物，其形式及用途。在某些方面和实施方案中，所述的化合物或其盐，其制剂，其缀合物，其衍生物，其形式在一种或多种蛋白激酶（包括Zeta-链相关蛋白激酶70（ZAP-70））和其任何突变。

12. 发明授权

US08143271B2 Compounds and methods for kinase modulation, and indications therefor 失效
公开(公告)号：US08143271B2
公开(公告)日：2012-03-27
申请号：US13216200
申请日：2011-08-23
申请人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Chao Zhang , Jiazhong Zhang , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Hanna Cho
发明人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Chao Zhang , Jiazhong Zhang , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Hanna Cho
IPC分类号： C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , A01N43/42 , A61K31/44
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

13. 发明申请

US20110319436A1 Methods and Compositions for Modulating IRE1, SRC, and ABL Activity 有权
标题翻译：调节IRE1，SRC和ABL活性的方法和组合
公开(公告)号：US20110319436A1
公开(公告)日：2011-12-29
申请号：US13119162
申请日：2009-09-15
申请人： Peter Walter , Alexei Korennykh , Kevan M. Shokat , Chao Zhang , Janet Finer-Moore , Robert Stroud , Pascal Egea , Andrei Korostelev , Arvin Dar , Sebastian Bernales
发明人： Peter Walter , Alexei Korennykh , Kevan M. Shokat , Chao Zhang , Janet Finer-Moore , Robert Stroud , Pascal Egea , Andrei Korostelev , Arvin Dar , Sebastian Bernales
IPC分类号： A61K31/517 , C07D403/12 , C07D409/14 , C07D417/14 , A61K31/506 , C12N5/071 , A61K31/404 , A61P35/00 , A61P29/00 , A61P25/00 , A61P3/10 , A61P27/02 , A61P25/28 , A61P25/16 , C12Q1/48 , C07D403/14
CPC分类号： C07D403/12 , A61K31/4155 , A61K31/497 , C07D401/14 , C07D403/14
摘要： Disclosed herein are, inter alia, compositions for modulating Ire1, Src, or Abl, methods for identifying modulating activity in test compounds, and methods for treating diseases caused by the activity or inactivity of Ire1, Src, or Abl.
摘要翻译：本文公开了尤其用于调节Ire1，Src或Ab1的组合物，用于鉴定测试化合物中调节活性的方法，以及用于治疗由Ire1，Src或Abl的活性或不活动引起的疾病的方法。

14. 发明授权

US08053463B2 PPAR active compounds 有权
标题翻译： PPAR活性化合物
公开(公告)号：US08053463B2
公开(公告)日：2011-11-08
申请号：US12043069
申请日：2008-03-05
申请人： Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
发明人： Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
IPC分类号： C07D209/04 , C07D401/02 , A61K31/454 , A61K31/404
CPC分类号： C07D401/12 , C07D209/18 , C07D403/12
摘要： Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ, wherein the compounds have the formula: wherein: X2 and X3 are independently CH or N; and one of X1 and X4 is N or CR4 and the other of X1 and X4 is N or CH.
摘要翻译：描述了对PPARα，PPARδ和PPARγ中的至少一种有活性的化合物，其可用于涉及调节PPARα，PPARδ和PPARγ中的至少一种的治疗和/或预防方法，其中所述化合物具有下式：其中：X2和X3独立地是CH或N; X1和X4之一是N或CR4，X1和X4中的另一个是N或CH。

15. 发明授权

US07702178B2 Method and apparatus for providing noise reduction 有权
标题翻译：用于提供降噪的方法和装置
公开(公告)号：US07702178B2
公开(公告)日：2010-04-20
申请号：US11081255
申请日：2005-03-15
申请人： James Bergen , Chao Zhang , Gooitzen Van Der Wal
发明人： James Bergen , Chao Zhang , Gooitzen Van Der Wal
IPC分类号： G06K9/40
CPC分类号： H04N5/144 , G06T5/002 , G06T5/30 , G06T5/50 , G06T2207/10016 , G06T2207/20016 , H04N5/21 , H04N5/213
摘要： A method and apparatus for reducing noise in at least one frame in an image sequence is disclosed. A minimum function is applied to the at least one frame to produce a plurality of minimum values. A mask is generated in accordance with the plurality of minimum values. The mask is applied to reduce the noise in the at least one frame. In one embodiment, impulse noise is reduced. In another embodiment wideband non-linear noise is reduced.
摘要翻译：公开了一种降低图像序列中的至少一帧中的噪声的方法和装置。最小功能被应用于至少一个帧以产生多个最小值。根据多个最小值生成掩模。应用掩模以减少至少一个帧中的噪声。在一个实施例中，脉冲噪声减小。在另一个实施例中，宽带非线性噪声减小。

16. 发明申请

US20090286793A1 PDE4B INHIBITORS AND USES THEREFOR 有权
标题翻译： PDE4B抑制剂及其用途
公开(公告)号：US20090286793A1
公开(公告)日：2009-11-19
申请号：US12506222
申请日：2009-07-20
申请人： Prabha N. Ibrahim , Hanna Cho , Bruce England , Sam Gillette , Dean R. Artis , Rebecca Zuckerman , Chao Zhang
发明人： Prabha N. Ibrahim , Hanna Cho , Bruce England , Sam Gillette , Dean R. Artis , Rebecca Zuckerman , Chao Zhang
IPC分类号： A61K31/4365 , C07D471/04 , C07D413/14 , A61K31/5377 , A61P11/00 , A61P25/00 , A61P35/00 , A61P19/00
CPC分类号： C07C311/48 , C07D215/36 , C07D215/40 , C07D231/12 , C07D239/18 , C07D239/46 , C07D275/04 , C07D277/42 , C07D277/62 , C07D333/36 , C07D333/38 , C07D333/40 , C07D401/12 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要： Compounds active on phosphodiesterase PDE4B are provided. Also provided herewith are compositions useful for treatment of PDE4B-mediated diseases or conditions, and methods for the use thereof.
摘要翻译：提供了磷酸二酯酶PDE4B活性的化合物。本文还提供了可用于治疗PDE4B介导的疾病或病症的组合物及其使用方法。

17. 发明授权

US07605168B2 PDE4B inhibitors 有权
标题翻译： PDE4B抑制剂
公开(公告)号：US07605168B2
公开(公告)日：2009-10-20
申请号：US11219635
申请日：2005-09-02
申请人： Prabha N. Ibrahim , Ryan Bremer , Sam Gillette , Hanna Cho , Marika Nespi , Shumeye Mamo , Chao Zhang , Dean R. Artis , Byunghun Lee , Rebecca Zuckerman
发明人： Prabha N. Ibrahim , Ryan Bremer , Sam Gillette , Hanna Cho , Marika Nespi , Shumeye Mamo , Chao Zhang , Dean R. Artis , Byunghun Lee , Rebecca Zuckerman
IPC分类号： A61K31/437 , A61K31/403 , C07D471/02 , C07D405/02
CPC分类号： C07D471/04 , C07D209/12 , C07D401/12 , C07D405/04 , G06F19/16 , G06F19/706
摘要： Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and structural information for identifying molecular scaffolds, for developing ligands that bind to and modulate PDE4B, and for identifying improved ligands based on known ligands.
摘要翻译：描述了在PDE4上有活性的化合物。还描述了使用X射线晶体学测定的PDE4B的晶体结构，使用PDE4B晶体和用于鉴定分子支架的结构信息，用于开发结合和调节PDE4B的配体，以及基于已知配体鉴定改进的配体。

18. 发明申请

US20090181988A1 Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof 审中-公开
标题翻译：吡唑并嘧啶衍生物及其使用方法
公开(公告)号：US20090181988A1
公开(公告)日：2009-07-16
申请号：US12194469
申请日：2008-08-19
申请人： Masahiro Tanaka , Chao Zhang , Kevan M. Shokat , Alma L. Burlingame , Kirk Hansen , Raynard L. Bateman , Stephen G. DiMagno
发明人： Masahiro Tanaka , Chao Zhang , Kevan M. Shokat , Alma L. Burlingame , Kirk Hansen , Raynard L. Bateman , Stephen G. DiMagno
IPC分类号： A61K31/522 , C12Q1/02 , C07D473/34 , A61K31/519 , C07D473/30 , A61K31/52 , C07D487/04 , A61P35/00
CPC分类号： C07D487/04
摘要： This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. More specifically, the invention relates to pyrazolo pyrimidine derivatives, including derivatives and analogs of SDR inhibitors, pharmaceutical compositions containing derivatives and analogs of SDR inhibitors, methods of making derivatives and analogs of SDR inhibitors and methods of use thereof.
摘要翻译：本发明一般涉及用作特别是NAD（P）（H）依赖性氧化还原酶的短链脱氢酶/还原酶（SDR）家族的抑制剂的吡唑并嘧啶衍生物。更具体地，本发明涉及吡唑并嘧啶衍生物，包括SDR抑制剂的衍生物和类似物，含有SDR抑制剂的衍生物和类似物的药物组合物，制备SDR抑制剂的衍生物和类似物的方法及其使用方法。

19. 发明授权

US07529781B2 Online initial mirror synchronization and mirror synchronization verification in storage area networks 有权
标题翻译：存储区域网络中的在线初始镜像同步和镜像同步验证
公开(公告)号：US07529781B2
公开(公告)日：2009-05-05
申请号：US10837248
申请日：2004-04-30
申请人： Robert Tower Frey , Chao Zhang , Poulo Kuriakose , Rajesh Ananthanarayanan , Hawkins Yao
发明人： Robert Tower Frey , Chao Zhang , Poulo Kuriakose , Rajesh Ananthanarayanan , Hawkins Yao
IPC分类号： G06F17/30
CPC分类号： G06F3/0611 , G06F3/065 , G06F3/0659 , G06F3/067 , G06F11/2069 , Y10S707/99931 , Y10S707/99945 , Y10S707/99955
摘要： Systems and methods in accordance with various disclosed embodiments can manage a mirrored virtual target to synchronize the members of the virtual target and/or to verify that the members of the virtual target are synchronized. In one embodiment, a mirrored virtual target is synchronized by first provisioning at least one first internal virtual logical unit (IVLU) corresponding to at least one destination target of the mirrored target and a second IVLU corresponding to a source target of the mirrored target. A write command is first issued, via one or more internal virtual logical units, to each of the destination target members of the mirrored target. When each destination target is available to receive data, as evidenced by a returned transfer ready signal, a read command is provided to the source target via the second internal virtual logical unit. In this manner, a data path between the source and destination targets is established prior to reading data from the source target. Accordingly, the data can be read from the source target, converted to write data, and routed to the destination targets at line speed without buffering of the data. A similar process is provided to verify that the members of a mirrored target are synchronized. In one embodiment, a system and method is provided to manage incoming commands for the mirrored target while synchronizing or verifying synchronization of the mirrored target. Incoming commands can be queued as they are received and provided to the mirrored target when pending synchronization or verification commands are completed.
摘要翻译：根据各种公开的实施例的系统和方法可以管理镜像的虚拟目标以同步虚拟目标的成员和/或验证虚拟目标的成员是否同步。在一个实施例中，通过首先配置对应于镜像目标的至少一个目的地目标的至少一个第一内部虚拟逻辑单元（IVLU）和对应于所述镜像目标的源目标的第二IVLU来同步镜像的虚拟目标。写入命令首先通过一个或多个内部虚拟逻辑单元发送到镜像目标的每个目标目标成员。当每个目标目标可用于接收数据时，如通过返回的传送就绪信号所证明的，经由第二内部虚拟逻辑单元向源目标提供读取命令。以这种方式，在从源目标读取数据之前建立源目标和目标目标之间的数据路径。因此，可以从源目标读取数据，转换为写入数据，并以线速度路由到目标目标，而不缓冲数据。提供了类似的过程来验证镜像目标的成员是否同步。在一个实施例中，提供了系统和方法来管理镜像目标的传入命令，同时或验证镜像目标的同步。接收到的命令可以被接收到排队，并在挂起同步或验证命令完成时提供给镜像目标。

20. 发明授权

US07429596B2 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof 有权
标题翻译： 1H-吡咯并[2,3-D]嘧啶衍生物及其使用方法
公开(公告)号：US07429596B2
公开(公告)日：2008-09-30
申请号：US10871732
申请日：2004-06-18
申请人： Masahiro Tanaka , Chao Zhang , Kevan M. Shokat , Alma L. Burlingame , Kirk Hansen , Raynard L. Bateman , Stephen G. DiMagno
发明人： Masahiro Tanaka , Chao Zhang , Kevan M. Shokat , Alma L. Burlingame , Kirk Hansen , Raynard L. Bateman , Stephen G. DiMagno
IPC分类号： C07D487/04 , C07D413/06 , A61K31/519 , A61K31/675 , A61K31/662 , A61K31/497 , A61K31/5355 , C07F9/38 , A61P35/04 , A61P35/02
CPC分类号： C07D487/04
摘要： This invention generally relates to pyrazolo pyrimidine derivatives useful as inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. The invention further relates to pharmaceutical compositions and methods of preventing or treating disease with 1H-Pyrrolo[2.3-d]pyrimidine derivatives. More specifically, the invention relates to a 1H-Pyrrolo[2.3-d]pyrimidine which is a compound of Formula I or II: or a pharmaceutically-acceptable salt or prodrug thereof; wherein: Y is N or CR5; Z is NR3R4, halo, H, OH, alkyl, alkyloxy, or haloalkyl; and R1a is indolyl, thiazolyl, benzyl, biphenylyl, thiophenyl, pyrrolyl, or phenyl, wherein said phenyl is substituted with at least one of OH, —NR3R4, —C(═O)NR6R7, —CN, NO2—C(═O)OH, —C(═O)O-alkyl, (C1-C4)alkyl, halo, haloalkyl or haloaryl; and wherein said indolyl, thiazolyl, benzyl, biphenylyl, thiophenyl, or pyrrolyl is optionally substituted with OH, —NR3R4, —C(═O)NR6R7, —CN, NO2, —C(═O)O—R3, (C1-C4)alkyl, halo, haloalkyl or haloaryl.
摘要翻译：本发明一般涉及可用作NAD（P）（H）依赖性氧化还原酶的短链脱氢酶/还原酶（SDR）家族的抑制剂的吡唑并嘧啶衍生物。本发明还涉及用1H-吡咯并[2,3-d]嘧啶衍生物预防或治疗疾病的药物组合物和方法。更具体地，本发明涉及作为式I或II化合物的1H-吡咯并[2,3-d]嘧啶或其药学上可接受的盐或前药; 其中：Y是N或CR 5; Z是NR 3 R 4，卤素，H，OH，烷基，烷氧基或卤代烷基; 并且R 1a是吲哚基，噻唑基，苄基，联苯基，噻吩基，吡咯基或苯基，其中所述苯基被OH，-NR 3 R 3中的至少一个取代， -C（-O）NR 6 R 7，-CN，NO 2 -C（-O（O））OH，-C（-O）O-烷基，（C 1 -C 4 -C 4）烷基，卤素，卤代烷基或卤代芳基; 并且其中所述吲哚基，噻唑基，苄基，联苯基，噻吩基或吡咯基任选被OH，-NR 3 R 4，-C（ - ）NR -C（O）OR 3，-C（-O）OR 3，（C 1 -C 6） C 1 -C 4烷基，卤素，卤代烷基或卤代芳基。

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